Species | Homo sapiens |
Species subgroup | |
Subgroup type | none |
Sequence Name | IGHV4-30-4*i02 |
IUIS Name | |
Alternative names | IGHV4-30-4*01 A70G A107G |
Affirmation Level | 1 |
Full Sequence | |
Coding Sequence | |
Functionality | F |
Inference Type | Rearranged |
Mapped | |
Paralogs | |
Paralog Rep |
Inferred sequences in VDJbase that match this sequence:
VDJbase Allele Name | Subjects | Sequence Match |
---|---|---|
IGHV4-30-4*01_a70g_a107g | 2 |
Un-rearranged sequence observations that support this sequence:
CDR1 Start | 76 |
CDR1 End | 105 |
CDR2 Start | 157 |
CDR2 End | 177 |
CDR3 Start | 292 |
UTR 5' Start | |
UTR 5' End | |
L-PART1 Start | |
L-PART1 End | |
L_PART1 | |
L-PART2 Start | |
L-PART2 End | |
L_PART2 | |
v_rs_start | |
v_rs_end | |
V_HEPTAMER | |
V_NONAMER |
3' Extension | |
3' start | |
3' end | |
5' start | |
5' end |
Sequence ID | A02562 |
Curator | Mats Ohlin |
Curator address | Dept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden |
Version | 1 |
Release Date | 2022-07-25 |
Release Notes | The allele was published by IARC on July 25th, 2022. |
Locus | IGH |
Sequence Type | V |
Gene Subgroup | 4 |
Gene Designation | 4-30-4 |
Allele Designation | i02 |
Gene start | 1 |
Gene end | 298 |
Notes are added by IARC reviewers.
This inferred allele was assessed at IARC meeting 100 on June 8th, 2022. IGHV4-30-4*01_A70G_A107G was inferred in subject S38 (VDJ-base: P1_I41_S1). The genotype carried no other allele of IGHV4-30-4. The inference was supported by a relative large number of sequences (388) and unmutated sequences (337), a high overall frequency in the unmutated population (0.95%) and a large and diverse set of unique CDR3s (324) in the unmutated sequence set. Its allelic ratio was 100%. Haplotyping based on allelic diversity in IGHJ6 was possible. All reads were associated to one haplotype, a haplotype that also carried IGHV4-30-2, IGHV3-30-3, and IGHV4-31. IARC affirms the sequence at level 1 up to and including base 319 in agreement with past practice. It is acknowledged that the allele most likely carries one additional base, typically A at base position 320. A trailing “.” indicates IARC’s opinion that the sequence is likely to contain one additional 3’-nucleotides for which there is insufficient evidence to make an affirmation. The allele is given the name IGHV4-30-4*i02. |
History logs the times and reasons for the publication of each version of this sequence.
Mats Ohlin 2022-07-25 10:53:54 | Version 1 published The allele was published by IARC on July 25th, 2022. |
All published versions of this sequence.
Sequence Name | IMGT Name | Version | Date |
---|---|---|---|
IGHV4-30-4*i02 | 1 | 2022-07-25 | |
IGHV4-30-4*i02 | 3 | 2023-07-24 | |
IGHV4-30-4*i02 | 4 | 2023-08-16 |