Details

SpeciesHuman
Species subgroup
Subgroup type
Sequence NameIGHV1-58*i01
IUIS NameIGHV1-58*03
Alternative namesIGHV1-58*p04
Affirmation Level1
Full Sequence
Coding Sequence
FunctionalityF
Inference TypeRearranged Only
Mapped
Paralogs
Paralog Rep

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

No Items

Observations in AIRR-seq Repertoires

Click here to review supporting data in VDJbase.

Clicking the link will take you to VDJbase. Open in a new tab if you want to keep this page open. In VDJbase, click on the count in the Apperances column to see a list of samples in which the sequence was found.

CDR delineation

CDR1 Start
CDR1 End
CDR2 Start
CDR2 End
CDR3 Start

Additional Information

Sequence IDA00014
Curator
Curator addressDept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden
Version2
Release Date2019-05-16
Release Notes

IMGT allele name added

LocusIGH
Sequence TypeV
Gene Subgroup1
Gene Designation58
Allele Designationi01

Acknowledgements

Individuals acknowledged as contributing to this sequence:

No Items

Notes

Notes are added by IARC reviewers.

This sequence represents IGHV1-58*01+G33A in the IMGT numbering system. The committee noted a rearrangement frequency of 0.15%, with 178 alignments including 127 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. The genotype showed the individual to be heterozygous at the IGHV1-58 locus, with the alternative IGHV1-58*01 allele being associated with 214 sequences for an allele ratio of 45:55. This sequence has previously been catalogued by IgPdb as IGHV1-58*p04, though the IgPdb sequence is derived from the S0008 dataset. All members of the committee agreed that the sequence should be accepted as a Level 1 sequence at IARC Meeting 34 on March 29, 2019. In line with previous policy, the submitted sequence will be recognized up to and including nucleotide 319. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation.

Attachments

No Items

History

History logs the times and reasons for the publication of each version of this sequence.

Mats Ohlin
2019-04-12 14:38:50
Version 1 published

Accepted as a Level 1 sequence at IARC Meeting 34 on March 29, 2019.

Mats Ohlin
2019-05-16 21:48:45
Version 2 published

IMGT allele name added

Changes from previous version

v1v2
IUIS NameIGHV1-58*03

Versions

All published versions of this sequence.

Sequence NameIMGT NameAlternative namesInference TypeAffirmation LevelSpecies subgroupSubgroup typeVersionDate
IGHV1-58*i01IGHV1-58*p04Rearranged Only112019-04-12
IGHV1-58*i01IGHV1-58*03IGHV1-58*p04Rearranged Only122019-05-16
IGHV1-58*03IGHV1-58*03IGHV1-58*i01Rearranged Only132023-07-10