Species subgroup
Subgroup type
Sequence NameIGHV4-4*i01
IUIS NameIGHV4-4*03 (now extended)
Alternative names
Affirmation Level1
Full Sequence
Coding Sequence
Inference TypeRearranged Only
Alternative names


The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.

'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.

Submission IDAccession NoSubject IDGenotype NameSequence NameSequence Match
S00006 MH779623B16B16IGHV4-4*01_S5769

Supporting Observations

Sequences in other published genotypes which have been identified by IARC and support the inference:

No Items

Observations in VDJbase

Inferred sequences in VDJbase that match this sequence:

No Items

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

No Items


3' Extensiontgcgagag
3' start312
3' end319

Additional Information

Sequence IDA00008
Curator addressSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney Australia
Release Date2018-12-21
Release Notes

Submission published by IARC on Dec 21, 2018.

Sequence TypeV
Gene Subgroup4
Gene Designation4
Allele Designationi01


Individuals acknowledged as contributing to this sequence:

NameInstitutionORCID ID
Davide BagnaraGenoa University, Department of Experimental Medicine, Laboratory of Molecular Immunology and Oncology, Genoa, Italy


Notes are added by IARC reviewers.

Originally approved by IARC on April 13, 2018.

“The sequence is present at relatively high frequency (0.6%), in the IgDiscover analysis. It was inferred by IgDiscover, TIger and Partis. Haplotype analysis showed two IGHV4-4-like sequences associated with the IGHJ6*02 haplotype – this inference and a second inference that is most similar to IGHV4-4*08. The likely major duplication of B16 is associated with the IGHJ6*03 haplotype. Given the similarities between IGHV4-4*08 and IGHV4-61, and given that this haplotype does not include an IGHV4-61 sequence, the committee concluded that this sequence could be accepted as Level 1. Although in this analysis the sequence was shown to be most similar to IGHV4-4*01, the committee believes that this inference extends the partial sequence IGHV4-4*03.”


No Items


History logs the times and reasons for the publication of each version of this sequence.

Mats Ohlin
2018-12-21 12:16:43
Version 1 published

Submission published by IARC on Dec 21, 2018.


All published versions of this sequence.

Sequence NameIMGT NameAlternative namesInference TypeAffirmation LevelSpecies subgroupSubgroup typeVersionDate
IGHV4-4*i01IGHV4-4*03 (now extended)Rearranged Only112018-12-21
IGHV4-4*i01IGHV4-4*03Rearranged Only122019-04-12