Sequence IGHV4-4*03
Details
| Species | Homo sapiens |
| Species subgroup | |
| Subgroup type | |
| Sequence Name | IGHV4-4*03 |
| IUIS Name | IGHV4-4*03 |
| Alternative names | IGHV4-4*i01 |
| Affirmation Level | 1 |
| Full Sequence | |
| Coding Sequence | |
| Functionality | ORF |
| Inference Type | Rearranged Only |
| Mapped | False |
| Paralogs | |
| Paralog Rep | False |
Un-rearranged Observations
Un-rearranged sequence observations that support this sequence:
| Accession | Type | Repository | Start | End |
|---|---|---|---|---|
| MH779623 | Inferred | GenBank | 1 | 295 |
Observations in AIRR-seq Repertoires
Click here to review supporting data in VDJbase.
Clicking the link will take you to VDJbase. Open in a new tab if you want to keep this page open. In VDJbase, click on the count in the Apperances column to see a list of samples in which the sequence was found.
CDR delineation
| CDR1 Start | 76 |
| CDR1 End | 102 |
| CDR2 Start | 154 |
| CDR2 End | 174 |
| CDR3 Start | 289 |
Extension
| 3' Extension | A |
| 3' start | |
| 3' end |
Additional Information
| Sequence ID | A00008 |
| Curator | William Lees |
| Curator address | Birkbeck College, University of London, Malet Street, London |
| Version | 3 |
| Release Date | 2023-07-10 |
| Release Notes | Bulk upload of sequences for the AIRR-C Human IG germline sets |
| Locus | IGH |
| Sequence Type | V |
| Gene Subgroup | 4 |
| Gene Designation | 4 |
| Allele Designation | 03 |
| Gene start | 1 |
| Gene end | 295 |
Notes
Notes are added by IARC reviewers.
| Originally approved by IARC on April 13, 2018. “The sequence is present at relatively high frequency (0.6%), in the IgDiscover analysis. It was inferred by IgDiscover, TIger and Partis. Haplotype analysis showed two IGHV4-4-like sequences associated with the IGHJ6*02 haplotype – this inference and a second inference that is most similar to IGHV4-4*08. The likely major duplication of B16 is associated with the IGHJ6*03 haplotype. Given the similarities between IGHV4-4*08 and IGHV4-61, and given that this haplotype does not include an IGHV4-61 sequence, the committee concluded that this sequence could be accepted as Level 1. Although in this analysis the sequence was shown to be most similar to IGHV4-4*01, the committee believes that this inference extends the partial sequence IGHV4-4*03.” (April 12, 2019) In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 319. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation. Additional information for this sequence was imported into OGRDB via bulk update with the following notes: |
Attachments
History
History logs the times and reasons for the publication of each version of this sequence.
| Mats Ohlin 2018-12-21 12:16:43 | Version 1 published Submission published by IARC on Dec 21, 2018. |
| Mats Ohlin 2019-04-12 14:35:18 | Version 2 published In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 319. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation. |
| William Lees 2023-07-10 11:24:41 | Version 3 published Bulk upload of sequences for the AIRR-C Human IG germline sets |
Changes from previous version
| v2 | v3 | |
|---|---|---|
| Curator | William Lees | |
| Curator address | School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney Australia | Birkbeck College, University of London, Malet Street, London |
| Sequence Name | IGHV4-4*i01 | IGHV4-4*03 |
| Alternative names | IGHV4-4*i01 | |
| Mapped | False | |
| Functionality | F | ORF |
| Species subgroup | ||
| Subgroup type | ||
| Allele Designation | i01 | 03 |
| Full Sequence | ||
| Gene start | 1 | |
| Gene end | 295 | |
| CDR1 Start | 76 | |
| CDR1 End | 102 | |
| CDR2 Start | 154 | |
| CDR2 End | 174 | |
| CDR3 Start | 289 | |
| Paralogs | ||
| Paralog Rep | False | |
| 3' Extension | tgcgagag | A |
| 3' start | 312 | |
| 3' end | 319 | |
| curational_tags | likely_truncated | |
| Notes | changed |
Versions
All published versions of this sequence.
| Sequence Name | IMGT Name | Version | Date |
|---|---|---|---|
| IGHV4-4*i01 | IGHV4-4*03 (now extended) | 1 | 2018-12-21 |
| IGHV4-4*i01 | IGHV4-4*03 | 2 | 2019-04-12 |
| IGHV4-4*03 | IGHV4-4*03 | 3 | 2023-07-10 |