Species subgroup
Subgroup typenone
Sequence NameIGHV3-43D*i02
Alternative namesIGHV3-43D*04 G4A
Affirmation Level1
Full Sequence
Coding Sequence
Inference TypeRearranged
Paralog Rep

Observations in VDJbase

Inferred sequences in VDJbase that match this sequence:

VDJbase Allele NameSubjectsSequence Match
IGHV3-43D*04_g4a 1

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

No Items

Non-Core Regions

UTR 5' Start
UTR 5' End
L-PART1 Start
L-PART2 Start


3' Extension
3' start
3' end
5' start
5' end

Additional Information

Sequence IDA02558
CuratorMats Ohlin
Curator addressDept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden
Release Date2022-07-25
Release Notes

The allele was published by IARC on July 25th, 2022.

Sequence TypeV
Gene Subgroup3
Gene Designation3-43D
Allele Designationi02


Individuals acknowledged as contributing to this sequence:

NameInstitutionORCID ID
William LeesBirkbeck College, University of London, Malet Street, London
Ayelet PeresBar-Ilan University, Ramat-Gan, Israel
Gur YaariBar-Ilan University, Ramat-Gan, Israel


Notes are added by IARC reviewers.

This inferred allele was assessed at IARC meeting 100 on June 8th, 2022. IGHV3-43D*04_G4A was inferred in subject S10 (VDJ-base: P1_I10_S1). The genotype also carried IGHV3-43*01 but no other allele of IGHV3-43D. The inference was supported by a relatively small number of sequences (104) and unmutated sequences (93), a low overall frequency in the unmutated population (0.3%) and a small but diverse set of unique CDR3s (89) in the unmutated sequence set. Its allelic ratio was 100%. Haplotyping based on allelic diversity in IGHJ6 was possible and the alleles distributed to one haplotype, a haplotype different from that associated with the allele IGHV3-43 (IGHV3-43D*04_G4A: 100:0; IGHV3-43*01: 0:100). Reads of IGHV3-43D*04_G4A were associated to the same haplotype as those of IGHV4-38-2, a common duplication combination. Reads of IGHV3-43D*04_G4A were associated to an upstream region similar to that of other alleles of IGHV3-43D (but not similar to alleles of IGHV3-43) (doi: 10.3389/fimmu.2021.730105). Altogether, the association of this allele to IGHV3-43D is reasonable. IARC affirms the sequence at level 1 up to and including base 321 in agreement with past practice. It is acknowledged that the allele most likely carries one additional base, typically A at base position 322. A trailing “.” indicates IARC’s opinion that the sequence is likely to contain one additional 3’-nucleotides for which there is insufficient evidence to make an affirmation. The allele is given the name IGHV3-43D*i02.


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History logs the times and reasons for the publication of each version of this sequence.

Mats Ohlin
2022-07-25 10:53:31
Version 1 published

The allele was published by IARC on July 25th, 2022.


All published versions of this sequence.

Sequence NameIMGT NameAlternative namesInference TypeAffirmation LevelSpecies subgroupSubgroup typeVersionDate
IGHV3-43D*i02IGHV3-43D*04 G4ARearranged1none12022-07-25
IGHV3-43D*i02Rearranged Only122023-07-10