Details

SpeciesHuman
Species subgroup
Subgroup type
Sequence NameIGHV1-3*04
IUIS NameIGHV1-3*04
Alternative namesIGHV1-3*i01
Affirmation Level1
Full Sequence
Coding Sequence
FunctionalityORF
Inference TypeRearranged Only
MappedFalse
Paralogs
Paralog RepFalse

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

AccessionTypeRepositoryStartEnd
MH779622InferredGenBank1295

Observations in AIRR-seq Repertoires

Click here to review supporting data in VDJbase.

Clicking the link will take you to VDJbase. Open in a new tab if you want to keep this page open. In VDJbase, click on the count in the Apperances column to see a list of samples in which the sequence was found.

Extension

3' ExtensionA
3' start
3' end

Additional Information

Sequence IDA00007
CuratorWilliam Lees
Curator addressBirkbeck College, University of London, Malet Street, London
Version6
Release Date2023-07-10
Release Notes

Bulk upload of sequences for the AIRR-C Human IG germline sets

LocusIGH
Sequence TypeV
Gene Subgroup1
Gene Designation3
Allele Designation04

Acknowledgements

Individuals acknowledged as contributing to this sequence:

No Items

Notes

Notes are added by IARC reviewers.

Originally approved by IARC on March 9, 2018.

“The sequence was inferred [..] using IgDiscover, and [..] using both Partis and TIgGER. The number of unique CDR3 used by sequences with exact matches to the inferred germline allele represents 1.3% of all unique CDR3 [unmutated frequency: 1.17%] associated to exact IGHV matches in the genotype, according to IgDiscover. There were at least 775 unique rearrangements, utilizing 22 D genes and 7 J genes. The allele was the more frequently utilized allele, with an expression ratio of 56:44 with the *01 allele. The inference was supported by haplotype analysis using IGHJ6*02/*03.”

(April 12, 2019) A trailing “.” in the sequence indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation.

Additional information for this sequence was imported into OGRDB via bulk update with the following notes:
Sequence annotation is based on Genbank sample MH779622

Attachments

No Items

History

History logs the times and reasons for the publication of each version of this sequence.

Mats Ohlin
2018-12-21 12:09:07
Version 1 published

Submission published by IARC on Dec 21, 2018.

Mats Ohlin
2019-04-12 14:30:09
Version 2 published

Version 2 published

Mats Ohlin
2019-04-12 14:31:16
Version 3 published

In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 319. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation.

Mats Ohlin
2019-04-12 14:52:06
Version 4 published

A trailing “.” in the sequence indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation.

Mats Ohlin
2019-05-16 21:46:24
Version 5 published

Updated with infomation of the IMGT gene name

William Lees
2023-07-10 11:24:35
Version 6 published

Bulk upload of sequences for the AIRR-C Human IG germline sets

Changes from previous version

v5v6
CuratorWilliam Lees
Curator addressSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney AustraliaBirkbeck College, University of London, Malet Street, London
Sequence NameIGHV1-3*i01IGHV1-3*04
Alternative namesIGHV1-3*i01
MappedFalse
FunctionalityFORF
Species subgroup
Subgroup type
Allele Designationi0104
Full Sequence
Coding Sequence
Gene start1
Gene end295
Paralog RepFalse
Extension?FalseTrue
3' ExtensionA
5' Extension
curational_tagslikely_truncated
Noteschanged

Versions

All published versions of this sequence.

Sequence NameIMGT NameAlternative namesInference TypeAffirmation LevelSpecies subgroupSubgroup typeVersionDate
IGHV1-3*i01Rearranged Only112018-12-21
IGHV1-3*i01Rearranged Only122019-04-12
IGHV1-3*i01Rearranged Only132019-04-12
IGHV1-3*i01Rearranged Only142019-04-12
IGHV1-3*i01IGHV1-3*04Rearranged Only152019-05-16
IGHV1-3*04IGHV1-3*04IGHV1-3*i01Rearranged Only162023-07-10