Details


Species	Human
Species subgroup
Subgroup type
Sequence Name	IGLV3-21*i01
IUIS Name	IGLV3-21*04
Alternative names
Affirmation Level	1
Full Sequence
Coding Sequence
Functionality	F
Inference Type	Rearranged Only
Alternative names
Paralogs

Evidence

The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.

'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.

Submission ID	Accession No	Subject ID	Genotype Name	Sequence Name	Sequence Match
S00028	MK308864	A007	A007 VL	IGLV3-21*01_S5562

Supporting Observations

Sequences in other published genotypes which have been identified by IARC and support the inference:

No Items

Observations in VDJbase

Inferred sequences in VDJbase that match this sequence:

No Items

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

No Items

Additional Information


Sequence ID	A00056
Curator address	School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney Australia
Version	1
Release Date	2020-08-01
Release Notes	Published by the IARC on 1/8/2020.
Locus	IGL
Sequence Type	V
Gene Subgroup	3
Gene Designation	21
Allele Designation	i01

Acknowledgements

Individuals acknowledged as contributing to this sequence:

Name	Institution	ORCID ID
Néstor Vázquez Bernat	Karolinska Institutet SE-171 77 Stockholm

Notes

Notes are added by IARC reviewers.


Originally approved by IARC at Meeting 57 on July 7, 2020, where it was noted: “The sequence was seen in 1.61% of all unmutated rearrangements, with 9,680 sequences including 1925 perfect alignments to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. A second IGLV3-21 allele, IGLV3-2103, was also present in the genotype, at a higher frequency, but the inferred allele still accounted for 35% of all IGLV3-21 alignments. Haplotype data is unavailable. Plots of the final 3’ nucleotides were considered, but the variability seen made it impossible to consider the final two nucleotides of the sequence. These were not part of the Genbank submission. The sequence, up to and including nucleotide 339, was affirmed as the Level 1 sequence, IGLV3-21i01. Uncertainty regarding nucleotides 340-341 will be indicated in IARC and OGRDB publications by two dots at the end of the affirmed sequence.”

Originally approved by IARC at Meeting 57 on July 7, 2020, where it was noted:

“The sequence was seen in 1.61% of all unmutated rearrangements, with 9,680 sequences including 1925 perfect alignments to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. A second IGLV3-21 allele, IGLV3-21*03, was also present in the genotype, at a higher frequency, but the inferred allele still accounted for 35% of all IGLV3-21 alignments. Haplotype data is unavailable. Plots of the final 3’ nucleotides were considered, but the variability seen made it impossible to consider the final two nucleotides of the sequence. These were not part of the Genbank submission. The sequence, up to and including nucleotide 339, was affirmed as the Level 1 sequence, IGLV3-21*i01. Uncertainty regarding nucleotides 340-341 will be indicated in IARC and OGRDB publications by two dots at the end of the affirmed sequence.”

Attachments

	Supplementary Files

History

History logs the times and reasons for the publication of each version of this sequence.


Andrew Collins 2020-08-01 13:21:02	Version 1 published Published by the IARC on 1/8/2020.

Versions

All published versions of this sequence.

Sequence Name	IMGT Name	Alternative names	Inference Type	Affirmation Level	Species subgroup	Subgroup type	Version	Date
IGLV3-21*i01	IGLV3-21*04		Rearranged Only	1			1	2020-08-01