Details

SpeciesHuman
Species subgroup
Subgroup type
Sequence NameIGLV-6-57*i01
IUIS Name
Alternative names
Affirmation Level1
Full Sequence
Coding Sequence
FunctionalityF
Inference TypeRearranged Only
Mapped
Paralogs
Paralog Rep

Observations in VDJbase

Inferred sequences in VDJbase that match this sequence:

VDJbase Allele NameSubjectsSequence Match
IGLV6-57*03_c21g 47

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

No Items

Additional Information

Sequence IDA00059
Curator
Curator addressSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney Australia
Version1
Release Date2020-08-01
Release Notes

Published by the IARC on 1/8/2020.

LocusIGL
Sequence TypeV
Gene Subgroup-6
Gene Designation57
Allele Designationi01

Acknowledgements

Individuals acknowledged as contributing to this sequence:

NameInstitutionORCID ID
Néstor Vázquez BernatKarolinska Institutet SE-171 77 Stockholm

Notes

Notes are added by IARC reviewers.

At the IARC meeting on July 20th 2020, the following features of the inference in the S000028 submission were noted:

The sequence was seen in 1.49% of all unmutated rearrangements, with 14,472 sequences including 1776 perfect alignments to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. The IGLV6-57*01 allele was also present in the genotype, at a somewhat lower frequency. Haplotype data is unavailable. Plots of the final 3’ nucleotides were considered, but the variability seen made it impossible to be certain of the final two nucleotides of the germline sequence. The sequence, up to and including nucleotide 333, was affirmed as the Level 1 sequence, IGLV6-57*i01. Uncertainty regarding nucleotides 334-335 will be indicated in IARC and OGRDB publications by two dots at the end of the affirmed sequence.

Attachments

Supplementary Files
 

History

History logs the times and reasons for the publication of each version of this sequence.

Andrew Collins
2020-08-01 13:19:38
Version 1 published

Published by the IARC on 1/8/2020.

Versions

All published versions of this sequence.

Sequence NameIMGT NameAlternative namesInference TypeAffirmation LevelSpecies subgroupSubgroup typeVersionDate
IGLV-6-57*i01Rearranged Only112020-08-01
IGLV6-57*i01IGLV6-57*04Rearranged Only122020-08-10
IGLV6-57*04IGLV6-57*04IGLV6-57*i01Genomic and rearranged132023-07-10
IGLV6-57*04IGLV6-57*04IGLV6-57*i01Genomic and rearranged1none42024-02-22