Species | Human |
Species subgroup | |
Subgroup type | |
Sequence Name | IGLV2-14*i01 |
IUIS Name | IGLV2-14*03 |
Alternative names | |
Affirmation Level | 1 |
Full Sequence | |
Coding Sequence | |
Functionality | F |
Inference Type | Rearranged Only |
Alternative names | |
Paralogs |
The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.
'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.
Submission ID | Accession No | Subject ID | Genotype Name | Sequence Name | Sequence Match |
---|---|---|---|---|---|
S00028 | MK308863 | A007 | A007 VL | IGLV2-14*03x |
Sequences in other published genotypes which have been identified by IARC and support the inference:
Inferred sequences in VDJbase that match this sequence:
Un-rearranged sequence observations that support this sequence:
Accession | Type | Repository | Start | End |
---|---|---|---|---|
MK587524 | Genbank |
5' Extension | CAGTCTGCCCTGACTCAGCCTGC |
5' start | 1 |
5' end | 23 |
Sequence ID | A00053 |
Curator address | Dept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden |
Version | 1 |
Release Date | 2020-07-30 |
Release Notes | Submission published by IARC on July 30th 2020. |
Locus | IGL |
Sequence Type | V |
Gene Subgroup | 2 |
Gene Designation | 14 |
Allele Designation | i01 |
Notes are added by IARC reviewers.
Assessed by IARC on July 7, 2020 during meeting 57. The committee considered IGLV2-14*03x (a 5’ extension of IGLV2-14*03) of submission S00028. The sequence was seen in 6.08% of all unmutated rearrangements, with 71826 sequences including 7262 perfect matches to the inferred allele. The library had been generated from PBMC that had not been sorted for naïve B cells, resulting in the presence of reads of somatically hypermutated sequences in the data set, a fact that complicates the analysis. There was abundant variation in the CDR3 regions of the aligned sequences to an extent similar to that of other lambda germline alleles of this donor. One other alleles was present in the genotype. Haplotyping could not be performed. The inferred sequence includes 23 bases added to the 5’-end of incomplete reference allele IGLV2-14*03. There was support for the sequence being affirmed up to and including nucleotide 337, in line with IARC policy not to infer bases substantially affected by trimming during the rearrangement process, as a Level 1 sequence, with two additional 3’ nucleotide being likely present in the sequence. This is indicated in IARC and OGRDB publications by two dots at the end of the sequence. A genomic sequence (MK587524) has following the inference been cloned from the genotype of the donor that confirms the inference. It also confirms that bases 338-339 that cannot be inferred with confidence of the gene are T and C, respectively. |
History logs the times and reasons for the publication of each version of this sequence.
Andrew Collins 2020-07-30 12:57:22 | Version 1 published Submission published by IARC on July 30th 2020. |
Mats Ohlin 2021-04-29 22:30:26 | IMGT Name updated to IGLV2-14*03 IMGT Name updated. |
Mats Ohlin 2021-04-29 22:30:39 | IMGT Name updated to IGLV2-14*03 IMGT Name updated. |
Mats Ohlin 2021-04-29 22:30:57 | IMGT Name updated to IGLV2-14*03 IMGT Name updated. |
Mats Ohlin 2021-04-29 22:30:57 | IMGT Name updated to IGLV2-14*03 IMGT Name updated. |
Mats Ohlin 2021-04-29 22:30:57 | IMGT Name updated to IGLV2-14*03 IMGT Name updated. |
All published versions of this sequence.
Sequence Name | IMGT Name | Alternative names | Inference Type | Affirmation Level | Species subgroup | Subgroup type | Version | Date |
---|---|---|---|---|---|---|---|---|
IGLV2-14*i01 | IGLV2-14*03 | Rearranged Only | 1 | 1 | 2020-07-30 |