Sequence IGHV1-3*i01
Details
| Species | Human |
| Species subgroup | |
| Subgroup type | |
| Sequence Name | IGHV1-3*i01 |
| IUIS Name | IGHV1-3*04 |
| Alternative names | |
| Affirmation Level | 1 |
| Full Sequence | |
| Coding Sequence | |
| Functionality | F |
| Inference Type | Rearranged Only |
| Alternative names | |
| Paralogs |
Evidence
The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.
'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.
| Submission ID | Accession No | Subject ID | Genotype Name | Sequence Name | Sequence Match |
|---|---|---|---|---|---|
| S00006 | MH779622 | B16 | B16 | IGHV1-3*01_S1455 |
Supporting Observations
Sequences in other published genotypes which have been identified by IARC and support the inference:
Observations in VDJbase
Inferred sequences in VDJbase that match this sequence:
Un-rearranged Observations
Un-rearranged sequence observations that support this sequence:
Additional Information
| Sequence ID | A00007 |
| Curator address | School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney Australia |
| Version | 5 |
| Release Date | 2019-05-16 |
| Release Notes | Updated with infomation of the IMGT gene name |
| Locus | IGH |
| Sequence Type | V |
| Gene Subgroup | 1 |
| Gene Designation | 3 |
| Allele Designation | i01 |
Notes
Notes are added by IARC reviewers.
| Originally approved by IARC on March 9, 2018. “The sequence was inferred [..] using IgDiscover, and [..] using both Partis and TIgGER. The number of unique CDR3 used by sequences with exact matches to the inferred germline allele represents 1.3% of all unique CDR3 [unmutated frequency: 1.17%] associated to exact IGHV matches in the genotype, according to IgDiscover. There were at least 775 unique rearrangements, utilizing 22 D genes and 7 J genes. The allele was the more frequently utilized allele, with an expression ratio of 56:44 with the *01 allele. The inference was supported by haplotype analysis using IGHJ6*02/*03.” (April 12, 2019) A trailing “.” in the sequence indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation. |
Attachments
History
History logs the times and reasons for the publication of each version of this sequence.
| Mats Ohlin 2018-12-21 12:09:07 | Version 1 published Submission published by IARC on Dec 21, 2018. |
| Mats Ohlin 2019-04-12 14:30:09 | Version 2 published Version 2 published |
| Mats Ohlin 2019-04-12 14:31:16 | Version 3 published In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 319. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation. |
| Mats Ohlin 2019-04-12 14:52:06 | Version 4 published A trailing “.” in the sequence indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation. |
| Mats Ohlin 2019-05-16 21:46:24 | Version 5 published Updated with infomation of the IMGT gene name |
Changes from previous version
| v4 | v5 | |
|---|---|---|
| IUIS Name | IGHV1-3*04 |
Versions
All published versions of this sequence.
| Sequence Name | IMGT Name | Alternative names | Inference Type | Affirmation Level | Species subgroup | Subgroup type | Version | Date |
|---|---|---|---|---|---|---|---|---|
| IGHV1-3*i01 | Rearranged Only | 1 | 1 | 2018-12-21 | ||||
| IGHV1-3*i01 | Rearranged Only | 1 | 2 | 2019-04-12 | ||||
| IGHV1-3*i01 | Rearranged Only | 1 | 3 | 2019-04-12 | ||||
| IGHV1-3*i01 | Rearranged Only | 1 | 4 | 2019-04-12 | ||||
| IGHV1-3*i01 | IGHV1-3*04 | Rearranged Only | 1 | 5 | 2019-05-16 |