Details

SpeciesHuman
Species subgroup
Subgroup type
Sequence NameIGHV1-69*i01
IUIS Name
Alternative names
Affirmation Level0
Full Sequence
Coding Sequence
FunctionalityF
Inference TypeRearranged Only
Alternative names
Paralogs

Evidence

The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.

'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.

Submission IDAccession NoSubject IDGenotype NameSequence NameSequence Match
S00010 MK471378B12B12IGHV1-69*14_S5279

Supporting Observations

Sequences in other published genotypes which have been identified by IARC and support the inference:

No Items

Observations in VDJbase

Inferred sequences in VDJbase that match this sequence:

VDJbase Allele NameSubjectsSequence Match
IGHV1-69*14_g163a 1

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

No Items

Additional Information

Sequence IDA00045
Curator addressDept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden
Version1
Release Date2019-12-12
Release Notes

Submission published by IARC on Dec 13, 2019.

LocusIGH
Sequence TypeV
Gene Subgroup1
Gene Designation69
Allele Designationi01

Acknowledgements

Individuals acknowledged as contributing to this sequence:

NameInstitutionORCID ID
Davide Bagnaradavide.bagnara@edu.unige.it
Martin CorcoranDepartment of Microbiology, Tumor and Cell Biology, Biomedicum, Karolinska Institute, Stockholm Sweden.

Notes

Notes are added by IARC reviewers.

Assessed by IARC on November 18, 2019 during meeting 45.

The committee considered IGHV1-69*14_S5279 (G163A) of Genotype B12 in submission S00010, which was previously evaluated as IGHV1-69*14_S3451 as part of submission S00004 at Meeting 8. It was affirmed as a Level 0 sequence at that time.

The sequence was seen in 2.29% of all unmutated rearrangements, with 11,849 sequences including 3889 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. Three other alleles were present in the genotype (none of which carries the allele-differentiating base A163), with IGHV1-69*13 also being present in the haplotype with this allele. In the earlier analysis (Meeting 8), an additional allele was reported. Haplotype data is supportive of the inference considering the existence of common duplications of the IGHV1-69 gene, but in light of the complex structural variation seen in this individual, the sequence was affirmed as a Level 0 sequence. In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 319. It is likely that one additional 3’ nucleotide is present in the sequence, and this is indicated in IARC and OGRDB publications by one dot at the end of the sequence.

Attachments

Supplementary Files
 

History

History logs the times and reasons for the publication of each version of this sequence.

Andrew Collins
2019-12-12 22:49:52
Version 1 published

Submission published by IARC on Dec 13, 2019.

Versions

All published versions of this sequence.

Sequence NameIMGT NameAlternative namesInference TypeAffirmation LevelSpecies subgroupSubgroup typeVersionDate
IGHV1-69*i01Rearranged Only012019-12-12