This sequence represents IGHV4-59*01 T288C in terms of the IMGT numbering system. The committee noted a rearrangement frequency of about 1.7%, with 1515 alignments including 341 perfect matches to the inferred allele. IGHV4-59*01 is also present in the genotype and is represented by larger number of reads than IGHV4-59*01 T288C (ratio: 17:83). The S0007 submission noted that haplotyping was not possible, but MC indicated that it was possible to haplotype this individual using the IGHJ4 locus. He suggested that a previously unreported J4 allele was present in this individual, and agreed to send his analysis to members of the committee. Diverse reads representing the IGHV4-59*01 T288C inference have been submitted to SRA/ENA under accession numbers SRR8298738 and SRR8298744. All members of the committee agreed that the sequence should be accepted as a Level 1 sequence at IARC Meeting 31 on February 8th, 2019. In line with previous policy, the submitted sequence will be recognized up to and including nucleotide 319.

(April 12, 2019) A trailing “.” in the sequence indicates IARC’s opinion that the sequence is likely to contain additional 3’ nucleotides for which there is insufficient evidence to make an affirmation.