Sequence IGHV5-51*06
Details
| Species | Human |
| Species subgroup | |
| Subgroup type | none |
| Sequence Name | IGHV5-51*06 |
| IUIS Name | IGHV5-51*06 |
| Alternative names | IGHV5-51*i01 |
| Affirmation Level | 1 |
| Full Sequence | |
| Coding Sequence | |
| Functionality | ORF |
| Inference Type | Unrearranged and Rearranged |
| Mapped | True |
| Paralogs | |
| Paralog Rep | False |
Un-rearranged Observations
Un-rearranged sequence observations that support this sequence:
Observations in AIRR-seq Repertoires
Click here to review supporting data in VDJbase.
Clicking the link will take you to VDJbase. Open in a new tab if you want to keep this page open. In VDJbase, click on the count in the Apperances column to see a list of samples in which the sequence was found.
CDR delineation
| CDR1 Start | 76 |
| CDR1 End | 99 |
| CDR2 Start | 151 |
| CDR2 End | 174 |
| CDR3 Start | 289 |
Non-Core Regions
| UTR 5' Start | |
| UTR 5' End | |
| L-PART1 Start | |
| L-PART1 End | |
| L_PART1 | |
| L-PART2 Start | |
| L-PART2 End | |
| L_PART2 | |
| v_rs_start | |
| v_rs_end | |
| V_HEPTAMER | |
| V_NONAMER |
Extension
| 3' Extension | |
| 3' start | |
| 3' end | |
| 5' start | |
| 5' end |
Additional Information
| Sequence ID | A00013 |
| Curator | William Lees |
| Curator address | Birkbeck College, University of London, Malet Street, London |
| Version | 5 |
| Release Date | 2023-07-24 |
| Release Notes | Remove unsupported extension |
| Locus | IGH |
| Sequence Type | V |
| Gene Subgroup | 5 |
| Gene Designation | 51 |
| Allele Designation | 06 |
Notes
Notes are added by IARC reviewers.
| This sequence represents IGHV5-51*03 C228T in the IMGT numbering system. The committee noted a rearrangement frequency of 1.25%, with 1128 alignments including 304 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. The genotype showed the individual to be heterozygous at the IGHV5-51 locus, with the alternative IGHV5-51*03 allele being associated with 1539 sequences for an allele ratio of 42:58. The sequence was affirmed at level 1 at IARC Meeting 33 on March 15, 2019. The sequence is affirmed only up to and including base 318, the final base of the inference and its GenBank record, and of the corresponding closest allele (IGHV5-51*03) in the IMGT database. (April 12, 2019) A trailing “.” indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation. Additional information for this sequence was imported into OGRDB via bulk update with the following notes: |
Attachments
History
History logs the times and reasons for the publication of each version of this sequence.
| Andrew Collins 2019-04-02 22:39:35 | Version 1 published Submission published by IARC on April 3, 2019 |
| Mats Ohlin 2019-04-12 14:47:01 | Version 2 published A trailing “.” indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation. |
| Mats Ohlin 2019-05-16 21:56:33 | Version 3 published IMGT allele name added |
| William Lees 2023-07-10 11:24:42 | Version 4 published Bulk upload of sequences for the AIRR-C Human IG germline sets |
| William Lees 2023-07-24 14:12:43 | Version 5 published Remove unsupported extension |
Changes from previous version
| v3 | v5 | |
|---|---|---|
| Curator | William Lees | |
| Curator address | Dept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden | Birkbeck College, University of London, Malet Street, London |
| Sequence Name | IGHV5-51*i01 | IGHV5-51*06 |
| Alternative names | IGHV5-51*p13 | IGHV5-51*i01 |
| Mapped | True | |
| Functionality | F | ORF |
| Inference Type | Rearranged Only | Unrearranged and Rearranged |
| Species subgroup | ||
| Subgroup type | none | |
| Allele Designation | i01 | 06 |
| Full Sequence | ||
| Gene start | 1 | |
| Gene end | 294 | |
| CDR1 Start | 76 | |
| CDR1 End | 99 | |
| CDR2 Start | 151 | |
| CDR2 End | 174 | |
| CDR3 Start | 289 | |
| Codon Frame | 1 | |
| Paralog Rep | False | |
| curational_tags | likely_truncated | |
| Notes | changed |
Versions
All published versions of this sequence.
| Sequence Name | IMGT Name | Alternative names | Inference Type | Affirmation Level | Species subgroup | Subgroup type | Gene start | Gene end | UTR 5' Start | UTR 5' End | L-PART1 Start | L-PART1 End | L-PART2 Start | L-PART2 End | CDR1 Start | CDR1 End | CDR2 Start | CDR2 End | CDR3 Start | v_rs_start | v_rs_end | d_rs_3_prime_start | d_rs_3_prime_end | d_rs_5_prime_start | d_rs_5_prime_end | j_rs_start | j_rs_end | Codon Frame | Version | Date |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IGHV5-51*i01 | IGHV5-51*p13 | Rearranged Only | 1 | 1 | 2019-04-02 | |||||||||||||||||||||||||
| IGHV5-51*i01 | IGHV5-51*p13 | Rearranged Only | 1 | 2 | 2019-04-12 | |||||||||||||||||||||||||
| IGHV5-51*i01 | IGHV5-51*06 | IGHV5-51*p13 | Rearranged Only | 1 | 3 | 2019-05-16 | ||||||||||||||||||||||||
| IGHV5-51*06 | IGHV5-51*06 | IGHV5-51*i01 | Unrearranged and Rearranged | 1 | none | 1 | 294 | 76 | 99 | 151 | 174 | 289 | 1 | 5 | 2023-07-24 | |||||||||||||||
| IGHV5-51*06 | IGHV5-51*06 | IGHV5-51*i01 | Genomic Only | 1 | none | 1 | 294 | 76 | 99 | 151 | 174 | 289 | 1 | 6 | 2023-08-16 |