Sequence IGLV10-54*i01
Details
| Species | Human |
| Sequence Name | IGLV10-54*i01 |
| IUIS Name | IGLV10-54*04 |
| Seq ID | OGRDB:6OBI |
| Affirmation Level | 1 |
| Full Sequence | |
| Coding Sequence | |
| Functional | True |
| Inference Type | Rearranged Only |
| Alternative names | |
| Paralogs |
Evidence
The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.
'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.
| Submission ID | Accession No | Subject ID | Genotype Name | Sequence Name | Sequence Match |
|---|---|---|---|---|---|
| S00028 | MK308862 | A007 | A007 VL | IGLV10-54*01_S4180 |
Supporting Observations
Sequences in other published genotypes which have been identified by IARC and support the inference:
Observations in VDJbase
Inferred sequences in VDJbase that match this sequence:
| VDJbase Allele Name | Subjects | Sequence Match |
|---|---|---|
| >IGLV10-54*01_a228c|Human|IGL | 24 |
Un-rearranged Observations
Un-rearranged sequence observations that support this sequence:
Additional Information
| Sequence ID | A00055 |
| Curator address | School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney Australia |
| Version | 1 |
| Release Date | 2020-07-30 |
| Release Notes | Submission published by IARC on July 30th 2020. |
| Locus | IGL |
| Sequence Type | V |
| Gene Subgroup | 10 |
| Gene Designation | 54 |
| Allele Designation | i01 |
Notes
Notes are added by IARC reviewers.
| The sequence was first affirmed at IARC Meeting 53 on April 14th 2020, where it was noted: “The sequence was seen in 1.79% of all unmutated rearrangements, with 11279 sequences including 2138 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. The IGLV10-54*01 allele was also present in the genotype, at a similar frequency (1.77% of all unmutated sequences; 7826 sequences; 2117 unmutated sequences). Haplotype data is unavailable. Plots of the final 3’ nucleotides showed a high level of variability, making it impossible to determine the final three nucleotides with certainty. The sequence, up to and including nucleotide 339, was affirmed as a Level 1 sequence. Uncertainty regarding nucleotides 340-341 will be indicated in IARC and OGRDB publications by two dots at the end of the affirmed sequence.” |
Attachments
History
History logs the times and reasons for the publication of each version of this sequence.
| Andrew Collins 2020-07-30 12:58:46 | Version 1 published Submission published by IARC on July 30th 2020. |
| Mats Ohlin 2021-04-29 22:33:15 | IMGT Name updated to IGLV10-54*04 IMGT Name updated. |
Versions
All published versions of this sequence.
| Sequence Name | IMGT Name | Affirmation Level | Seq ID | Version | Date |
|---|---|---|---|---|---|
| IGLV10-54*i01 | IGLV10-54*04 | 1 | OGRDB:6OBI | 1 | 2020-07-30 |