Details

SpeciesHuman
Species subgroup
Subgroup type
Sequence NameIGLV10-54*i01
IUIS NameIGLV10-54*04
Alternative names
Affirmation Level1
Full Sequence
Coding Sequence
FunctionalityF
Inference TypeRearranged Only
Mapped
Paralogs
Paralog Rep

Observations in VDJbase

Inferred sequences in VDJbase that match this sequence:

VDJbase Allele NameSubjectsSequence Match
IGLV10-54*01_a228c 24

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

No Items

CDR delineation

CDR1 Start76
CDR1 End99
CDR2 Start151
CDR2 End159
CDR3 Start268

Additional Information

Sequence IDA00055
Curator
Curator addressSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney Australia
Version1
Release Date2020-07-30
Release Notes

Submission published by IARC on July 30th 2020.

LocusIGL
Sequence TypeV
Gene Subgroup10
Gene Designation54
Allele Designationi01

Acknowledgements

Individuals acknowledged as contributing to this sequence:

NameInstitutionORCID ID
Néstor Vázquez BernatKarolinska Institutet SE-171 77 Stockholm

Notes

Notes are added by IARC reviewers.

The sequence was first affirmed at IARC Meeting 53 on April 14th 2020, where it was noted:

“The sequence was seen in 1.79% of all unmutated rearrangements, with 11279 sequences including 2138 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. The IGLV10-54*01 allele was also present in the genotype, at a similar frequency (1.77% of all unmutated sequences; 7826 sequences; 2117 unmutated sequences). Haplotype data is unavailable. Plots of the final 3’ nucleotides showed a high level of variability, making it impossible to determine the final three nucleotides with certainty. The sequence, up to and including nucleotide 339, was affirmed as a Level 1 sequence. Uncertainty regarding nucleotides 340-341 will be indicated in IARC and OGRDB publications by two dots at the end of the affirmed sequence.”

Attachments

Attachment File Name
 

History

History logs the times and reasons for the publication of each version of this sequence.

Andrew Collins
2020-07-30 12:58:46
Version 1 published

Submission published by IARC on July 30th 2020.

Mats Ohlin
2021-04-29 22:33:15
IMGT Name updated to IGLV10-54*04

IMGT Name updated.

Versions

All published versions of this sequence.

Sequence NameIMGT NameAlternative namesInference TypeAffirmation LevelSpecies subgroupSubgroup typeGene startGene endUTR 5' StartUTR 5' EndL-PART1 StartL-PART1 EndL-PART2 StartL-PART2 EndCDR1 StartCDR1 EndCDR2 StartCDR2 EndCDR3 Startv_rs_startv_rs_endd_rs_3_prime_startd_rs_3_prime_endd_rs_5_prime_startd_rs_5_prime_endj_rs_startj_rs_endCodon FrameVersionDate
IGLV10-54*i01IGLV10-54*04Rearranged Only11294769915115926812020-07-30
IGLV10-54*04IGLV10-54*04IGLV10-54*i01Genomic and rearranged131761030631639241546747558461365122023-07-10
IGLV10-54*04IGLV10-54*04IGLV10-54*i01Genomic and rearranged1none170463146159169245268320328437466504132024-02-22