Details

OrganismHuman
Sequence NameIGHV4-61*i02
IMGT NameIGHV4-61*10
Affirmation Level1
Full Sequence
Coding Sequence
FunctionalTrue
Inference TypeRearranged Only
Alternative names
Paralogs

Evidence

The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.

'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.

Submission IDAccession NoSubject IDGenotype NameSequence NameSequence Match
S00010 MK471386B16B16IGHV4-61*01_S5549

Supporting Observations

Sequences in other published genotypes which have been identified by IARC and support the inference:

No Items

Observations in VDJbase

Inferred sequences in VDJbase that match this sequence:

No Items

Additional Information

Sequence IDA00049
CuratorMats Ohlin
Curator addressDept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden
Version1
Release Date2019-12-12 00:00:00
Release Notes

Submission published by IARC on Dec 13, 2019.

LocusIGH
Sequence TypeV
Gene Subgroup4
Gene Designation61
Allele Designationi02

Acknowledgements

Individuals acknowledged as contributing to this sequence:

NameInstitutionORCID ID
Davide Bagnaradavide.bagnara@edu.unige.it
Martin CorcoranDepartment of Microbiology, Tumor and Cell Biology, Biomedicum, Karolinska Institute, Stockholm Sweden.

Notes

Notes are added by IARC reviewers.

Assessed by IARC on November 18, 2019 during meeting 45 and on December 2, 2019 during meeting 46.

The committee considered IGHV4-61*01_S5549 (C136G A138G) of Genotype B16 of submission S00010, which was previously evaluated as IGHV4-61*01_S0787 of submission S00006 at Meeting 12. It was affirmed as a Level 0 sequence at that time.

The sequence was seen in 1.68% of all unmutated rearrangements, with 11,785 sequences including 4732 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. No other allele of IGHV4-61 was present in the genotype. Haplotype data is supportive of the inference, with the sequence being strongly associated with one haplotype. However, two alleles of IGHV4-4 (a gene closely related to IGHV4-61) were present on the other haplotype, highlighting the possibility that one of these alleles might be an allele of IGHV4-61. There was strong support for the sequence being affirmed up to and including nucleotide 319, in line with IARC policy, as a Level 1 sequence, with one additional 3’ nucleotide being likely present in the sequence. This is indicated in IARC and OGRDB publications by one dot at the end of the sequence.

Attachments

Attachment File Name
 

History

History records log the times and reasons for the publication of each version of this sequence record.

Andrew Collins
2019-12-12 22:52:18
Version 1 published

Submission published by IARC on Dec 13, 2019.

Andrew Collins
2020-01-12 01:39:10
IMGT Name updated to IGHV4-61*10

IMGT Name updated.