Help & Documentation
Data Access Quick Start
You can browse and download all data without creating an account.
Sequences
Review our database of allele sequences, supporting evidence and curation history.
View SequencesInside OGRDB
Explore the background and development of OGRDB through these key articles and publications.
Germline Databases, or adventures into the allelic underworld
A podcast exploring the challenges and discoveries in germline database development
Introduction to OGRDB
A short introduction to the Open Germline Receptor Database
AIRR community curation and standardised representation for immunoglobulin and T cell receptor germline sets
Scientific publication on AIRR community standards and curation processes
Key Features
Curated Germline Sets
High-quality, reviewed germline gene sequences for multiple species
AIRR Compliance
Data formatted according to AIRR Community standards
Multiple Formats
Download in FASTA, JSON, or custom formats
Regular Updates
Continuously updated with newly discovered alleles
Citation Information
If you use OGRDB in your research, please cite:
Lees et al., Nucleic Acids Research, September 2019.
View Paper
Individual sequences and submissions may have additional citation requirements listed on their respective pages.
OGRDB Documentation
Website updated
We have redesigned the front page and added a new help page which brings together all information on how to use OGRDB. O...
OGRDB API v2
The OGRDB API has been upgraded to provide new features: This guide describes the new API. The old API is still availabl...
Additional support for germline sets
We have created step-by-step walk-throughs showing how to use the AIRR-C germline sets with local installations of IgBLA...
Mouse IG Reference Sets Updated
Fixes have been made to two mouse reference sets. In C57BL/6 IGH, a stray character in the coding sequence for IGHV-KAOG...
Human IG Reference Sets Updated
The human IG reference sets on OGRDB have been updated and carry new versions, but no coding sequences are affected. The...
OGRDB Updated
OGRDB has been updated to use binomial (latin) species names instead of colloquial names. The former names can still be ...
Collaboration Opportunities
OGRDB and VDJbase are part of the AIRR Knowledge Commons project – bringing together immune repertoires from the AIRR Da...
Novel Allele Submission Process Simplified
Following an IARC decision in December 2023, the submission process for inferred novel alleles has been simplified. Prev...
Germline Databases, or adventures into the allelic underworld
If you are interested in receptor germlines, you might enjoy this On-AIRR podcast with Corey Watson and William Lees, ho...
Human IG germline sets now available
Germline sets for human IGH, IGK and IGL are now available for download. They are described in a forthcoming publication...
Downloading germline sets from the command line or API
In this post, we’re going to look briefly at the different ways that you can download germline sets from the command lin...
Germline Set format updates
The JSON format in which germline sets are distributed has been updated (germline sets are also available from OGRDB in ...
Preprint on germline set development now available
The AIRR Community has recently published a preprint on the community development of IG and TR germline sets. This sets ...
Using the OGRDB mouse germline sets
For many analyses, it is important to annotate AIRR-seq repertoires with an accurate and comprehensive germline set. As ...
Germline sets now have DOIs
Germline sets on OGRDB are copied to Zenodo.org for long-term security and have DOIs issued by Zenodo which you will see...
Downloading OGRDB Data
OGRDB provides facilities on various pages to download key items of data. Some tables also provide buttons to download i...
Tools for working with germline sets
The AIRR-C standard germline sets published in OGRDB use a new naming scheme: please see this poster for details. Becaus...
First Germline Sets Published on OGRDB
We have published IGHV germline sets for laboratory mouse strains BALB/c and C75BL/6, as recently reported in preprint b...
New inferred sequences accepted by IMGT
A new batch of inferred receptor sequences, submitted for review through OGRDB, has been accepted by IMGT and should be ...
Introduction to OGRDB
Introduction to OGRDB In recent years it has become possible to sequence immune receptor repertoires (immunoglobulins an...
Submitting inferences to OGRDB
If you have identified previously undocumented alleles in AIRR-Seq repertoires, we invite you to submit them to OGRDB fo...
Creating a select set
A select set is a set of reads taken from a single repertoire that directly support a specific inference. In outline, th...
OGRDB – Depositing records in NIH repositories
At the end of this deposition process, NCBI will contain two types of record for use in your submission: A sequence reco...
IARC Submission Guide Updated
We welcome submissions of previously undocumented alleles of human receptor genes. The Submission Guide explains the pro...
Allele Review Extended
OGRDB is now accepting V- and J- sequence inferences from the human BCR light and heavy chain. Analysis scripts and subm...