Species | Human |
Species subgroup | |
Subgroup type | none |
Sequence Name | IGHV4-61*i03 |
IUIS Name | IGHV4-61*11 |
Alternative names | |
Affirmation Level | 1 |
Full Sequence | |
Coding Sequence | |
Functionality | F |
Inference Type | Rearranged Only |
Alternative names | |
Paralogs |
The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.
'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.
Submission ID | Accession No | Subject ID | Genotype Name | Sequence Name | Sequence Match |
---|---|---|---|---|---|
S00031 | OU596109 | S82 | P1_I86_S1 | IGHV4-61*02_A234G |
Sequences in other published genotypes which have been identified by IARC and support the inference:
Inferred sequences in VDJbase that match this sequence:
VDJbase Allele Name | Subjects | Sequence Match |
---|---|---|
IGHV4-61*02_a234g | 13 |
Un-rearranged sequence observations that support this sequence:
Sequence ID | A00073 |
Curator address | Dept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden |
Version | 1 |
Release Date | 2021-11-01 |
Release Notes | Submission published by IARC on November 1st, 2021 |
Locus | IGH |
Sequence Type | V |
Gene Subgroup | 4 |
Gene Designation | 61 |
Allele Designation | i03 |
Notes are added by IARC reviewers.
IARC meeting 63, Nov 20th, 2020: IARC meeting 84, Oct 25th, 2021: It has been noted that IGHV4-61*02_A234G was also found in subject S39 (P1_I42_S1; ERR2567216) used to assess the inference of IGHV4-4*i03 (although this data set was not submitted to IARC for assessment of IGHV4-61*02_A234G). In this sample, IGHV4-61*02_A234G was supported by many sequences (476) and unmutated sequences (395), a high overall frequency in the unmutated population (2.4%) and many unique CDR3s (390) in the unmutated sequence set. No other allele named as IGHV4-61 had been inferred in this subject but IGHV4-59*08, an allele suspected to residue in gene IGHV4-61 (DOI: 10.1038/ncomms14946), was found. The allelic ratio of IGHV4-61*02_A234G in this context would be 61%. Haplotyping of this subject was possible based on an allele of IGHD3-10 (10.3389/fimmu.2019.00987) not documented by the IMGT database. In this context, the two alleles of the genotype believed to be associated to IGHV4-61, IGHV4-61*02_A234G and IGHV4-59*08, showed excellent separation (see also documentation associated to the affirmation of IGHV4-4*i03). IARC, taking all of the collective evidence under consideration, affirms the sequence at level 1 up to and including base 319 in agreement with past practice. It is acknowledged that the allele most likely carries one additional base, typically A at base position 320. Although there is nothing in the data, including haplotype assessment, that suggest that the allele does not reside in gene IGHV4-61, it must be recognised, in particular in view of the similarity of alleles linked to IGHV4-4/IGHV4-59/IGHV4-61, that IARC gene naming does not reflect an absolute position on the precise location of the allele to a specific gene. The allele is given the name IGHV4-61*i03. >IGHV4-61*i03 |
History logs the times and reasons for the publication of each version of this sequence.
Mats Ohlin 2021-11-01 22:51:18 | Version 1 published Submission published by IARC on November 1st, 2021 |
Mats Ohlin 2021-11-17 15:26:17 | IMGT Name updated to IGHV4-61*11 IMGT Name updated. |
All published versions of this sequence.
Sequence Name | IMGT Name | Alternative names | Inference Type | Affirmation Level | Species subgroup | Subgroup type | Version | Date |
---|---|---|---|---|---|---|---|---|
IGHV4-61*i03 | IGHV4-61*11 | Rearranged Only | 1 | none | 1 | 2021-11-01 |