Details


Species	Human_TCR
Species subgroup
Subgroup type	none
Sequence Name	TRBV19*i01
IUIS Name
Alternative names	TRBV19*01 A24G
Affirmation Level	1
Full Sequence
Coding Sequence
Functionality	F
Inference Type	Rearranged
Mapped
Paralogs
Paralog Rep

Evidence

The table below lists submissions to IARC , and the inferences within them, on which this IARC-affirmed sequence is based.

'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.

Submission ID	Accession No	Subject ID	Genotype Name	Sequence Name	Sequence Match
S00036	OW166726	S24	P4_I24_S1_ogrdb_report	TRBV19*01_A24G

Observations in VDJbase

Inferred sequences in VDJbase that match this sequence:

VDJbase Allele Name	Subjects	Sequence Match
TRBV19*01_a24g	14

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

No Items

CDR delineation


CDR1 Start	79
CDR1 End	93
CDR2 Start	145
CDR2 End	162
CDR3 Start	274

Non-Core Regions


UTR 5' Start
UTR 5' End
L-PART1 Start
L-PART1 End
L_PART1
L-PART2 Start
L-PART2 End
L_PART2
v_rs_start
v_rs_end
V_HEPTAMER
V_NONAMER

Extension


3' Extension
3' start
3' end
5' start
5' end

Additional Information


Sequence ID	A02563
Curator	Mats Ohlin
Curator address	Dept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden
Version	1
Release Date	2022-07-26
Release Notes	The allele was published by IARC on July 26th, 2022.
Locus	TRB
Sequence Type	V
Gene Subgroup	19
Gene Designation	19
Allele Designation	i01

Acknowledgements

Individuals acknowledged as contributing to this sequence:

Name	Institution	ORCID ID
William Lees	Birkbeck College, University of London, Malet Street, London
Ayelet Peres	Bar-Ilan University, Ramat-Gan, Israel
Gur Yaari	Bar-Ilan University, Ramat-Gan, Israel

Notes

Notes are added by IARC reviewers.


This allele was affirmed at IARC meeting 99 on May 9th, 2022. TRBV1901_A24G has been inferred in six genotypes in the VDJbase P4 data set, including in VDJbase P4_I24_S1, a haplotypable data set (based on heterozygocity in TRBJ1-6). The genotype is also implied to carry TRBV1901. No other gene in the IMGT database is closely related to these alleles of TRBV19. The novel allele is the most expressed allele in the repertoire (53% allelic frequency; 0.71% of the total error-free population). It is represented by 240 error-free sequences and 202 unique CDR3s in the error-free set. Haplotyping based on allelic diversity in TRBJ1-6 demonstrates perfect separation from TRBV19*01. IARC affirms the sequence at Level 1 up to and including base 322. It is acknowledged that the allele most likely carries 4 additional bases, typically TAGA, at base positions 323-326. Trailing “.” indicates IARC’s opinion that the sequence is likely to contain additional 3’-nucleotides for which there is insufficient evidence to make an affirmation.

This allele was affirmed at IARC meeting 99 on May 9th, 2022. TRBV19*01_A24G has been inferred in six genotypes in the VDJbase P4 data set, including in VDJbase P4_I24_S1, a haplotypable data set (based on heterozygocity in TRBJ1-6). The genotype is also implied to carry TRBV19*01. No other gene in the IMGT database is closely related to these alleles of TRBV19. The novel allele is the most expressed allele in the repertoire (53% allelic frequency; 0.71% of the total error-free population). It is represented by 240 error-free sequences and 202 unique CDR3s in the error-free set. Haplotyping based on allelic diversity in TRBJ1-6 demonstrates perfect separation from TRBV19*01. IARC affirms the sequence at Level 1 up to and including base 322. It is acknowledged that the allele most likely carries 4 additional bases, typically TAGA, at base positions 323-326. Trailing “.” indicates IARC’s opinion that the sequence is likely to contain additional 3’-nucleotides for which there is insufficient evidence to make an affirmation.

Attachments

No Items

History

History logs the times and reasons for the publication of each version of this sequence.


Mats Ohlin 2022-07-26 09:52:44	Version 1 published The allele was published by IARC on July 26th, 2022.

Versions

All published versions of this sequence.

Sequence Name	IMGT Name	Alternative names	Inference Type	Affirmation Level	Species subgroup	Subgroup type	Gene start	Gene end	UTR 5' Start	UTR 5' End	L-PART1 Start	L-PART1 End	L-PART2 Start	L-PART2 End	CDR1 Start	CDR1 End	CDR2 Start	CDR2 End	CDR3 Start	v_rs_start	v_rs_end	d_rs_3_prime_start	d_rs_3_prime_end	d_rs_5_prime_start	d_rs_5_prime_end	j_rs_start	j_rs_end	Codon Frame	Version	Date
TRBV19*i01		TRBV19*01 A24G	Rearranged	1		none	1	283							79	93	145	162	274									1	1	2022-07-26