Details

SpeciesHuman
Species subgroup
Subgroup type
Sequence NameIGHV3-43D*04
IUIS NameIGHV3-43D*04
Alternative namesIGHV3-43D*i01
Affirmation Level1
Full Sequence
Coding Sequence
FunctionalityORF
Inference TypeRearranged Only
MappedFalse
Paralogs
Paralog RepFalse

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

AccessionTypeRepositoryStartEnd
BK010573InferredGenBank1297

Observations in AIRR-seq Repertoires

Click here to review supporting data in VDJbase.

Clicking the link will take you to VDJbase. Open in a new tab if you want to keep this page open. In VDJbase, click on the count in the Apperances column to see a list of samples in which the sequence was found.

Extension

3' ExtensionA
3' start
3' end

Additional Information

Sequence IDA00005
CuratorWilliam Lees
Curator addressBirkbeck College, University of London, Malet Street, London
Version3
Release Date2023-07-10
Release Notes

Bulk upload of sequences for the AIRR-C Human IG germline sets

LocusIGH
Sequence TypeV
Gene Subgroup3
Gene Designation43D
Allele Designation04

Acknowledgements

Individuals acknowledged as contributing to this sequence:

No Items

Notes

Notes are added by IARC reviewers.

Originally approved by IARC on May 11, 2018.

“The sequence is present at low frequency (0.07%), in the IgDiscover analysis. It was inferred by IgDiscover. No information was provided by the submitter regarding analysis with partis or TIgGER. Haplotype analysis could not be performed. Analysis for chimerism did not provide evidence against the existence of the sequence. It was agreed that the sequence should be moved to Level 1, subject to the provision of additional information.”

Further deliberation on May 25, 2018
“MO provided information regarding primers used to generate the data upon which the submission of Linnea Thornquist was based. It was agreed that the information was sufficient for the previous decisions of IARC to be ratified (see minutes Meeting 14).”

The allele was incorporated into IMGT on October 4, 2018 as IGHV3-43D*04.
The other most similar allele IGHV3-43D*01 has since this inference was performed been renamed by IMGT as IGHV3-43D*03.

(April 12, 2019) In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 321. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation.

Additional information for this sequence was imported into OGRDB via bulk update with the following notes:
Sequence annotation is based on Genbank sample BK010573
VDJbase example haplotype: P1_I23

Attachments

No Items

History

History logs the times and reasons for the publication of each version of this sequence.

Mats Ohlin
2018-12-21 12:10:41
Version 1 published

Submission published by IARC on Dec 21, 2018.

Mats Ohlin
2019-04-12 14:33:49
Version 2 published

In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 321. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation.

William Lees
2023-07-10 11:24:39
Version 3 published

Bulk upload of sequences for the AIRR-C Human IG germline sets

Changes from previous version

v2v3
CuratorWilliam Lees
Curator addressSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney AustraliaBirkbeck College, University of London, Malet Street, London
Sequence NameIGHV3-43D*i01IGHV3-43D*04
Alternative namesIGHV3-43D*i01
MappedFalse
FunctionalityFORF
Species subgroup
Subgroup type
Allele Designationi0104
Full Sequence
Coding Sequence
Gene start1
Gene end297
Paralog RepFalse
Extension?FalseTrue
3' ExtensionA
5' Extension
curational_tagslikely_truncated
Noteschanged

Versions

All published versions of this sequence.

Sequence NameIMGT NameAlternative namesInference TypeAffirmation LevelSpecies subgroupSubgroup typeVersionDate
IGHV3-43D*i01IGHV3-43D*04Rearranged Only112018-12-21
IGHV3-43D*i01IGHV3-43D*04Rearranged Only122019-04-12
IGHV3-43D*04IGHV3-43D*04IGHV3-43D*i01Rearranged Only132023-07-10