Sequence IGHV4-61*i02
Details
| Species | Human |
| Species subgroup | |
| Subgroup type | |
| Sequence Name | IGHV4-61*i02 |
| IUIS Name | IGHV4-61*10 |
| Alternative names | |
| Affirmation Level | 1 |
| Full Sequence | |
| Coding Sequence | |
| Functionality | F |
| Inference Type | Rearranged Only |
| Alternative names | |
| Paralogs |
Evidence
The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.
'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.
| Submission ID | Accession No | Subject ID | Genotype Name | Sequence Name | Sequence Match |
|---|---|---|---|---|---|
| S00010 | MK471386 | B16 | B16 | IGHV4-61*01_S5549 |
Supporting Observations
Sequences in other published genotypes which have been identified by IARC and support the inference:
Observations in VDJbase
Inferred sequences in VDJbase that match this sequence:
Un-rearranged Observations
Un-rearranged sequence observations that support this sequence:
Additional Information
| Sequence ID | A00049 |
| Curator address | Dept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden |
| Version | 1 |
| Release Date | 2019-12-12 |
| Release Notes | Submission published by IARC on Dec 13, 2019. |
| Locus | IGH |
| Sequence Type | V |
| Gene Subgroup | 4 |
| Gene Designation | 61 |
| Allele Designation | i02 |
Notes
Notes are added by IARC reviewers.
| Assessed by IARC on November 18, 2019 during meeting 45 and on December 2, 2019 during meeting 46. The committee considered IGHV4-61*01_S5549 (C136G A138G) of Genotype B16 of submission S00010, which was previously evaluated as IGHV4-61*01_S0787 of submission S00006 at Meeting 12. It was affirmed as a Level 0 sequence at that time. The sequence was seen in 1.68% of all unmutated rearrangements, with 11,785 sequences including 4732 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. No other allele of IGHV4-61 was present in the genotype. Haplotype data is supportive of the inference, with the sequence being strongly associated with one haplotype. However, two alleles of IGHV4-4 (a gene closely related to IGHV4-61) were present on the other haplotype, highlighting the possibility that one of these alleles might be an allele of IGHV4-61. There was strong support for the sequence being affirmed up to and including nucleotide 319, in line with IARC policy, as a Level 1 sequence, with one additional 3’ nucleotide being likely present in the sequence. This is indicated in IARC and OGRDB publications by one dot at the end of the sequence. |
Attachments
History
History logs the times and reasons for the publication of each version of this sequence.
| Andrew Collins 2019-12-12 22:52:18 | Version 1 published Submission published by IARC on Dec 13, 2019. |
| Andrew Collins 2020-01-12 01:39:10 | IMGT Name updated to IGHV4-61*10 IMGT Name updated. |
Versions
All published versions of this sequence.
| Sequence Name | IMGT Name | Alternative names | Inference Type | Affirmation Level | Species subgroup | Subgroup type | Version | Date |
|---|---|---|---|---|---|---|---|---|
| IGHV4-61*i02 | IGHV4-61*10 | Rearranged Only | 1 | 1 | 2019-12-12 |