SpeciesHomo sapiens
Species subgroup
Subgroup type
Sequence NameIGHV4-61*10
IUIS NameIGHV4-61*10
Alternative namesIGHV4-61*i02
Affirmation Level1
Full Sequence
Coding Sequence
Inference TypeRearranged Only
Paralog RepFalse

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:


Observations in AIRR-seq Repertoires

Click here to review supporting data in VDJbase.

Clicking the link will take you to VDJbase. Open in a new tab if you want to keep this page open. In VDJbase, click on the count in the Apperances column to see a list of samples in which the sequence was found.

CDR delineation

CDR1 Start76
CDR1 End105
CDR2 Start157
CDR2 End177
CDR3 Start292


3' ExtensionA
3' start
3' end

Additional Information

Sequence IDA00049
CuratorWilliam Lees
Curator addressBirkbeck College, University of London, Malet Street, London
Release Date2023-07-10
Release Notes

Bulk upload of sequences for the AIRR-C Human IG germline sets

Sequence TypeV
Gene Subgroup4
Gene Designation61
Allele Designation10


Individuals acknowledged as contributing to this sequence:

No Items


Notes are added by IARC reviewers.

Assessed by IARC on November 18, 2019 during meeting 45 and on December 2, 2019 during meeting 46.

The committee considered IGHV4-61*01_S5549 (C136G A138G) of Genotype B16 of submission S00010, which was previously evaluated as IGHV4-61*01_S0787 of submission S00006 at Meeting 12. It was affirmed as a Level 0 sequence at that time.

The sequence was seen in 1.68% of all unmutated rearrangements, with 11,785 sequences including 4732 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. No other allele of IGHV4-61 was present in the genotype. Haplotype data is supportive of the inference, with the sequence being strongly associated with one haplotype. However, two alleles of IGHV4-4 (a gene closely related to IGHV4-61) were present on the other haplotype, highlighting the possibility that one of these alleles might be an allele of IGHV4-61. There was strong support for the sequence being affirmed up to and including nucleotide 319, in line with IARC policy, as a Level 1 sequence, with one additional 3’ nucleotide being likely present in the sequence. This is indicated in IARC and OGRDB publications by one dot at the end of the sequence.

Additional information for this sequence was imported into OGRDB via bulk update with the following notes:
Sequence annotation is based on Genbank sample MK471386


No Items


History logs the times and reasons for the publication of each version of this sequence.

Andrew Collins
2019-12-12 22:52:18
Version 1 published

Submission published by IARC on Dec 13, 2019.

Andrew Collins
2020-01-12 01:39:10
IMGT Name updated to IGHV4-61*10

IMGT Name updated.

William Lees
2023-07-10 11:24:41
Version 2 published

Bulk upload of sequences for the AIRR-C Human IG germline sets

Changes from previous version

CuratorWilliam Lees
Curator addressDept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, SwedenBirkbeck College, University of London, Malet Street, London
Sequence NameIGHV4-61*i02IGHV4-61*10
Alternative namesIGHV4-61*i02
Species subgroup
Subgroup type
Allele Designationi0210
Full Sequence
Paralog RepFalse
3' ExtensionA
5' Extension


All published versions of this sequence.

Sequence NameIMGT NameVersionDate