Details

SpeciesHomo sapiens
Species subgroup
Subgroup typenone
Sequence NameIGHV4-30-4*i02
IUIS Name
Alternative namesIGHV4-30-4*01 A70G A107G
Affirmation Level1
Full Sequence
Coding Sequence
FunctionalityF
Inference TypeRearranged Only
Mapped
Paralogs
Paralog Rep

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

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Observations in AIRR-seq Repertoires

Click here to review supporting data in VDJbase.

Clicking the link will take you to VDJbase. Open in a new tab if you want to keep this page open. In VDJbase, click on the count in the Apperances column to see a list of samples in which the sequence was found.

CDR delineation

CDR1 Start76
CDR1 End105
CDR2 Start157
CDR2 End177
CDR3 Start292

Additional Information

Sequence IDA02562
CuratorMats Ohlin
Curator addressDept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden
Version1
Release Date2022-07-25
Release Notes

The allele was published by IARC on July 25th, 2022.

LocusIGH
Sequence TypeV
Gene Subgroup4
Gene Designation4-30-4
Allele Designationi02
Gene start1
Gene end298

Acknowledgements

Individuals acknowledged as contributing to this sequence:

NameInstitutionORCID ID
William LeesBirkbeck College, University of London, Malet Street, London
Ayelet PeresBar-Ilan University, Ramat-Gan, Israel
Gur YaariBar-Ilan University, Ramat-Gan, Israel

Notes

Notes are added by IARC reviewers.

This inferred allele was assessed at IARC meeting 100 on June 8th, 2022. IGHV4-30-4*01_A70G_A107G was inferred in subject S38 (VDJ-base: P1_I41_S1). The genotype carried no other allele of IGHV4-30-4. The inference was supported by a relative large number of sequences (388) and unmutated sequences (337), a high overall frequency in the unmutated population (0.95%) and a large and diverse set of unique CDR3s (324) in the unmutated sequence set. Its allelic ratio was 100%. Haplotyping based on allelic diversity in IGHJ6 was possible. All reads were associated to one haplotype, a haplotype that also carried IGHV4-30-2, IGHV3-30-3, and IGHV4-31. IARC affirms the sequence at level 1 up to and including base 319 in agreement with past practice. It is acknowledged that the allele most likely carries one additional base, typically A at base position 320. A trailing “.” indicates IARC’s opinion that the sequence is likely to contain one additional 3’-nucleotides for which there is insufficient evidence to make an affirmation. The allele is given the name IGHV4-30-4*i02.

Attachments

No Items

History

History logs the times and reasons for the publication of each version of this sequence.

Mats Ohlin
2022-07-25 10:53:54
Version 1 published

The allele was published by IARC on July 25th, 2022.

Versions

All published versions of this sequence.

Sequence NameIMGT NameVersionDate
IGHV4-30-4*i0212022-07-25
IGHV4-30-4*i0232023-07-24
IGHV4-30-4*i0242023-08-16