SpeciesHomo sapiens
Species subgroup
Subgroup type
Sequence NameIGKV1D-8*04
IUIS NameIGKV1D-8*04
Alternative namesIGKV1D-8*i01
Affirmation Level1
Full Sequence
Coding Sequence
Inference TypeRearranged Only
Paralog RepFalse

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:


Observations in AIRR-seq Repertoires

Click here to review supporting data in VDJbase.

Clicking the link will take you to VDJbase. Open in a new tab if you want to keep this page open. In VDJbase, click on the count in the Apperances column to see a list of samples in which the sequence was found.

CDR delineation

CDR1 Start79
CDR1 End96
CDR2 Start148
CDR2 End156
CDR3 Start265


3' ExtensionTCC
3' start
3' end

Additional Information

Sequence IDA00052
CuratorWilliam Lees
Curator addressBirkbeck College, University of London, Malet Street, London
Release Date2023-07-10
Release Notes

Bulk upload of sequences for the AIRR-C Human IG germline sets

Sequence TypeV
Gene Subgroup1D
Gene Designation8
Allele Designation04


Individuals acknowledged as contributing to this sequence:

No Items


Notes are added by IARC reviewers.

This inference was considered at IARC Meeting 49 on February 4th 2020, at which it was noted:

The sequence was seen in 0.3% of all unmutated rearrangements, with 747 sequences including 538 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences, though relatively large numbers of sequences were clonally related (42 “Unique CDR3s with unmutated”). The IGKV1D-8*01 allele was also present in the genotype, at a similar frequency (0.4% of all unmutated sequences; 976 sequences; 758 unmutated sequences). It was noted that the select set available in SRA/ENA is very limited in size (essentially only representing 2 different rearrangements, either involving IGKJ1 or IGKJ2) as only full-length sequences (covering all bases of the V gene up to and including base 335) had been included in the submitted set. IGKV1-8*01 was also present at high frequency (7743 sequences), but this sequence has 12 nucleotide differences to the inference under consideration. Haplotype data is unavailable. Plots of the final 3’ nucleotides showed a high level of variability, making it impossible to determine the final three nucleotides with certainty. The sequence, up to and including nucleotide 332, was affirmed as a Level 1 sequence. Uncertainty regarding nucleotides 333-335 will be indicated in IARC and OGRDB publications by three dots at the end of the affirmed sequence.

Additional information for this sequence was imported into OGRDB via bulk update with the following notes:
Sequence annotation is based on Genbank sample MK308861


No Items


History logs the times and reasons for the publication of each version of this sequence.

Andrew Collins
2020-08-01 13:31:50
Version 1 published

Published by IARC on 1/8/2020.

Mats Ohlin
2021-04-29 22:34:53
IMGT Name updated to IGKV1D-8*04

IMGT Name updated.

William Lees
2023-07-10 11:24:43
Version 2 published

Bulk upload of sequences for the AIRR-C Human IG germline sets

Changes from previous version

CuratorWilliam Lees
Curator addressDept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, SwedenBirkbeck College, University of London, Malet Street, London
Sequence NameIGKV1D-8*i01IGKV1D-8*04
Alternative namesIGKV1D-8*i01
Species subgroup
Subgroup type
Allele Designationi0104
Full Sequence
Paralog RepFalse
3' ExtensionTCC
5' Extension


All published versions of this sequence.

Sequence NameIMGT NameVersionDate