Sequence IGHV4-30-4*i02
Details
| Species | Homo sapiens |
| Species subgroup | |
| Subgroup type | none |
| Sequence Name | IGHV4-30-4*i02 |
| IUIS Name | |
| Alternative names | |
| Affirmation Level | 1 |
| Full Sequence | |
| Coding Sequence | |
| Functionality | ORF |
| Inference Type | Unrearranged and Rearranged |
| Mapped | False |
| Paralogs | |
| Paralog Rep | False |
Observations in VDJbase
Inferred sequences in VDJbase that match this sequence:
| VDJbase Allele Name | Subjects | Sequence Match |
|---|---|---|
| IGHV4-30-4*01_a70g_a107g | 2 |
Un-rearranged Observations
Un-rearranged sequence observations that support this sequence:
CDR delineation
| CDR1 Start | 76 |
| CDR1 End | 105 |
| CDR2 Start | 157 |
| CDR2 End | 177 |
| CDR3 Start | 292 |
Non-Core Regions
| UTR 5' Start | |
| UTR 5' End | |
| L-PART1 Start | |
| L-PART1 End | |
| L_PART1 | |
| L-PART2 Start | |
| L-PART2 End | |
| L_PART2 | |
| v_rs_start | |
| v_rs_end | |
| V_HEPTAMER | |
| V_NONAMER |
Extension
| 3' Extension | |
| 3' start | |
| 3' end | |
| 5' start | |
| 5' end |
Additional Information
| Sequence ID | A02562 |
| Curator | William Lees |
| Curator address | Birkbeck College, University of London, Malet Street, London |
| Version | 3 |
| Release Date | 2023-07-24 |
| Release Notes | Remove unsupported extension |
| Locus | IGH |
| Sequence Type | V |
| Gene Subgroup | 4-30 |
| Gene Designation | 4 |
| Allele Designation | i02 |
| Gene start | 1 |
| Gene end | 298 |
Notes
Notes are added by IARC reviewers.
| This inferred allele was assessed at IARC meeting 100 on June 8th, 2022. IGHV4-30-4*01_A70G_A107G was inferred in subject S38 (VDJ-base: P1_I41_S1). The genotype carried no other allele of IGHV4-30-4. The inference was supported by a relative large number of sequences (388) and unmutated sequences (337), a high overall frequency in the unmutated population (0.95%) and a large and diverse set of unique CDR3s (324) in the unmutated sequence set. Its allelic ratio was 100%. Haplotyping based on allelic diversity in IGHJ6 was possible. All reads were associated to one haplotype, a haplotype that also carried IGHV4-30-2, IGHV3-30-3, and IGHV4-31. IARC affirms the sequence at level 1 up to and including base 319 in agreement with past practice. It is acknowledged that the allele most likely carries one additional base, typically A at base position 320. A trailing “.” indicates IARC’s opinion that the sequence is likely to contain one additional 3’-nucleotides for which there is insufficient evidence to make an affirmation. The allele is given the name IGHV4-30-4*i02. Additional information for this sequence was imported into OGRDB via bulk update with the following notes: |
Attachments
History
History logs the times and reasons for the publication of each version of this sequence.
| Mats Ohlin 2022-07-25 10:53:54 | Version 1 published The allele was published by IARC on July 25th, 2022. |
| William Lees 2023-07-10 11:24:40 | Version 2 published Bulk upload of sequences for the AIRR-C Human IG germline sets |
| William Lees 2023-07-24 14:15:26 | Version 3 published Remove unsupported extension |
Changes from previous version
| v1 | v3 | |
|---|---|---|
| Curator | Mats Ohlin | William Lees |
| Curator address | Dept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden | Birkbeck College, University of London, Malet Street, London |
| Alternative names | IGHV4-30-4*01 A70G A107G | |
| Chromosome | 14 | |
| Mapped | False | |
| Functionality | F | ORF |
| Inference Type | Rearranged | Unrearranged and Rearranged |
| Gene Subgroup | 4 | 4-30 |
| Gene Designation | 4-30-4 | 4 |
| Full Sequence | ||
| Paralog Rep | False | |
| Notes | changed |
Versions
All published versions of this sequence.
| Sequence Name | IMGT Name | Version | Date |
|---|---|---|---|
| IGHV4-30-4*i02 | 1 | 2022-07-25 | |
| IGHV4-30-4*i02 | 3 | 2023-07-24 | |
| IGHV4-30-4*i02 | 4 | 2023-08-16 |