Species | Homo sapiens |
Species subgroup | |
Subgroup type | |
Sequence Name | IGHV4-4*09 |
IUIS Name | IGHV4-4*09 |
Alternative names | IGHV4-4*i02 |
Affirmation Level | 1 |
Full Sequence | |
Coding Sequence | |
Functionality | ORF |
Inference Type | Rearranged Only |
Mapped | False |
Paralogs | |
Paralog Rep | False |
Un-rearranged sequence observations that support this sequence:
Accession | Type | Repository | Start | End |
---|---|---|---|---|
MK471384 | Inferred | GenBank | 1 | 291 |
Click here to review supporting data in VDJbase.
Clicking the link will take you to VDJbase. Open in a new tab if you want to keep this page open. In VDJbase, click on the count in the Apperances column to see a list of samples in which the sequence was found.
CDR1 Start | 76 |
CDR1 End | 99 |
CDR2 Start | 151 |
CDR2 End | 171 |
CDR3 Start | 286 |
3' Extension | GA |
3' start | |
3' end |
Sequence ID | A00047 |
Curator | William Lees |
Curator address | Birkbeck College, University of London, Malet Street, London |
Version | 2 |
Release Date | 2023-07-10 |
Release Notes | Bulk upload of sequences for the AIRR-C Human IG germline sets |
Locus | IGH |
Sequence Type | V |
Gene Subgroup | 4 |
Gene Designation | 4 |
Allele Designation | 09 |
Notes are added by IARC reviewers.
Assessed by IARC on December 2, 2019 during meeting 46. The committee considered IGHV4-4*08_S8301 (T165C,C237A) of Genotype B16 of submission S00010, which was previously evaluated as IGHV4-4*08_S4567 as part of submission S00006 at Meeting 12. It was affirmed as a Level 0 sequence at that time, because of haplotype analysis that at the time was considered inconclusive. The sequence was seen in 1.81% of all unmutated rearrangements, with 12648 sequences including 5107 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. One other IGHV4-4 allele was present in the genotype, as well as two likely IGHV4-59 sequences and one IGHV4-61 sequence. Haplotype data is supportive of the inference, though the haplotype ratios likely reflect the presence of some artefacts within the dataset. The ratios for the two IGHV4-4 sequences were 75:25 and 81:19, suggesting that both sequences are carried on the IGHJ6*02-bearing chromosome. The sequence, up to and including nucleotide 318, was affirmed as a Level 1 sequence. Uncertainty regarding nucleotides 319 and 320 is indicated in IARC and OGRDB publications by two dots at the end of the affirmed sequence. The committee believes it is most likely that the 319th nucleotide is āCā. Additional information for this sequence was imported into OGRDB via bulk update with the following notes: |
History logs the times and reasons for the publication of each version of this sequence.
Andrew Collins 2019-12-12 22:51:16 | Version 1 published Submission published by IARC on Dec 13, 2019. |
Andrew Collins 2020-01-12 01:36:42 | IMGT Name updated to IMGT4-4*09 IMGT Name updated. |
Andrew Collins 2020-01-12 01:39:38 | IMGT Name updated to IGHV4-4*09 IMGT Name updated. |
William Lees 2023-07-10 11:24:41 | Version 2 published Bulk upload of sequences for the AIRR-C Human IG germline sets |
v1 | v2 | |
---|---|---|
Curator | William Lees | |
Curator address | Dept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden | Birkbeck College, University of London, Malet Street, London |
Sequence Name | IGHV4-4*i02 | IGHV4-4*09 |
Alternative names | IGHV4-4*i02 | |
Mapped | False | |
Functionality | F | ORF |
Species subgroup | ||
Subgroup type | ||
Allele Designation | i02 | 09 |
Full Sequence | ||
Paralog Rep | False | |
Extension? | False | True |
3' Extension | GA | |
5' Extension | ||
curational_tags | likely_truncated | |
Notes | changed |
All published versions of this sequence.
Sequence Name | IMGT Name | Version | Date |
---|---|---|---|
IGHV4-4*i02 | IGHV4-4*09 | 1 | 2019-12-12 |
IGHV4-4*09 | IGHV4-4*09 | 2 | 2023-07-10 |