Species | Human |
Species subgroup | |
Subgroup type | |
Sequence Name | IGHV4-4*03 |
IUIS Name | IGHV4-4*03 |
Alternative names | IGHV4-4*i01 |
Affirmation Level | 1 |
Full Sequence | |
Coding Sequence | |
Functionality | ORF |
Inference Type | Rearranged Only |
Mapped | False |
Paralogs | |
Paralog Rep | False |
Un-rearranged sequence observations that support this sequence:
Accession | Type | Repository | Start | End |
---|---|---|---|---|
MH779623 | Inferred | GenBank | 1 | 295 |
Click here to review supporting data in VDJbase.
Clicking the link will take you to VDJbase. Open in a new tab if you want to keep this page open. In VDJbase, click on the count in the Apperances column to see a list of samples in which the sequence was found.
CDR1 Start | 76 |
CDR1 End | 102 |
CDR2 Start | 154 |
CDR2 End | 174 |
CDR3 Start | 289 |
3' Extension | A |
3' start | |
3' end |
Sequence ID | A00008 |
Curator | William Lees |
Curator address | Birkbeck College, University of London, Malet Street, London |
Version | 3 |
Release Date | 2023-07-10 |
Release Notes | Bulk upload of sequences for the AIRR-C Human IG germline sets |
Locus | IGH |
Sequence Type | V |
Gene Subgroup | 4 |
Gene Designation | 4 |
Allele Designation | 03 |
Notes are added by IARC reviewers.
Originally approved by IARC on April 13, 2018. “The sequence is present at relatively high frequency (0.6%), in the IgDiscover analysis. It was inferred by IgDiscover, TIger and Partis. Haplotype analysis showed two IGHV4-4-like sequences associated with the IGHJ6*02 haplotype – this inference and a second inference that is most similar to IGHV4-4*08. The likely major duplication of B16 is associated with the IGHJ6*03 haplotype. Given the similarities between IGHV4-4*08 and IGHV4-61, and given that this haplotype does not include an IGHV4-61 sequence, the committee concluded that this sequence could be accepted as Level 1. Although in this analysis the sequence was shown to be most similar to IGHV4-4*01, the committee believes that this inference extends the partial sequence IGHV4-4*03.” (April 12, 2019) In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 319. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation. Additional information for this sequence was imported into OGRDB via bulk update with the following notes: |
History logs the times and reasons for the publication of each version of this sequence.
Mats Ohlin 2018-12-21 12:16:43 | Version 1 published Submission published by IARC on Dec 21, 2018. |
Mats Ohlin 2019-04-12 14:35:18 | Version 2 published In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 319. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation. |
William Lees 2023-07-10 11:24:41 | Version 3 published Bulk upload of sequences for the AIRR-C Human IG germline sets |
v2 | v3 | |
---|---|---|
Curator | William Lees | |
Curator address | School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney Australia | Birkbeck College, University of London, Malet Street, London |
Sequence Name | IGHV4-4*i01 | IGHV4-4*03 |
Alternative names | IGHV4-4*i01 | |
Mapped | False | |
Functionality | F | ORF |
Species subgroup | ||
Subgroup type | ||
Allele Designation | i01 | 03 |
Full Sequence | ||
Gene start | 1 | |
Gene end | 295 | |
CDR1 Start | 76 | |
CDR1 End | 102 | |
CDR2 Start | 154 | |
CDR2 End | 174 | |
CDR3 Start | 289 | |
Paralogs | ||
Paralog Rep | False | |
3' Extension | tgcgagag | A |
3' start | 312 | |
3' end | 319 | |
curational_tags | likely_truncated | |
Notes | changed |
All published versions of this sequence.
Sequence Name | IMGT Name | Alternative names | Inference Type | Affirmation Level | Species subgroup | Subgroup type | Gene start | Gene end | UTR 5' Start | UTR 5' End | L-PART1 Start | L-PART1 End | L-PART2 Start | L-PART2 End | CDR1 Start | CDR1 End | CDR2 Start | CDR2 End | CDR3 Start | v_rs_start | v_rs_end | d_rs_3_prime_start | d_rs_3_prime_end | d_rs_5_prime_start | d_rs_5_prime_end | j_rs_start | j_rs_end | Codon Frame | Version | Date |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IGHV4-4*i01 | IGHV4-4*03 (now extended) | Rearranged Only | 1 | 1 | 2018-12-21 | |||||||||||||||||||||||||
IGHV4-4*i01 | IGHV4-4*03 | Rearranged Only | 1 | 2 | 2019-04-12 | |||||||||||||||||||||||||
IGHV4-4*03 | IGHV4-4*03 | IGHV4-4*i01 | Rearranged Only | 1 | 1 | 295 | 76 | 102 | 154 | 174 | 289 | 3 | 2023-07-10 |