Details


Organism	Human
Sequence Name	IGLV10-54*i01
IMGT Name	IGLV10-54*04
Affirmation Level	1
Full Sequence
Coding Sequence
Functional	True
Inference Type	Rearranged Only
Alternative names
Paralogs

Evidence

The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.

'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.

Submission ID	Accession No	Subject ID	Genotype Name	Sequence Name	Sequence Match
S00028	MK308862	A007	A007 VL	IGLV10-54*01_S4180

Supporting Observations

Sequences in other published genotypes which have been identified by IARC and support the inference:

No Items

Observations in VDJbase

Inferred sequences in VDJbase that match this sequence:

No Items

Additional Information


Sequence ID	A00055
Curator	Andrew Collins
Curator address	School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney Australia
Version	1
Release Date	2020-07-30 00:00:00
Release Notes	Submission published by IARC on July 30th 2020.
Locus	IGL
Sequence Type	V
Gene Subgroup	10
Gene Designation	54
Allele Designation	i01

Acknowledgements

Individuals acknowledged as contributing to this sequence:

Name	Institution	ORCID ID
Néstor Vázquez Bernat	Karolinska Institutet SE-171 77 Stockholm

Notes

Notes are added by IARC reviewers.


The sequence was first affirmed at IARC Meeting 53 on April 14th 2020, where it was noted: “The sequence was seen in 1.79% of all unmutated rearrangements, with 11279 sequences including 2138 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. The IGLV10-54*01 allele was also present in the genotype, at a similar frequency (1.77% of all unmutated sequences; 7826 sequences; 2117 unmutated sequences). Haplotype data is unavailable. Plots of the final 3’ nucleotides showed a high level of variability, making it impossible to determine the final three nucleotides with certainty. The sequence, up to and including nucleotide 339, was affirmed as a Level 1 sequence. Uncertainty regarding nucleotides 340-341 will be indicated in IARC and OGRDB publications by two dots at the end of the affirmed sequence.”

The sequence was first affirmed at IARC Meeting 53 on April 14th 2020, where it was noted:

“The sequence was seen in 1.79% of all unmutated rearrangements, with 11279 sequences including 2138 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. The IGLV10-54*01 allele was also present in the genotype, at a similar frequency (1.77% of all unmutated sequences; 7826 sequences; 2117 unmutated sequences). Haplotype data is unavailable. Plots of the final 3’ nucleotides showed a high level of variability, making it impossible to determine the final three nucleotides with certainty. The sequence, up to and including nucleotide 339, was affirmed as a Level 1 sequence. Uncertainty regarding nucleotides 340-341 will be indicated in IARC and OGRDB publications by two dots at the end of the affirmed sequence.”

Attachments

	Attachment File Name

History

History records log the times and reasons for the publication of each version of this sequence record.


Andrew Collins 2020-07-30 12:58:46	Version 1 published Submission published by IARC on July 30th 2020.


Mats Ohlin 2021-04-29 22:33:15	*IMGT Name updated to IGLV10-5404** IMGT Name updated.