Details

SpeciesHuman
Species subgroup
Subgroup type
Sequence NameIGHV4-4*09
IUIS NameIGHV4-4*09
Alternative namesIGHV4-4*i02
Affirmation Level1
Full Sequence
Coding Sequence
FunctionalityORF
Inference TypeRearranged Only
MappedFalse
Paralogs
Paralog RepFalse

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

AccessionTypeRepositoryStartEnd
MK471384InferredGenBank1291

Observations in AIRR-seq Repertoires

Click here to review supporting data in VDJbase.

Clicking the link will take you to VDJbase. Open in a new tab if you want to keep this page open. In VDJbase, click on the count in the Apperances column to see a list of samples in which the sequence was found.

Extension

3' ExtensionGA
3' start
3' end

Additional Information

Sequence IDA00047
CuratorWilliam Lees
Curator addressBirkbeck College, University of London, Malet Street, London
Version2
Release Date2023-07-10
Release Notes

Bulk upload of sequences for the AIRR-C Human IG germline sets

LocusIGH
Sequence TypeV
Gene Subgroup4
Gene Designation4
Allele Designation09

Acknowledgements

Individuals acknowledged as contributing to this sequence:

No Items

Notes

Notes are added by IARC reviewers.

Assessed by IARC on December 2, 2019 during meeting 46.

The committee considered IGHV4-4*08_S8301 (T165C,C237A) of Genotype B16 of submission S00010, which was previously evaluated as IGHV4-4*08_S4567 as part of submission S00006 at Meeting 12. It was affirmed as a Level 0 sequence at that time, because of haplotype analysis that at the time was considered inconclusive.

The sequence was seen in 1.81% of all unmutated rearrangements, with 12648 sequences including 5107 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. One other IGHV4-4 allele was present in the genotype, as well as two likely IGHV4-59 sequences and one IGHV4-61 sequence. Haplotype data is supportive of the inference, though the haplotype ratios likely reflect the presence of some artefacts within the dataset. The ratios for the two IGHV4-4 sequences were 75:25 and 81:19, suggesting that both sequences are carried on the IGHJ6*02-bearing chromosome. The sequence, up to and including nucleotide 318, was affirmed as a Level 1 sequence. Uncertainty regarding nucleotides 319 and 320 is indicated in IARC and OGRDB publications by two dots at the end of the affirmed sequence. The committee believes it is most likely that the 319th nucleotide is ā€˜Cā€™.

Additional information for this sequence was imported into OGRDB via bulk update with the following notes:
Sequence annotation is based on Genbank sample MK471384

Attachments

No Items

History

History logs the times and reasons for the publication of each version of this sequence.

Andrew Collins
2019-12-12 22:51:16
Version 1 published

Submission published by IARC on Dec 13, 2019.

Andrew Collins
2020-01-12 01:36:42
IMGT Name updated to IMGT4-4*09

IMGT Name updated.

Andrew Collins
2020-01-12 01:39:38
IMGT Name updated to IGHV4-4*09

IMGT Name updated.

William Lees
2023-07-10 11:24:41
Version 2 published

Bulk upload of sequences for the AIRR-C Human IG germline sets

Changes from previous version

v1v2
CuratorWilliam Lees
Curator addressDept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, SwedenBirkbeck College, University of London, Malet Street, London
Sequence NameIGHV4-4*i02IGHV4-4*09
Alternative namesIGHV4-4*i02
MappedFalse
FunctionalityFORF
Species subgroup
Subgroup type
Allele Designationi0209
Full Sequence
Gene start1
Gene end291
Paralog RepFalse
Extension?FalseTrue
3' ExtensionGA
5' Extension
curational_tagslikely_truncated
Noteschanged

Versions

All published versions of this sequence.

Sequence NameIMGT NameAlternative namesInference TypeAffirmation LevelSpecies subgroupSubgroup typeVersionDate
IGHV4-4*i02IGHV4-4*09Rearranged Only112019-12-12
IGHV4-4*09IGHV4-4*09IGHV4-4*i02Rearranged Only122023-07-10