Details

OrganismHuman
Sequence NameIGHV3-43D*i01
IMGT NameIGHV3-43D*04
Affirmation Level1
Full Sequence
Coding Sequence
FunctionalTrue
Inference TypeRearranged Only
Alternative names
Paralogs

Evidence

The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.

'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.

Submission IDAccession NoSubject IDGenotype NameSequence NameSequence Match
S00003 BK010573IBGenotype - with Database 3IGHV3-43D*01_S3103

Supporting Observations

Sequences in other published genotypes which have been identified by IARC and support the inference:

No Items

Observations in VDJbase

Inferred sequences in VDJbase that match this sequence:

VDJbase Allele NameSubjectsSequence Match
IGHV3-43D*04 116

Additional Information

Sequence IDA00005
CuratorAndrew Collins
Curator addressSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney Australia
Version2
Release Date2019-04-12 00:00:00
Release Notes

In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 321. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation.

LocusIGH
Sequence TypeV
Gene Subgroup3
Gene Designation43D
Allele Designationi01

Acknowledgements

Individuals acknowledged as contributing to this sequence:

No Items

Notes

Notes are added by IARC reviewers.

Originally approved by IARC on May 11, 2018.

“The sequence is present at low frequency (0.07%), in the IgDiscover analysis. It was inferred by IgDiscover. No information was provided by the submitter regarding analysis with partis or TIgGER. Haplotype analysis could not be performed. Analysis for chimerism did not provide evidence against the existence of the sequence. It was agreed that the sequence should be moved to Level 1, subject to the provision of additional information.”

Further deliberation on May 25, 2018
“MO provided information regarding primers used to generate the data upon which the submission of Linnea Thornquist was based. It was agreed that the information was sufficient for the previous decisions of IARC to be ratified (see minutes Meeting 14).”

The allele was incorporated into IMGT on October 4, 2018 as IGHV3-43D*04.
The other most similar allele IGHV3-43D*01 has since this inference was performed been renamed by IMGT as IGHV3-43D*03.

(April 12, 2019) In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 321. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation.

Attachments

No Items

History

History records log the times and reasons for the publication of each version of this sequence record.

Mats Ohlin
2018-12-21 12:10:41
Version 1 published

Submission published by IARC on Dec 21, 2018.

Mats Ohlin
2019-04-12 14:33:49
Version 2 published

In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 321. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation.