SpeciesHomo sapiens
Species subgroup
Subgroup type
Sequence NameIGHV3-21*07
IUIS NameIGHV3-21*07
Alternative namesIGHV3-21*i02
Affirmation Level1
Full Sequence
Coding Sequence
Inference TypeRearranged Only
Paralog RepFalse

Observations in VDJbase

Inferred sequences in VDJbase that match this sequence:

VDJbase Allele NameSubjectsSequence Match
IGHV3-21*01_a184g_t190a_a191c 1

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:


CDR delineation

CDR1 Start76
CDR1 End99
CDR2 Start151
CDR2 End174
CDR3 Start289

Additional Information

Sequence IDA00065
CuratorWilliam Lees
Curator addressBirkbeck College, University of London, Malet Street, London
Release Date2023-07-10
Release Notes

Bulk upload of sequences for the AIRR-C Human IG germline sets

Sequence TypeV
Gene Subgroup3
Gene Designation21
Allele Designation07


Individuals acknowledged as contributing to this sequence:

No Items


Notes are added by IARC reviewers.

IARC Meeting 61 (October 13th 2020):
The meeting considered the inference of the variant IGHV3-21*01_a184g_t190a_a191c in the VDJbase dataset of sample P1_I80_S1. The sequence was seen in 2.73% of all unmutated rearrangements, with 1207 sequences including 1054 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. IGHV3-21*01 was also present in the genotype, at a similar frequency (2.37% of all unmutated sequences, 1066 sequences, 917 unmutated sequences). Plots of the final 3’ nucleotides were unavailable, and no haplotyping data was available. The sequence was tentatively affirmed as a Level 1 sequence, and the final 3’ nucleotides will be considered at a later date, when terminal nucleotide plots become available, at which time the affirmed sequence will be noted in the IARC minutes.

IARC meeting 80 (September 27th, 2021):
IGHV3-21*01_A184G_T190A_A191C was inferred in the genotype of subject S76 (VDJbase: P1_I80). This inference has previously been pre-assessed at IARC meeting 61 ( The genotype also carried IGHV3-21*01. Both alleles were represented in high numbers (2.9% and 2.5% of the total unmutated population). IGHV3-21*01_A184G_T190A_A191 was represented by 1306 sequences, 1092 unmutated sequences, an allelic frequency of 53%, and 1069 unique CDR3s in the unmutated sequence set. Haplotyping based on differences in IGHJ6 alleles was not possible for this dataset.


The sequence is inferred at Level 1. IARC affirms the sequence up to and including base 320 based on the convincing evidence of the sequence end as presented in the OGRDBplot.

Additional information for this sequence was imported into OGRDB via bulk update with the following notes:
Sequence annotation is based on Genbank sample OU596107
VDJbase example haplotype: P1_I80


No Items


History logs the times and reasons for the publication of each version of this sequence.

Mats Ohlin
2021-11-01 22:48:38
Version 1 published

Submission published by IARC on November 1st, 2021

Mats Ohlin
2021-11-17 15:24:26
IMGT Name updated to IGHV3-21*07

IMGT Name updated.

William Lees
2023-07-10 11:24:37
Version 2 published

Bulk upload of sequences for the AIRR-C Human IG germline sets

Changes from previous version

CuratorMats OhlinWilliam Lees
Curator addressDept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, SwedenBirkbeck College, University of London, Malet Street, London
Sequence NameIGHV3-21*i02IGHV3-21*07
Alternative namesIGHV3-21*i02
Subgroup typenone
Allele Designationi0207
Codon Frame1
Paralog RepFalse
3' Extension
5' Extension


All published versions of this sequence.

Sequence NameIMGT NameVersionDate