This inferred allele was assessed at IARC meeting 100 on June 8th, 2022. IGHV4-39*01_G315A was inferred in subject S57 (VDJ-base: P1_I60_S1). The genotype carried one other allele of IGHV4-39 (IGHV4-39*01, and a variant allele with a low number of associated reads that likely represents 3’-trimmed reads of IGHV4-39*01). The inference was supported by a large number of sequences (1424) and unmutated sequences (1151), a high overall frequency in the unmutated population (2.47%) and a large set of unique diverse CDR3s (1048) in the unmutated sequence set. It represented 48% of sequences associated with the gene. Haplotyping based on allelic diversity in IGHJ6 was not possible. IARC affirms the sequence at level 1 up to and including base 319 in agreement with past practice. It is acknowledged that the allele most likely carries one additional base, typically A at base position 320. A trailing “.” indicates IARC’s opinion that the sequence is likely to contain one additional 3’-nucleotides for which there is insufficient evidence to make an affirmation. The allele is given the name IGHV4-39*i03.

Additional information for this sequence was imported into OGRDB via bulk update with the following notes:
Sequence annotation is based on Genbank sample OW151140
VDJbase example haplotype: P1_I60