Sequence TRBV19*i01
Details
| Species | Human_TCR |
| Species subgroup | |
| Subgroup type | none |
| Sequence Name | TRBV19*i01 |
| IUIS Name | |
| Alternative names | TRBV19*01 A24G |
| Affirmation Level | 1 |
| Full Sequence | |
| Coding Sequence | |
| Functionality | F |
| Inference Type | Rearranged |
| Alternative names | TRBV19*01 A24G |
| Paralogs |
Evidence
The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.
'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.
| Submission ID | Accession No | Subject ID | Genotype Name | Sequence Name | Sequence Match |
|---|---|---|---|---|---|
| S00036 | OW166726 | S24 | P4_I24_S1_ogrdb_report | TRBV19*01_A24G |
Supporting Observations
Sequences in other published genotypes which have been identified by IARC and support the inference:
Observations in VDJbase
Inferred sequences in VDJbase that match this sequence:
Un-rearranged Observations
Un-rearranged sequence observations that support this sequence:
Non-Core Regions
| UTR 5' Start | |
| UTR 5' End | |
| L-PART1 Start | |
| L-PART1 End | |
| L-PART2 Start | |
| L-PART2 End | |
| v_rs_start | |
| v_rs_end |
Extension
| 3' Extension | |
| 3' start | |
| 3' end | |
| 5' start | |
| 5' end |
Additional Information
| Sequence ID | A02563 |
| Curator address | Dept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden |
| Version | 1 |
| Release Date | 2022-07-26 |
| Release Notes | The allele was published by IARC on July 26th, 2022. |
| Locus | TRA |
| Sequence Type | V |
| Gene Subgroup | 19 |
| Gene Designation | 19 |
| Allele Designation | i01 |
Notes
Notes are added by IARC reviewers.
| This allele was affirmed at IARC meeting 99 on May 9th, 2022. TRBV19*01_A24G has been inferred in six genotypes in the VDJbase P4 data set, including in VDJbase P4_I24_S1, a haplotypable data set (based on heterozygocity in TRBJ1-6). The genotype is also implied to carry TRBV19*01. No other gene in the IMGT database is closely related to these alleles of TRBV19. The novel allele is the most expressed allele in the repertoire (53% allelic frequency; 0.71% of the total error-free population). It is represented by 240 error-free sequences and 202 unique CDR3s in the error-free set. Haplotyping based on allelic diversity in TRBJ1-6 demonstrates perfect separation from TRBV19*01. IARC affirms the sequence at Level 1 up to and including base 322. It is acknowledged that the allele most likely carries 4 additional bases, typically TAGA, at base positions 323-326. Trailing “.” indicates IARC’s opinion that the sequence is likely to contain additional 3’-nucleotides for which there is insufficient evidence to make an affirmation. |
Attachments
History
History logs the times and reasons for the publication of each version of this sequence.
| Mats Ohlin 2022-07-26 09:52:44 | Version 1 published The allele was published by IARC on July 26th, 2022. |
Versions
All published versions of this sequence.
| Sequence Name | IMGT Name | Alternative names | Inference Type | Affirmation Level | Species subgroup | Subgroup type | Version | Date |
|---|---|---|---|---|---|---|---|---|
| TRBV19*i01 | TRBV19*01 A24G | Rearranged | 1 | none | 1 | 2022-07-26 |