Details

SpeciesHomo sapiens
Species subgroup
Subgroup type
Sequence NameIGHV3-49*05
IUIS NameIGHV3-49*05
Alternative names
Affirmation Level1
Full Sequence
Coding Sequence
FunctionalityORF
Inference TypeUnrearranged
MappedTrue
Paralogs
Paralog RepFalse

Un-rearranged Observations

Un-rearranged sequence observations that support this sequence:

AccessionTypeRepositoryStartEndCoding SequenceSC Coding Sequence
HM855748NonlocationalGenBank11351
SRX19354839VGenbank1501

Observations in AIRR-seq Repertoires

Click here to review supporting data in VDJbase.

Clicking the link will take you to VDJbase. Open in a new tab if you want to keep this page open. In VDJbase, click on the count in the Apperances column to see a list of samples in which the sequence was found.

CDR delineation

CDR1 Start236
CDR1 End259
CDR2 Start311
CDR2 End340
CDR3 Start455

Non-Core Regions

UTR 5' Start
UTR 5' End
L-PART1 Start1
L-PART1 End46
L_PART1ATGGAGTTTGGGCTTAGCTGGGTTTTCCTTGTTGCTATTTTAAAAG
L-PART2 Start150
L-PART2 End160
L_PART2GTGTCCAATGT
v_rs_start463
v_rs_end501
V_HEPTAMERCACAGTG
V_NONAMERACACAAACC
Exon 1 Start
Exon 1 End
Exon 2 Start
Exon 2 End
Exon 3 Start
Exon 3 End
Exon 4 Start
Exon 4 End
Exon 5 Start
Exon 5 End
Exon 6 Start
Exon 6 End
Exon 7 Start
Exon 7 End
Exon 8 Start
Exon 8 End
Exon 9 Start
Exon 9 End
UTR 3' Start
UTR 3' End

Extension

3' Extension
3' start
3' end
5' start
5' end

Additional Information

Sequence IDA02732
CuratorWilliam Lees
Curator addressClareo Biosciences, Louisville, Kentucky, USA
Version3
Release Date2026-05-27
Release Notes

Repeat – had to roll back yesterday’s changes.

Added genomic evidence from VDJbase study P25 (PMID37479682), including leaders/RSS for many sequences and additional alleles that currently have IUIS/IMGT names

LocusIGH
Sequence TypeV
Gene Subgroup3
Gene Designation49
Allele Designation05
Gene start161
Gene end462

Acknowledgements

Individuals acknowledged as contributing to this sequence:

No Items

Notes

Notes are added by IARC reviewers.

Sequence annotation is based on Genbank sample HM855748
VDJbase example haplotype: P1_I100
Mapped by P1_I100 haplotype
An alternative L-PART2 sequence GTGTCCAATGT is observed in Rodriguez et al., who report both forms. This alternative is observed by Huang, Thörnqvist and Ohlin, 2021

Additional information for this sequence was imported into OGRDB via bulk update with the following notes:
Annotation is based on VDJbase record P25_I143_S1 for sample W-86 (Genbank: SRX19354839).

Attachments

No Items

History

History logs the times and reasons for the publication of each version of this sequence.

William Lees
2023-07-10 11:24:39
Version 1 published

Bulk upload of sequences for the AIRR-C Human IG germline sets

William Lees
2024-02-24 08:32:06
Version 2 published

Note alternatve L-PART2 sequence observed in other contexts

William Lees
2026-05-27 07:52:10
Version 3 published

Repeat – had to roll back yesterday’s changes.

Added genomic evidence from VDJbase study P25 (PMID37479682), including leaders/RSS for many sequences and additional alleles that currently have IUIS/IMGT names

Changes from previous version

v2v3
Curator addressBirkbeck College, University of London, Malet Street, LondonClareo Biosciences, Louisville, Kentucky, USA
Inference TypeUnrearranged and RearrangedUnrearranged
Subgroup typenone
Full Sequence
Gene start22161
Gene end323462
L-PART1 Start1
L-PART1 End46
L-PART2 Start11150
L-PART2 End21160
CDR1 Start97236
CDR1 End120259
CDR2 Start172311
CDR2 End201340
CDR3 Start316455
v_rs_start324463
v_rs_end352501
3' Extension
5' Extension
curational_tagslikely_full-lengthlikely_full_length
Noteschanged

Versions

All published versions of this sequence.

Sequence NameIMGT NameVersionDate
IGHV3-49*05IGHV3-49*0512023-07-10
IGHV3-49*05IGHV3-49*0522024-02-24
IGHV3-49*05IGHV3-49*0532026-05-27