|Inference Type||Rearranged Only|
The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.
'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.
Sequences in other published genotypes which have been identified by IARC and support the inference:
Inferred sequences in VDJbase that match this sequence:
Un-rearranged sequence observations that support this sequence:
|Curator address||Dept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden|
|Release Notes|| |
IMGT allele name added
Notes are added by IARC reviewers.
This sequence represents IGHV4-59*01 T288C in terms of the IMGT numbering system. The committee noted a rearrangement frequency of about 1.7%, with 1515 alignments including 341 perfect matches to the inferred allele. IGHV4-59*01 is also present in the genotype and is represented by larger number of reads than IGHV4-59*01 T288C (ratio: 17:83). The S0007 submission noted that haplotyping was not possible, but MC indicated that it was possible to haplotype this individual using the IGHJ4 locus. He suggested that a previously unreported J4 allele was present in this individual, and agreed to send his analysis to members of the committee. Diverse reads representing the IGHV4-59*01 T288C inference have been submitted to SRA/ENA under accession numbers SRR8298738 and SRR8298744. All members of the committee agreed that the sequence should be accepted as a Level 1 sequence at IARC Meeting 31 on February 8th, 2019. In line with previous policy, the submitted sequence will be recognized up to and including nucleotide 319.
(April 12, 2019) A trailing “.” in the sequence indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation.
History logs the times and reasons for the publication of each version of this sequence.
|Version 1 published|
Submission published by IARC on April 3, 2019
|Version 2 published|
A trailing “.” in the sequence indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation.
|Version 3 published|
IMGT allele name added