Details


Species	Human
Species subgroup
Subgroup type
Sequence Name	IGHV3-43D*04
IUIS Name	IGHV3-43D*04
Alternative names	IGHV3-43D*i01
Affirmation Level	1
Full Sequence
Coding Sequence
Functionality	ORF
Inference Type	Rearranged Only
Mapped	False
Paralogs
Paralog Rep	False

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

Accession	Type	Repository	Start	End
BK010573	Inferred	GenBank	1	297

Observations in AIRR-seq Repertoires

Click here to review supporting data in VDJbase.

Clicking the link will take you to VDJbase. Open in a new tab if you want to keep this page open. In VDJbase, click on the count in the Apperances column to see a list of samples in which the sequence was found.

CDR delineation


CDR1 Start	76
CDR1 End	99
CDR2 Start	151
CDR2 End	174
CDR3 Start	289

Extension


3' Extension	A
3' start
3' end

Additional Information


Sequence ID	A00005
Curator	William Lees
Curator address	Birkbeck College, University of London, Malet Street, London
Version	3
Release Date	2023-07-10
Release Notes	Bulk upload of sequences for the AIRR-C Human IG germline sets
Locus	IGH
Sequence Type	V
Gene Subgroup	3
Gene Designation	43D
Allele Designation	04

Acknowledgements

Individuals acknowledged as contributing to this sequence:

No Items

Notes

Notes are added by IARC reviewers.


Originally approved by IARC on May 11, 2018. “The sequence is present at low frequency (0.07%), in the IgDiscover analysis. It was inferred by IgDiscover. No information was provided by the submitter regarding analysis with partis or TIgGER. Haplotype analysis could not be performed. Analysis for chimerism did not provide evidence against the existence of the sequence. It was agreed that the sequence should be moved to Level 1, subject to the provision of additional information.” Further deliberation on May 25, 2018 “MO provided information regarding primers used to generate the data upon which the submission of Linnea Thornquist was based. It was agreed that the information was sufficient for the previous decisions of IARC to be ratified (see minutes Meeting 14).” The allele was incorporated into IMGT on October 4, 2018 as IGHV3-43D04. The other most similar allele IGHV3-43D01 has since this inference was performed been renamed by IMGT as IGHV3-43D*03. (April 12, 2019) In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 321. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation. Additional information for this sequence was imported into OGRDB via bulk update with the following notes: Sequence annotation is based on Genbank sample BK010573 VDJbase example haplotype: P1_I23

Originally approved by IARC on May 11, 2018.

“The sequence is present at low frequency (0.07%), in the IgDiscover analysis. It was inferred by IgDiscover. No information was provided by the submitter regarding analysis with partis or TIgGER. Haplotype analysis could not be performed. Analysis for chimerism did not provide evidence against the existence of the sequence. It was agreed that the sequence should be moved to Level 1, subject to the provision of additional information.”

Further deliberation on May 25, 2018
“MO provided information regarding primers used to generate the data upon which the submission of Linnea Thornquist was based. It was agreed that the information was sufficient for the previous decisions of IARC to be ratified (see minutes Meeting 14).”

The allele was incorporated into IMGT on October 4, 2018 as IGHV3-43D*04.
The other most similar allele IGHV3-43D*01 has since this inference was performed been renamed by IMGT as IGHV3-43D*03.

(April 12, 2019) In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 321. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation.

Additional information for this sequence was imported into OGRDB via bulk update with the following notes:
Sequence annotation is based on Genbank sample BK010573
VDJbase example haplotype: P1_I23

Attachments

No Items

History

History logs the times and reasons for the publication of each version of this sequence.


Mats Ohlin 2018-12-21 12:10:41	Version 1 published Submission published by IARC on Dec 21, 2018.


Mats Ohlin 2019-04-12 14:33:49	Version 2 published In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 321. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation.


William Lees 2023-07-10 11:24:39	Version 3 published Bulk upload of sequences for the AIRR-C Human IG germline sets

Changes from previous version

	v2	v3
Curator		William Lees
Curator address	School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney Australia	Birkbeck College, University of London, Malet Street, London
Sequence Name	IGHV3-43D*i01	IGHV3-43D*04
Alternative names		IGHV3-43D*i01
Mapped		False
Functionality	F	ORF
Species subgroup
Subgroup type
Allele Designation	i01	04
Full Sequence
Gene start		1
Gene end		297
CDR1 Start		76
CDR1 End		99
CDR2 Start		151
CDR2 End		174
CDR3 Start		289
Paralog Rep		False
Extension?	False	True
3' Extension		A
5' Extension
curational_tags		likely_truncated
Notes		changed

Versions

All published versions of this sequence.

Sequence Name	IMGT Name	Alternative names	Inference Type	Affirmation Level	Gene start	Gene end	CDR1 Start	CDR1 End	CDR2 Start	CDR2 End	CDR3 Start	Version	Date
IGHV3-43D*i01	IGHV3-43D*04		Rearranged Only	1								1	2018-12-21
IGHV3-43D*i01	IGHV3-43D*04		Rearranged Only	1								2	2019-04-12
IGHV3-43D*04	IGHV3-43D*04	IGHV3-43D*i01	Rearranged Only	1	1	297	76	99	151	174	289	3	2023-07-10