Details

SpeciesHomo sapiens
Species subgroup
Subgroup type
Sequence NameIGHV4-31*11
IUIS NameIGHV4-31*11
Alternative namesIGHV4-31*i01
Affirmation Level1
Full Sequence
Coding Sequence
FunctionalityORF
Inference TypeRearranged Only
MappedFalse
Paralogs
Paralog RepFalse

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

AccessionTypeRepositoryStartEnd
MK321691InferredGenBank1298

Observations in AIRR-seq Repertoires

Click here to review supporting data in VDJbase.

Clicking the link will take you to VDJbase. Open in a new tab if you want to keep this page open. In VDJbase, click on the count in the Apperances column to see a list of samples in which the sequence was found.

CDR delineation

CDR1 Start76
CDR1 End105
CDR2 Start157
CDR2 End177
CDR3 Start292

Extension

3' ExtensionA
3' start
3' end

Additional Information

Sequence IDA00012
CuratorWilliam Lees
Curator addressBirkbeck College, University of London, Malet Street, London
Version4
Release Date2023-07-10
Release Notes

Bulk upload of sequences for the AIRR-C Human IG germline sets

LocusIGH
Sequence TypeV
Gene Subgroup4
Gene Designation31
Allele Designation11
Gene start1
Gene end298

Acknowledgements

Individuals acknowledged as contributing to this sequence:

No Items

Notes

Notes are added by IARC reviewers.

This sequence represents IGHV4-31*03 A70G in the IMGT numbering system. The committee noted a rearrangement frequency of 0.9%, with 812 alignments including 293 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. There was no alternative allele present in the genotype, but there are published reports (eg Gidoni et al 2019) of a deletion polymorphism involving the IGHV4-31 locus. All members of the committee agreed that the sequence should be accepted as a Level 1 sequence. Sequences have been submitted to SRA/ENA with acession numbers SRR8298743 and SRR8298742. The sequence was affirmed at level 1 at IARC Meeting 32 on March 1, 2019. In line with previous policy, the submitted sequence will be recognized up to and including nucleotide 319.

(April 12, 2019) A trailing “.” in the sequence indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation.

Additional information for this sequence was imported into OGRDB via bulk update with the following notes:
Sequence annotation is based on Genbank sample MK321691

Attachments

No Items

History

History logs the times and reasons for the publication of each version of this sequence.

Andrew Collins
2019-04-02 22:38:37
Version 1 published

Submission published by IARC on April 3, 2019.

Mats Ohlin
2019-04-12 14:50:24
Version 2 published

A trailing “.” in the sequence indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation.

Mats Ohlin
2019-05-16 21:53:47
Version 3 published

IMGT allele name added

William Lees
2023-07-10 11:24:41
Version 4 published

Bulk upload of sequences for the AIRR-C Human IG germline sets

Changes from previous version

v3v4
CuratorWilliam Lees
Curator addressSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney AustraliaBirkbeck College, University of London, Malet Street, London
Sequence NameIGHV4-31*i01IGHV4-31*11
Alternative namesIGHV4-31*p13IGHV4-31*i01
MappedFalse
FunctionalityFORF
Species subgroup
Subgroup type
Allele Designationi0111
Full Sequence
Gene start1
Gene end298
CDR1 Start76
CDR1 End105
CDR2 Start157
CDR2 End177
CDR3 Start292
Paralog RepFalse
Extension?FalseTrue
3' ExtensionA
5' Extension
curational_tagslikely_full-length
Noteschanged

Versions

All published versions of this sequence.

Sequence NameIMGT NameVersionDate
IGHV4-31*i0112019-04-02
IGHV4-31*i0122019-04-12
IGHV4-31*i01IGHV4-31*1132019-05-16
IGHV4-31*11IGHV4-31*1142023-07-10