Species | Homo sapiens |
Species subgroup | |
Subgroup type | |
Sequence Name | IGHV4-39*i03 |
IUIS Name | |
Alternative names | |
Affirmation Level | 1 |
Full Sequence | |
Coding Sequence | |
Functionality | ORF |
Inference Type | Rearranged Only |
Mapped | False |
Paralogs | |
Paralog Rep | False |
Inferred sequences in VDJbase that match this sequence:
VDJbase Allele Name | Subjects | Sequence Match |
---|---|---|
IGHV4-39*01_g315a | 3 |
Un-rearranged sequence observations that support this sequence:
Accession | Type | Repository | Start | End |
---|---|---|---|---|
OW151140 | Inferred | GenBank | 1 | 297 |
CDR1 Start | 76 |
CDR1 End | 105 |
CDR2 Start | 157 |
CDR2 End | 177 |
CDR3 Start | 292 |
3' Extension | A |
3' start | |
3' end |
Sequence ID | A02561 |
Curator | William Lees |
Curator address | Birkbeck College, University of London, Malet Street, London |
Version | 3 |
Release Date | 2023-07-10 |
Release Notes | Bulk upload of sequences for the AIRR-C Human IG germline sets |
Locus | IGH |
Sequence Type | V |
Gene Subgroup | 4 |
Gene Designation | 39 |
Allele Designation | i03 |
Notes are added by IARC reviewers.
This inferred allele was assessed at IARC meeting 100 on June 8th, 2022. IGHV4-39*01_G315A was inferred in subject S57 (VDJ-base: P1_I60_S1). The genotype carried one other allele of IGHV4-39 (IGHV4-39*01, and a variant allele with a low number of associated reads that likely represents 3’-trimmed reads of IGHV4-39*01). The inference was supported by a large number of sequences (1424) and unmutated sequences (1151), a high overall frequency in the unmutated population (2.47%) and a large set of unique diverse CDR3s (1048) in the unmutated sequence set. It represented 48% of sequences associated with the gene. Haplotyping based on allelic diversity in IGHJ6 was not possible. IARC affirms the sequence at level 1 up to and including base 319 in agreement with past practice. It is acknowledged that the allele most likely carries one additional base, typically A at base position 320. A trailing “.” indicates IARC’s opinion that the sequence is likely to contain one additional 3’-nucleotides for which there is insufficient evidence to make an affirmation. The allele is given the name IGHV4-39*i03. Additional information for this sequence was imported into OGRDB via bulk update with the following notes: |
History logs the times and reasons for the publication of each version of this sequence.
Mats Ohlin 2022-07-25 10:54:25 | Version 1 published The allele was published by IARC on July 25th, 2022. |
Mats Ohlin 2023-06-02 14:44:22 | Version 2 published A typographical error in the Notes section was corrected: “The genotype carried one other allele of IGHV4-39 (IGHV4-31*01, and a variant allele with a low number of associated reads that likely represents 3’-trimmed reads of IGHV4-39*01).” was corrected to “The genotype carried one other allele of IGHV4-39 (IGHV4-39*01, and a variant allele with a low number of associated reads that likely represents 3’-trimmed reads of IGHV4-39*01).”. |
William Lees 2023-07-10 11:24:41 | Version 3 published Bulk upload of sequences for the AIRR-C Human IG germline sets |
v2 | v3 | |
---|---|---|
Curator | Mats Ohlin | William Lees |
Curator address | Dept. of Immunotechnology, Lund University, Medicon Village building 406, S-22381 Lund, Sweden | Birkbeck College, University of London, Malet Street, London |
Alternative names | IGHV4-39*01 G315A | |
Chromosome | 14 | |
Mapped | False | |
Functionality | F | ORF |
Inference Type | Rearranged | Rearranged Only |
Subgroup type | none | |
Full Sequence | ||
Codon Frame | 1 | |
Paralog Rep | False | |
Extension? | False | True |
3' Extension | A | |
5' Extension | ||
Notes | changed |
All published versions of this sequence.
Sequence Name | IMGT Name | Version | Date |
---|---|---|---|
IGHV4-39*i03 | 1 | 2022-07-25 | |
IGHV4-39*i03 | 2 | 2023-06-02 | |
IGHV4-39*i03 | 3 | 2023-07-10 |