Sequence IGHV1-58*i01
Details
| Species | Human |
| Species subgroup | |
| Subgroup type | |
| Sequence Name | IGHV1-58*i01 |
| IUIS Name | IGHV1-58*03 |
| Alternative names | IGHV1-58*p04 |
| Affirmation Level | 1 |
| Full Sequence | |
| Coding Sequence | |
| Functionality | F |
| Inference Type | Rearranged Only |
| Alternative names | IGHV1-58*p04 |
| Paralogs |
Evidence
The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.
'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.
| Submission ID | Accession No | Subject ID | Genotype Name | Sequence Name | Sequence Match |
|---|---|---|---|---|---|
| S00008 | MK321684 | LP23810 | LP23810 | IGHV1-58*01+G29A |
Supporting Observations
Sequences in other published genotypes which have been identified by IARC and support the inference:
Observations in VDJbase
Inferred sequences in VDJbase that match this sequence:
Un-rearranged Observations
Un-rearranged sequence observations that support this sequence:
Additional Information
| Sequence ID | A00014 |
| Curator address | Dept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden |
| Version | 2 |
| Release Date | 2019-05-16 |
| Release Notes | IMGT allele name added |
| Locus | IGH |
| Sequence Type | V |
| Gene Subgroup | 1 |
| Gene Designation | 58 |
| Allele Designation | i01 |
Notes
Notes are added by IARC reviewers.
| This sequence represents IGHV1-58*01+G33A in the IMGT numbering system. The committee noted a rearrangement frequency of 0.15%, with 178 alignments including 127 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. The genotype showed the individual to be heterozygous at the IGHV1-58 locus, with the alternative IGHV1-58*01 allele being associated with 214 sequences for an allele ratio of 45:55. This sequence has previously been catalogued by IgPdb as IGHV1-58*p04, though the IgPdb sequence is derived from the S0008 dataset. All members of the committee agreed that the sequence should be accepted as a Level 1 sequence at IARC Meeting 34 on March 29, 2019. In line with previous policy, the submitted sequence will be recognized up to and including nucleotide 319. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation. |
Attachments
History
History logs the times and reasons for the publication of each version of this sequence.
| Mats Ohlin 2019-04-12 14:38:50 | Version 1 published Accepted as a Level 1 sequence at IARC Meeting 34 on March 29, 2019. |
| Mats Ohlin 2019-05-16 21:48:45 | Version 2 published IMGT allele name added |
Changes from previous version
| v1 | v2 | |
|---|---|---|
| IUIS Name | IGHV1-58*03 |
Versions
All published versions of this sequence.
| Sequence Name | IMGT Name | Alternative names | Inference Type | Affirmation Level | Species subgroup | Subgroup type | Version | Date |
|---|---|---|---|---|---|---|---|---|
| IGHV1-58*i01 | IGHV1-58*p04 | Rearranged Only | 1 | 1 | 2019-04-12 | |||
| IGHV1-58*i01 | IGHV1-58*03 | IGHV1-58*p04 | Rearranged Only | 1 | 2 | 2019-05-16 |