Details

SpeciesHuman
Species subgroup
Subgroup type
Sequence NameIGHV4-59*i01
IUIS NameIGHV4-59*12
Alternative namesIGHV4-59*p20
Affirmation Level1
Full Sequence
Coding Sequence
FunctionalityF
Inference TypeRearranged Only
Mapped
Paralogs
Paralog Rep

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

No Items

Observations in AIRR-seq Repertoires

Click here to review supporting data in VDJbase.

Clicking the link will take you to VDJbase. Open in a new tab if you want to keep this page open. In VDJbase, click on the count in the Apperances column to see a list of samples in which the sequence was found.

CDR delineation

CDR1 Start76
CDR1 End99
CDR2 Start151
CDR2 End171
CDR3 Start286

Additional Information

Sequence IDA00010
Curator
Curator addressDept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden
Version3
Release Date2019-05-16
Release Notes

IMGT allele name added

LocusIGH
Sequence TypeV
Gene Subgroup4
Gene Designation59
Allele Designationi01

Acknowledgements

Individuals acknowledged as contributing to this sequence:

No Items

Notes

Notes are added by IARC reviewers.

This sequence represents IGHV4-59*01 T288C in terms of the IMGT numbering system. The committee noted a rearrangement frequency of about 1.7%, with 1515 alignments including 341 perfect matches to the inferred allele. IGHV4-59*01 is also present in the genotype and is represented by larger number of reads than IGHV4-59*01 T288C (ratio: 17:83). The S0007 submission noted that haplotyping was not possible, but MC indicated that it was possible to haplotype this individual using the IGHJ4 locus. He suggested that a previously unreported J4 allele was present in this individual, and agreed to send his analysis to members of the committee. Diverse reads representing the IGHV4-59*01 T288C inference have been submitted to SRA/ENA under accession numbers SRR8298738 and SRR8298744. All members of the committee agreed that the sequence should be accepted as a Level 1 sequence at IARC Meeting 31 on February 8th, 2019. In line with previous policy, the submitted sequence will be recognized up to and including nucleotide 319.

(April 12, 2019) A trailing “.” in the sequence indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation.

Attachments

No Items

History

History logs the times and reasons for the publication of each version of this sequence.

Andrew Collins
2019-04-02 22:39:06
Version 1 published

Submission published by IARC on April 3, 2019

Mats Ohlin
2019-04-12 14:49:26
Version 2 published

A trailing “.” in the sequence indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation.

Mats Ohlin
2019-05-16 21:55:10
Version 3 published

IMGT allele name added

Changes from previous version

v2v3
IUIS NameIGHV4-59*12

Versions

All published versions of this sequence.

Sequence NameIMGT NameAlternative namesInference TypeAffirmation LevelSpecies subgroupSubgroup typeVersionDate
IGHV4-59*i01IGHV4-59*p20Rearranged Only112019-04-02
IGHV4-59*i01IGHV4-59*p20Rearranged Only122019-04-12
IGHV4-59*i01IGHV4-59*12IGHV4-59*p20Rearranged Only132019-05-16
IGHV4-59*12IGHV4-59*12IGHV4-59*i01Rearranged Only142023-07-10