Details

SpeciesHuman
Species subgroup
Subgroup typenone
Sequence NameIGHV5-51*06
IUIS NameIGHV5-51*06
Alternative namesIGHV5-51*i01
Affirmation Level1
Full Sequence
Coding Sequence
FunctionalityORF
Inference TypeGenomic Only
MappedTrue
Paralogs
Paralog RepFalse

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

AccessionTypeRepositoryStartEnd
MK321694InferredGenBank1294

Observations in AIRR-seq Repertoires

Click here to review supporting data in VDJbase.

Clicking the link will take you to VDJbase. Open in a new tab if you want to keep this page open. In VDJbase, click on the count in the Apperances column to see a list of samples in which the sequence was found.

CDR delineation

CDR1 Start76
CDR1 End99
CDR2 Start151
CDR2 End174
CDR3 Start289

Non-Core Regions

UTR 5' Start
UTR 5' End
L-PART1 Start
L-PART1 End
L_PART1
L-PART2 Start
L-PART2 End
L_PART2
v_rs_start
v_rs_end
V_HEPTAMER
V_NONAMER

Extension

3' ExtensionCA
3' start319
3' end320
5' start
5' end

Additional Information

Sequence IDA00013
CuratorWilliam Lees
Curator addressBirkbeck College, University of London, Malet Street, London
Version6
Release Date2023-08-16
Release Notes

Further D sequences added with the support of Rodriguez et al. ‘Likely’ extensions added to three IGHV alleles. See Notes for details.

LocusIGH
Sequence TypeV
Gene Subgroup5
Gene Designation51
Allele Designation06

Acknowledgements

Individuals acknowledged as contributing to this sequence:

No Items

Notes

Notes are added by IARC reviewers.

This sequence represents IGHV5-51*03 C228T in the IMGT numbering system. The committee noted a rearrangement frequency of 1.25%, with 1128 alignments including 304 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. The genotype showed the individual to be heterozygous at the IGHV5-51 locus, with the alternative IGHV5-51*03 allele being associated with 1539 sequences for an allele ratio of 42:58. The sequence was affirmed at level 1 at IARC Meeting 33 on March 15, 2019. The sequence is affirmed only up to and including base 318, the final base of the inference and its GenBank record, and of the corresponding closest allele (IGHV5-51*03) in the IMGT database.

(April 12, 2019) A trailing “.” indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation.

Additional information for this sequence was imported into OGRDB via bulk update with the following notes:
Sequence annotation is based on Genbank sample MK321694
Mapped by IARC haplotype
Two nucleotide truncation at 3’ end

Attachments

No Items

History

History logs the times and reasons for the publication of each version of this sequence.

Andrew Collins
2019-04-02 22:39:35
Version 1 published

Submission published by IARC on April 3, 2019

Mats Ohlin
2019-04-12 14:47:01
Version 2 published

A trailing “.” indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation.

Mats Ohlin
2019-05-16 21:56:33
Version 3 published

IMGT allele name added

William Lees
2023-07-10 11:24:42
Version 4 published

Bulk upload of sequences for the AIRR-C Human IG germline sets

William Lees
2023-07-24 14:12:43
Version 5 published

Remove unsupported extension

William Lees
2023-08-16 13:47:31
Version 6 published

Further D sequences added with the support of Rodriguez et al. ‘Likely’ extensions added to three IGHV alleles. See Notes for details.

Changes from previous version

v5v6
Inference TypeUnrearranged and RearrangedGenomic Only
Extension?FalseTrue
3' ExtensionCA
3' start319
3' end320
5' Extension

Versions

All published versions of this sequence.

Sequence NameIMGT NameAlternative namesInference TypeAffirmation LevelSpecies subgroupSubgroup typeVersionDate
IGHV5-51*i01IGHV5-51*p13Rearranged Only112019-04-02
IGHV5-51*i01IGHV5-51*p13Rearranged Only122019-04-12
IGHV5-51*i01IGHV5-51*06IGHV5-51*p13Rearranged Only132019-05-16
IGHV5-51*06IGHV5-51*06IGHV5-51*i01Unrearranged and Rearranged1none52023-07-24
IGHV5-51*06IGHV5-51*06IGHV5-51*i01Genomic Only1none62023-08-16