Species | Human |
Species subgroup | |
Subgroup type | |
Sequence Name | IGHV1-69*i02 |
IUIS Name | IGHV1-69*18 |
Alternative names | |
Affirmation Level | 1 |
Full Sequence | |
Coding Sequence | |
Functionality | F |
Inference Type | Rearranged Only |
Alternative names | |
Paralogs |
The table below lists the submissions, and the inferences within them, on which this published sequence is based. The list may be short when the sequence is first published, containing, for example, reference to just a single submission, but is expected to grow over time as additional inferences are submitted.
'Sequence Match' indicates whether the inference exactly matches the sequence, and clicking on the tick or cross will provide an alignment. Mismatches may be caused, for example, by the inclusion of leader sequences, or nucleotides in the inference which do not in IARC's opinion have sufficient evidence for inclusion in the sequence.
Submission ID | Accession No | Subject ID | Genotype Name | Sequence Name | Sequence Match |
---|---|---|---|---|---|
S00010 | MK471382 | B16 | B16 | IGHV1-69*01_S7220 |
Sequences in other published genotypes which have been identified by IARC and support the inference:
Inferred sequences in VDJbase that match this sequence:
Un-rearranged sequence observations that support this sequence:
3' Extension | GACACGGCCGTGTATTACTGTGCGAGAG |
3' start | 292 |
3' end | 319 |
5' Extension | CAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGA |
5' start | 1 |
5' end | 37 |
Sequence ID | A00050 |
Curator address | Dept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden |
Version | 1 |
Release Date | 2019-12-12 |
Release Notes | Submission published by IARC on Dec 13, 2019. |
Locus | IGH |
Sequence Type | V |
Gene Subgroup | 1 |
Gene Designation | 69 |
Allele Designation | i02 |
Notes are added by IARC reviewers.
Assessed by IARC on November 18, 2019 during meeting 45 and on December 2, 2019 during meeting 46. The committee considered IGHV1-69*01_S7220 (G163A) of submission S00010 of Genotype B16, which was previously evaluated as IGHV1-69*01_S5096 of submission S00006 at Meeting 10. It was affirmed as a Level 0 sequence at that time. The sequence was seen in 8.02% of all unmutated rearrangements, with 53668 sequences including 22586 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. Three other alleles were present in the genotype, with IGHV1-69*02 also being present in the haplotype with this allele, likely a consequence of the presence of the IGHV1-69D gene in the haplotype in question. The inferred sequence includes six differences to the *02 allele. Haplotype data is supportive of the inference. There was strong support for the sequence being affirmed up to and including nucleotide 319, in line with IARC policy, as a Level 1 sequence, with one additional 3’ nucleotide being likely present in the sequence. This is indicated in IARC and OGRDB publications by one dot at the end of the sequence. It is noted that this sequences represents a 5’- and a 3’-extension of the partial allele IGHV1-69*07 already recognized by IMGT. |
History logs the times and reasons for the publication of each version of this sequence.
Andrew Collins 2019-12-12 22:50:33 | Version 1 published Submission published by IARC on Dec 13, 2019. |
Andrew Collins 2020-01-12 01:33:00 | IMGT Name updated to IGHV1-69*18 IMGT Name updated. |
Andrew Collins 2020-01-12 01:33:00 | IMGT Name updated to IGHV1-69*18 IMGT Name updated. |
Andrew Collins 2020-01-12 01:33:00 | IMGT Name updated to IGHV1-69*18 IMGT Name updated. |
Andrew Collins 2020-01-12 01:33:06 | IMGT Name updated to IGHV1-69*18 IMGT Name updated. |
Andrew Collins 2020-01-12 01:33:06 | IMGT Name updated to IGHV1-69*18 IMGT Name updated. |
Andrew Collins 2020-01-12 01:33:06 | IMGT Name updated to IGHV1-69*18 IMGT Name updated. |
All published versions of this sequence.
Sequence Name | IMGT Name | Alternative names | Inference Type | Affirmation Level | Species subgroup | Subgroup type | Version | Date |
---|---|---|---|---|---|---|---|---|
IGHV1-69*i02 | IGHV1-69*18 | Rearranged Only | 1 | 1 | 2019-12-12 |