|Inference Type||Rearranged Only|
The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.
'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.
Sequences in other published genotypes which have been identified by IARC and support the inference:
Inferred sequences in VDJbase that match this sequence:
Un-rearranged sequence observations that support this sequence:
|Curator address||School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney Australia|
|Release Notes|| |
IMGT allele name added
Notes are added by IARC reviewers.
This sequence represents IGHV4-31*03 A70G in the IMGT numbering system. The committee noted a rearrangement frequency of 0.9%, with 812 alignments including 293 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. There was no alternative allele present in the genotype, but there are published reports (eg Gidoni et al 2019) of a deletion polymorphism involving the IGHV4-31 locus. All members of the committee agreed that the sequence should be accepted as a Level 1 sequence. Sequences have been submitted to SRA/ENA with acession numbers SRR8298743 and SRR8298742. The sequence was affirmed at level 1 at IARC Meeting 32 on March 1, 2019. In line with previous policy, the submitted sequence will be recognized up to and including nucleotide 319.
(April 12, 2019) A trailing “.” in the sequence indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation.
History logs the times and reasons for the publication of each version of this sequence.
|Version 1 published|
Submission published by IARC on April 3, 2019.
|Version 2 published|
A trailing “.” in the sequence indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation.
|Version 3 published|
IMGT allele name added