Sequence TRBV7-7*i01
Details
| Species | Human_TCR |
| Species subgroup | |
| Subgroup type | none |
| Sequence Name | TRBV7-7*i01 |
| IUIS Name | |
| Alternative names | TRBV7-7*01 C315T, TRBV7-7*01_S0326 |
| Affirmation Level | 1 |
| Full Sequence | |
| Coding Sequence | |
| Functionality | F |
| Inference Type | Unrearranged and Rearranged |
| Mapped | |
| Paralogs | |
| Paralog Rep |
Evidence
The table below lists submissions to IARC , and the inferences within them, on which this IARC-affirmed sequence is based.
'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.
| Submission ID | Accession No | Subject ID | Genotype Name | Sequence Name | Sequence Match |
|---|---|---|---|---|---|
| S00036 | OW165666 | C9 | P4_I9_S1_ogrdb_report | TRBV7-7*01_C315T |
Observations in VDJbase
Inferred sequences in VDJbase that match this sequence:
| VDJbase Allele Name | Subjects | Sequence Match |
|---|---|---|
| TRBV7-7*01_c315t | 28 |
Un-rearranged Observations
Un-rearranged sequence observations that support this sequence:
CDR delineation
| CDR1 Start | 79 |
| CDR1 End | 93 |
| CDR2 Start | 145 |
| CDR2 End | 162 |
| CDR3 Start | 277 |
Non-Core Regions
| UTR 5' Start | |
| UTR 5' End | |
| L-PART1 Start | |
| L-PART1 End | |
| L_PART1 | |
| L-PART2 Start | |
| L-PART2 End | |
| L_PART2 | |
| v_rs_start | |
| v_rs_end | |
| V_HEPTAMER | |
| V_NONAMER |
Extension
| 3' Extension | |
| 3' start | |
| 3' end | |
| 5' start | |
| 5' end |
Additional Information
| Sequence ID | A02570 |
| Curator | Mats Ohlin |
| Curator address | Dept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden |
| Version | 1 |
| Release Date | 2023-06-01 |
| Release Notes | IARC affirms the sequence at Meeting 121 on May 8th, 2023 |
| Locus | TRB |
| Sequence Type | V |
| Gene Subgroup | 7 |
| Gene Designation | 7 |
| Allele Designation | i01 |
Notes
Notes are added by IARC reviewers.
| This inference was assessed at multiple meetings and a decision was taken during meeting 121 on May 8th, 2023. TRBV7-7*01_C315T has been inferred in seventeen genotypes in the VDJbase P4 data set, including in VDJbase P4_I9_S1, a haplotypable data set (based on heterozygocity in TRBJ1-6). The genotype is also implied to carry TRBV7-7*01. No other gene apart from IGHV7-6 (alleles of which also carry C315) in the IMGT database is highly similar to these alleles of TRBV7-7. The novel allele is the most expressed allele in the repertoire (58% allelic frequency; 0.16% of the total error-free population). It is represented by 37 error-free sequences and 33 unique CDR3s in the error-free set. Haplotyping based on allelic diversity in TRBJ1-6 demonstrates association of TRBV7-7*01_C315T with only one of the haplotypes (only few recorded cases; TRBV7-7*01 was not associated with any allele of TRBJ1-6). IARC affirms the sequence based on inference of expression data alone at Level 1 up to and including base 325. It is acknowledged that the allele most likely carries 1 additional base, typically C, at base position 326. Trailing “.” indicates IARC’s opinion that the sequence is likely to contain additional 3’-nucleotides for which there is insufficient evidence to make an affirmation. >TRBV7-7*i01 (TRBV7-7*01_C315T) The allele has also been identified in a separate study as TRBV7-7*01_S0326 and Sanger validated (GenBank MZ339373) (Corcoran et al. (2023) Immunity 56, 635-652.E6 (DOI: 10.1016/j.immuni.2023.01.026)). It has been seen in a total of six Sanger sequenced genomic clones derived from two subjects. >MZ339373 It has also been identified in a BAC clone with accession number AC229888. IARC affirms the sequence based on combined inference and genomic evidence at Level 1 up to and including base 326. >TRBV7-7*i01 (TRBV7-7*01_C315T) |
Attachments
History
History logs the times and reasons for the publication of each version of this sequence.
| Mats Ohlin 2023-06-01 22:13:07 | Version 1 published IARC affirms the sequence at Meeting 121 on May 8th, 2023 |
Versions
All published versions of this sequence.
| Sequence Name | IMGT Name | Alternative names | Inference Type | Affirmation Level | Species subgroup | Subgroup type | Gene start | Gene end | UTR 5' Start | UTR 5' End | L-PART1 Start | L-PART1 End | L-PART2 Start | L-PART2 End | CDR1 Start | CDR1 End | CDR2 Start | CDR2 End | CDR3 Start | v_rs_start | v_rs_end | d_rs_3_prime_start | d_rs_3_prime_end | d_rs_5_prime_start | d_rs_5_prime_end | j_rs_start | j_rs_end | Codon Frame | Version | Date |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TRBV7-7*i01 | TRBV7-7*01 C315T, TRBV7-7*01_S0326 | Unrearranged and Rearranged | 1 | none | 1 | 290 | 79 | 93 | 145 | 162 | 277 | 1 | 1 | 2023-06-01 |