Sequence IGHV4-4*i01
Details
| Species | Human |
| Species subgroup | |
| Subgroup type | |
| Sequence Name | IGHV4-4*i01 |
| IUIS Name | IGHV4-4*03 |
| Alternative names | |
| Affirmation Level | 1 |
| Full Sequence | |
| Coding Sequence | |
| Functionality | F |
| Inference Type | Rearranged Only |
| Alternative names | |
| Paralogs |
Evidence
The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.
'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.
| Submission ID | Accession No | Subject ID | Genotype Name | Sequence Name | Sequence Match |
|---|---|---|---|---|---|
| S00006 | MH779623 | B16 | B16 | IGHV4-4*01_S5769 |
Supporting Observations
Sequences in other published genotypes which have been identified by IARC and support the inference:
Observations in VDJbase
Inferred sequences in VDJbase that match this sequence:
Un-rearranged Observations
Un-rearranged sequence observations that support this sequence:
Extension
| 3' Extension | tgcgagag |
| 3' start | 312 |
| 3' end | 319 |
Additional Information
| Sequence ID | A00008 |
| Curator address | School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney Australia |
| Version | 2 |
| Release Date | 2019-04-12 |
| Release Notes | In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 319. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation. |
| Locus | IGH |
| Sequence Type | V |
| Gene Subgroup | 4 |
| Gene Designation | 4 |
| Allele Designation | i01 |
Notes
Notes are added by IARC reviewers.
| Originally approved by IARC on April 13, 2018. “The sequence is present at relatively high frequency (0.6%), in the IgDiscover analysis. It was inferred by IgDiscover, TIger and Partis. Haplotype analysis showed two IGHV4-4-like sequences associated with the IGHJ6*02 haplotype – this inference and a second inference that is most similar to IGHV4-4*08. The likely major duplication of B16 is associated with the IGHJ6*03 haplotype. Given the similarities between IGHV4-4*08 and IGHV4-61, and given that this haplotype does not include an IGHV4-61 sequence, the committee concluded that this sequence could be accepted as Level 1. Although in this analysis the sequence was shown to be most similar to IGHV4-4*01, the committee believes that this inference extends the partial sequence IGHV4-4*03.” (April 12, 2019) In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 319. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation. |
Attachments
History
History logs the times and reasons for the publication of each version of this sequence.
| Mats Ohlin 2018-12-21 12:16:43 | Version 1 published Submission published by IARC on Dec 21, 2018. |
| Mats Ohlin 2019-04-12 14:35:18 | Version 2 published In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 319. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation. |
Changes from previous version
| v1 | v2 | |
|---|---|---|
| IUIS Name | IGHV4-4*03 (now extended) | IGHV4-4*03 |
| Alternative names | ||
| Full Sequence | ||
| Coding Sequence | ||
| Paralogs | ||
| Notes | changed |
Versions
All published versions of this sequence.
| Sequence Name | IMGT Name | Alternative names | Inference Type | Affirmation Level | Species subgroup | Subgroup type | Version | Date |
|---|---|---|---|---|---|---|---|---|
| IGHV4-4*i01 | IGHV4-4*03 (now extended) | Rearranged Only | 1 | 1 | 2018-12-21 | |||
| IGHV4-4*i01 | IGHV4-4*03 | Rearranged Only | 1 | 2 | 2019-04-12 |