Details

SpeciesHuman
Species subgroup
Subgroup type
Sequence NameIGHV1-69*18
IUIS NameIGHV1-69*18
Alternative namesIGHV1-69*i02
Affirmation Level1
Full Sequence
Coding Sequence
FunctionalityORF
Inference TypeRearranged Only
MappedFalse
Paralogs
Paralog RepFalse

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

AccessionTypeRepositoryStartEnd
MK471382InferredGenBank1295

Observations in AIRR-seq Repertoires

Click here to review supporting data in VDJbase.

Clicking the link will take you to VDJbase. Open in a new tab if you want to keep this page open. In VDJbase, click on the count in the Apperances column to see a list of samples in which the sequence was found.

CDR delineation

CDR1 Start76
CDR1 End99
CDR2 Start151
CDR2 End174
CDR3 Start289

Extension

3' ExtensionA
3' start
3' end

Additional Information

Sequence IDA00050
CuratorWilliam Lees
Curator addressBirkbeck College, University of London, Malet Street, London
Version2
Release Date2023-07-10
Release Notes

Bulk upload of sequences for the AIRR-C Human IG germline sets

LocusIGH
Sequence TypeV
Gene Subgroup1
Gene Designation69
Allele Designation18

Acknowledgements

Individuals acknowledged as contributing to this sequence:

No Items

Notes

Notes are added by IARC reviewers.

Assessed by IARC on November 18, 2019 during meeting 45 and on December 2, 2019 during meeting 46.

The committee considered IGHV1-69*01_S7220 (G163A) of submission S00010 of Genotype B16, which was previously evaluated as IGHV1-69*01_S5096 of submission S00006 at Meeting 10. It was affirmed as a Level 0 sequence at that time.

The sequence was seen in 8.02% of all unmutated rearrangements, with 53668 sequences including 22586 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. Three other alleles were present in the genotype, with IGHV1-69*02 also being present in the haplotype with this allele, likely a consequence of the presence of the IGHV1-69D gene in the haplotype in question. The inferred sequence includes six differences to the *02 allele. Haplotype data is supportive of the inference. There was strong support for the sequence being affirmed up to and including nucleotide 319, in line with IARC policy, as a Level 1 sequence, with one additional 3’ nucleotide being likely present in the sequence. This is indicated in IARC and OGRDB publications by one dot at the end of the sequence. It is noted that this sequences represents a 5’- and a 3’-extension of the partial allele IGHV1-69*07 already recognized by IMGT.

Additional information for this sequence was imported into OGRDB via bulk update with the following notes:
Sequence annotation is based on Genbank sample MK471382

Attachments

No Items

History

History logs the times and reasons for the publication of each version of this sequence.

Andrew Collins
2019-12-12 22:50:33
Version 1 published

Submission published by IARC on Dec 13, 2019.

Andrew Collins
2020-01-12 01:33:00
IMGT Name updated to IGHV1-69*18

IMGT Name updated.

Andrew Collins
2020-01-12 01:33:00
IMGT Name updated to IGHV1-69*18

IMGT Name updated.

Andrew Collins
2020-01-12 01:33:00
IMGT Name updated to IGHV1-69*18

IMGT Name updated.

Andrew Collins
2020-01-12 01:33:06
IMGT Name updated to IGHV1-69*18

IMGT Name updated.

Andrew Collins
2020-01-12 01:33:06
IMGT Name updated to IGHV1-69*18

IMGT Name updated.

Andrew Collins
2020-01-12 01:33:06
IMGT Name updated to IGHV1-69*18

IMGT Name updated.

William Lees
2023-07-10 11:24:36
Version 2 published

Bulk upload of sequences for the AIRR-C Human IG germline sets

Changes from previous version

v1v2
CuratorWilliam Lees
Curator addressDept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, SwedenBirkbeck College, University of London, Malet Street, London
Sequence NameIGHV1-69*i02IGHV1-69*18
Alternative namesIGHV1-69*i02
MappedFalse
FunctionalityFORF
Species subgroup
Subgroup type
Allele Designationi0218
Full Sequence
Paralog RepFalse
3' ExtensionGACACGGCCGTGTATTACTGTGCGAGAGA
3' start292
3' end319
5' ExtensionCAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGA
5' start1
5' end37
curational_tagslikely_truncated
Noteschanged

Versions

All published versions of this sequence.

Sequence NameIMGT NameAlternative namesInference TypeAffirmation LevelSpecies subgroupSubgroup typeVersionDate
IGHV1-69*i02IGHV1-69*18Rearranged Only112019-12-12
IGHV1-69*18IGHV1-69*18IGHV1-69*i02Rearranged Only122023-07-10