Species subgroup
Subgroup type
Sequence NameIGHV4-31*i01
IUIS NameIGHV4-31*11
Alternative namesIGHV4-31*p13
Affirmation Level1
Full Sequence
Coding Sequence
Inference TypeRearranged Only
Alternative namesIGHV4-31*p13


The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.

'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.

Submission IDAccession NoSubject IDGenotype NameSequence NameSequence Match
S00007 MK321691LP08248LP08248IGHV4-31*03+A66G

Supporting Observations

Sequences in other published genotypes which have been identified by IARC and support the inference:

No Items

Observations in VDJbase

Inferred sequences in VDJbase that match this sequence:

No Items

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

No Items

Additional Information

Sequence IDA00012
Curator addressSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney Australia
Release Date2019-05-16
Release Notes

IMGT allele name added

Sequence TypeV
Gene Subgroup4
Gene Designation31
Allele Designationi01


Individuals acknowledged as contributing to this sequence:

No Items


Notes are added by IARC reviewers.

This sequence represents IGHV4-31*03 A70G in the IMGT numbering system. The committee noted a rearrangement frequency of 0.9%, with 812 alignments including 293 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. There was no alternative allele present in the genotype, but there are published reports (eg Gidoni et al 2019) of a deletion polymorphism involving the IGHV4-31 locus. All members of the committee agreed that the sequence should be accepted as a Level 1 sequence. Sequences have been submitted to SRA/ENA with acession numbers SRR8298743 and SRR8298742. The sequence was affirmed at level 1 at IARC Meeting 32 on March 1, 2019. In line with previous policy, the submitted sequence will be recognized up to and including nucleotide 319.

(April 12, 2019) A trailing “.” in the sequence indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation.


No Items


History logs the times and reasons for the publication of each version of this sequence.

Andrew Collins
2019-04-02 22:38:37
Version 1 published

Submission published by IARC on April 3, 2019.

Mats Ohlin
2019-04-12 14:50:24
Version 2 published

A trailing “.” in the sequence indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation.

Mats Ohlin
2019-05-16 21:53:47
Version 3 published

IMGT allele name added

Changes from previous version

IUIS NameIGHV4-31*11


All published versions of this sequence.

Sequence NameIMGT NameAlternative namesInference TypeAffirmation LevelSpecies subgroupSubgroup typeVersionDate
IGHV4-31*i01IGHV4-31*p13Rearranged Only112019-04-02
IGHV4-31*i01IGHV4-31*p13Rearranged Only122019-04-12
IGHV4-31*i01IGHV4-31*11IGHV4-31*p13Rearranged Only132019-05-16