Species | Human |
Species subgroup | |
Subgroup type | |
Sequence Name | IGHV4-4*i02 |
IUIS Name | IGHV4-4*09 |
Alternative names | |
Affirmation Level | 1 |
Full Sequence | |
Coding Sequence | |
Functionality | F |
Inference Type | Rearranged Only |
Alternative names | |
Paralogs |
The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.
'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.
Submission ID | Accession No | Subject ID | Genotype Name | Sequence Name | Sequence Match |
---|---|---|---|---|---|
S00010 | MK471384 | B16 | B16 | IGHV4-4*08_S8301 |
Sequences in other published genotypes which have been identified by IARC and support the inference:
Inferred sequences in VDJbase that match this sequence:
Un-rearranged sequence observations that support this sequence:
Sequence ID | A00047 |
Curator address | Dept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden |
Version | 1 |
Release Date | 2019-12-12 |
Release Notes | Submission published by IARC on Dec 13, 2019. |
Locus | IGH |
Sequence Type | V |
Gene Subgroup | 4 |
Gene Designation | 4 |
Allele Designation | i02 |
Notes are added by IARC reviewers.
Assessed by IARC on December 2, 2019 during meeting 46. The committee considered IGHV4-4*08_S8301 (T165C,C237A) of Genotype B16 of submission S00010, which was previously evaluated as IGHV4-4*08_S4567 as part of submission S00006 at Meeting 12. It was affirmed as a Level 0 sequence at that time, because of haplotype analysis that at the time was considered inconclusive. The sequence was seen in 1.81% of all unmutated rearrangements, with 12648 sequences including 5107 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. One other IGHV4-4 allele was present in the genotype, as well as two likely IGHV4-59 sequences and one IGHV4-61 sequence. Haplotype data is supportive of the inference, though the haplotype ratios likely reflect the presence of some artefacts within the dataset. The ratios for the two IGHV4-4 sequences were 75:25 and 81:19, suggesting that both sequences are carried on the IGHJ6*02-bearing chromosome. The sequence, up to and including nucleotide 318, was affirmed as a Level 1 sequence. Uncertainty regarding nucleotides 319 and 320 is indicated in IARC and OGRDB publications by two dots at the end of the affirmed sequence. The committee believes it is most likely that the 319th nucleotide is āCā. |
History logs the times and reasons for the publication of each version of this sequence.
Andrew Collins 2019-12-12 22:51:16 | Version 1 published Submission published by IARC on Dec 13, 2019. |
Andrew Collins 2020-01-12 01:36:42 | IMGT Name updated to IMGT4-4*09 IMGT Name updated. |
Andrew Collins 2020-01-12 01:39:38 | IMGT Name updated to IGHV4-4*09 IMGT Name updated. |
All published versions of this sequence.
Sequence Name | IMGT Name | Alternative names | Inference Type | Affirmation Level | Species subgroup | Subgroup type | Version | Date |
---|---|---|---|---|---|---|---|---|
IGHV4-4*i02 | IGHV4-4*09 | Rearranged Only | 1 | 1 | 2019-12-12 |