Sequence IGHV4-59*i03
Details
| Species | Homo sapiens |
| Species subgroup | |
| Subgroup type | |
| Sequence Name | IGHV4-59*i03 |
| IUIS Name | |
| Alternative names | |
| Affirmation Level | 1 |
| Full Sequence | |
| Coding Sequence | |
| Functionality | ORF |
| Inference Type | Rearranged Only |
| Mapped | False |
| Paralogs | |
| Paralog Rep | False |
Observations in VDJbase
Inferred sequences in VDJbase that match this sequence:
| VDJbase Allele Name | Subjects | Sequence Match |
|---|---|---|
| IGHV4-59*01_g267a | 1 |
Un-rearranged Observations
Un-rearranged sequence observations that support this sequence:
| Accession | Type | Repository | Start | End |
|---|---|---|---|---|
| OW151138 | Inferred | GenBank | 1 | 292 |
CDR delineation
| CDR1 Start | 76 |
| CDR1 End | 99 |
| CDR2 Start | 151 |
| CDR2 End | 171 |
| CDR3 Start | 286 |
Extension
| 3' Extension | A |
| 3' start | |
| 3' end |
Additional Information
| Sequence ID | A02564 |
| Curator | William Lees |
| Curator address | Birkbeck College, University of London, Malet Street, London |
| Version | 2 |
| Release Date | 2023-07-10 |
| Release Notes | Bulk upload of sequences for the AIRR-C Human IG germline sets |
| Locus | IGH |
| Sequence Type | V |
| Gene Subgroup | 4 |
| Gene Designation | 59 |
| Allele Designation | i03 |
| Gene start | 1 |
| Gene end | 292 |
Notes
Notes are added by IARC reviewers.
| This inference was assessed at IARC meeting 100 (June 8th, 2022) and meeting 101 (July 21st, 2022). IGHV4-59*01_G267A was inferred in subject S36 (VDJ-base: P1_I39_S1). The genotype carried one other allele of IGHV4-59. This sample carries few IGHV reads. The inference was consequently supported by a relative small number of sequences (60) and unmutated sequences (43), a relatively low overall frequency in the unmutated population (0.58%) and a small but diverse set of unique CDR3s (43) in the unmutated sequence set. Its allelic ratio was 31%. Haplotyping based on allelic diversity in IGHJ6 was possible with excellent separation from reads associated to IGHV4-59*01 (IGHV4-59*01_G267A: 0:100; IGHV4-59*01: 100:0). IARC affirms the sequence at level 1 up to and including base 319 in agreement with past practice. It is acknowledged that the allele most likely carries one additional base, typically A at base position 320. A trailing “.” indicates IARC’s opinion that the sequence is likely to contain one additional 3’-nucleotides for which there is insufficient evidence to make an affirmation. The allele is given the name IGHV4-59*i03. Additional information for this sequence was imported into OGRDB via bulk update with the following notes: |
Attachments
History
History logs the times and reasons for the publication of each version of this sequence.
| Mats Ohlin 2022-09-28 10:41:40 | Version 1 published The allele was published by IARC on Sept 28, 2022. |
| William Lees 2023-07-10 11:24:41 | Version 2 published Bulk upload of sequences for the AIRR-C Human IG germline sets |
Changes from previous version
| v1 | v2 | |
|---|---|---|
| Curator | Mats Ohlin | William Lees |
| Curator address | Dept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden | Birkbeck College, University of London, Malet Street, London |
| Alternative names | IGHV4-59*01 G267A | |
| Chromosome | 14 | |
| Mapped | False | |
| Functionality | F | ORF |
| Inference Type | Rearranged | Rearranged Only |
| Subgroup type | none | |
| Full Sequence | ||
| Codon Frame | 1 | |
| Paralog Rep | False | |
| Extension? | False | True |
| 3' Extension | A | |
| 5' Extension | ||
| curational_tags | likely_truncated | likely_full-length |
| Notes | changed |
Versions
All published versions of this sequence.
| Sequence Name | IMGT Name | Version | Date |
|---|---|---|---|
| IGHV4-59*i03 | 1 | 2022-09-28 | |
| IGHV4-59*i03 | 2 | 2023-07-10 |