Sequence IGHV4-30-4*i02
Details
| Species | Human |
| Species subgroup | |
| Subgroup type | none |
| Sequence Name | IGHV4-30-4*i02 |
| IUIS Name | |
| Alternative names | IGHV4-30-4*01 A70G A107G |
| Affirmation Level | 1 |
| Full Sequence | |
| Coding Sequence | |
| Functionality | F |
| Inference Type | Rearranged |
| Alternative names | IGHV4-30-4*01 A70G A107G |
| Paralogs |
Evidence
The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.
'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.
| Submission ID | Accession No | Subject ID | Genotype Name | Sequence Name | Sequence Match |
|---|---|---|---|---|---|
| S00037 | OW151139 | S38 | P1_I41_S1_ogrdb_report | IGHV4-30-4*01_A70G_A107G |
Supporting Observations
Sequences in other published genotypes which have been identified by IARC and support the inference:
Observations in VDJbase
Inferred sequences in VDJbase that match this sequence:
| VDJbase Allele Name | Subjects | Sequence Match |
|---|---|---|
| IGHV4-30-4*01_a70g_a107g | 2 |
Un-rearranged Observations
Un-rearranged sequence observations that support this sequence:
Non-Core Regions
| UTR 5' Start | |
| UTR 5' End | |
| L-PART1 Start | |
| L-PART1 End | |
| L-PART2 Start | |
| L-PART2 End | |
| v_rs_start | |
| v_rs_end |
Extension
| 3' Extension | |
| 3' start | |
| 3' end | |
| 5' start | |
| 5' end |
Additional Information
| Sequence ID | A02562 |
| Curator address | Dept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden |
| Version | 1 |
| Release Date | 2022-07-25 |
| Release Notes | The allele was published by IARC on July 25th, 2022. |
| Locus | IGH |
| Sequence Type | V |
| Gene Subgroup | 4 |
| Gene Designation | 4-30-4 |
| Allele Designation | i02 |
Notes
Notes are added by IARC reviewers.
| This inferred allele was assessed at IARC meeting 100 on June 8th, 2022. IGHV4-30-4*01_A70G_A107G was inferred in subject S38 (VDJ-base: P1_I41_S1). The genotype carried no other allele of IGHV4-30-4. The inference was supported by a relative large number of sequences (388) and unmutated sequences (337), a high overall frequency in the unmutated population (0.95%) and a large and diverse set of unique CDR3s (324) in the unmutated sequence set. Its allelic ratio was 100%. Haplotyping based on allelic diversity in IGHJ6 was possible. All reads were associated to one haplotype, a haplotype that also carried IGHV4-30-2, IGHV3-30-3, and IGHV4-31. IARC affirms the sequence at level 1 up to and including base 319 in agreement with past practice. It is acknowledged that the allele most likely carries one additional base, typically A at base position 320. A trailing “.” indicates IARC’s opinion that the sequence is likely to contain one additional 3’-nucleotides for which there is insufficient evidence to make an affirmation. The allele is given the name IGHV4-30-4*i02. |
Attachments
History
History logs the times and reasons for the publication of each version of this sequence.
| Mats Ohlin 2022-07-25 10:53:54 | Version 1 published The allele was published by IARC on July 25th, 2022. |
Versions
All published versions of this sequence.
| Sequence Name | IMGT Name | Alternative names | Inference Type | Affirmation Level | Species subgroup | Subgroup type | Version | Date |
|---|---|---|---|---|---|---|---|---|
| IGHV4-30-4*i02 | IGHV4-30-4*01 A70G A107G | Rearranged | 1 | none | 1 | 2022-07-25 |