The immune receptors of B and T cells are central to the body's response to pathogens, and implicated in autoimmune disease. High-throughput sequencing of receptor repertoires - AIRR-Seq - is widely used to study receptor development, however a comprehensive understanding of the genes from which development starts - the germline genes - is crucial for accurate interpretation. Our knowledge of human receptor alleles is incomplete, and that of other species at an early stage. OGRDB is an open database of newly discovered alleles, through which researchers can contribute newly discovered alleles for analysis, and download those that have been reviewed and affirmed. Read more...
We have published IGHV germline sets for laboratory mouse strains BALB/c and C75BL/6, as recently reported in preprint by Jackson et al.The sets will be curated by the AIRR Community Germline Database Working Group with the aim of maintaining sets that are tuned for use in AIRR-seq, taking advantage of the latest research. We hope… Continue reading First Germline Sets Published on OGRDB
A new batch of inferred receptor sequences, submitted for review through OGRDB, has been accepted by IMGT and should be added to their reference sets shortly. This batch included the first IGK and IGL alleles. We have now affirmed a total of 32 sequences, details of which can be found on the Sequences page.
We welcome submissions of previously undocumented alleles of human receptor genes. The Submission Guide explains the process, which involves deposition of sequences and sequence sets in NIH or ENA repositories. Your submission will be reviewed by AIRR‘s Inferred Allele Review Committee, and, if there is sufficient evidence, the sequence will be published on this site… Continue reading IARC Submission Guide Updated
OGRDB is now accepting V- and J- sequence inferences from the human BCR light and heavy chain. Analysis scripts and submission pages have been updated accordingly.
If you use OGRDB in your research, please cite this paper:
OGRDB: a reference database of inferred immune receptor genes
Lees et al., Nucleic Acids Research, September 2019.
Acknowledgements and citations for individual sequences are provided under each sequence and submission.