Sequence IGLV6-57*i01
Details
| Species | Human |
| Sequence Name | IGLV6-57*i01 |
| IUIS Name | IGLV6-57*04 |
| Seq ID | OGRDB:B3B9 |
| Affirmation Level | 1 |
| Full Sequence | |
| Coding Sequence | |
| Functional | True |
| Inference Type | Rearranged Only |
| Alternative names | |
| Paralogs |
Evidence
The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.
'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.
| Submission ID | Accession No | Subject ID | Genotype Name | Sequence Name | Sequence Match |
|---|---|---|---|---|---|
| S00028 | MK308866 | A007 | A007 VL | IGLV6-57*01_S1429 |
Supporting Observations
Sequences in other published genotypes which have been identified by IARC and support the inference:
Observations in VDJbase
Inferred sequences in VDJbase that match this sequence:
| VDJbase Allele Name | Subjects | Sequence Match |
|---|---|---|
| >IGLV6-57*03_c21g|Human|IGL | 47 |
Un-rearranged Observations
Un-rearranged sequence observations that support this sequence:
Additional Information
| Sequence ID | A00059 |
| Curator address | School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney Australia |
| Version | 2 |
| Release Date | 2020-08-10 |
| Release Notes | Correct sequence name from IGLV-6-57*i01 |
| Locus | IGL |
| Sequence Type | V |
| Gene Subgroup | -6 |
| Gene Designation | 57 |
| Allele Designation | i01 |
Notes
Notes are added by IARC reviewers.
| At the IARC meeting on July 20th 2020, the following features of the inference in the S000028 submission were noted: The sequence was seen in 1.49% of all unmutated rearrangements, with 14,472 sequences including 1776 perfect alignments to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. The IGLV6-57*01 allele was also present in the genotype, at a somewhat lower frequency. Haplotype data is unavailable. Plots of the final 3’ nucleotides were considered, but the variability seen made it impossible to be certain of the final two nucleotides of the germline sequence. The sequence, up to and including nucleotide 333, was affirmed as the Level 1 sequence, IGLV6-57*i01. Uncertainty regarding nucleotides 334-335 will be indicated in IARC and OGRDB publications by two dots at the end of the affirmed sequence. |
Attachments
History
History logs the times and reasons for the publication of each version of this sequence.
| Andrew Collins 2020-08-01 13:19:38 | Version 1 published Published by the IARC on 1/8/2020. |
| William Lees 2020-08-10 15:55:56 | Version 2 published Correct sequence name from IGLV-6-57*i01 |
| Mats Ohlin 2021-04-29 22:32:20 | IMGT Name updated to IGLV6-57*04 IMGT Name updated. |
Changes from previous version
| v1 | v2 | |
|---|---|---|
| IUIS Name | IGLV6-57*04 | |
| Sequence Name | IGLV-6-57*i01 | IGLV6-57*i01 |
Versions
All published versions of this sequence.
| Sequence Name | IMGT Name | Affirmation Level | Seq ID | Version | Date |
|---|---|---|---|---|---|
| IGLV-6-57*i01 | 1 | OGRDB:B3B9 | 1 | 2020-08-01 | |
| IGLV6-57*i01 | IGLV6-57*04 | 1 | OGRDB:B3B9 | 2 | 2020-08-10 |