Details


Species	Human
Species subgroup
Subgroup type
Sequence Name	IGHV3-43D*i01
IUIS Name	IGHV3-43D*04
Alternative names
Affirmation Level	1
Full Sequence
Coding Sequence
Functionality	F
Inference Type	Rearranged Only
Alternative names
Paralogs

Evidence

The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.

'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.

Submission ID	Accession No	Subject ID	Genotype Name	Sequence Name	Sequence Match
S00003	BK010573	IB	Genotype - with Database 3	IGHV3-43D*01_S3103

Supporting Observations

Sequences in other published genotypes which have been identified by IARC and support the inference:

No Items

Observations in VDJbase

Inferred sequences in VDJbase that match this sequence:

No Items

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

No Items

Additional Information


Sequence ID	A00005
Curator address	School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney Australia
Version	2
Release Date	2019-04-12
Release Notes	In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 321. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation.
Locus	IGH
Sequence Type	V
Gene Subgroup	3
Gene Designation	43D
Allele Designation	i01

Acknowledgements

Individuals acknowledged as contributing to this sequence:

No Items

Notes

Notes are added by IARC reviewers.


Originally approved by IARC on May 11, 2018. “The sequence is present at low frequency (0.07%), in the IgDiscover analysis. It was inferred by IgDiscover. No information was provided by the submitter regarding analysis with partis or TIgGER. Haplotype analysis could not be performed. Analysis for chimerism did not provide evidence against the existence of the sequence. It was agreed that the sequence should be moved to Level 1, subject to the provision of additional information.” Further deliberation on May 25, 2018 “MO provided information regarding primers used to generate the data upon which the submission of Linnea Thornquist was based. It was agreed that the information was sufficient for the previous decisions of IARC to be ratified (see minutes Meeting 14).” The allele was incorporated into IMGT on October 4, 2018 as IGHV3-43D04. The other most similar allele IGHV3-43D01 has since this inference was performed been renamed by IMGT as IGHV3-43D*03. (April 12, 2019) In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 321. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation.

Originally approved by IARC on May 11, 2018.

“The sequence is present at low frequency (0.07%), in the IgDiscover analysis. It was inferred by IgDiscover. No information was provided by the submitter regarding analysis with partis or TIgGER. Haplotype analysis could not be performed. Analysis for chimerism did not provide evidence against the existence of the sequence. It was agreed that the sequence should be moved to Level 1, subject to the provision of additional information.”

Further deliberation on May 25, 2018
“MO provided information regarding primers used to generate the data upon which the submission of Linnea Thornquist was based. It was agreed that the information was sufficient for the previous decisions of IARC to be ratified (see minutes Meeting 14).”

The allele was incorporated into IMGT on October 4, 2018 as IGHV3-43D*04.
The other most similar allele IGHV3-43D*01 has since this inference was performed been renamed by IMGT as IGHV3-43D*03.

(April 12, 2019) In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 321. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation.

Attachments

No Items

History

History logs the times and reasons for the publication of each version of this sequence.


Mats Ohlin 2018-12-21 12:10:41	Version 1 published Submission published by IARC on Dec 21, 2018.


Mats Ohlin 2019-04-12 14:33:49	Version 2 published In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 321. A trailing “.” indicates IARC’s opinion that the sequences likely to contain an additional/additional 3’ nucleotide(s) for which there is insufficient evidence to make an affirmation.

Changes from previous version

	v1	v2
Full Sequence
Coding Sequence
Notes		changed

Versions

All published versions of this sequence.

Sequence Name	IMGT Name	Alternative names	Inference Type	Affirmation Level	Species subgroup	Subgroup type	Version	Date
IGHV3-43D*i01	IGHV3-43D*04		Rearranged Only	1			1	2018-12-21
IGHV3-43D*i01	IGHV3-43D*04		Rearranged Only	1			2	2019-04-12