Details

SpeciesHomo sapiens
Species subgroup
Subgroup type
Sequence NameIGHV4-30-4*08
IUIS NameIGHV4-30-4*08
Alternative namesIGHV4-30-4*i01
Affirmation Level1
Full Sequence
Coding Sequence
FunctionalityORF
Inference TypeRearranged Only
MappedFalse
Paralogs
Paralog RepFalse

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

AccessionTypeRepositoryStartEnd
MH779624InferredGenBank1298

Observations in AIRR-seq Repertoires

Click here to review supporting data in VDJbase.

Clicking the link will take you to VDJbase. Open in a new tab if you want to keep this page open. In VDJbase, click on the count in the Apperances column to see a list of samples in which the sequence was found.

CDR delineation

CDR1 Start76
CDR1 End105
CDR2 Start157
CDR2 End177
CDR3 Start292

Extension

3' ExtensionA
3' start
3' end

Additional Information

Sequence IDA00009
CuratorWilliam Lees
Curator addressBirkbeck College, University of London, Malet Street, London
Version5
Release Date2023-07-10
Release Notes

Bulk upload of sequences for the AIRR-C Human IG germline sets

LocusIGH
Sequence TypeV
Gene Subgroup4-30
Gene Designation4
Allele Designation08
Gene start1
Gene end298

Acknowledgements

Individuals acknowledged as contributing to this sequence:

No Items

Notes

Notes are added by IARC reviewers.

Originally approved by IARC on April 13, 2018.

“The sequence is present at high frequency (1.3%), in the IgDiscover analysis. It was inferred by IgDiscover, TIger and Partis. Haplotype analysis was supportive of the inference, as the sequence was strongly associated with the IGHJ6*03 haplotype. The sequence has previously been reported from genomic sequencing, and by inference from VDJ data, and is documented in IgPdb as IGHV4-30-4*p08. It was agreed that the sequence should be moved to Level 1.”

In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 319.

(April 12, 2019) A trailing “.” in the sequence indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation.

Additional information for this sequence was imported into OGRDB via bulk update with the following notes:
Sequence annotation is based on Genbank sample MH779624
VDJbase example haplotype: P1_I64

Attachments

No Items

History

History logs the times and reasons for the publication of each version of this sequence.

Mats Ohlin
2018-12-21 12:11:12
Version 1 published

Submission published by IARC on Dec 21, 2018.

Andrew Collins
2019-04-03 04:21:41
Version 2 published

This version was created to include details highlighting the fact that the published sequence was affirmed up to and including nucleotide 319, but the submitted sequence was one nucleotide longer.

Mats Ohlin
2019-04-12 14:51:13
Version 3 published

A trailing “.” in the sequence indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation.

Mats Ohlin
2019-05-16 21:50:41
Version 4 published

IMGT allele name added

William Lees
2023-07-10 11:24:40
Version 5 published

Bulk upload of sequences for the AIRR-C Human IG germline sets

Changes from previous version

v4v5
CuratorWilliam Lees
Curator addressSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney AustraliaBirkbeck College, University of London, Malet Street, London
Sequence NameIGHV4-30-4*i01IGHV4-30-4*08
Alternative namesIGHV4-30-4*p08IGHV4-30-4*i01
MappedFalse
FunctionalityFORF
Species subgroup
Subgroup type
Gene Subgroup44-30
Gene Designation30-44
Allele Designationi0108
Full Sequence
Gene start1
Gene end298
CDR1 Start76
CDR1 End105
CDR2 Start157
CDR2 End177
CDR3 Start292
Paralog RepFalse
Extension?FalseTrue
3' ExtensionA
5' Extension
curational_tagslikely_truncated
Noteschanged

Versions

All published versions of this sequence.

Sequence NameIMGT NameVersionDate
IGHV4-30-4*i0112018-12-21
IGHV4-30-4*i0122019-04-03
IGHV4-30-4*i0132019-04-12
IGHV4-30-4*i01IGHV4-30-4*0842019-05-16
IGHV4-30-4*08IGHV4-30-4*0852023-07-10