Species subgroup
Subgroup type
Sequence NameIGLV2-14*i01
IUIS NameIGLV2-14*03
Alternative names
Affirmation Level1
Full Sequence
Coding Sequence
Inference TypeRearranged Only
Paralog Rep

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

No Items

Observations in AIRR-seq Repertoires

Click here to review supporting data in VDJbase.

Clicking the link will take you to VDJbase. Open in a new tab if you want to keep this page open. In VDJbase, click on the count in the Apperances column to see a list of samples in which the sequence was found.

CDR delineation

CDR1 Start76
CDR1 End102
CDR2 Start154
CDR2 End162
CDR3 Start271


5' start1
5' end23

Additional Information

Sequence IDA00053
Curator addressDept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden
Release Date2020-07-30
Release Notes

Submission published by IARC on July 30th 2020.

Sequence TypeV
Gene Subgroup2
Gene Designation14
Allele Designationi01


Individuals acknowledged as contributing to this sequence:

NameInstitutionORCID ID
Néstor Vázquez BernatKarolinska Institutet SE-171 77 Stockholm


Notes are added by IARC reviewers.

Assessed by IARC on July 7, 2020 during meeting 57.

The committee considered IGLV2-14*03x (a 5’ extension of IGLV2-14*03) of submission S00028.

The sequence was seen in 6.08% of all unmutated rearrangements, with 71826 sequences including 7262 perfect matches to the inferred allele. The library had been generated from PBMC that had not been sorted for naïve B cells, resulting in the presence of reads of somatically hypermutated sequences in the data set, a fact that complicates the analysis. There was abundant variation in the CDR3 regions of the aligned sequences to an extent similar to that of other lambda germline alleles of this donor. One other alleles was present in the genotype. Haplotyping could not be performed. The inferred sequence includes 23 bases added to the 5’-end of incomplete reference allele IGLV2-14*03. There was support for the sequence being affirmed up to and including nucleotide 337, in line with IARC policy not to infer bases substantially affected by trimming during the rearrangement process, as a Level 1 sequence, with two additional 3’ nucleotide being likely present in the sequence. This is indicated in IARC and OGRDB publications by two dots at the end of the sequence. A genomic sequence (MK587524) has following the inference been cloned from the genotype of the donor that confirms the inference. It also confirms that bases 338-339 that cannot be inferred with confidence of the gene are T and C, respectively.


Supplementary Files


History logs the times and reasons for the publication of each version of this sequence.

Andrew Collins
2020-07-30 12:57:22
Version 1 published

Submission published by IARC on July 30th 2020.

Mats Ohlin
2021-04-29 22:30:26
IMGT Name updated to IGLV2-14*03

IMGT Name updated.

Mats Ohlin
2021-04-29 22:30:39
IMGT Name updated to IGLV2-14*03

IMGT Name updated.

Mats Ohlin
2021-04-29 22:30:57
IMGT Name updated to IGLV2-14*03

IMGT Name updated.

Mats Ohlin
2021-04-29 22:30:57
IMGT Name updated to IGLV2-14*03

IMGT Name updated.

Mats Ohlin
2021-04-29 22:30:57
IMGT Name updated to IGLV2-14*03

IMGT Name updated.


All published versions of this sequence.

Sequence NameIMGT NameAlternative namesInference TypeAffirmation LevelSpecies subgroupSubgroup typeGene startGene endUTR 5' StartUTR 5' EndL-PART1 StartL-PART1 EndL-PART2 StartL-PART2 EndCDR1 StartCDR1 EndCDR2 StartCDR2 EndCDR3 Startv_rs_startv_rs_endd_rs_3_prime_startd_rs_3_prime_endd_rs_5_prime_startd_rs_5_prime_endj_rs_startj_rs_endCodon FrameVersionDate
IGLV2-14*i01IGLV2-14*03Rearranged Only112957610215416227112020-07-30
IGLV2-14*03IGLV2-14*03IGLV2-14*i01Genomic and rearranged121651020521529131736937748651355122023-07-10
IGLV2-14*03IGLV2-14*03IGLV2-14*i01Genomic and rearranged1none175469146164174250276328336445472510132024-02-22