{ "GermlineSet": [ { "germline_set_id": "OGRDB:G00060", "author": "William Lees", "lab_name": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "acknowledgements": null, "release_version": 8, "release_description": "First published version", "release_date": "2024-01-11", "germline_set_name": "IGH_VDJ_extended", "germline_set_ref": "OGRDB:IGH_VDJ.8", "pub_ids": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "locus": "IGH", "allele_descriptions": [ { "allele_description_id": "OGRDB:A02968", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-16*04.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV3-16*04", "sequence": "ATGGAATTTGGGCTGAGCTGGGTTTTTCTTGCTGGTATTTTAAAAGGTGATTCATGGAGAACTAAGGATATTGAGTGAGTGGACATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGATACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGCCCGCAAGGCTCCAGGAAAGGGGCTGAAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGTGGACTCCGTGAAGCGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTCCCTGTATCTGCAAAAGAACAGACGGAGAGCCGAGGACATGGCTGTGTATTACTGTGTGAGAAATCCTGTGAGGGGACACAAGTGCGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGATACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGCCCGCAAGGCTCCAGGAAAGGGGCTGAAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGTGGACTCCGTGAAGCGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTCCCTGTATCTGCAAAAGAACAGACGGAGAGCCGAGGACATGGCTGTGTATTACTGTGTGAGAAA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "16", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 159, "gene_end": 454, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 148, "leader_2_end": 158, "v_rs_start": 455, "v_rs_end": 493, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGATACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGCCCGCAAGGCTCCAGGAAAGGGGCTGAAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGTGGACTCCGTGAAGCGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTCCCTGTATCTGCAAAAGAACAGACGGAGAGCCGAGGACATGGCTGTGTATTACTGTGTGAGAAA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGGGGGTCCCTGATACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAACAGTGACATGAACTGGGCCCGCAAGGCTCCAGGAAAGGGGCTGAAGTGGGTATCGGGTGTTAGTTGGAAT......GGCAGTAGGACGCACTATGTGGACTCCGTGAAG...CGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTCCCTGTATCTGCAAAAGAACAGACGGAGAGCCGAGGACATGGCTGTGTATTACTGTGTGAGAAA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1415", "sequence": "ATGGAATTTGGGCTGAGCTGGGTTTTTCTTGCTGGTATTTTAAAAGGTGATTCATGGAGAACTAAGGATATTGAGTGAGTGGACATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGATACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGCCCGCAAGGCTCCAGGAAAGGGGCTGAAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGTGGACTCCGTGAAGCGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTCCCTGTATCTGCAAAAGAACAGACGGAGAGCCGAGGACATGGCTGTGTATTACTGTGTGAGAAATCCTGTGAGGGGACACAAGTGCGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AC244478", "patch_no": "2", "gff_seqid": null, "gff_start": 10265, "gff_end": 10757, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AC244478. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (10 samples). Example subject: P25_I73.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02653", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-3*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-3*01", "sequence": "GATCCTCTTTTTGGTGGCAGCAGCCACAGGTAAGGGGCTGCCAAATCCCAGTGAGGAGGAAGGGATCGAGGCCAGTCAAGGGGAATTCCATCCACTCCTGTGTCTTCTCTACAGGTGCCCACTCCCAGGTCCAGCTTGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGATCAACGCTGGCAATGGTAACACAAAATATTCACAGAAGTTCCAGGGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAAGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCAC", "coding_sequence": "CAGGTCCAGCTTGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGATCAACGCTGGCAATGGTAACACAAAATATTCACAGAAGTTCCAGGGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAAGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "3", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 126, "gene_end": 421, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 115, "leader_2_end": 125, "v_rs_start": 422, "v_rs_end": 450, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCCAGCTTGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGATCAACGCTGGCAATGGTAACACAAAATATTCACAGAAGTTCCAGGGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAAGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTCCAGCTTGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTC............ACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGATCAACGCTGGC......AATGGTAACACAAAATATTCACAGAAGTTCCAG...GGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAAGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1081", "sequence": "CACAGGTAAGGGGCTGCCAAATCCCAGTGAGGAGGAAGGGATCGAGGCCAGTCAAGGGGAATTCCATCCACTCCTGTGTCTTCTCTACAGGTGCCCACTCCCAGGTCCAGCTTGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGATCAACGCTGGCAATGGTAACACAAAATATTCACAGAAGTTCCAGGGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAAGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCAC", "repository_name": "GenBank", "repository_ref": "MG719307", "patch_no": "1", "gff_seqid": null, "gff_start": 25, "gff_end": 439, "strand": null }, { "sequence_id": "1082", "sequence": "AGGATGTGGTTTTCACACTGTGTCTCTCGCACAGTAATACACAGCCGTGTCTTCAGATCTCAGGCTGCTCAGCTCCATGTAGGCTGTGCTCGCGGATGTGTCCCTGGTAATGGTGACTCTGCCCTGGAACTTCTGTGAATATTTTGTGTTACCATTGCCAGCGTTGATCCATCCCATCCACTCAAGCCTTTGTCCGGGGGCCTGGCGCACCCAATGCATAGCATAGCTAGTGAAGGTGTATCCAGAAGCCTTGCAGGAAACCTTCACTGAGGCCCCAGGCTTCTTCACCTCAGCCCCAGACTGCACAAGCTGGACCTGGGAGTGGACACCTGTGGAGACTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855936", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 345, "strand": null }, { "sequence_id": "1083", "sequence": "ATGGACTGGACCTGGAGGATCCTCTTTTTGGTGGCAGCAGCCACAGGTAAGGGGCTGCCAAATCCCAGTGAGGAGGAAGGGATCGAGGCCAGTCAAGGGGAATTCCATCCACTCCTGTGTCTTCTCTACAGGTGCCCACTCCCAGGTCCAGCTTGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGATCAACGCTGGCAATGGTAACACAAAATATTCACAGAAGTTCCAGGGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAAGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGAGTGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "ON052032", "patch_no": "1", "gff_seqid": null, "gff_start": 261, "gff_end": 737, "strand": null }, { "sequence_id": "1084", "sequence": "ATGGACTGGACCTGGAGGATCCTCTTTTTGGTGGCAGCAGCCACAGGTAAGGGGCTGCCAAATCCCAGTGAGGAGGAAGGGATCGAGGCCAGTCAAGGGGAATTCCATCCACTCCTGTGTCTTCTCTACAGGTGCCCACTCCCAGGTCCAGCTTGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGATCAACGCTGGCAATGGTAACACAAAATATTCACAGAAGTTCCAGGGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAAGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGAGTGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 874313, "gff_end": 874789, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MG719307\r\nVDJbase example haplotype: P1_I10_S1", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02651", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-2*07.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-2*07", "sequence": "ATGGACTGGACCTGGAGGATCCTCTTCTTGGTGGCAGCAGCCACAGGTAAGAGGCTCCCTAGTCCCAGTGATGAGAAAGAGATTGAGTCCAGTCCAGGGAGATCTCATCCACTTCTGTGTTCTCTCCACAGGAGCCCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACCCTAACAGTGGTGGCACAAACTATGCACATAAGTTTCAGGGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGGGTGTCAGAAACC", "coding_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACCCTAACAGTGGTGGCACAAACTATGCACATAAGTTTCAGGGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "2", "allele_designation": "07", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 143, "gene_end": 438, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 132, "leader_2_end": 142, "v_rs_start": 439, "v_rs_end": 477, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACCCTAACAGTGGTGGCACAAACTATGCACATAAGTTTCAGGGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTC............ACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACCCTAAC......AGTGGTGGCACAAACTATGCACATAAGTTTCAG...GGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1076", "sequence": "ATGGACTGGACCTGGAGGATCCTCTTCTTGGTGGCAGCAGCCACAGGTAAGAGGCTCCCTAGTCCCAGTGATGAGAAAGAGATTGAGTCCAGTCCAGGGAGATCTCATCCACTTCTGTGTTCTCTCCACAGGAGCCCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACCCTAACAGTGGTGGCACAAACTATGCACATAAGTTTCAGGGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGGGTGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "MN337615", "patch_no": "1", "gff_seqid": null, "gff_start": 282, "gff_end": 758, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MN337615\r\nVDJbase example haplotype: P1_I24\r\nMapped by P1_I24 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02764", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-31*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-31*03", "sequence": "ATGAAACATCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGTGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAATGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "31", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 140, "gene_end": 438, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 129, "leader_2_end": 139, "v_rs_start": 439, "v_rs_end": 477, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGC......AGTGGTGGTTACTACTGGAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCGAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1339", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGTGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAATGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AC244476", "patch_no": "2", "gff_seqid": null, "gff_start": 8194, "gff_end": 8670, "strand": null }, { "sequence_id": "1341", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGTGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAATGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052082", "patch_no": "1", "gff_seqid": null, "gff_start": 248, "gff_end": 724, "strand": null } ], "rearranged_support": [], "paralogs": [ "IGHV4-30-4*09" ], "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample KC162925\r\nVDJbase example haplotype: P1_I40\r\nMapped by P1_I40 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02754", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-9*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-9*02", "sequence": "TTGTTTGCAGGTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTCTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGGAGGTCGATTGCTCGCGA", "coding_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTCTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATTACTGTGCAAAAGATA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "9", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 22, "gene_end": 319, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 11, "leader_2_end": 21, "v_rs_start": 320, "v_rs_end": 348, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTCTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATTACTGTGCAAAAGATA", "aligned_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTCT............GATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAAT......AGTGGTAGCATAGGCTATGCGGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATTACTGTGCAAAAGATA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1312", "sequence": "GTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTCTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGGAGGTCGATTGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855577", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 347, "strand": null }, { "sequence_id": "1313", "sequence": "GTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTCTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGGGAAGTCATTGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855778", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 347, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855577", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02742", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-66*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-66*02", "sequence": "ATCTGCACTGGGCCCGGCCTCTCCTCAGATGTCCCATCACAGAGCTTGCTATATAATGGGGGACATGCAAATAGGGCCCTCCCTCTGCTGATGAAAACCAGCCCAGCCCTGACCCTGCAGCTCTGGGAGAGGAGCCCAGCACTGGGATTCCGAGGTGTTTCCATTCAGTGATCTGCACTGAACACAGAGGACTCGCCATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGAGAACTAGAGATATCGAGTGTGAGTGAAGATGAGTGAGAGAAACAGTGGGTATGTGTGGCAGTTTCTGACCAATGCCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGCCATTGTGCGCCCAGA", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "66", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 356, "gene_end": 648, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 345, "leader_2_end": 355, "v_rs_start": 649, "v_rs_end": 679, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTC............AGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGT.........GGTAGCACATACTACGCAGACTCCGTGAAG...GGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1280", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGAGAACTAGAGATATCGAGTGTGAGTGAAGATGAGTGAGAGAAACAGTGGGTATGTGTGGCAGTTTCTGACCAATGCCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGCCATTGTGCGCCCA", "repository_name": "GenBank", "repository_ref": "ON052070", "patch_no": "1", "gff_seqid": null, "gff_start": 198, "gff_end": 677, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052070\r\nVDJbase example haplotype: P1_I10\r\nMapped by P1_I10 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02728", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-48*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-48*03", "sequence": "ATGGAGTTGGGGCTGTGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGATTCATGGAAAACTAGAGAGATTTAGTGTGTGTGGATATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGTTATGAAATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTTTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGTTATGAAATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTTTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "48", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 456, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 457, "v_rs_end": 495, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGTTATGAAATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTTTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGTTATGAAATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGT......GGTAGTACCATATACTACGCAGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTTTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1254", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGTTATGAAATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTTTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCATTG", "repository_name": "GenBank", "repository_ref": "HM855544", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 328, "strand": null }, { "sequence_id": "1255", "sequence": "ATGGAGTTGGGGCTGTGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGATTCATGGAAAACTAGAGAGATTTAGTGTGTGTGGATATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGTTATGAAATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTTTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 341580, "gff_end": 342074, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample GRCh38:CM000676.2\r\nVDJbase example haplotype: P1_I10", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02774", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-NL1*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-NL1*01", "sequence": "TTGCGAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGACACACAGTGAGGGGAGGTGAGTGTGAG", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGACA", "ext_3prime": null, "aliases": [ "IGHV4-59*08" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "NL1", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 47, "gene_end": 339, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 36, "leader_2_end": 46, "v_rs_start": 340, "v_rs_end": 368, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGACA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATC............AGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGT.........GGGAGCACCAACTACAACCCCTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGACA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1372", "sequence": "GGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGACACACAGTGAGGGGAGGTGAGTGTGAG", "repository_name": "GenBank", "repository_ref": "HM855902", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 329, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855902\r\nVDJbase example haplotype: P1_I10_S1\r\nMapped by P1_I10 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02752", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-74*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-74*01", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGAGAACTGGAGATATGGAGTGTGAATGGACATGAGTGAGATAAGCAGTGGATGTGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCCGGGGGAGGCTTAGTTCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACTGGATGCACTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGTGTGGGTCTCACGTATTAATAGTGATGGGAGTAGCACAAGCTACGCGGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACACGCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGGAAGTCAATGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCCGGGGGAGGCTTAGTTCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACTGGATGCACTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGTGTGGGTCTCACGTATTAATAGTGATGGGAGTAGCACAAGCTACGCGGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACACGCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCAAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "74", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 456, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 457, "v_rs_end": 495, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCCGGGGGAGGCTTAGTTCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACTGGATGCACTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGTGTGGGTCTCACGTATTAATAGTGATGGGAGTAGCACAAGCTACGCGGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACACGCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCAAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCCGGGGGA...GGCTTAGTTCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTACTGGATGCACTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGTGTGGGTCTCACGTATTAATAGTGAT......GGGAGTAGCACAAGCTACGCGGACTCCGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACACGCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCAAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1305", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGAGAACTGGAGATATGGAGTGTGAATGGACATGAGTGAGATAAGCAGTGGATGTGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCCGGGGGAGGCTTAGTTCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACTGGATGCACTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGTGTGGGTCTCACGTATTAATAGTGATGGGAGTAGCACAAGCTACGCGGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACACGCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGGAAGTCAATGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AB019437", "patch_no": "1", "gff_seqid": null, "gff_start": 70412, "gff_end": 70906, "strand": null }, { "sequence_id": "1306", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCCGGGGGAGGCTTAGTTCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACTGGATGCACTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGTGTGGGTCTCACGTATTAATAGTGATGGGAGTAGCACAAGCTACGCGGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACACGCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGGAGGTCAATG", "repository_name": "GenBank", "repository_ref": "HM855884", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 328, "strand": null }, { "sequence_id": "1307", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGAGAACTGGAGATATGGAGTGTGAATGGACATGAGTGAGATAAGCAGTGGATGTGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCCGGGGGAGGCTTAGTTCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACTGGATGCACTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGTGTGGGTCTCACGTATTAATAGTGATGGGAGTAGCACAAGCTACGCGGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACACGCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGGAAGTCAATGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052077", "patch_no": "1", "gff_seqid": null, "gff_start": 370, "gff_end": 864, "strand": null }, { "sequence_id": "1308", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGAGAACTGGAGATATGGAGTGTGAATGGACATGAGTGAGATAAGCAGTGGATGTGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCCGGGGGAGGCTTAGTTCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACTGGATGCACTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGTGTGGGTCTCACGTATTAATAGTGATGGGAGTAGCACAAGCTACGCGGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACACGCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGGAAGTCAATGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 68950, "gff_end": 69444, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019437\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00037", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-21*05.3_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 3, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-21*05", "sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": "A", "aliases": [ "IGHV3-21*i01" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "21", "allele_designation": "05", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 295, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGT......AGTAGTTACATATACTACGCAGACTCAGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1186", "sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "repository_name": "GenBank", "repository_ref": "MK308859", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 295, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "The 40th meeting of the IARC on August 7th 2019 considered the sequence IGHV3-21*01_S5868. The sequence represents IGHV3-21*01 C159T C164A in the IMGT numbering system. The committee noted a rearrangement frequency of 1.5%, with 9064 alignments including 5167 perfect matches to the inferred allele. Alignments were also seen to four other IGHV3-21 sequences, though only one of these sequences was abundant (IGHV3-21*01: 12914 alignments, 8386 unmutated alignments). Haplotyping based on IGHJ6 alleles confirmed the segregation of reads associated with these two alleles to the different haplotypes Alignments to the three other alleles shown in the genotype were at trivial levels (<0.01% of \u2018unmutated\u2019 alignments, in each case). There were 1394 different CDR3s associated with the inference, including 614 different CDR3s associated with unmutated alignments. The committee agreed that the sequence should be accepted as a Level 1 sequence as IGHV3-21*i01. In line with previous policy, the submitted sequence is recognized up to and including nucleotide 319. A trailing \u201c.\u201d in the affirmed sequence indicates IARC\u2019s opinion that the sequence is likely to contain an additional 3\u2019 nucleotide for which there is insufficient evidence to make an affirmation. \r\n\r\nReanalysis of the original submission at Meeting 43 of the IARC on October 7, 2019 again identified the same novel allele IGHV3-21*01_S5868 (IGHV3-21*01 C159T C164A) with 9370 sequences and 5226 perfect matches and 628 Unique CDR3s with unmutated Seqs. In this analysis only one other allele of IGHV3-21 was seen (as very rare inferences had been removed by IgDiscover filtering), IGHV3-21*01 with 13799 sequences and 8576 perfect matches giving a 40:60 allelic ratio. These alleles were very well separated by IGHJ6-based haplotype analysis (1:99 and 99:1, respectively). The re-analysis thus confirmed the inference of IGHV3-21*i01 as a Level 1 sequence. In line with previous policy, the submitted sequence is recognized up to and including nucleotide 319. A trailing \u201c.\u201d in the affirmed sequence indicates IARC\u2019s opinion that the sequence is likely to contain an additional 3\u2019 nucleotide for which there is insufficient evidence to make an affirmation.\r\n\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MK308859\r\nMapped by IARC haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02771", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-4*07.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-4*07", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGGGATATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGCGTATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGCGTATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "4", "allele_designation": "07", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 140, "gene_end": 432, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 129, "leader_2_end": 139, "v_rs_start": 433, "v_rs_end": 471, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGCGTATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATC............AGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGCGTATCTATACCAGT.........GGGAGCACCAACTACAACCCCTCCCTCAAG...AGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1362", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGGGATATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGCGTATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 11002, "gff_end": 11472, "strand": null }, { "sequence_id": "1363", "sequence": "GGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGCGTATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAG", "repository_name": "GenBank", "repository_ref": "HM855907", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 329, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019441\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02750", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-73*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-73*01", "sequence": "TGTGCACAGCCTTCTCGTCAGGCGTCCCAGCCCAGACCTTGCTATGTAGCAGAAGACATGCAAATAAGACCCCCCTTTTTGCTGATGAAAAGCAGCCCAGCCCTGACCCTGCAGCTCTGGGAGAGGAGCTCCAGCCTTGGGATTCCCAGCTGTCTCCACTCGGTGATCGGCACTGAATACAGGAGACTCACCATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGGGAACTAGAGATACTGAGTGTGAGTGGACATGAGTGAGAGAAACAGTGGACGTGTGTGGCACTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAAACTCTCCTGTGCAGCCTCTGGGTTCACCTTCAGTGGCTCTGCTATGCACTGGGTCCGCCAGGCTTCCGGGAAAGGGCTGGAGTGGGTTGGCCGTATTAGAAGCAAAGCTAACAGTTACGCGACAGCATATGCTGCGTCGGTGAAAGGCAGGTTCACCATCTCCAGAGATGATTCAAAGAACACGGCGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTACTAGACACACAGTGAGGGGAGGTCAGTGTGAGCCCGGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAAACTCTCCTGTGCAGCCTCTGGGTTCACCTTCAGTGGCTCTGCTATGCACTGGGTCCGCCAGGCTTCCGGGAAAGGGCTGGAGTGGGTTGGCCGTATTAGAAGCAAAGCTAACAGTTACGCGACAGCATATGCTGCGTCGGTGAAAGGCAGGTTCACCATCTCCAGAGATGATTCAAAGAACACGGCGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTACTAGACA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "73", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 353, "gene_end": 654, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 342, "leader_2_end": 352, "v_rs_start": 655, "v_rs_end": 693, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAAACTCTCCTGTGCAGCCTCTGGGTTCACCTTCAGTGGCTCTGCTATGCACTGGGTCCGCCAGGCTTCCGGGAAAGGGCTGGAGTGGGTTGGCCGTATTAGAAGCAAAGCTAACAGTTACGCGACAGCATATGCTGCGTCGGTGAAAGGCAGGTTCACCATCTCCAGAGATGATTCAAAGAACACGGCGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTACTAGACA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTCCAGCCTGGGGGGTCCCTGAAACTCTCCTGTGCAGCCTCTGGGTTCACCTTC............AGTGGCTCTGCTATGCACTGGGTCCGCCAGGCTTCCGGGAAAGGGCTGGAGTGGGTTGGCCGTATTAGAAGCAAAGCTAACAGTTACGCGACAGCATATGCTGCGTCGGTGAAA...GGCAGGTTCACCATCTCCAGAGATGATTCAAAGAACACGGCGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTACTAGACA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 180, "fwr3_start": 181, "fwr3_end": 294, "cdr3_start": 295, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1299", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAAACTCTCCTGTGCAGCCTCTGGGTTCACCTTCAGTGGCTCTGCTATGCACTGGGTCCGCCAGGCTTCCGGGAAAGGGCTGGAGTGGGTTGGCCGTATTAGAAGCAAAGCTAACAGTTACGCGACAGCATATGCTGCGTCGGTGAAAGGCAGGTTCACCATCTCCAGAGATGATTCAAAGAACACGGCGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTACTAGACACACAGTGAGGGGAAGTCATTG", "repository_name": "GenBank", "repository_ref": "HM855781", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 334, "strand": null }, { "sequence_id": "1300", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGGGAACTAGAGATACTGAGTGTGAGTGGACATGAGTGAGAGAAACAGTGGACGTGTGTGGCACTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAAACTCTCCTGTGCAGCCTCTGGGTTCACCTTCAGTGGCTCTGCTATGCACTGGGTCCGCCAGGCTTCCGGGAAAGGGCTGGAGTGGGTTGGCCGTATTAGAAGCAAAGCTAACAGTTACGCGACAGCATATGCTGCGTCGGTGAAAGGCAGGTTCACCATCTCCAGAGATGATTCAAAGAACACGGCGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTACTAGACACACAGTGAGGGGAGGTCAGTGTGAGCCCGGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052075", "patch_no": "1", "gff_seqid": null, "gff_start": 193, "gff_end": 693, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052075\r\nVDJbase example haplotype: P1_I12\r\nMapped by P1_I12 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02980", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-28*07.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV4-28*07", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGAGCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTACAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "coding_sequence": "CAGGTACAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "28", "allele_designation": "07", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 140, "gene_end": 435, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 129, "leader_2_end": 139, "v_rs_start": 436, "v_rs_end": 474, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTACAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAA", "aligned_sequence": "CAGGTACAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGC.........AGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 102, "fwr2_start": 103, "fwr2_end": 153, "cdr2_start": 154, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1427", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGAGCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTACAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 555157, "gff_end": 555630, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample GRCh38:CM000676.2. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (1 samples). Example subject: P25_I16.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02740", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-64D*09.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-64D*09", "sequence": "ATGGAGTTCTGGCTGAGCTGGGTTCTCCTTGTTGCCATTTTAAAAGGTAATTCATGGAGAACTAGAGATAGTGTGAGTGGACGTGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGATGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTTCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATACTACGCAGACTCAGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAGCAGTCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGTGAAAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTTCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATACTACGCAGACTCAGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAGCAGTCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGTGAAAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "64D", "allele_designation": "09", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 157, "gene_end": 452, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 146, "leader_2_end": 156, "v_rs_start": 453, "v_rs_end": 491, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTTCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATACTACGCAGACTCAGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAGCAGTCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGTGAAAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTTCAGCCTCTGGATTCACCTTC............AGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAAT......GGGGGTAGCACATACTACGCAGACTCAGTGAAG...GGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAGCAGTCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGTGAAAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1278", "sequence": "ATGGAGTTCTGGCTGAGCTGGGTTCTCCTTGTTGCCATTTTAAAAGGTAATTCATGGAGAACTAGAGATAGTGTGAGTGGACGTGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGATGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTTCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATACTACGCAGACTCAGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAGCAGTCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGTGAAAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "MN337625", "patch_no": "1", "gff_seqid": null, "gff_start": 192, "gff_end": 682, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MN337625\r\nVDJbase example haplotype: P1_I12\r\nMapped by P1_I12 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02773", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-59*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-59*01", "sequence": "ATGAAACATCTGTGGTTCTTCCTTCTCCTGGTGGCAGCTCCCAGATGTGAGTATCTCAGGGATCCAGACATGGGGATATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACAAAAACC", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "59", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 140, "gene_end": 432, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 129, "leader_2_end": 139, "v_rs_start": 433, "v_rs_end": 471, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATC............AGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGT.........GGGAGCACCAACTACAACCCCTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1368", "sequence": "ATGAAACATCTGTGGTTCTTCCTTCTCCTGGTGGCAGCTCCCAGATGTGAGTATCTCAGGGATCCAGACATGGGGATATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACAAAAACC", "repository_name": "GenBank", "repository_ref": "AB019438", "patch_no": "1", "gff_seqid": null, "gff_start": 5856, "gff_end": 6326, "strand": null }, { "sequence_id": "1369", "sequence": "GGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAG", "repository_name": "GenBank", "repository_ref": "HM855825", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 329, "strand": null }, { "sequence_id": "1370", "sequence": "ATGAAACATCTGTGGTTCTTCCTTCTCCTGGTGGCAGCTCCCAGATGTGAGTATCTCAGGGATCCAGACATGGGGATATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACAAAAACC", "repository_name": "GenBank", "repository_ref": "ON052087", "patch_no": "1", "gff_seqid": null, "gff_start": 268, "gff_end": 738, "strand": null }, { "sequence_id": "1371", "sequence": "ATGAAACATCTGTGGTTCTTCCTTCTCCTGGTGGCAGCTCCCAGATGTGAGTATCTCAGGGATCCAGACATGGGGATATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACAAAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 252165, "gff_end": 252635, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019438\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02718", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-38*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-38*02", "sequence": "ATGCAGTTTGTGCTGAGCTGGGTTTTCCTTGTTGGTATTTTAAAAGGTGATTCATGGAGAACTACAGATGTTGAGTGTGAGTGGACATGAGTGAGCAAAACAGTGGGTTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTAGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAACCTGAGAGCTGAGGGCACGGCCGTGTATTACTGTGCCAGATATACACAGAGGGGAAGTCATTGTGCGCCCAGACACAAACCTC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTAGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAACCTGAGAGCTGAGGGCACGGCCGTGTATTACTGTGCCAGATATA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "38", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 452, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 453, "v_rs_end": 491, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTAGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAACCTGAGAGCTGAGGGCACGGCCGTGTATTACTGTGCCAGATATA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTAGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTC............AGTAGCAATGAGATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTGGT............GGTAGCACATACTACGCAGACTCCAGGAAG...GGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAACCTGAGAGCTGAGGGCACGGCCGTGTATTACTGTGCCAGATATA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 168, "fwr3_start": 169, "fwr3_end": 282, "cdr3_start": 283, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1230", "sequence": "ATGCAGTTTGTGCTGAGCTGGGTTTTCCTTGTTGGTATTTTAAAAGGTGATTCATGGAGAACTACAGATGTTGAGTGTGAGTGGACATGAGTGAGCAAAACAGTGGGTTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTAGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAACCTGAGAGCTGAGGGCACGGCCGTGTATTACTGTGCCAGATATACACAGAGGGGAAGTCATTGTGCGCCCAGACACAAACCTC", "repository_name": "GenBank", "repository_ref": "AB019439", "patch_no": "1", "gff_seqid": null, "gff_start": 22685, "gff_end": 23175, "strand": null }, { "sequence_id": "1231", "sequence": "ATGCAGTTTGTGCTGAGCTGGGTTTTCCTTGTTGGTATTTTAAAAGGTGATTCATGGAGAACTACAGATGTTGAGTGTGAGTGGACATGAGTGAGCAAAACAGTGGGTTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTAGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAACCTGAGAGCTGAGGGCACGGCCGTGTATTACTGTGCCAGATATACACAGAGGGGAAGTCATTGTGCGCCCAGACACAAACCTC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 468902, "gff_end": 469392, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019439", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02701", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-23*04.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-23*04", "sequence": "ATGGAGTTTGGGCTGAGCTGGCTTTTTCTTGTGGCTATTTTAAAAGGTAATTCATGGAGAAATAGAAAAATTGAGTGTGAATGGATAAGAGTGAGAGAAACAGTGGATACGTGTGGCAGTTTCTGACCAGGGTTTCTTTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCTATGCCATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGCTATTAGTGGTAGTGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAAAGACACAGTGAGGGGAAGTCATTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCTATGCCATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGCTATTAGTGGTAGTGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAAAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "23", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 456, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 457, "v_rs_end": 495, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCTATGCCATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGCTATTAGTGGTAGTGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAAAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTT............AGCAGCTATGCCATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGCTATTAGTGGTAGT......GGTGGTAGCACATACTACGCAGACTCCGTGAAG...GGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAAAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1192", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCTATGCCATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGCTATTAGTGGTAGTGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAAAGACACAGTGAGGGGAAGTCAGTG", "repository_name": "GenBank", "repository_ref": "HM855868", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 328, "strand": null }, { "sequence_id": "1193", "sequence": "ATGGAGTTTGGGCTGAGCTGGCTTTTTCTTGTGGCTATTTTAAAAGGTAATTCATGGAGAAATAGAAAAATTGAGTGTGAATGGATAAGAGTGAGAGAAACAGTGGATACGTGTGGCAGTTTCTGACCAGGGTTTCTTTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCTATGCCATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGCTATTAGTGGTAGTGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAAAGACACAGTGAGGGGAAGTCATTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 610784, "gff_end": 611278, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample GRCh38:CM000676.2\r\nVDJbase example haplotype: P1_I29", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02781", "allele_description_ref": "OGRDB:Homo sapiens:IGHV6-1*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV6-1*01", "sequence": "ATGTCTGTCTCCTTCCTCATCTTCCTGCCCGTGCTGGGCCTCCCATGGGGTCAGTGTCAGGGAGATGCCGTATTCACAGCAGCATTCACAGACTGAGGGGTGTTTCACTTTGCTGTTTCCTTTTGTCTCCAGGTGTCCTGTCACAGGTACAGCTGCAGCAGTCAGGTCCAGGACTGGTGAAGCCCTCGCAGACCCTCTCACTCACCTGTGCCATCTCCGGGGACAGTGTCTCTAGCAACAGTGCTGCTTGGAACTGGATCAGGCAGTCCCCATCGAGAGGCCTTGAGTGGCTGGGAAGGACATACTACAGGTCCAAGTGGTATAATGATTATGCAGTATCTGTGAAAAGTCGAATAACCATCAACCCAGACACATCCAAGAACCAGTTCTCCCTGCAGCTGAACTCTGTGACTCCCGAGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "CAGGTACAGCTGCAGCAGTCAGGTCCAGGACTGGTGAAGCCCTCGCAGACCCTCTCACTCACCTGTGCCATCTCCGGGGACAGTGTCTCTAGCAACAGTGCTGCTTGGAACTGGATCAGGCAGTCCCCATCGAGAGGCCTTGAGTGGCTGGGAAGGACATACTACAGGTCCAAGTGGTATAATGATTATGCAGTATCTGTGAAAAGTCGAATAACCATCAACCCAGACACATCCAAGAACCAGTTCTCCCTGCAGCTGAACTCTGTGACTCCCGAGGACACGGCTGTGTATTACTGTGCAAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "6", "subgroup_designation": "1", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 144, "gene_end": 448, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 49, "leader_2_start": 133, "leader_2_end": 143, "v_rs_start": 449, "v_rs_end": 487, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTACAGCTGCAGCAGTCAGGTCCAGGACTGGTGAAGCCCTCGCAGACCCTCTCACTCACCTGTGCCATCTCCGGGGACAGTGTCTCTAGCAACAGTGCTGCTTGGAACTGGATCAGGCAGTCCCCATCGAGAGGCCTTGAGTGGCTGGGAAGGACATACTACAGGTCCAAGTGGTATAATGATTATGCAGTATCTGTGAAAAGTCGAATAACCATCAACCCAGACACATCCAAGAACCAGTTCTCCCTGCAGCTGAACTCTGTGACTCCCGAGGACACGGCTGTGTATTACTGTGCAAGAGA", "aligned_sequence": "CAGGTACAGCTGCAGCAGTCAGGTCCA...GGACTGGTGAAGCCCTCGCAGACCCTCTCACTCACCTGTGCCATCTCCGGGGACAGTGTCTCT......AGCAACAGTGCTGCTTGGAACTGGATCAGGCAGTCCCCATCGAGAGGCCTTGAGTGGCTGGGAAGGACATACTACAGGTCC...AAGTGGTATAATGATTATGCAGTATCTGTGAAA...AGTCGAATAACCATCAACCCAGACACATCCAAGAACCAGTTCTCCCTGCAGCTGAACTCTGTGACTCCCGAGGACACGGCTGTGTATTACTGTGCAAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 183, "fwr3_start": 184, "fwr3_end": 297, "cdr3_start": 298, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1391", "sequence": "ATGTCTGTCTCCTTCCTCATCTTCCTGCCCGTGCTGGGCCTCCCATGGGGTCAGTGTCAGGGAGATGCCGTATTCACAGCAGCATTCACAGACTGAGGGGTGTTTCACTTTGCTGTTTCCTTTTGTCTCCAGGTGTCCTGTCACAGGTACAGCTGCAGCAGTCAGGTCCAGGACTGGTGAAGCCCTCGCAGACCCTCTCACTCACCTGTGCCATCTCCGGGGACAGTGTCTCTAGCAACAGTGCTGCTTGGAACTGGATCAGGCAGTCCCCATCGAGAGGCCTTGAGTGGCTGGGAAGGACATACTACAGGTCCAAGTGGTATAATGATTATGCAGTATCTGTGAAAAGTCGAATAACCATCAACCCAGACACATCCAAGAACCAGTTCTCCCTGCAGCTGAACTCTGTGACTCCCGAGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 83485, "gff_end": 83971, "strand": null }, { "sequence_id": "1392", "sequence": "ATGTCTGTCTCCTTCCTCATCTTCCTGCCCGTGCTGGGCCTCCCATGGGGTCAGTGTCAGGGAGATGCCGTATTCACAGCAGCATTCACAGACTGAGGGGTGTTTCACTTTGCTGTTTCCTTTTGTCTCCAGGTGTCCTGTCACAGGTACAGCTGCAGCAGTCAGGTCCAGGACTGGTGAAGCCCTCGCAGACCCTCTCACTCACCTGTGCCATCTCCGGGGACAGTGTCTCTAGCAACAGTGCTGCTTGGAACTGGATCAGGCAGTCCCCATCGAGAGGCCTTGAGTGGCTGGGAAGGACATACTACAGGTCCAAGTGGTATAATGATTATGCAGTATCTGTGAAAAGTCGAATAACCATCAACCCAGACACATCCAAGAACCAGTTCTCCCTGCAGCTGAACTCTGTGACTCCCGAGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCA", "repository_name": "GenBank", "repository_ref": "ON052091", "patch_no": "1", "gff_seqid": null, "gff_start": 262, "gff_end": 738, "strand": null }, { "sequence_id": "1393", "sequence": "ATGTCTGTCTCCTTCCTCATCTTCCTGCCCGTGCTGGGCCTCCCATGGGGTCAGTGTCAGGGAGATGCCGTATTCACAGCAGCATTCACAGACTGAGGGGTGTTTCACTTTGCTGTTTCCTTTTGTCTCCAGGTGTCCTGTCACAGGTACAGCTGCAGCAGTCAGGTCCAGGACTGGTGAAGCCCTCGCAGACCCTCTCACTCACCTGTGCCATCTCCGGGGACAGTGTCTCTAGCAACAGTGCTGCTTGGAACTGGATCAGGCAGTCCCCATCGAGAGGCCTTGAGTGGCTGGGAAGGACATACTACAGGTCCAAGTGGTATAATGATTATGCAGTATCTGTGAAAAGTCGAATAACCATCAACCCAGACACATCCAAGAACCAGTTCTCCCTGCAGCTGAACTCTGTGACTCCCGAGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 939644, "gff_end": 940130, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019441\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02710", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-30*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-30*02", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTCGTTGCTCTTTTAAGAGGTGATTCACGGAGAAATAGAGAGACTGAGTGTGAGTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCAGTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATACGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGACACAGTGAGGGGAAGTCATTGTGCGCCCAGACACAAACC", "coding_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATACGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "30", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 159, "gene_end": 454, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 148, "leader_2_end": 158, "v_rs_start": 455, "v_rs_end": 493, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATACGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGA", "aligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTC............AGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATACGGTATGAT......GGAAGTAATAAATACTATGCAGACTCCGTGAAG...GGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1211", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTCGTTGCTCTTTTAAGAGGTGATTCACGGAGAAATAGAGAGACTGAGTGTGAGTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCAGTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCATTTATACGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGACACAGTGAGGGGAAGTCATTGTGCGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AC234301", "patch_no": "2", "gff_seqid": null, "gff_start": 38703, "gff_end": 39195, "strand": null } ], "rearranged_support": [], "paralogs": [ "IGHV3-30-5*02" ], "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AC234301\r\nVDJbase example haplotype: P1_I29\r\nVDJbase example haplotype: P1_I76", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02731", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-49*04.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-49*04", "sequence": "ATGGAGTTTGGGCTTAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTAATTCATGGTGTACTAGAGATACTGAGTGTGAGGGGACATGAGTGGTAGAAACAGTGGATATGTGTGGCAGTTTCTGACCTTGGTGTTTCTGTGTTTGCAGGTGTCCAATGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCAGGGCGGTCCCTGAGACTCTCCTGTACAGCTTCTGGATTCACCTTTGGTGATTATGCTATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTAGGTTTCATTAGAAGCAAAGCTTATGGTGGGACAACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCCAAAAGCATCGCCTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACTAGAGACACAGTGAGGGGAGGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCAGGGCGGTCCCTGAGACTCTCCTGTACAGCTTCTGGATTCACCTTTGGTGATTATGCTATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTAGGTTTCATTAGAAGCAAAGCTTATGGTGGGACAACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCCAAAAGCATCGCCTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACTAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "49", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 462, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 463, "v_rs_end": 501, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCAGGGCGGTCCCTGAGACTCTCCTGTACAGCTTCTGGATTCACCTTTGGTGATTATGCTATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTAGGTTTCATTAGAAGCAAAGCTTATGGTGGGACAACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCCAAAAGCATCGCCTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACTAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCAGGGCGGTCCCTGAGACTCTCCTGTACAGCTTCTGGATTCACCTTT............GGTGATTATGCTATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTAGGTTTCATTAGAAGCAAAGCTTATGGTGGGACAACAGAATACGCCGCGTCTGTGAAA...GGCAGATTCACCATCTCAAGAGATGATTCCAAAAGCATCGCCTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACTAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 180, "fwr3_start": 181, "fwr3_end": 294, "cdr3_start": 295, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1261", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCAGGGCGGTCCCTGAGACTCTCCTGTACAGCTTCTGGATTCACCTTTGGTGATTATGCTATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTAGGTTTCATTAGAAGCAAAGCTTATGGTGGGACAACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCCAAAAGCATCGCCTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACTAGAGACACAGTGAGGGGAAGTCATTGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855797", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 351, "strand": null }, { "sequence_id": "1262", "sequence": "ATGGAGTTTGGGCTTAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTAATTCATGGTGTACTAGAGATACTGAGTGTGAGGGGACATGAGTGGTAGAAACAGTGGATATGTGTGGCAGTTTCTGACCTTGGTGTTTCTGTGTTTGCAGGTGTCCAATGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCAGGGCGGTCCCTGAGACTCTCCTGTACAGCTTCTGGATTCACCTTTGGTGATTATGCTATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTAGGTTTCATTAGAAGCAAAGCTTATGGTGGGACAACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCCAAAAGCATCGCCTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACTAGAGACACAGTGAGGGGAGGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 322448, "gff_end": 322948, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample GRCh38:CM000676.2\r\nVDJbase example haplotype: P1_I10", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02976", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-62*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV3-62*03", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAGAGGTGATTCATAGATAAATAGAGATGTTGAGTGGGAGTGGACATGAGTGAGAGAAACAGTGGATGTGTGTGGCAGTTTCTGACCTTGGTGTCTTTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGAAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTCTGCTATGCACTGGGTCCGCCAGGCTCCAAGAAAGGGTTTGTAGTGGGTCTCAGTTATTAGTACAAGTGGTGATACCGTACTCTACACAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAATGCCCAGAATTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGACGACATGGCTGTGTATTACTGTGTGAAAGACGCAGTGAGAAGTCAGTGTGAGCCCAGACACAAACCTC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGAAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTCTGCTATGCACTGGGTCCGCCAGGCTCCAAGAAAGGGTTTGTAGTGGGTCTCAGTTATTAGTACAAGTGGTGATACCGTACTCTACACAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAATGCCCAGAATTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGACGACATGGCTGTGTATTACTGTGTGAAAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": false, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "62", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 456, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 457, "v_rs_end": 494, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGAAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTCTGCTATGCACTGGGTCCGCCAGGCTCCAAGAAAGGGTTTGTAGTGGGTCTCAGTTATTAGTACAAGTGGTGATACCGTACTCTACACAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAATGCCCAGAATTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGACGACATGGCTGTGTATTACTGTGTGAAAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGAA...GGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTCTGCTATGCACTGGGTCCGCCAGGCTCCAAGAAAGGGTTTGTAGTGGGTCTCAGTTATTAGTACAAGT......GGTGATACCGTACTCTACACAGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAATGCCCAGAATTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGACGACATGGCTGTGTATTACTGTGTGAAAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1423", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAGAGGTGATTCATAGATAAATAGAGATGTTGAGTGGGAGTGGACATGAGTGAGAGAAACAGTGGATGTGTGTGGCAGTTTCTGACCTTGGTGTCTTTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGAAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTCTGCTATGCACTGGGTCCGCCAGGCTCCAAGAAAGGGTTTGTAGTGGGTCTCAGTTATTAGTACAAGTGGTGATACCGTACTCTACACAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAATGCCCAGAATTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGACGACATGGCTGTGTATTACTGTGTGAAAGACGCAGTGAGAAGTCAGTGTGAGCCCAGACACAAACCTC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 236260, "gff_end": 236753, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample GRCh38:CM000676.2. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (90 samples). Example subject: P25_I1.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02670", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-69*12.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-69*12", "sequence": "GTTCCTCTTTGTGGTGGCAGCAGCTACAGGTAAGGGGCTTCCTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTGTCCACAGGTGTCCAGTCCCAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCAC", "coding_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "69", "allele_designation": "12", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 127, "gene_end": 422, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 116, "leader_2_end": 126, "v_rs_start": 423, "v_rs_end": 451, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTC............AGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATC......TTTGGTACAGCAAACTACGCACAGAAGTTCCAG...GGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1119", "sequence": "CTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTGTCCACAGGTGTCCAGTCCCAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCAC", "repository_name": "GenBank", "repository_ref": "MG719327", "patch_no": "1", "gff_seqid": null, "gff_start": 42, "gff_end": 440, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MG719327\r\nVDJbase example haplotype: P1_I98\r\nMapped by P1_I98 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02978", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-28*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV4-28*02", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGAGCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCATCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCATCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "28", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 140, "gene_end": 435, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 129, "leader_2_end": 139, "v_rs_start": 436, "v_rs_end": 474, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCATCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGC.........AGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGT.........GGGAGCATCTACTACAACCCGTCCCTCAAG...AGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 102, "fwr2_start": 103, "fwr2_end": 153, "cdr2_start": 154, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1425", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGAGCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCATCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "M83133", "patch_no": "1", "gff_seqid": null, "gff_start": 672, "gff_end": 1145, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample M83133. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (8 samples). Example subject: P25_I1.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02667", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-69*06.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-69*06", "sequence": "ATGGACTGGACCTGGAGGTTCCTCTTTGTGGTGGCAGCAGCTACAGGTAAGGGGCTTCCTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTCTCCACAGGTGTCCAGTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGAGTGTCAGAAACC", "coding_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "69", "allele_designation": "06", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 144, "gene_end": 439, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 133, "leader_2_end": 143, "v_rs_start": 440, "v_rs_end": 478, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTC............AGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATC......TTTGGTACAGCAAACTACGCACAGAAGTTCCAG...GGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1114", "sequence": "ATGGACTGGACCTGGAGGTTCCTCTTTGTGGTGGCAGCAGCTACAGGTAAGGGGCTTCCTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTCTCCACAGGTGTCCAGTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGAGTGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "AB019437", "patch_no": "1", "gff_seqid": null, "gff_start": 119174, "gff_end": 119651, "strand": null }, { "sequence_id": "1115", "sequence": "ATGGACTGGACCTGGAGGTTCCTCTTTGTGGTGGCAGCAGCTACAGGTAAGGGGCTTCCTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTGTCCACAGGTGTCCAGTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGAGT", "repository_name": "GenBank", "repository_ref": "ON052040", "patch_no": "1", "gff_seqid": null, "gff_start": 43, "gff_end": 510, "strand": null }, { "sequence_id": "1116", "sequence": "ATGGACTGGACCTGGAGGTTCCTCTTTGTGGTGGCAGCAGCTACAGGTAAGGGGCTTCCTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTCTCCACAGGTGTCCAGTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGAGTGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 164725, "gff_end": 165202, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019437\r\nVDJbase example haplotype: P1_I46_S1", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02703", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-25*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-25*02", "sequence": "ATGGAGTTTGTGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAACGTGATCTATAGAGAACTAGAGATATTGAGTATGAATGGATATGAGTGAGAAACAGTGGATACGTGTGGCAGTTTCTGACCGGGGTGTCTCTGTGTTTGCAGGTATCCAGTGTGAGATGCAGCTGGTGGAGTCTGGGGGAGGCTTGGCAAAGCCTGCGTGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTCAGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTTGACAAGTTAATCCTAATGGGGGTAGCACATACCTCATAGACTCCGGTAAGGACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTCTATTAGTGTACCAGAGACACAGTGAGGGGAGGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGATGCAGCTGGTGGAGTCTGGGGGAGGCTTGGCAAAGCCTGCGTGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTCAGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTTGACAAGTTAATCCTAATGGGGGTAGCACATACCTCATAGACTCCGGTAAGGACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTCTATTAGTGTACCAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": false, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "25", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 159, "gene_end": 454, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 148, "leader_2_end": 158, "v_rs_start": 455, "v_rs_end": 493, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGATGCAGCTGGTGGAGTCTGGGGGAGGCTTGGCAAAGCCTGCGTGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTCAGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTTGACAAGTTAATCCTAATGGGGGTAGCACATACCTCATAGACTCCGGTAAGGACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTCTATTAGTGTACCAGAGA", "aligned_sequence": "GAGATGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGCAAAGCCTGCGTGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTC............AGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTTGACAAGTTAATCCTAAT......GGGGGTAGCACATACCTCATAGACTCCGGTAAG...GACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTCTATTAGTGTACCAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1196", "sequence": "ATGGAGTTTGTGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAACGTGATCTATAGAGAACTAGAGATATTGAGTATGAATGGATATGAGTGAGAAACAGTGGATACGTGTGGCAGTTTCTGACCGGGGTGTCTCTGTGTTTGCAGGTATCCAGTGTGAGATGCAGCTGGTGGAGTCTGGGGGAGGCTTGGCAAAGCCTGCGTGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTCAGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTTGACAAGTTAATCCTAATGGGGGTAGCACATACCTCATAGACTCCGGTAAGGACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTCTATTAGTGTACCAGAGACACAGTGAGGGGAGGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AC244492", "patch_no": "2", "gff_seqid": null, "gff_start": 1213, "gff_end": 1705, "strand": null }, { "sequence_id": "1197", "sequence": "GTGTCCAGTGTGAGATGCAGCTGGTGGAGTCTGGGGGAGGCTTGGCAAAGCCTGCGTGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTCAGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTTGACAAGTTAATCCTAATGGGGGTAGCACATACCTCATAGACTCCGGTAAGGACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTCTATTAGTGTACCAGAGACACAGTGAGGGGAAGTCATTGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855669", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 345, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AC244492", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00065", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-21*07.2_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 2, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-21*07", "sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": [ "IGHV3-21*i02" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "21", "allele_designation": "07", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 296, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGT......GGTAGTACCATATACTACGCAGACTCAGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1188", "sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "repository_name": "GenBank", "repository_ref": "OU596107", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 296, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "IARC Meeting 61 (October 13th 2020):\r\nThe meeting considered the inference of the variant IGHV3-21*01_a184g_t190a_a191c in the VDJbase dataset of sample P1_I80_S1. The sequence was seen in 2.73% of all unmutated rearrangements, with 1207 sequences including 1054 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. IGHV3-21*01 was also present in the genotype, at a similar frequency (2.37% of all unmutated sequences, 1066 sequences, 917 unmutated sequences). Plots of the final 3\u2019 nucleotides were unavailable, and no haplotyping data was available. The sequence was tentatively affirmed as a Level 1 sequence, and the final 3\u2019 nucleotides will be considered at a later date, when terminal nucleotide plots become available, at which time the affirmed sequence will be noted in the IARC minutes.\r\n\r\nIARC meeting 80 (September 27th, 2021):\r\nIGHV3-21*01_A184G_T190A_A191C was inferred in the genotype of subject S76 (VDJbase: P1_I80). This inference has previously been pre-assessed at IARC meeting 61 (https://www.antibodysociety.org/wordpress/wp-content/uploads/2020/12/Meeting-61-13_10_20-minutes.pdf). The genotype also carried IGHV3-21*01. Both alleles were represented in high numbers (2.9% and 2.5% of the total unmutated population). IGHV3-21*01_A184G_T190A_A191 was represented by 1306 sequences, 1092 unmutated sequences, an allelic frequency of 53%, and 1069 unique CDR3s in the unmutated sequence set. Haplotyping based on differences in IGHJ6 alleles was not possible for this dataset.\r\n\r\n>IGHV3-21*01_A184G_T190A_A191C\r\nGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA\r\n\r\nThe sequence is inferred at Level 1. IARC affirms the sequence up to and including base 320 based on the convincing evidence of the sequence end as presented in the OGRDBplot. \r\n\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample OU596107\r\nVDJbase example haplotype: P1_I80", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02654", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-3*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-3*02", "sequence": "ATGGACTGGACCTGGAGGATCCTCTTTTTGGTGGCAGCAGCCACAGGTAAGGGGCTGCCAAATCCCAGTGAGGAGGAAGGGATCGAAGCCAGTCAAGGGGGCTTCCATCCACTCCTGTGTCTTCTCTACAGGTGTCCACTCCCAGGTTCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGAGCAACGCTGGCAATGGTAACACAAAATATTCACAGGAGTTCCAGGGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACATGGCTGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGAGTGTCAGAAACC", "coding_sequence": "CAGGTTCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGAGCAACGCTGGCAATGGTAACACAAAATATTCACAGGAGTTCCAGGGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACATGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "3", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 143, "gene_end": 438, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 132, "leader_2_end": 142, "v_rs_start": 439, "v_rs_end": 477, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTTCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGAGCAACGCTGGCAATGGTAACACAAAATATTCACAGGAGTTCCAGGGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACATGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTTCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTC............ACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGAGCAACGCTGGC......AATGGTAACACAAAATATTCACAGGAGTTCCAG...GGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACATGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1085", "sequence": "ATGGACTGGACCTGGAGGATCCTCTTTTTGGTGGCAGCAGCCACAGGTAAGGGGCTGCCAAATCCCAGTGAGGAGGAAGGGATCGAAGCCAGTCAAGGGGGCTTCCATCCACTCCTGTGTCTTCTCTACAGGTGTCCACTCCCAGGTTCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGAGCAACGCTGGCAATGGTAACACAAAATATTCACAGGAGTTCCAGGGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACATGGCTGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGAGTGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 17860, "gff_end": 18336, "strand": null }, { "sequence_id": "1086", "sequence": "CACAGGTAAGGGGCTGCCAAATCCCAGTGAGGAGGAAGGGATCGAAGCCAGTCAAGGGGGCTTCCATCCACTCCTGTGTCTTCTCTACAGGTGTCCACTCCCAGGTTCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGAGCAACGCTGGCAATGGTAACACAAAATATTCACAGGAGTTCCAGGGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACATGGCTGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCAC", "repository_name": "GenBank", "repository_ref": "MG719308", "patch_no": "1", "gff_seqid": null, "gff_start": 25, "gff_end": 439, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019441", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00038", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-53*05.3_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 3, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-53*05", "sequence": "GAGGTGCAGCTGGTGGAGACTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "coding_sequence": "GAGGTGCAGCTGGTGGAGACTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": "A", "aliases": [ "IGHV3-53*i01" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "53", "allele_designation": "05", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 292, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGACTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGACTGGAGGA...GGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTC............AGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGT.........GGTAGCACATACTACGCAGACTCCGTGAAG...GGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1270", "sequence": "GAGGTGCAGCTGGTGGAGACTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "repository_name": "GenBank", "repository_ref": "MK308860", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 292, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "The 40th meeting of the IARC on August 7th 2019 considered the sequence IGHV3-53*02_S0744. The sequence represents IGHV3-53*02 C288T in the IMGT numbering system. The committee noted a rearrangement frequency of 0.7%, with 5149 alignments including 2426 perfect matches to the inferred allele. Alignments were also seen to three other IGHV3-53 sequences, though only one of these sequences was abundant (IGHV3-53*04: 3448 alignments, 2149 unmutated alignments). Haplotyping based on IGHJ6 alleles confirmed the segregation of reads associated with these two alleles to the different haplotypes Alignments to the two other alleles shown in the genotype were at trivial levels (<0.01% of \u2018unmutated\u2019 alignments, in each case). There were 742 different CDR3s associated with the inference, including 292 different CDR3s associated with unmutated alignments. The committee agreed that the sequence should be accepted as a Level 1 sequence as IGHV3-53*i01. In line with previous policy, the submitted sequence was recognized up to and including nucleotide 319. A trailing \u201c.\u201d in the affirmed sequence indicates IARC\u2019s opinion that the sequence is likely to contain an additional 3\u2019 nucleotide for which there is insufficient evidence to make an affirmation. \r\n\r\nReanalysis of the original submission at Meeting 43 of the IARC on October 7, 2019 again identified the same novel allele IGHV3-53*02_S0744 (IGHV3-53*02 C288T) with 5425 sequences aand 2447 perfect matches and 300 Unique CDR3s with unmutated Seqs. In this analysis only one other allele of IGHV3-53 was seen (as very rare inferences had been removed by IgDiscover filtering), IGHV3-53*04 with 3551 sequences and 2163 perfect matches giving a 60:40 allelic ratio. These alleles were very well separated by IGHJ6-based haplotype analysis (1:99 and 99:1, respectively). The re-analysis thus confirmed the inference of IGHV3-53*i01 as a Level 1 sequence. In line with previous policy, the submitted sequence is recognized up to and including nucleotide 319. A trailing \u201c.\u201d in the affirmed sequence indicates IARC\u2019s opinion that the sequence is likely to contain an additional 3\u2019 nucleotide for which there is insufficient evidence to make an affirmation.\r\n\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MK308860\r\nMapped by IARC haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02970", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-21*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV3-21*03", "sequence": "TTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACAGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCATTGCTCGCGA", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACAGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "21", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 22, "gene_end": 317, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 11, "leader_2_end": 21, "v_rs_start": 318, "v_rs_end": 346, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACAGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGT......AGTAGTTACATATACTACGCAGACTCAGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACAGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1417", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACAGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCATTGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855855", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 345, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855855. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (2 samples). Example subject: P25_I55.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02726", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-48*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-48*01", "sequence": "ATGGAGTTGGGGCTGTGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGATTCATGGAAAACTAGAGAGATTTAGTGTGTGTGGATATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAATGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCAGTGTGACACCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAATGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "48", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 456, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 457, "v_rs_end": 495, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAATGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGT......AGTAGTACCATATACTACGCAGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAATGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1249", "sequence": "ATGGAGTTGGGGCTGTGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGATTCATGGAAAACTAGAGAGATTTAGTGTGTGTGGATATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAATGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCAGTGTGACACCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "M99675", "patch_no": "1", "gff_seqid": null, "gff_start": 174, "gff_end": 668, "strand": null }, { "sequence_id": "1250", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAATGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGTCAATGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855869", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 344, "strand": null }, { "sequence_id": "1251", "sequence": "ATGGAGTTGGGGCTGTGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGATTCATGGAAAACTAGAGAGATTTAGTGTGTGTGGATATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAATGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCAGTGTGAGCCCA", "repository_name": "GenBank", "repository_ref": "ON052063", "patch_no": "1", "gff_seqid": null, "gff_start": 269, "gff_end": 753, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample M99675\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02647", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-18*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-18*03", "sequence": "TCTCCACAGGTGCCCACTCCCAGGTTCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTACCAGCTATGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTACAATGGTAACACAAACTATGCACAGAAGCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACATGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTCTCGCGA", "coding_sequence": "CAGGTTCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTACCAGCTATGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTACAATGGTAACACAAACTATGCACAGAAGCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACATGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "18", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 21, "gene_end": 316, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 10, "leader_2_end": 20, "v_rs_start": 317, "v_rs_end": 346, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTTCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTACCAGCTATGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTACAATGGTAACACAAACTATGCACAGAAGCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACATGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTTCAGCTGGTGCAGTCTGGAGCT...GAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTT............ACCAGCTATGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTAC......AATGGTAACACAAACTATGCACAGAAGCTCCAG...GGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACATGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1067", "sequence": "GTGCCCACTCCCAGGTTCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTACCAGCTATGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTACAATGGTAACACAAACTATGCACAGAAGCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACATGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTCTCGCG", "repository_name": "GenBank", "repository_ref": "HM855850", "patch_no": "1", "gff_seqid": null, "gff_start": 10, "gff_end": 345, "strand": null }, { "sequence_id": "1068", "sequence": "GTGCCCACTCCCAGGTTCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTACCAGCTATGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTACAATGGTAACACAAACTATGCACAGAAGCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACATGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCT", "repository_name": "GenBank", "repository_ref": "HM855623", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 330, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855850", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00013", "allele_description_ref": "OGRDB:Homo sapiens:IGHV5-51*06.6_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 6, "release_date": "16-Aug-2023", "release_description": "Further D sequences added with the support of Rodriguez et al. 'Likely' extensions added to three IGHV alleles. See Notes for details.", "label": "IGHV5-51*06", "sequence": "GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCGGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTTACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGA", "coding_sequence": "GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCGGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTTACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACA", "ext_3prime": "CA", "aliases": [ "IGHV5-51*i01" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "5", "subgroup_designation": "51", "allele_designation": "06", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 294, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCGGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTTACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACA", "aligned_sequence": "GAGGTGCAGCTGGTGCAGTCTGGAGCA...GAGGTGAAAAAGCCGGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTT............ACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGT......GACTCTGATACCAGATACAGCCCGTCCTTCCAA...GGCCAGGTTACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1390", "sequence": "GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCGGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTTACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGA", "repository_name": "GenBank", "repository_ref": "MK321694", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 294, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "This sequence represents IGHV5-51*03 C228T in the IMGT numbering system. The committee noted a rearrangement frequency of 1.25%, with 1128 alignments including 304 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. The genotype showed the individual to be heterozygous at the IGHV5-51 locus, with the alternative IGHV5-51*03 allele being associated with 1539 sequences for an allele ratio of 42:58. The sequence was affirmed at level 1 at IARC Meeting 33 on March 15, 2019. The sequence is affirmed only up to and including base 318, the final base of the inference and its GenBank record, and of the corresponding closest allele (IGHV5-51*03) in the IMGT database.\r\n\r\n(April 12, 2019) A trailing \".\" indicates IARC's opinion that the sequence is likely to contain additional 3' nucleotides for which there is insufficient evidence to make an affirmation.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MK321694\r\nMapped by IARC haplotype\r\nTwo nucleotide truncation at 3' end", "curational_tags": [ "likely_truncated" ] }, { "allele_description_id": "OGRDB:A02753", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-9*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-9*01", "sequence": "CAAATAGGGCCCTCCCTCTGCTGATGAAAACCAGCCCAGCCCTGACCCTGCAGCTCTGGGAGAGGAGCCCCAGCCCTGAGATTCCCAGGTGTTTCCATTCAGTGATCAGCACTGAACACAGAGGACTCACCATGGAGTTGGGACTGAGCTGGATTTTCCTTTTGGCTATTTTAAAAGGTGATTCATGGAGAAATAGAGAGATTGAGTGTGAGTGGACATGAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGGGAAGTCAGCGAGAGCCCAGACAAAAACC", "coding_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATTACTGTGCAAAAGATA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "9", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 280, "gene_end": 577, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 269, "leader_2_end": 279, "v_rs_start": 578, "v_rs_end": 616, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATTACTGTGCAAAAGATA", "aligned_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTT............GATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAAT......AGTGGTAGCATAGGCTATGCGGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATTACTGTGCAAAAGATA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1309", "sequence": "ATGGAGTTGGGACTGAGCTGGATTTTCCTTTTGGCTATTTTAAAAGGTGATTCATGGAGAAATAGAGAGATTGAGTGTGAGTGGACATGAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGGGAAGTCAGCGAGAGCCCAGACAAAAACC", "repository_name": "GenBank", "repository_ref": "M99651", "patch_no": "1", "gff_seqid": null, "gff_start": 132, "gff_end": 616, "strand": null }, { "sequence_id": "1310", "sequence": "GTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGGGAAGTCATTG", "repository_name": "GenBank", "repository_ref": "HM855810", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 330, "strand": null }, { "sequence_id": "1311", "sequence": "ATGGAGTTGGGACTGAGCTGGATTTTCCTTTTGGCTATTTTAAAAGGTGATTCATGGAGAAATAGAGAGATTGAGTGTGAGTGGACATGAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGGGAAGTCAGCGAGAGCCCAGACAAAAACC", "repository_name": "GenBank", "repository_ref": "ON052078", "patch_no": "1", "gff_seqid": null, "gff_start": 313, "gff_end": 797, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample M99651\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02711", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-30*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-30*03", "sequence": "GGACTCACCATGGAGTTTGGGCTGAGCTGGGTTTTCCTCGTTGCTCTTTTAAGAGGTGATTCATGGAGAAATAGAGAGACTGAGTGTGAGTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCATTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCATTGTGCGCCCAGACACAAACC", "coding_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "30", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 168, "gene_end": 463, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 157, "leader_2_end": 167, "v_rs_start": 464, "v_rs_end": 502, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGAT......GGAAGTAATAAATACTATGCAGACTCCGTGAAG...GGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1212", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTCGTTGCTCTTTTAAGAGGTGATTCATGGAGAAATAGAGAGACTGAGTGTGAGTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCATTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCATTGTGCGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "M99663", "patch_no": "1", "gff_seqid": null, "gff_start": 10, "gff_end": 502, "strand": null }, { "sequence_id": "1213", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTCGTTGCTCTTTTAAGAGGTGATTCATGGAGAAATAGAGAGACTGAGTGTGAGTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCATTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCATTGTGCGCCCA", "repository_name": "GenBank", "repository_ref": "ON052059", "patch_no": "1", "gff_seqid": null, "gff_start": 96, "gff_end": 578, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample M99663", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02697", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-20*04.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-20*04", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGATCAATAGAGATGTTGAGTGTGAGTGAACACGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGTGTGGTACGGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGGCATGAGCTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGAGTGGGTCTCTGGTATTAATTGGAATGGTGGTAGCACAGGTTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCCTTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGCCAGTGAGAGCCCAGACACAAACG", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGTGTGGTACGGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGGCATGAGCTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGAGTGGGTCTCTGGTATTAATTGGAATGGTGGTAGCACAGGTTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCCTTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "20", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 456, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 457, "v_rs_end": 495, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGTGTGGTACGGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGGCATGAGCTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGAGTGGGTCTCTGGTATTAATTGGAATGGTGGTAGCACAGGTTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCCTTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGTGTGGTACGGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTT............GATGATTATGGCATGAGCTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGAGTGGGTCTCTGGTATTAATTGGAAT......GGTGGTAGCACAGGTTATGCAGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCCTTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1179", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGATCAATAGAGATGTTGAGTGTGAGTGAACACGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGTGTGGTACGGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGGCATGAGCTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGAGTGGGTCTCTGGTATTAATTGGAATGGTGGTAGCACAGGTTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCCTTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGCCAGTGAGAGCCCAGACACAAACG", "repository_name": "GenBank", "repository_ref": "MN337622", "patch_no": "1", "gff_seqid": null, "gff_start": 370, "gff_end": 864, "strand": null }, { "sequence_id": "1180", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGTGTGGTACGGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGGCATGAGCTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGAGTGGGTCTCTGGTATTAATTGGAATGGTGGTAGCACAGGTTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCCTTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCATTGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855876", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 345, "strand": null }, { "sequence_id": "1181", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGATCAATAGAGATGTTGAGTGTGAGTGAACACGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGTGTGGTACGGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGGCATGAGCTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGAGTGGGTCTCTGGTATTAATTGGAATGGTGGTAGCACAGGTTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCCTTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGCCAGTGAGAGCCCA", "repository_name": "GenBank", "repository_ref": "ON052053", "patch_no": "1", "gff_seqid": null, "gff_start": 362, "gff_end": 844, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MN337622\r\nVDJbase example haplotype: P1_I10\r\nMapped by P1_I10 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02658", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-46*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-46*01", "sequence": "ATGGACTGGACCTGGAGGGTCTTCTGCTTGCTGGCTGTAGCTCCAGGTAAAGGGCCAACTGGTTCCAGGGCTGAGGAAGGGATTTTTTCCAGTTTAGAGGACTGTCATTCTCTACTGTGTCCTCTCCGCAGGTGCTCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCAGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGTGGTGGTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAGAAACCACATCCTCAGAGTGTCAGAAACC", "coding_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCAGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGTGGTGGTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "46", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 143, "gene_end": 438, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 132, "leader_2_end": 142, "v_rs_start": 439, "v_rs_end": 477, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCAGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGTGGTGGTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTC............ACCAGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGT......GGTGGTAGCACAAGCTACGCACAGAAGTTCCAG...GGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1094", "sequence": "ATGGACTGGACCTGGAGGGTCTTCTGCTTGCTGGCTGTAGCTCCAGGTAAAGGGCCAACTGGTTCCAGGGCTGAGGAAGGGATTTTTTCCAGTTTAGAGGACTGTCATTCTCTACTGTGTCCTCTCCGCAGGTGCTCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCAGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGTGGTGGTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAGAAACCACATCCTCAGAGTGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "AB019438", "patch_no": "1", "gff_seqid": null, "gff_start": 122057, "gff_end": 122533, "strand": null }, { "sequence_id": "1095", "sequence": "CTGAGGAAGGGATTTTTTCCAGTTTAGAGGACTGTCATTCTCTACTGTGTCCTCTCCGCAGGTGCTCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCAGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGTGGTGGTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAGAAACCAC", "repository_name": "GenBank", "repository_ref": "MG719321", "patch_no": "1", "gff_seqid": null, "gff_start": 54, "gff_end": 439, "strand": null }, { "sequence_id": "1096", "sequence": "ATGGACTGGACCTGGAGGGTCTTCTGCTTGCTGGCTGTAGCTCCAGGTAAAGGGCCAACTGGTTCCAGGGCTGAGGAAGGGATTTTTTCCAGTTTAGAGGACTGTCATTCTCTACTGTGTCCTCTCCGCAGGTGCTCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCAGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGTGGTGGTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAGAAACCACATCCTCAGAGT", "repository_name": "GenBank", "repository_ref": "ON052034", "patch_no": "1", "gff_seqid": null, "gff_start": 391, "gff_end": 857, "strand": null }, { "sequence_id": "1097", "sequence": "ATGGACTGGACCTGGAGGGTCTTCTGCTTGCTGGCTGTAGCTCCAGGTAAAGGGCCAACTGGTTCCAGGGCTGAGGAAGGGATTTTTTCCAGTTTAGAGGACTGTCATTCTCTACTGTGTCCTCTCCGCAGGTGCTCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCAGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGTGGTGGTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAGAAACCACATCCTCAGAGTGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 368293, "gff_end": 368769, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019438\r\nVDJbase example haplotype: P1_I10", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02685", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-11*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-11*01", "sequence": "CCAGGAGTTTCCATTCGGTGATCAGCACTGAACACAGAGGACTCACCATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATAATAAAAGGTGATTTATGGAGAACTAGAGACATTGAGTGGACGTGAGTGAGATAAGCAGTGAATATATGTGGCAGTTTCTGACTAGGTTGTCTCTGTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGGGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGGGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "11", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 202, "gene_end": 497, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 191, "leader_2_end": 201, "v_rs_start": 498, "v_rs_end": 536, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGGGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGT......GGTAGTACCATATACTACGCAGACTCTGTGAAG...GGCCGATTCACCATCTCCAGGGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1153", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATAATAAAAGGTGATTTATGGAGAACTAGAGACATTGAGTGGACGTGAGTGAGATAAGCAGTGAATATATGTGGCAGTTTCTGACTAGGTTGTCTCTGTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGGGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "M99652", "patch_no": "1", "gff_seqid": null, "gff_start": 48, "gff_end": 536, "strand": null }, { "sequence_id": "1154", "sequence": "GTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGGGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAATGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855540", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 345, "strand": null }, { "sequence_id": "1155", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTATAAAAGGTGATTTATGGAGAACTAGAGACATTGAGTGGACGTGAGTGAGATAAGCAGTGAATATATGTGGCAGTTTCTGACTAGGTTGTCTCTGTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGGGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052046", "patch_no": "1", "gff_seqid": null, "gff_start": 214, "gff_end": 702, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample M99652\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02690", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-13*04.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-13*04", "sequence": "TCGCGAGTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAATGGGTCTCAGCTATTGGTACTGCTGGTGACACATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGGGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGGAGGTCAGTG", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAATGGGTCTCAGCTATTGGTACTGCTGGTGACACATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGGGGACACGGCTGTGTATTACTGTGCAAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "13", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 321, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 18, "leader_2_end": 28, "v_rs_start": 322, "v_rs_end": 350, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAATGGGTCTCAGCTATTGGTACTGCTGGTGACACATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGGGGACACGGCTGTGTATTACTGTGCAAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAATGGGTCTCAGCTATTGGTACTGCT.........GGTGACACATACTATCCAGGCTCCGTGAAG...GGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGGGGACACGGCTGTGTATTACTGTGCAAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1163", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAATGGGTCTCAGCTATTGGTACTGCTGGTGACACATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGGGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGGAGGTCAGTG", "repository_name": "GenBank", "repository_ref": "HM855727", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 325, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855727\r\nVDJbase example haplotype: P1_I27_S1\r\nMapped by P1_I27 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02650", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-2*04.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-2*04", "sequence": "TCGCGAGTCTCCACAGGTGTCCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACCCTAACAGTGGTGGCACAAACTATGCACAGAAGTTTCAGGGCTGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCT", "coding_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACCCTAACAGTGGTGGCACAAACTATGCACAGAAGTTTCAGGGCTGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "2", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 28, "gene_end": 323, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 17, "leader_2_end": 27, "v_rs_start": 324, "v_rs_end": 352, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACCCTAACAGTGGTGGCACAAACTATGCACAGAAGTTTCAGGGCTGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTC............ACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACCCTAAC......AGTGGTGGCACAAACTATGCACAGAAGTTTCAG...GGCTGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1073", "sequence": "ATGGACTGGACCTGGAGGATCCTCTTCTTGGTGGCAGCAGCCACAGGTAAGAGGCTCCCTAGTCCCAGTGATGAGAAAGAGATTGAGTCCAGTCCAGGGAGATCTCATCCACTTCTGTGTTCTCTCCACAGGAGCCCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACCCTAACAGTGGTGGCACAAACTATGCACAGAAGTTTCAGGGCTGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGGGTGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "ON052030", "patch_no": "1", "gff_seqid": null, "gff_start": 207, "gff_end": 683, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855893\r\nVDJbase example haplotype: P1_I27_S1", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02717", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-38*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-38*01", "sequence": "CAACTCATCATGCAGTTTGTGCTGAGCTGGGTTTTCCTTGTTGGTATTTTAAAAGGTGATTCATGGAGAACTACAGATGTTGAGTGTGAGTGGACATGAGTGAGCCAAACAGTGGGTTTGTGTGGCAGTTTCTGACCTGGTGTCTCTGTGTTTACAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTAGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAACCTGAGAGCTGAGGGCACGGCCGCGTATTACTGTGCCAGATATACACAGAGGGGAAGTCATTGTGCGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTAGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAACCTGAGAGCTGAGGGCACGGCCGCGTATTACTGTGCCAGATATA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "38", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 169, "gene_end": 460, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 158, "leader_2_end": 168, "v_rs_start": 452, "v_rs_end": 490, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTAGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAACCTGAGAGCTGAGGGCACGGCCGCGTATTACTGTGCCAGATATA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTAGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTC............AGTAGCAATGAGATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTGGT............GGTAGCACATACTACGCAGACTCCAGGAAG...GGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAACCTGAGAGCTGAGGGCACGGCCGCGTATTACTGTGCCAGATATA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 168, "fwr3_start": 169, "fwr3_end": 282, "cdr3_start": 283, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1229", "sequence": "ATGCAGTTTGTGCTGAGCTGGGTTTTCCTTGTTGGTATTTTAAAAGGTGATTCATGGAGAACTACAGATGTTGAGTGTGAGTGGACATGAGTGAGCCAAACAGTGGGTTTGTGTGGCAGTTTCTGACCTGGTGTCTCTGTGTTTACAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTAGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAACCTGAGAGCTGAGGGCACGGCCGCGTATTACTGTGCCAGATATACACAGAGGGGAAGTCATTGTGCGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "M99669", "patch_no": "1", "gff_seqid": null, "gff_start": 10, "gff_end": 497, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample M99669\r\nVDJbase example haplotype: P1_I12 (1 exact)", "curational_tags": [ "likely_truncated" ] }, { "allele_description_id": "OGRDB:A02737", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-64*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-64*02", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTTAAAGGTGATTCATGAGGAAATAGAGATATTGAGTGTGAGTGGACATGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGAAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATATTATGCAGACTCTGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGGGCAGCCTGAGAGCTGAGGACATGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGAGAAGTTAATGTGGGACCATGCAGAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGAAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATATTATGCAGACTCTGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGGGCAGCCTGAGAGCTGAGGACATGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "64", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 456, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 457, "v_rs_end": 495, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGAAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATATTATGCAGACTCTGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGGGCAGCCTGAGAGCTGAGGACATGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGAA...GGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAAT......GGGGGTAGCACATATTATGCAGACTCTGTGAAG...GGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGGGCAGCCTGAGAGCTGAGGACATGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1273", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTTAAAGGTGATTCATGAGGAAATAGAGATATTGAGTGTGAGTGGACATGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGAAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATATTATGCAGACTCTGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGGGCAGCCTGAGAGCTGAGGACATGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGAGAAGTTAATGTGGGACCATGCAGAAACC", "repository_name": "GenBank", "repository_ref": "AB019437", "patch_no": "1", "gff_seqid": null, "gff_start": 175347, "gff_end": 175841, "strand": null }, { "sequence_id": "1274", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTTAAAGGTGATTCATGAGGAAATAGAGATATTGAGTGTGAGTGGACATGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGAAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATATTATGCAGACTCTGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGGGCAGCCTGAGAGCTGAGGACATGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGAGAAGTTAATGTGGGACCATGCAGAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 221667, "gff_end": 222161, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019437\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02739", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-64D*08.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-64D*08", "sequence": "ATGGAGTTCTGGCTGAGCTGGGTTCTCCTTGTTGCCGTTTTAAAAGGTAATTCATGGAGAACTAGAGATAGTGTGAGTGGACGTGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGATGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTTCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATACTACGCAGACTCCGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACTCTGTATCTTCAAATGAGCAGTCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGTGAAAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTTCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATACTACGCAGACTCCGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACTCTGTATCTTCAAATGAGCAGTCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGTGAAAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "64D", "allele_designation": "08", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 157, "gene_end": 452, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 146, "leader_2_end": 156, "v_rs_start": 453, "v_rs_end": 491, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTTCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATACTACGCAGACTCCGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACTCTGTATCTTCAAATGAGCAGTCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGTGAAAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTTCAGCCTCTGGATTCACCTTC............AGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAAT......GGGGGTAGCACATACTACGCAGACTCCGTGAAG...GGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACTCTGTATCTTCAAATGAGCAGTCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGTGAAAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1277", "sequence": "ATGGAGTTCTGGCTGAGCTGGGTTCTCCTTGTTGCCGTTTTAAAAGGTAATTCATGGAGAACTAGAGATAGTGTGAGTGGACGTGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGATGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTTCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATACTACGCAGACTCCGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACTCTGTATCTTCAAATGAGCAGTCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGTGAAAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "MN337624", "patch_no": "1", "gff_seqid": null, "gff_start": 192, "gff_end": 682, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MN337624\r\nVDJbase example haplotype: P1_I56\r\nMapped by P1_I56 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02634", "allele_description_ref": "OGRDB:Homo sapiens:IGHD6-13*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD6-13*01", "sequence": "GGTTTCTGAAGGTGTCTGTGTCACAGTGGGGTATAGCAGCAGCTGGTACCACAGTGACACTCACCCAGCCAGAAACC", "coding_sequence": "GGGTATAGCAGCAGCTGGTAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "6", "subgroup_designation": "13", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 49, "d_rs_3_prime_start": 50, "d_rs_3_prime_end": 77, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "1020", "sequence": "GGTTTCTGAAGGTGTCTGTGTCACAGTGGGGTATAGCAGCAGCTGGTACCACAGTGACACTCACCCAGCCAGAAACC", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 52032, "gff_end": 52108, "strand": null }, { "sequence_id": "1021", "sequence": "GGTTTCTGAAGGTGTCTGTGTCACAGTGGGGTATAGCAGCAGCTGGTACCACAGTGACACTCACCCAGCCAGAAACC", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 122493, "gff_end": 122569, "strand": null }, { "sequence_id": "1022", "sequence": "GGTTTCTGAAGGTGTCTGTGTCACAGTGGGGTATAGCAGCAGCTGGTACCACAGTGACACTCACCCAGCCAGAAACC", "repository_name": "GenBank", "repository_ref": "ON052115", "patch_no": "1", "gff_seqid": null, "gff_start": 160, "gff_end": 236, "strand": null }, { "sequence_id": "1023", "sequence": "GGTTTCTGAAGGTGTCTGTGTCACAGTGGGGTATAGCAGCAGCTGGTACCACAGTGACACTCACCCAGCCAGAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 978655, "gff_end": 978731, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02696", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-20*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-20*01", "sequence": "GGACTCGCCATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGATCAATAGAGATGTTGAGTGTGAGTGAACACGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGTGTGGTACGGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGGCATGAGCTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGAGTGGGTCTCTGGTATTAATTGGAATGGTGGTAGCACAGGTTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCCTTGTATCACTGTGCGAGAGACACAGTGAGGGGAAGCCAGTGAGAGCCCAGACACAAACG", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGTGTGGTACGGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGGCATGAGCTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGAGTGGGTCTCTGGTATTAATTGGAATGGTGGTAGCACAGGTTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCCTTGTATCACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "20", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 170, "gene_end": 465, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 159, "leader_2_end": 169, "v_rs_start": 466, "v_rs_end": 504, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGTGTGGTACGGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGGCATGAGCTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGAGTGGGTCTCTGGTATTAATTGGAATGGTGGTAGCACAGGTTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCCTTGTATCACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGTGTGGTACGGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTT............GATGATTATGGCATGAGCTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGAGTGGGTCTCTGGTATTAATTGGAAT......GGTGGTAGCACAGGTTATGCAGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCCTTGTATCACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1176", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGATCAATAGAGATGTTGAGTGTGAGTGAACACGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGTGTGGTACGGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGGCATGAGCTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGAGTGGGTCTCTGGTATTAATTGGAATGGTGGTAGCACAGGTTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCCTTGTATCACTGTGCGAGAGACACAGTGAGGGGAAGCCAGTGAGAGCCCAGACACAAACG", "repository_name": "GenBank", "repository_ref": "M99657", "patch_no": "1", "gff_seqid": null, "gff_start": 10, "gff_end": 504, "strand": null }, { "sequence_id": "1177", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGTGTGGTACGGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGGCATGAGCTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGAGTGGGTCTCTGGTATTAATTGGAATGGTGGTAGCACAGGTTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCCTTGTATCACTGTGCGAGAGACACAGTGAGGGGAAGTCAATG", "repository_name": "GenBank", "repository_ref": "HM855941", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 328, "strand": null }, { "sequence_id": "1178", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGATCAATAGAGATGTTGAGTGTGAGTGAACACGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGTGTGGTACGGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGGCATGAGCTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGAGTGGGTCTCTGGTATTAATTGGAATGGTGGTAGCACAGGTTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCCTTGTATCACTGTGCGAGAGACACAGTGAGGGGAAGCCAGTGAGAGCCCA", "repository_name": "GenBank", "repository_ref": "ON052052", "patch_no": "1", "gff_seqid": null, "gff_start": 362, "gff_end": 846, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample M99657\r\nVDJbase example haplotype: P1_I23", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02714", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-33*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-33*01", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTCGTTGCTCTTTTAAGAGGTGATTCATGGAGAAATAGAGAGACTGAGTGTGAGTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCATTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCATTGTGCGCCCAGACACAAACC", "coding_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "33", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 159, "gene_end": 454, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 148, "leader_2_end": 158, "v_rs_start": 455, "v_rs_end": 493, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTC............AGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGAT......GGAAGTAATAAATACTATGCAGACTCCGTGAAG...GGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1219", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTCGTTGCTCTTTTAAGAGGTGATTCATGGAGAAATAGAGAGACTGAGTGTGAGTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCATTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCATTGTGCGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AB019439", "patch_no": "1", "gff_seqid": null, "gff_start": 73368, "gff_end": 73860, "strand": null }, { "sequence_id": "1220", "sequence": "GTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCATTGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855938", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 345, "strand": null }, { "sequence_id": "1221", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTCGTTGCTCTTTTAAGAGGTGATTCATGGAGAAATAGAGAGACTGAGTGTGAGTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCATTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCATTGTGCGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052060", "patch_no": "1", "gff_seqid": null, "gff_start": 232, "gff_end": 724, "strand": null }, { "sequence_id": "1222", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTCGTTGCTCTTTTAAGAGGTGATTCATGGAGAAATAGAGAGACTGAGTGTGAGTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCATTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCATTGTGCGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 519601, "gff_end": 520093, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019439\r\nVDJbase example haplotype: P1_I22_S1", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00047", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-4*09.2_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 2, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-4*09", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGA", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": "GA", "aliases": [ "IGHV4-4*i02" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "4", "allele_designation": "09", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 291, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATC............AGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATACCAGT.........GGGAGCACCAACTACAACCCCTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1366", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGA", "repository_name": "GenBank", "repository_ref": "MK471384", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 291, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Assessed by IARC on December 2, 2019 during meeting 46.\r\n\r\nThe committee considered IGHV4-4*08_S8301 (T165C,C237A) of Genotype B16 of submission S00010, which was previously evaluated as IGHV4-4*08_S4567 as part of submission S00006 at Meeting 12. It was affirmed as a Level 0 sequence at that time, because of haplotype analysis that at the time was considered inconclusive.\r\n\r\nThe sequence was seen in 1.81% of all unmutated rearrangements, with 12648 sequences including 5107 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. One other IGHV4-4 allele was present in the genotype, as well as two likely IGHV4-59 sequences and one IGHV4-61 sequence. Haplotype data is supportive of the inference, though the haplotype ratios likely reflect the presence of some artefacts within the dataset. The ratios for the two IGHV4-4 sequences were 75:25 and 81:19, suggesting that both sequences are carried on the IGHJ6*02-bearing chromosome. The sequence, up to and including nucleotide 318, was affirmed as a Level 1 sequence. Uncertainty regarding nucleotides 319 and 320 is indicated in IARC and OGRDB publications by two dots at the end of the affirmed sequence. The committee believes it is most likely that the 319th nucleotide is \u2018C\u2019.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MK471384", "curational_tags": [ "likely_truncated" ] }, { "allele_description_id": "OGRDB:A02700", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-23*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-23*01", "sequence": "GAACTCACCATGGAGTTTGGGCTGAGCTGGCTTTTTCTTGTGGCTAAAATAAAAGGTAATTCATGGAGAAATAGAAAAATTGAGTGTGAATGGATAAGAGTGAGAGAAACAGTGGATACGTGTGGCAGTTTCTGACCAGGGTTTCTTTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCTATGCCATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGCTATTAGTGGTAGTGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAAAGACACAGTGAGGGGAAGTCATTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCTATGCCATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGCTATTAGTGGTAGTGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAAAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "23", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 170, "gene_end": 465, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 159, "leader_2_end": 169, "v_rs_start": 466, "v_rs_end": 504, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCTATGCCATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGCTATTAGTGGTAGTGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAAAGA", "aligned_sequence": "GAGGTGCAGCTGTTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTT............AGCAGCTATGCCATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGCTATTAGTGGTAGT......GGTGGTAGCACATACTACGCAGACTCCGTGAAG...GGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAAAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1189", "sequence": "ATGGAGTTTGGGCTGAGCTGGCTTTTTCTTGTGGCTAAAATAAAAGGTAATTCATGGAGAAATAGAAAAATTGAGTGTGAATGGATAAGAGTGAGAGAAACAGTGGATACGTGTGGCAGTTTCTGACCAGGGTTTCTTTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCTATGCCATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGCTATTAGTGGTAGTGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAAAGACACAGTGAGGGGAAGTCATTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "M99660", "patch_no": "1", "gff_seqid": null, "gff_start": 10, "gff_end": 504, "strand": null }, { "sequence_id": "1190", "sequence": "ATGGAGTTTGGGCTGAGCTGGCTTTTTCTTGTGGCTATTTTAAAAGGTAATTCATGGAGAAATAGAAAAATTGAGTGTGAATGGATAAGAGTGAGAGAAACAGTGGATACGTGTGGCAGTTTCTGACCAGGGTTTCTTTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCTATGCCATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGCTATTAGTGGTAGTGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAAAGACACAGTGAGGGGAAGTCATTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AC244492", "patch_no": "2", "gff_seqid": null, "gff_start": 21635, "gff_end": 22129, "strand": null }, { "sequence_id": "1191", "sequence": "ATGGAGTTTGGGCTGAGCTGGCTTTTTCTTGTGGCTATTTTAAAAGGTAATTCATGGAGAAATAGAAAAATTGAGTGTGAATGGATAAGAGTGAGAGAAACAGTGGATACGTGTGGCAGTTTCTGACCAGGGTTTCTTTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCTATGCCATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGCTATTAGTGGTAGTGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAAAGACACAGTGAGGGGAAGTCATTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052055", "patch_no": "1", "gff_seqid": null, "gff_start": 191, "gff_end": 685, "strand": null } ], "rearranged_support": [], "paralogs": [ "IGHV3-23D*01" ], "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample M99660\r\nVDJbase example haplotype: P1_I29", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02785", "allele_description_ref": "OGRDB:Homo sapiens:IGHV7-4-1*05.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV7-4-1*05", "sequence": "TCTCCACAGGTGCCCACTCCCAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCATGGCATATCTGCAGATCAGCAGCCTAAAGGCTGAGGACACTGCCGTGTGTTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTCTCGCGA", "coding_sequence": "CAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCATGGCATATCTGCAGATCAGCAGCCTAAAGGCTGAGGACACTGCCGTGTGTTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "7-4", "subgroup_designation": "1", "allele_designation": "05", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 21, "gene_end": 316, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 10, "leader_2_end": 20, "v_rs_start": 317, "v_rs_end": 346, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCATGGCATATCTGCAGATCAGCAGCCTAAAGGCTGAGGACACTGCCGTGTGTTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGCAATCTGGGTCT...GAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTC............ACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAAC......ACTGGGAACCCAACGTATGCCCAGGGCTTCACA...GGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCATGGCATATCTGCAGATCAGCAGCCTAAAGGCTGAGGACACTGCCGTGTGTTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1401", "sequence": "TCTCCACAGGTGCCCACTCCCAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCATGGCATATCTGCAGATCAGCAGCCTAAAGGCTGAGGACACTGCCGTGTGTTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855507", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 346, "strand": null }, { "sequence_id": "1402", "sequence": "TCTCCACAGGTGTCCACTCCCAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCATGGCATATCTGCAGATCAGCAGCCTAAAGGCTGAGGACACTGCCGTGTGTTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855826", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 346, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855507", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00067", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-30*20.2_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 2, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-30*20", "sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGCAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "coding_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGCAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": "A", "aliases": [ "IGHV3-30*i01" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "30", "allele_designation": "20", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 295, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGCAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTC............AGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGAT......GGAAGCAATAAATACTACGCAGACTCCGTGAAG...GGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1217", "sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGCAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "repository_name": "GenBank", "repository_ref": "OU596105", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 295, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "IARC meeting 61 (Oct 13, 2020)\r\nThe meeting considered the inference of the variant IGHV3-30*19_t189c, in the VDJbase dataset of sample P1_I49_S1. The sequence was seen in 2.35% of all unmutated rearrangements, with 313 sequences including 113 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. IGHV3-30*18 also present in the genotype. Plots of the final 3\u2019 nucleotides of the inference were unavailable. Discussion particularly focused upon haplotype data relating to IGHV3-30, IGHV3-33 and IGHV3-30-3. These data raise the possibility that the inference is an allele of IGHV3-30-3, though it is most similar to IGHV3-30*19. IARC policy has been that sequences are given an IMGT gene name based upon the sequence to which they are most similar. Consideration of this particular inference led this policy to be reconsidered, and it was agreed that further discussion is required before the policy can be confirmed or modified. Because of the uncertainty regarding the most suitable name for the inferred sequence, it was affirmed as a Level 0 sequence. The final 3\u2019 nucleotides will be considered at a later date, at which time the affirmed sequence will be noted in the IARC minutes. It was noted\r\nthat the P1_I49_S1 dataset had a relatively low percentage of unmutated sequences for all genes in the dataset. GY agreed to investigate why this P1 dataset does not share the high percentage of unmutated sequences that is seen in other P1_S1 datasets.\r\n\r\nIARC meeting 82 (Oct 11, 2021)\r\nIGHV3-30*19_T189C was inferred in one genotype (VDJbase P1_I49). This inference has previously been pre-assessed at IARC meeting 61 (https://www.antibodysociety.org/wordpress/wp-content/uploads/2020/12/Meeting-61-13_10_20-minutes.pdf). Among alleles of the IGHV3-30/IGHV3-30-3/IGHV3-33 set the genotype in addition also carried IGHV3-30-3*01 and IGHV3-33*01 as defined in OGRDB. The three alleles are supported by similar numbers of sequences (357, 141, and 540), multiple (116, 59, 200) unique CDR3s among unmutated reads. Haplotyping based on alleles of IGHJ6 supported its presence (IGHV3-30*19_T189C ratio: 100:0; IGHV3-30-3*01: 0:100; IGHV3-33*01: 56:44). The sequences are quite similar and theoretically IGHV3-30*19_T189C could have been generated as a chimeric PCR products of rearranged sequences derived from the 5\u2019-part IGHV3-33*01 and the 3\u2019-part of IGHV3-30-3*01. However, haplotyping based on IGHJ6 associates IGHV3-30*19_G189C and IGHV3-30-3*01 to different alleles of IGHJ6. Furthermore, a separate study of this data set (DOI: 10.3389/fimmu.2021.730105) defined that the upstream sequences of IGHV3-30*19_T189C and IGHV3-33*01 are substantially different. IGHV3-30*18 have also been found associated to this genotype but it will currently not feature in OGRDB as two alleles have the same sequence, preventing their inclusion in the genotype (it had been observed in the original inference as discussed at meeting 61, above). This allele cannot easily have contributed (by being involved in PCR chimeras) to the inference of IGHV3-30*19_T189C as it differs from the novel allele both in the allele\u2019s 5\u2019- and 3\u2019 end. In addition, its upstream sequence is different from that of IGHV3-30*19_T189C. Altogether there is no evidence that IGHV3-30*19_T189C has been generated as a PCR chimera. IARC affirms the sequence at Level 1 up to and including base 319 in agreement with past practice. It is acknowledged that the allele most likely carries one additional base, typically A at base position 320. A trailing \u201c.\u201d indicates IARC\u2019s opinion that the sequence is likely to contain an additional 3\u2019 nucleotide for which there is insufficient evidence to make an affirmation. The allele is given the name IGHV3-30*i01.\r\n\r\n>IGHV3-30*i01\r\nCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGCAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAG.\r\n \r\nWe recognise that this allele might be located at IGHV3-30, IGHV3-30-3, IGHV3-30-5, and/or IGHV3-33 and IARC gene naming does not reflect a position on this matter.\r\n\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample OU596105\r\nVDJbase example haplotype: P1_I49", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02767", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-38-2*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-38-2*02", "sequence": "ATGAAGCACCTGTGGTTTTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAGGGATCCAGACGTGAAGATATGGGAAGTGCCTCTGATCCCAGGGCTCACCGTGGGTTTTTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTTACTCCATCAGCAGTGGTTACTACTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTTACTCCATCAGCAGTGGTTACTACTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4-38", "subgroup_designation": "2", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 140, "gene_end": 435, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 129, "leader_2_end": 139, "v_rs_start": 436, "v_rs_end": 474, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTTACTCCATCAGCAGTGGTTACTACTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTTACTCCATCAGC.........AGTGGTTACTACTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATCATAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 102, "fwr2_start": 103, "fwr2_end": 153, "cdr2_start": 154, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1348", "sequence": "ATGAAGCACCTGTGGTTTTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAGGGATCCAGACGTGAAGATATGGGAAGTGCCTCTGATCCCAGGGCTCACCGTGGGTTTTTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTTACTCCATCAGCAGTGGTTACTACTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "KC162926", "patch_no": "1", "gff_seqid": null, "gff_start": 10749, "gff_end": 11222, "strand": null }, { "sequence_id": "1349", "sequence": "ATGAAGCACCTGTGGTTTTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAGGGATCCAGACGTGAAGATATGGGAAGTGCCTCTGATCCCAGGGCTCACCGTGGGTTTTTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTTACTCCATCAGCAGTGGTTACTACTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AC233755", "patch_no": "2", "gff_seqid": null, "gff_start": 41444, "gff_end": 41917, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample KC162926\r\nVDJbase example haplotype: P1_I12\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02744", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-69-1*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-69-1*01", "sequence": "CTCAATAGAACTGTTTTAAAATAAAAATTACAAAATTATAAGATTTATAGGTTTTAAGGTTTTATCACAGAGCAGATTTACCATAAGAAACCACAATTTCCCAAATGCTATCAATATCACAAATCTCCCCAGGACACTGTCACGTGCTCTGAGCCCCACTCTCTCCAAAGGCCTCTAACCAGAGAGCTTACTATATAGTAGGAGACATGGAAATAGAGCCCTCCCTCTGCTTATGAAAACCAGCCCAGCCCTGACCCTGCAGCTCTGGGACAGGAGCCCCAGCCCTGGGATTTTCAGGTGTTTTCATTTGGTGATCAGGACTGAACACAGAGGACCACCAAGGAGTCATGGCTGAGCTGGCTTTTTCTTGTGGCTATTTTAAAAGGTAATTCATGGAGAAATAGAAAAATTGAGTGTGAGTGGATAAGAGTGAGATAAACAGTGGATTTGTGTGGAAGTTTCTGACCAGGTTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3-69", "subgroup_designation": "1", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 500, "gene_end": 792, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 489, "leader_2_end": 499, "v_rs_start": 793, "v_rs_end": 831, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTAAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTGACTACTACATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGT.........AGTACCATATACTACGCAGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1284", "sequence": "AAGGAGTCATGGCTGAGCTGGCTTTTTCTTGTGGCTATTTTAAAAGGTAATTCATGGAGAAATAGAAAAATTGAGTGTGAGTGGATAAGAGTGAGATAAACAGTGGATTTGTGTGGAAGTTTCTGACCAGGTTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 151230, "gff_end": 151721, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample GRCh38:CM000676.2\r\nVDJbase example haplotype: P1_I56 (1 exact match)", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02778", "allele_description_ref": "OGRDB:Homo sapiens:IGHV5-10-1*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV5-10-1*03", "sequence": "ATGGGGTCAACCGCCATCCTCGCCCTCCTCCTGGCTGTTCTCCAAGGTCAGTCCTGCCGAGGGCTTGAGGTCACAGAGGAGAACGGGTGGAAAGCAACTCCTGATTCAAATTTTGTGTCTTCCATACAGGAGTCTGTGCCGAAGTGCAGCTGGTGCAGTCCGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAGGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCAGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGAGGATTGATCCTAGTGACTCTTATACCAACTACAGCCCGTCCTTCCAAGGCCACGTCACCATCTCAGCTGACAAGTCCATCAGCACTGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACACACAGTGAGAGAAACCAGCACTGAGCCCGTCTAAAACC", "coding_sequence": "GAAGTGCAGCTGGTGCAGTCCGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAGGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCAGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGAGGATTGATCCTAGTGACTCTTATACCAACTACAGCCCGTCCTTCCAAGGCCACGTCACCATCTCAGCTGACAAGTCCATCAGCACTGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "5-10", "subgroup_designation": "1", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 141, "gene_end": 436, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 130, "leader_2_end": 140, "v_rs_start": 437, "v_rs_end": 474, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAAGTGCAGCTGGTGCAGTCCGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAGGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCAGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGAGGATTGATCCTAGTGACTCTTATACCAACTACAGCCCGTCCTTCCAAGGCCACGTCACCATCTCAGCTGACAAGTCCATCAGCACTGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACA", "aligned_sequence": "GAAGTGCAGCTGGTGCAGTCCGGAGCA...GAGGTGAAAAAGCCCGGGGAGTCTCTGAGGATCTCCTGTAAGGGTTCTGGATACAGCTTT............ACCAGCTACTGGATCAGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGAGGATTGATCCTAGT......GACTCTTATACCAACTACAGCCCGTCCTTCCAA...GGCCACGTCACCATCTCAGCTGACAAGTCCATCAGCACTGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1385", "sequence": "ATGGGGTCAACCGCCATCCTCGCCCTCCTCCTGGCTGTTCTCCAAGGTCAGTCCTGCCGAGGGCTTGAGGTCACAGAGGAGAACGGGTGGAAAGCAACTCCTGATTCAAATTTTGTGTCTTCCATACAGGAGTCTGTGCCGAAGTGCAGCTGGTGCAGTCCGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAGGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCAGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGAGGATTGATCCTAGTGACTCTTATACCAACTACAGCCCGTCCTTCCAAGGCCACGTCACCATCTCAGCTGACAAGTCCATCAGCACTGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACACACAGTGAGAGAAACCAGCACTGAGCCCGTCTAAAACC", "repository_name": "GenBank", "repository_ref": "ON052089", "patch_no": "1", "gff_seqid": null, "gff_start": 302, "gff_end": 775, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052089\r\nVDJbase example haplotype: P1_I12\r\nVDJbase example haplotype: P1_I52\r\nMapped by P1_I12 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02709", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-30*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-30*01", "sequence": "GATTCATGGAGAAATAGAGAGACTGAGTGTGAGTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCACTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTAGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAG", "coding_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTAGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "30", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 111, "gene_end": 406, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 100, "leader_2_end": 110, "v_rs_start": 407, "v_rs_end": 429, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTAGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTAGAGTGGGTGGCAGTTATATCATATGAT......GGAAGTAATAAATACTACGCAGACTCCGTGAAG...GGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1210", "sequence": "GTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCACTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTAGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGACACA", "repository_name": "GenBank", "repository_ref": "M77325", "patch_no": "1", "gff_seqid": null, "gff_start": 33, "gff_end": 410, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample M77325\r\nVDJbase example haplotype: P1_I40\r\nVDJbase example haplotype: P1_I100\r\nMapped by P1_I40 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02559", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-69*i04.3_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 3, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-69*i04", "sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCAGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAG", "coding_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCAGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": "A", "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "69", "allele_designation": "i04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 295, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCAGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTC............AGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATC......TTTGGTACAGCAAACTACGCACAGAAGTTCCAG...GGCAGAGTCACGATTACCGCAGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [], "rearranged_support": [ { "sequence_id": "141", "sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCAGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "derivation": null, "observation_type": "inference from repertoire", "repository_name": "NCBI SRA", "repository_ref": "OW151137", "deposited_version": "1", "sequence_start": 1, "sequence_end": 296 } ], "paralogs": null, "curation": "This inferred allele was assessed at IARC meeting 100 on June 8th, 2022. IGHV1-69*06_G240A was inferred in subject S45 (VDJ-base: P1_I48_S1). The genotype also carried IGHV1-69*01 and IGHV1-69*06. Given the common duplication of IGHV1-69 in the human IGHV locus, this is not an unexpected finding. The inference was supported by a relative large number of sequences (680) and unmutated sequences (627), a high overall frequency in the unmutated population (2.4%) and a large and diverse set of unique CDR3s (607) in the unmutated sequence set. Its allelic ratio was 22%. Haplotyping based on allelic diversity in IGHJ6 was not possible. IARC affirms the sequence at level 1 up to and including base 319 in agreement with past practice. It is acknowledged that the allele most likely carries one additional base, typically A at base position 320. A trailing \u201c.\u201d indicates IARC\u2019s opinion that the sequence is likely to contain one additional 3\u2019-nucleotides for which there is insufficient evidence to make an affirmation. The allele is given the name IGHV1-69(D)*i04. This name highlights the uncertainty of which of the two duplicated genes the allele is most likely associated with.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on VDJbase sample(s)\r\nVDJbase example haplotype: P1_I48", "curational_tags": [ "likely_truncated" ] }, { "allele_description_id": "OGRDB:A02988", "allele_description_ref": "OGRDB:Homo sapiens:IGHV8-51-1*04.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV8-51-1*04", "sequence": "ATGAAAACAGGGCCCAAGCTGGAGAACGGGTTTCCTGTCACCCTCACGTTTCACCGTTAGATACTCTACACTATGCCTATGCTGAGGTGTGTGTTTAATATAATTAGAAAATGGTATTTATATACGTGTATAATCATATCTAGTGTAAGAATTTGTAGTTTCCACCTTATGTGACCATTAAAGACAACATCTCTCACGTTATTCAAGGACCTTATAAAGTATAATACTTTTACATAAGATTTATCTCCTTTTTTGTGTTTCTCCTTCTGTCTATATTCTCTCTGTCTCTCTCTTCCTCCCTCTTTCTCTCTCTCTCTCCATCTCTCTCTCTCTGTCTCTCTCTCACACACAAATACACACACATGCAATCGTTGACAGTATATAGGCTAATTAAGAATATATTCCCATATGATTTAAAAATAACAGTTTTACAAATATTTGCCTTTAATTTTTCAAAGAAAATTAAATCCAAATGCCAGTGATTTTTTATGTGACTTTTAAAATTTAAATTGTTAATTTTTGTTTTCATCAATGCTTGTATGTGTGCTTTTGTATTCTTTCAGATTATTTGGTGCCTTCACAGAATTAAACATGTGAAACTCTCCACTTGAATTTCTGTGACTCAGGACTGGTGAGCAAAAAGTTAGAAGTCACTCTCCTGATCCTTCCCTACAGCTGCAGATTCCTGAAGGTAATGACCTCACAGTAGACCAAGGCCCTCAAAGGTGACCTTGAGTTTCCAGCACATCTTGGGAGGCCAAGCGGATGTTTGTGAAAGAAATAGTGGCTATGTGACAGTTTCTAACCAGAATATCTCTGTGTTTTCAGGTATCCAGGGTGAGGCCCAGCTTACAGAGTCTGGGGGAGACTTGGTACACTTAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTCAGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGTGAAAGTCATCAATACAATGCAGACTATGTTAGGGGCAGACTCACCACTTCCAGAGACAACACCAAGTACATGCTGTACATGCAAATGAACAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAACATCGTGATGGGAAGTCCACGTGGGCTCAGAGACAGACT", "coding_sequence": "GAGGCCCAGCTTACAGAGTCTGGGGGAGACTTGGTACACTTAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTCAGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGTGAAAGTCATCAATACAATGCAGACTATGTTAGGGGCAGACTCACCACTTCCAGAGACAACACCAAGTACATGCTGTACATGCAAATGAACAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "8-51", "subgroup_designation": "1", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 840, "gene_end": 1135, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 55, "leader_2_start": 829, "leader_2_end": 839, "v_rs_start": 1136, "v_rs_end": 1174, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGCCCAGCTTACAGAGTCTGGGGGAGACTTGGTACACTTAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTCAGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGTGAAAGTCATCAATACAATGCAGACTATGTTAGGGGCAGACTCACCACTTCCAGAGACAACACCAAGTACATGCTGTACATGCAAATGAACAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAA", "aligned_sequence": "GAGGCCCAGCTTACAGAGTCTGGGGGA...GACTTGGTACACTTAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTC............AGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGT......GAAAGTCATCAATACAATGCAGACTATGTTAGG...GGCAGACTCACCACTTCCAGAGACAACACCAAGTACATGCTGTACATGCAAATGAACAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1435", "sequence": "ATGAAAACAGGGCCCAAGCTGGAGAACGGGTTTCCTGTCACCCTCACGTTTCACCGTTAGATACTCTACACTATGCCTATGCTGAGGTGTGTGTTTAATATAATTAGAAAATGGTATTTATATACGTGTATAATCATATCTAGTGTAAGAATTTGTAGTTTCCACCTTATGTGACCATTAAAGACAACATCTCTCACGTTATTCAAGGACCTTATAAAGTATAATACTTTTACATAAGATTTATCTCCTTTTTTGTGTTTCTCCTTCTGTCTATATTCTCTCTGTCTCTCTCTTCCTCCCTCTTTCTCTCTCTCTCTCCATCTCTCTCTCTCTGTCTCTCTCTCACACACAAATACACACACATGCAATCGTTGACAGTATATAGGCTAATTAAGAATATATTCCCATATGATTTAAAAATAACAGTTTTACAAATATTTGCCTTTAATTTTTCAAAGAAAATTAAATCCAAATGCCAGTGATTTTTTATGTGACTTTTAAAATTTAAATTGTTAATTTTTGTTTTCATCAATGCTTGTATGTGTGCTTTTGTATTCTTTCAGATTATTTGGTGCCTTCACAGAATTAAACATGTGAAACTCTCCACTTGAATTTCTGTGACTCAGGACTGGTGAGCAAAAAGTTAGAAGTCACTCTCCTGATCCTTCCCTACAGCTGCAGATTCCTGAAGGTAATGACCTCACAGTAGACCAAGGCCCTCAAAGGTGACCTTGAGTTTCCAGCACATCTTGGGAGGCCAAGCGGATGTTTGTGAAAGAAATAGTGGCTATGTGACAGTTTCTAACCAGAATATCTCTGTGTTTTCAGGTATCCAGGGTGAGGCCCAGCTTACAGAGTCTGGGGGAGACTTGGTACACTTAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTCAGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGTGAAAGTCATCAATACAATGCAGACTATGTTAGGGGCAGACTCACCACTTCCAGAGACAACACCAAGTACATGCTGTACATGCAAATGAACAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAACATCGTGATGGGAAGTCCACGTGGGCTCAGAGACAGACT", "repository_name": "GenBank", "repository_ref": "AC279961", "patch_no": "1", "gff_seqid": null, "gff_start": 20203, "gff_end": 21376, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AC279961. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (40 samples). Example subject: P25_I1.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00007", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-3*04.6_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 6, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-3*04", "sequence": "CAGGTCCAGCTTGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGATCAACACTGGCAATGGTAACACAAAATATTCACAGAAGTTCCAGGGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAAGACACGGCTGTGTATTACTGTGCGAGAG", "coding_sequence": "CAGGTCCAGCTTGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGATCAACACTGGCAATGGTAACACAAAATATTCACAGAAGTTCCAGGGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAAGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": "A", "aliases": [ "IGHV1-3*i01" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "3", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 295, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCCAGCTTGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGATCAACACTGGCAATGGTAACACAAAATATTCACAGAAGTTCCAGGGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAAGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTCCAGCTTGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTC............ACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGATCAACACTGGC......AATGGTAACACAAAATATTCACAGAAGTTCCAG...GGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAAGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1087", "sequence": "CAGGTCCAGCTTGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGATCAACACTGGCAATGGTAACACAAAATATTCACAGAAGTTCCAGGGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAAGACACGGCTGTGTATTACTGTGCGAGAG", "repository_name": "GenBank", "repository_ref": "MH779622", "patch_no": "2", "gff_seqid": null, "gff_start": 1, "gff_end": 295, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Originally approved by IARC on March 9, 2018.\r\n\r\n\"The sequence was inferred [..] using IgDiscover, and [..] using both Partis and TIgGER. The number of unique CDR3 used by sequences with exact matches to the inferred germline allele represents 1.3% of all unique CDR3 [unmutated frequency: 1.17%] associated to exact IGHV matches in the genotype, according to IgDiscover. There were at least 775 unique rearrangements, utilizing 22 D genes and 7 J genes. The allele was the more frequently utilized allele, with an expression ratio of 56:44 with the *01 allele. The inference was supported by haplotype analysis using IGHJ6*02/*03.\"\r\n\r\n(April 12, 2019) A trailing \".\" in the sequence indicates IARC's opinion that the sequence is likely to contain additional 3' nucleotides for which there is insufficient evidence to make an affirmation.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MH779622", "curational_tags": [ "likely_truncated" ] }, { "allele_description_id": "OGRDB:A02699", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-21*06.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-21*06", "sequence": "ATGGAACTGGGGCTCCGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGAATCATGGAAAAGTAGAGAGATTTAGTGTGTGTGGATATGAGTGAGAGAAACGGTGGATGTGTGTGACAGTTTCTGACCAATGTCTCTCTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAATTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAATTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "21", "allele_designation": "06", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 159, "gene_end": 454, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 148, "leader_2_end": 158, "v_rs_start": 455, "v_rs_end": 493, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAATTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGT......AGTAGTTACATATACTACGCAGACTCAGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAATTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1187", "sequence": "ATGGAACTGGGGCTCCGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGAATCATGGAAAAGTAGAGAGATTTAGTGTGTGTGGATATGAGTGAGAGAAACGGTGGATGTGTGTGACAGTTTCTGACCAATGTCTCTCTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAATTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "MN337623", "patch_no": "1", "gff_seqid": null, "gff_start": 149, "gff_end": 641, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MN337623\r\nVDJbase example haplotype: P1_I63", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02610", "allele_description_ref": "OGRDB:Homo sapiens:IGHD1-14*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD1-14*01", "sequence": "GGATTCCGAACAGCCCCGAGTCACAGCGGGTATAACCGGAACCACCACTGTCAGAATAGCTACGTCAAAAACT", "coding_sequence": "GGTATAACCGGAACCAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "14", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 45, "d_rs_3_prime_start": 46, "d_rs_3_prime_end": 73, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "936", "sequence": "GGATTCCGAACAGCCCCGAGTCACAGCGGGTATAACCGGAACCACCACTGTCAGAATAGCTACGTCAAAAACT", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 52540, "gff_end": 52612, "strand": null }, { "sequence_id": "937", "sequence": "GGATTCCGAACAGCCCCGAGTCACAGCGGGTATAACCGGAACCACCACTGTCAGAATAGCTACGTCAAAAACT", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 123001, "gff_end": 123073, "strand": null }, { "sequence_id": "938", "sequence": "GGATTCCGAACAGCCCCGAGTCACAGCGGGTATAACCGGAACCACCACTGTCAGAATAGCTACGTCAAAAACT", "repository_name": "GenBank", "repository_ref": "ON052094", "patch_no": "1", "gff_seqid": null, "gff_start": 136, "gff_end": 208, "strand": null }, { "sequence_id": "939", "sequence": "GGATTCCGAACAGCCCCGAGTCACAGCGGGTATAACCGGAACCACCACTGTCAGAATAGCTACGTCAAAAACT", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 979163, "gff_end": 979235, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00066", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-69*20.2_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 2, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-69*20", "sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCTTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "coding_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCTTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": "A", "aliases": [ "IGHV1-69*i03" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "69", "allele_designation": "20", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 295, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCTTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTC............AGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATC......TTTGGTATAGCAAACTACGCACAGAAGTTCCAG...GGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1125", "sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCTTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "repository_name": "GenBank", "repository_ref": "OU596106", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 295, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "IARC Meeting 60 (Sept 1st, 2020):\r\nThe meeting considered the inference of the variant IGHV1-69*04_c184t. The sequence was\r\nhighlighted in samples P1_I77_S1 and P4_I27_S1. The committee particularly focused on\r\nthe evidence from the P1 sample, but noted the strong evidence in support of this inference\r\nfrom haplotype data of the P4 sample. In the P1 sample, the sequence was seen in 1.79%\r\nof all unmutated rearrangements, with 410 sequences including 351 perfect matches to the\r\ninferred allele. There was abundant variation in the CDR3 regions of the aligned sequences.\r\nIGHV1-69*02 and IGHV1-69*08 were also present in the genotype. IGHV1-69*02 was\r\npresent at a similar frequency (1.52% of all unmutated sequences, 334 sequences, 297\r\nunmutated sequences). The IGHV1-69*08 sequence was seen in 232 alignments, but only 3\r\nof these were perfect matches. MO pointed out that the *08 allele is almost identical to the\r\n*02 allele, and they are both quite different to most other reported alleles. Although a\r\nfull-length version of the *02 allele has been published, the IMGT reference sequence is 2\r\nnucleotides shorter than the *08 sequence. This results in frequency misalignments. MO and\r\nCW agreed that it is likely that the *08 \u2018allele\u2019 was reported in error. Plots of the final 3\u2019\r\nnucleotides of the IGHV1-69*04_c184t inference are presently unavailable The sequence\r\nwas affirmed as a Level 1 sequence, and the final 3\u2019 nucleotides will be considered at a later\r\ndate, at which time the affirmed sequence will be noted in the IARC minutes.\r\n\r\nIARC Meeting 81 (Oct 4th, 2021), updated IARC Meeting 82 (Oct 11th, 2021):\r\nIGHV1-69*04_C184T, an allelic variant that affects amino acid residue 62, implicated in some stereotypic immune responses. It was inferred in one genotype in VDJbase P1 data sets (VDJbase P1_I50_S1). This inference has previously been pre-assessed at IARC meeting 60 (https://www.antibodysociety.org/wordpress/wp-content/uploads/2020/12/Meeting-60-1_9_20-minutes.pdf) in P1_I77_S1. In contrast to the original assessment (above) the most recent release of VDJbase does not feature IGHV1-69*04_C184T as being inferred in P1_I77_S1. Instead IGHV1-69*04 with 1 mutation is called in that sample demonstrating the presence of an allele different from IGHV1-64*04 in this sample.\r\nThe genotype is also implied to carry IGHV1-69*02, IGHV1-69*04 and IGHV1-69*08, the latter of which are all mutated and likely represent rearrangements derived from IGHV1-69*02 (a short allele in the reference database that differs by one base from IGHV1-69*08) that also incorporated the final base(s) of the IGHV gene into their sequence and thus were misassigned to IGHV1-69*08 by IgBLAST. The novel allele is the most expressed allele of IGHV1-69 in the repertoire (40% allelic frequency; 2.4% of the total unmutated population). It is represented by 121 sequences, 108 unmutated sequences and 108 unique CDR3s in the unmutated set. Haplotyping based on allelic diversity in IGHJ6 is not possible. IARC affirms the sequence at Level 1 only up to and including base 319 in agreement with past practice. It is acknowledged that the allele most likely carries one additional base, typically A, at base position 320. A trailing \u201c.\u201d indicates IARC\u2019s opinion that the sequence is likely to contain an additional 3\u2019 nucleotide for which there is insufficient evidence to make an affirmation. The allele is given the name IGHV1-69*i03.\r\n \r\n>IGHV1-69*i03 (IGHV1-69*04_C184T)\r\nCAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCTTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAG.\r\n \r\nWe recognize that this allele might be located at IGHV1-69 and/or IGHV1-69D and IARC gene naming does not reflect a position on this matter.\r\n\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample OU596106", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02623", "allele_description_ref": "OGRDB:Homo sapiens:IGHD3-22*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD3-22*01", "sequence": "GGTTTGAAGTGAGGTCTGTGTCACTGTGGTATTACTATGATAGTAGTGGTTATTACTACCACAGTGTCACAGAGTCCATCAAAAACT", "coding_sequence": "GTATTACTATGATAGTAGTGGTTATTACTAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "22", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 59, "d_rs_3_prime_start": 60, "d_rs_3_prime_end": 87, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "977", "sequence": "GGTTTGAAGTGAGGTCTGTGTCACTGTGGTATTACTATGATAGTAGTGGTTATTACTACCACAGTGTCACAGAGTCCATCAAAAACT", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 67133, "gff_end": 67219, "strand": null }, { "sequence_id": "978", "sequence": "GGTTTGAAGTGAGGTCTGTGTCACTGTGGTATTACTATGATAGTAGTGGTTATTACTACCACAGTGTCACAGAGTCCATCAAAAACT", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 137592, "gff_end": 137678, "strand": null }, { "sequence_id": "979", "sequence": "GGTTTGAAGTGAGGTCTGTGTCACTGTGGTATTACTATGATAGTAGTGGTTATTACTACCACAGTGTCACAGAGTCCATCAAAAACT", "repository_name": "GenBank", "repository_ref": "ON052104", "patch_no": "1", "gff_seqid": null, "gff_start": 87, "gff_end": 173, "strand": null }, { "sequence_id": "980", "sequence": "GGTTTGAAGTGAGGTCTGTGTCACTGTGGTATTACTATGATAGTAGTGGTTATTACTACCACAGTGTCACAGAGTCCATCAAAAACT", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 993756, "gff_end": 993842, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02613", "allele_description_ref": "OGRDB:Homo sapiens:IGHD1-7*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD1-7*01", "sequence": "GGATTCTGAACAGCCCCGAGTCACAGTGGGTATAACTGGAACTACCACTGTGAGAAAAGCTTCGTCCAAAACG", "coding_sequence": "GGTATAACTGGAACTAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "7", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 45, "d_rs_3_prime_start": 46, "d_rs_3_prime_end": 73, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "948", "sequence": "GGATTCTGAACAGCCCCGAGTCACAGTGGGTATAACTGGAACTACCACTGTGAGAAAAGCTTCGTCCAAAACG", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 43272, "gff_end": 43344, "strand": null }, { "sequence_id": "949", "sequence": "GGATTCTGAACAGCCCCGAGTCACAGTGGGTATAACTGGAACTACCACTGTGAGAAAAGCTTCGTCCAAAACG", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 113731, "gff_end": 113803, "strand": null }, { "sequence_id": "950", "sequence": "GGATTCTGAACAGCCCCGAGTCACAGTGGGTATAACTGGAACTACCACTGTGAGAAAAGCTTCGTCCAAAACG", "repository_name": "GenBank", "repository_ref": "ON052097", "patch_no": "1", "gff_seqid": null, "gff_start": 56, "gff_end": 128, "strand": null }, { "sequence_id": "951", "sequence": "GGATTCTGAACAGCCCCGAGTCACAGTGGGTATAACTGGAACTACCACTGTGAGAAAAGCTTCGTCCAAAACG", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 969894, "gff_end": 969966, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02561", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-39*i03.3_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 3, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-39*i03", "sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCTGTGTATTACTGTGCAAGAC", "coding_sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCTGTGTATTACTGTGCAAGACA", "ext_3prime": "A", "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "39", "allele_designation": "i03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 298, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCTGTGTATTACTGTGCAAGACA", "aligned_sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGC......AGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCTGTGTATTACTGTGCAAGACA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1357", "sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCTGTGTATTACTGTGCAAGA", "repository_name": "GenBank", "repository_ref": "OW151140", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 297, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "This inferred allele was assessed at IARC meeting 100 on June 8th, 2022. IGHV4-39*01_G315A was inferred in subject S57 (VDJ-base: P1_I60_S1). The genotype carried one other allele of IGHV4-39 (IGHV4-39*01, and a variant allele with a low number of associated reads that likely represents 3\u2019-trimmed reads of IGHV4-39*01). The inference was supported by a large number of sequences (1424) and unmutated sequences (1151), a high overall frequency in the unmutated population (2.47%) and a large set of unique diverse CDR3s (1048) in the unmutated sequence set. It represented 48% of sequences associated with the gene. Haplotyping based on allelic diversity in IGHJ6 was not possible. IARC affirms the sequence at level 1 up to and including base 319 in agreement with past practice. It is acknowledged that the allele most likely carries one additional base, typically A at base position 320. A trailing \u201c.\u201d indicates IARC\u2019s opinion that the sequence is likely to contain one additional 3\u2019-nucleotides for which there is insufficient evidence to make an affirmation. The allele is given the name IGHV4-39*i03.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample OW151140\r\nVDJbase example haplotype: P1_I60", "curational_tags": [ "likely_truncated" ] }, { "allele_description_id": "OGRDB:A02622", "allele_description_ref": "OGRDB:Homo sapiens:IGHD3-16*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD3-16*02", "sequence": "GGTTTGAAGTGAGGTCTGTGTCACTGTGGTATTATGATTACGTTTGGGGGAGTTATCGTTATACCCACAGCATCACACGGTCCATCAGAAACC", "coding_sequence": "GTATTATGATTACGTTTGGGGGAGTTATCGTTATACC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "16", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 65, "d_rs_3_prime_start": 66, "d_rs_3_prime_end": 93, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "974", "sequence": "GGTTTGAAGTGAGGTCTGTGTCACTGTGGTATTATGATTACGTTTGGGGGAGTTATCGTTATACCCACAGCATCACACGGTCCATCAGAAACC", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 127984, "gff_end": 128076, "strand": null }, { "sequence_id": "975", "sequence": "GGTTTGAAGTGAGGTCTGTGTCACTGTGGTATTATGATTACGTTTGGGGGAGTTATCGTTATACCCACAGCATCACACGGTCCATCAGAAACC", "repository_name": "GenBank", "repository_ref": "ON052103", "patch_no": "1", "gff_seqid": null, "gff_start": 242, "gff_end": 334, "strand": null }, { "sequence_id": "976", "sequence": "GGTTTGAAGTGAGGTCTGTGTCACTGTGGTATTATGATTACGTTTGGGGGAGTTATCGTTATACCCACAGCATCACACGGTCCATCAGAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 984147, "gff_end": 984239, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019441\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02768", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-39*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-39*01", "sequence": "ATGAAGCACCTGTGGTTCTTCCTCCTGCTGGTGGCGGCTCCCAGATGTGAGTGTTTCTAGGATGCAGACATGGAGATATGGGAGGCTGCCTCTGATCCCAGGGCTCACTGTGGGTTTTTCTGTTCACAGGGGTCCTGTCCCAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCTGTGTATTACTGTGCGAGACACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACAAAAACC", "coding_sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCTGTGTATTACTGTGCGAGACA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "39", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 141, "gene_end": 439, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 130, "leader_2_end": 140, "v_rs_start": 440, "v_rs_end": 478, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCTGTGTATTACTGTGCGAGACA", "aligned_sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGC......AGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCTGTGTATTACTGTGCGAGACA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1350", "sequence": "ATGAAGCACCTGTGGTTCTTCCTCCTGCTGGTGGCGGCTCCCAGATGTGAGTGTTTCTAGGATGCAGACATGGAGATATGGGAGGCTGCCTCTGATCCCAGGGCTCACTGTGGGTTTTTCTGTTCACAGGGGTCCTGTCCCAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCTGTGTATTACTGTGCGAGACACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACAAAAACC", "repository_name": "GenBank", "repository_ref": "AB019439", "patch_no": "1", "gff_seqid": null, "gff_start": 11486, "gff_end": 11963, "strand": null }, { "sequence_id": "1351", "sequence": "GGGTCCTGTCCCAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCTGTGTATTACTGTGCGAGACACACAGTGAGGGGAGGTGAGTGTGAG", "repository_name": "GenBank", "repository_ref": "HM855897", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 335, "strand": null }, { "sequence_id": "1352", "sequence": "ATGAAGCACCTGTGGTTCTTCCTCCTGCTGGTGGCGGCTCCCAGATGTGAGTGTTTCTAGGATGCAGACATGGAGATATGGGAGGCTGCCTCTGATCCCAGGGCTCACTGTGGGTTTTTCTGTTCACAGGGGTCCTGTCCCAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCTGTGTATTACTGTGCGAGACACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACAAAAACC", "repository_name": "GenBank", "repository_ref": "ON052085", "patch_no": "1", "gff_seqid": null, "gff_start": 267, "gff_end": 744, "strand": null }, { "sequence_id": "1353", "sequence": "ATGAAGCACCTGTGGTTCTTCCTCCTGCTGGTGGCGGCTCCCAGATGTGAGTGTTTCTAGGATGCAGACATGGAGATATGGGAGGCTGCCTCTGATCCCAGGGCTCACTGTGGGTTTTTCTGTTCACAGGGGTCCTGTCCCAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCTGTGTATTACTGTGCGAGACACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACAAAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 457698, "gff_end": 458175, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019439\r\nVDJbase example haplotype: P1_I22_S1\r\nVDJbase example haplotype: P1_I22_S1", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02642", "allele_description_ref": "OGRDB:Homo sapiens:IGHJ4*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHJ4*02", "sequence": "GGTTTTTGTGCACCCCTTAATGGGGCCTCCCACAATGTGACTACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG", "coding_sequence": "ACTACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "J", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": null, "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 40, "gene_end": 87, "j_codon_frame": 2, "j_cdr3_end": 87, "j_rs_start": 1, "j_rs_end": 39, "unrearranged_support": [ { "sequence_id": "1052", "sequence": "GGTTTTTGTGCACCCCTTAATGGGGCCTCCCACAATGTGACTACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 88719, "gff_end": 88805, "strand": null }, { "sequence_id": "1053", "sequence": "GGTTTTTGTGCACCCCTTAATGGGGCCTCCCACAATGTGACTACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG", "repository_name": "GenBank", "repository_ref": "X86359", "patch_no": "1", "gff_seqid": null, "gff_start": 1441, "gff_end": 1527, "strand": null }, { "sequence_id": "1054", "sequence": "GGTTTTTGTGCACCCCTTAATGGGGCCTCCCACAATGTGACTACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG", "repository_name": "GenBank", "repository_ref": "ON023004", "patch_no": "1", "gff_seqid": null, "gff_start": 90, "gff_end": 176, "strand": null }, { "sequence_id": "1055", "sequence": "GGTTTTTGTGCACCCCTTAATGGGGCCTCCCACAATGTGACTACTTTGACTACTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 1015544, "gff_end": 1015630, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02638", "allele_description_ref": "OGRDB:Homo sapiens:IGHD7-27*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD7-27*01", "sequence": "GGTTTTGGCTGAGCTGAGAACCACTGTGCTAACTGGGGACACAGTGATTGGCAGCTCTACAAAAACC", "coding_sequence": "CTAACTGGGGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "7", "subgroup_designation": "27", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 39, "d_rs_3_prime_start": 40, "d_rs_3_prime_end": 67, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "1036", "sequence": "GGTTTTGGCTGAGCTGAGAACCACTGTGCTAACTGGGGACACAGTGATTGGCAGCTCTACAAAAACC", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 87431, "gff_end": 87497, "strand": null }, { "sequence_id": "1037", "sequence": "GGTTTTGGCTGAGCTGAGAACCACTGTGCTAACTGGGGACACAGTGATTGGCAGCTCTACAAAAACC", "repository_name": "GenBank", "repository_ref": "X86359", "patch_no": "1", "gff_seqid": null, "gff_start": 154, "gff_end": 220, "strand": null }, { "sequence_id": "1038", "sequence": "GGTTTTGGCTGAGCTGAGAACCACTGTGCTAACTGGGGACACAGTGATTGGCAGCTCTACAAAAACC", "repository_name": "GenBank", "repository_ref": "ON052119", "patch_no": "1", "gff_seqid": null, "gff_start": 260, "gff_end": 326, "strand": null }, { "sequence_id": "1039", "sequence": "GGTTTTGGCTGAGCTGAGAACCACTGTGCTAACTGGGGACACAGTGATTGGCAGCTCTACAAAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 1014256, "gff_end": 1014322, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02562", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-30-4*i02.4_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 4, "release_date": "16-Aug-2023", "release_description": "Further D sequences added with the support of Rodriguez et al. 'Likely' extensions added to three IGHV alleles. See Notes for details.", "label": "IGHV4-30-4*i02", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTACTGGAGTTGGATCCGCCAGCCCCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAG", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTACTGGAGTTGGATCCGCCAGCCCCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAGA", "ext_3prime": "A", "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Genomic only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4-30", "subgroup_designation": "4", "allele_designation": "i02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 298, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTACTGGAGTTGGATCCGCCAGCCCCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGC......AGTGGTGGTTACTACTGGAGTTGGATCCGCCAGCCCCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1336", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTACTGGAGTTGGATCCGCCAGCCCCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGA", "repository_name": "GenBank", "repository_ref": "OW151139", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 297, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "This inferred allele was assessed at IARC meeting 100 on June 8th, 2022. IGHV4-30-4*01_A70G_A107G was inferred in subject S38 (VDJ-base: P1_I41_S1). The genotype carried no other allele of IGHV4-30-4. The inference was supported by a relative large number of sequences (388) and unmutated sequences (337), a high overall frequency in the unmutated population (0.95%) and a large and diverse set of unique CDR3s (324) in the unmutated sequence set. Its allelic ratio was 100%. Haplotyping based on allelic diversity in IGHJ6 was possible. All reads were associated to one haplotype, a haplotype that also carried IGHV4-30-2, IGHV3-30-3, and IGHV4-31. IARC affirms the sequence at level 1 up to and including base 319 in agreement with past practice. It is acknowledged that the allele most likely carries one additional base, typically A at base position 320. A trailing \u201c.\u201d indicates IARC\u2019s opinion that the sequence is likely to contain one additional 3\u2019-nucleotides for which there is insufficient evidence to make an affirmation. The allele is given the name IGHV4-30-4*i02.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample OW151139\r\nVDJbase example haplotype: P1_I41\r\nOne nucleotide truncation at 3' end", "curational_tags": [ "likely_truncated" ] }, { "allele_description_id": "OGRDB:A02698", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-21*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-21*01", "sequence": "ATGGAACTGGGGCTCCGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGAATCATGGAAAAGTAGAGAGATTTAGTGTGTGTGGATATGAGTGAGAGAAACGGTGGATGTGTGTGACAGTTTCTGACCAATGTCTCTCTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "21", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 159, "gene_end": 454, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 148, "leader_2_end": 158, "v_rs_start": 455, "v_rs_end": 493, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGT......AGTAGTTACATATACTACGCAGACTCAGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1182", "sequence": "ATGGAACTGGGGCTCCGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGAATCATGGAAAAGTAGAGAGATTTAGTGTGTGTGGATATGAGTGAGAGAAACGGTGGATGTGTGTGACAGTTTCTGACCAATGTCTCTCTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AB019439", "patch_no": "1", "gff_seqid": null, "gff_start": 197417, "gff_end": 197909, "strand": null }, { "sequence_id": "1183", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855881", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 345, "strand": null }, { "sequence_id": "1184", "sequence": "ATGGAACTGGGGCTCCGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGAATCATGGAAAAGTAGAGAGATTTAGTGTGTGTGGATATGAGTGAGAGAAACGGTGGATGTGTGTGACAGTTTCTGACCAATGTCTCTCTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052054", "patch_no": "1", "gff_seqid": null, "gff_start": 263, "gff_end": 755, "strand": null }, { "sequence_id": "1185", "sequence": "ATGGAACTGGGGCTCCGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGAATCATGGAAAAGTAGAGAGATTTAGTGTGTGTGGATATGAGTGAGAGAAACGGTGGATGTGTGTGACAGTTTCTGACCAATGTCTCTCTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCCTGGTCAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTAGTTACATATACTACGCAGACTCAGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 644330, "gff_end": 644822, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019439\r\nVDJbase example haplotype: P1_I10", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02666", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-69*04.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-69*04", "sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCCTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "coding_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCCTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "69", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 296, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCCTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTC............AGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATC......CTTGGTATAGCAAACTACGCACAGAAGTTCCAG...GGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1113", "sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCCTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "repository_name": "GenBank", "repository_ref": "KY198885", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 296, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample KY198885\r\nVDJbase example haplotype: P1_I10\r\nVDJbase example haplotype: P1_I41\r\nMapped by P1_I10 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02619", "allele_description_ref": "OGRDB:Homo sapiens:IGHD2-8*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD2-8*01", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGGATATTGTACTAATGGTGTATGCTATACCCACAGTGACACAGCCCCATTCCCAAAGC", "coding_sequence": "AGGATATTGTACTAATGGTGTATGCTATACC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "2", "subgroup_designation": "8", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 59, "d_rs_3_prime_start": 60, "d_rs_3_prime_end": 87, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "965", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGGATATTGTACTAATGGTGTATGCTATACCCACAGTGACACAGCCCCATTCCCAAAGC", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 45954, "gff_end": 46040, "strand": null }, { "sequence_id": "966", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGGATATTGTACTAATGGTGTATGCTATACCCACAGTGACACAGCCCCATTCCCAAAGC", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 116414, "gff_end": 116500, "strand": null }, { "sequence_id": "967", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGGATATTGTACTAATGGTGTATGCTATACCCACAGTGACACAGCCCCATTCCCAAAGC", "repository_name": "GenBank", "repository_ref": "ON052101", "patch_no": "1", "gff_seqid": null, "gff_start": 160, "gff_end": 246, "strand": null }, { "sequence_id": "968", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGGATATTGTACTAATGGTGTATGCTATACCCACAGTGACACAGCCCCATTCCCAAAGC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 972576, "gff_end": 972662, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02786", "allele_description_ref": "OGRDB:Homo sapiens:IGHV7-81*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV7-81*01", "sequence": "ATGGACTGGACCTGGAGCATCCTCTTCTTGGTGGCAGCAGCAACAGGTAAGGGGCTCCCCAGTCTCGGGGTTGAGGCAGAAACCAGGCCACTCAAGTGAGGCTTTACCCACCCCTGTGTCCTCTCCACAGGTACCTACTCCCAGGTGCAGCTGGTGCAGTCTGGCCATGAGGTGAAGCAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACAGTTTCACCACCTATGGTATGAATTGGGTGCCACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGTTCAACACCTACACTGGGAACCCAACATATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCATGGACACCTCTGCCAGCACAGCATACCTGCAGATCAGCAGCCTAAAGGCTGAGGACATGGCCATGTATTACTGTGCGAGATACACCATGTGGAAACCCACATCCTGAGAGTGTCAGAAATC", "coding_sequence": "CAGGTGCAGCTGGTGCAGTCTGGCCATGAGGTGAAGCAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACAGTTTCACCACCTATGGTATGAATTGGGTGCCACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGTTCAACACCTACACTGGGAACCCAACATATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCATGGACACCTCTGCCAGCACAGCATACCTGCAGATCAGCAGCCTAAAGGCTGAGGACATGGCCATGTATTACTGTGCGAGATA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "7", "subgroup_designation": "81", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 142, "gene_end": 437, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 131, "leader_2_end": 141, "v_rs_start": 438, "v_rs_end": 476, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGCCATGAGGTGAAGCAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACAGTTTCACCACCTATGGTATGAATTGGGTGCCACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGTTCAACACCTACACTGGGAACCCAACATATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCATGGACACCTCTGCCAGCACAGCATACCTGCAGATCAGCAGCCTAAAGGCTGAGGACATGGCCATGTATTACTGTGCGAGATA", "aligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGCCAT...GAGGTGAAGCAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACAGTTTC............ACCACCTATGGTATGAATTGGGTGCCACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGTTCAACACCTAC......ACTGGGAACCCAACATATGCCCAGGGCTTCACA...GGACGGTTTGTCTTCTCCATGGACACCTCTGCCAGCACAGCATACCTGCAGATCAGCAGCCTAAAGGCTGAGGACATGGCCATGTATTACTGTGCGAGATA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1403", "sequence": "ATGGACTGGACCTGGAGCATCCTCTTCTTGGTGGCAGCAGCAACAGGTAAGGGGCTCCCCAGTCTCGGGGTTGAGGCAGAAACCAGGCCACTCAAGTGAGGCTTTACCCACCCCTGTGTCCTCTCCACAGGTACCTACTCCCAGGTGCAGCTGGTGCAGTCTGGCCATGAGGTGAAGCAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACAGTTTCACCACCTATGGTATGAATTGGGTGCCACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGTTCAACACCTACACTGGGAACCCAACATATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCATGGACACCTCTGCCAGCACAGCATACCTGCAGATCAGCAGCCTAAAGGCTGAGGACATGGCCATGTATTACTGTGCGAGATACACCATGTGGAAACCCACATCCTGAGAGTGTCAGAAATC", "repository_name": "GenBank", "repository_ref": "AB019437", "patch_no": "1", "gff_seqid": null, "gff_start": 6315, "gff_end": 6790, "strand": null }, { "sequence_id": "1404", "sequence": "ATGGACTGGACCTGGAGCATCCTCTTCTTGGTGGCAGCAGCAACAGGTAAGGGGCTCCCCAGTCTCAGGGCTGAGGAAGAAACCAGGCCACTCAAGTGAGGCTTTACCCACCCCTGTGTCCTCTCCACAGGTACCTACTCCCAGGTGCAGCTGGTGCAGTCTGGCCATGAGGTGAAGCAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACAGTTTCACCACCTATGGTATGAATTGGGTGCCACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGTTCAACACCTACACTGGGAACCCAACATATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCATGGACACCTCTGCCAGCACAGCATACCTGCAGATCAGCAGCCTAAAGGCTGAGGACATGGCCATGTATTACTGTGCGAGATACACCATGTGGAAACCCACATCCTGAGAGTGTCAGAAATC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 4828, "gff_end": 5303, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019437\r\nVDJbase example haplotype: P1_I10 (1 exact match)", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02979", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-28*05.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV4-28*05", "sequence": "TCGCGAGGGCTCACTGTGGGTTTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCATCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAACACAGTGAGGGGAGGTGAGTGTGAG", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCATCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "28", "allele_designation": "05", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 47, "gene_end": 342, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 36, "leader_2_end": 46, "v_rs_start": 343, "v_rs_end": 371, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCATCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGC.........AGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGT.........GGGAGCATCTACTACAACCCGTCCCTCAAG...AGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 102, "fwr2_start": 103, "fwr2_end": 153, "cdr2_start": 154, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1426", "sequence": "GGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCATCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAACACAGTGAGGGGAGGTGAGTGTGAG", "repository_name": "GenBank", "repository_ref": "HM855916", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 332, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855916. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (10 samples). Example subject: P25_I34.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02612", "allele_description_ref": "OGRDB:Homo sapiens:IGHD1-26*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD1-26*01", "sequence": "GGATTCTGAACAGCCCCGAGTCACGGTGGGTATAGTGGGAGCTACTACCACTGTGAGAAAAGCTATGTCCAAAACT", "coding_sequence": "GGTATAGTGGGAGCTACTAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "26", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 48, "d_rs_3_prime_start": 49, "d_rs_3_prime_end": 76, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "944", "sequence": "GGATTCTGAACAGCCCCGAGTCACGGTGGGTATAGTGGGAGCTACTACCACTGTGAGAAAAGCTATGTCCAAAACT", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 72141, "gff_end": 72216, "strand": null }, { "sequence_id": "945", "sequence": "GGATTCTGAACAGCCCCGAGTCACGGTGGGTATAGTGGGAGCTACTACCACTGTGAGAAAAGCTATGTCCAAAACT", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 142598, "gff_end": 142673, "strand": null }, { "sequence_id": "946", "sequence": "GGATTCTGAACAGCCCCGAGTCACGGTGGGTATAGTGGGAGCTACTACCACTGTGAGAAAAGCTATGTCCAAAACT", "repository_name": "GenBank", "repository_ref": "ON052096", "patch_no": "1", "gff_seqid": null, "gff_start": 79, "gff_end": 154, "strand": null }, { "sequence_id": "947", "sequence": "GGATTCTGAACAGCCCCGAGTCACGGTGGGTATAGTGGGAGCTACTACCACTGTGAGAAAAGCTATGTCCAAAACT", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 998764, "gff_end": 998839, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02755", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-9*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-9*03", "sequence": "ATGGAGTTGGGACTGAGCTGGATTTTCCTTTTGGCTATTTTAAAAGGTGATTCATGGAGAAATAGAGAGATTGAGTGTGAGTGGACATGAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACATGGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGGGAAGTCAGCGAGAGCCCAGACAAAAACC", "coding_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACATGGCCTTGTATTACTGTGCAAAAGATA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "9", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 149, "gene_end": 446, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 138, "leader_2_end": 148, "v_rs_start": 447, "v_rs_end": 485, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACATGGCCTTGTATTACTGTGCAAAAGATA", "aligned_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTT............GATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAAT......AGTGGTAGCATAGGCTATGCGGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACATGGCCTTGTATTACTGTGCAAAAGATA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1314", "sequence": "ATGGAGTTGGGACTGAGCTGGATTTTCCTTTTGGCTATTTTAAAAGGTGATTCATGGAGAAATAGAGAGATTGAGTGTGAGTGGACATGAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACATGGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGGGAAGTCAGCGAGAGCCCAGACAAAAACC", "repository_name": "GenBank", "repository_ref": "KC713947", "patch_no": "1", "gff_seqid": null, "gff_start": 251, "gff_end": 735, "strand": null }, { "sequence_id": "1315", "sequence": "ATGGAGTTGGGACTGAGCTGGATTTTCCTTTTGGCTATTTTAAAAGGTGATTCATGGAGAAATAGAGAGATTGAGTGTGAGTGGACATGAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACATGGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGGGAAGTCAGCGAGAGCCCAGACAAAAACC", "repository_name": "GenBank", "repository_ref": "AC244463", "patch_no": "2", "gff_seqid": null, "gff_start": 8885, "gff_end": 9369, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample KC713947\r\nVDJbase example haplotype: P1_I64", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02618", "allele_description_ref": "OGRDB:Homo sapiens:IGHD2-21*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD2-21*02", "sequence": "GGATTTTGTGGGGGTTCGTGTCACTGTGAGCATATTGTGGTGGTGACTGCTATTCCCACAGTGACACAACCCCATTCCTAAAGC", "coding_sequence": "AGCATATTGTGGTGGTGACTGCTATTCC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "2", "subgroup_designation": "21", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 56, "d_rs_3_prime_start": 57, "d_rs_3_prime_end": 84, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "961", "sequence": "GGATTTTGTGGGGGTTCGTGTCACTGTGAGCATATTGTGGTGGTGACTGCTATTCCCACAGTGACACAACCCCATTCCTAAAGC", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 64616, "gff_end": 64699, "strand": null }, { "sequence_id": "962", "sequence": "GGATTTTGTGGGGGTTCGTGTCACTGTGAGCATATTGTGGTGGTGACTGCTATTCCCACAGTGACACAACCCCATTCCTAAAGC", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 135075, "gff_end": 135158, "strand": null }, { "sequence_id": "963", "sequence": "GGATTTTGTGGGGGTTCGTGTCACTGTGAGCATATTGTGGTGGTGACTGCTATTCCCACAGTGACACAACCCCATTCCTAAAGC", "repository_name": "GenBank", "repository_ref": "ON052100", "patch_no": "1", "gff_seqid": null, "gff_start": 112, "gff_end": 195, "strand": null }, { "sequence_id": "964", "sequence": "GGATTTTGTGGGGGTTCGTGTCACTGTGAGCATATTGTGGTGGTGACTGCTATTCCCACAGTGACACAACCCCATTCCTAAAGC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 991239, "gff_end": 991322, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I24", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02632", "allele_description_ref": "OGRDB:Homo sapiens:IGHD5-24*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD5-24*01", "sequence": "GGTTATTGTCAGGGGGTGCCAGGCCGTGGTAGAGATGGCTACAATTACCACAGTGGTGCCGCCCATAGCAGCAACC", "coding_sequence": "GTAGAGATGGCTACAATTAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "5", "subgroup_designation": "24", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 48, "d_rs_3_prime_start": 49, "d_rs_3_prime_end": 76, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "1013", "sequence": "GGTTATTGTCAGGGGGTGCCAGGCCGTGGTAGAGATGGCTACAATTACCACAGTGGTGCCGCCCATAGCAGCAACC", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 69272, "gff_end": 69347, "strand": null }, { "sequence_id": "1014", "sequence": "GGTTATTGTCAGGGGGTGCCAGGCCGTGGTAGAGATGGCTACAATTACCACAGTGGTGCCGCCCATAGCAGCAACC", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 139730, "gff_end": 139805, "strand": null }, { "sequence_id": "1015", "sequence": "GGTTATTGTCAGGGGGTGCCAGGCCGTGGTAGAGATGGCTACAATTACCACAGTGGTGCCGCCCATAGCAGCAACC", "repository_name": "GenBank", "repository_ref": "ON052112", "patch_no": "1", "gff_seqid": null, "gff_start": 135, "gff_end": 210, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02723", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-43D*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-43D*03", "sequence": "ATGGAGTTTGGACTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGATAAATAGAGATGTTGAGTGTGAGTGAACATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTGTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACCTACTATGCAGACTCTGTGAAGGGTCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACCGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGAGAAGTCAGTGAGAGCCCAGACAAAAACC", "coding_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACCTACTATGCAGACTCTGTGAAGGGTCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACCGCCTTGTATTACTGTGCAAAAGATA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "43D", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 458, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 459, "v_rs_end": 497, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACCTACTATGCAGACTCTGTGAAGGGTCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACCGCCTTGTATTACTGTGCAAAAGATA", "aligned_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGA...GTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTT............GATGATTATGCCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGAT......GGTGGTAGCACCTACTATGCAGACTCTGTGAAG...GGTCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACCGCCTTGTATTACTGTGCAAAAGATA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1241", "sequence": "ATGGAGTTTGGACTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGATAAATAGAGATGTTGAGTGTGAGTGAACATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTGTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACCTACTATGCAGACTCTGTGAAGGGTCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACCGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGAGAAGTCAGTGAGAGCCCAGACAAAAACC", "repository_name": "GenBank", "repository_ref": "KC713950", "patch_no": "1", "gff_seqid": null, "gff_start": 251, "gff_end": 747, "strand": null }, { "sequence_id": "1242", "sequence": "ATGGAGTTTGGACTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGATAAATAGAGATGTTGAGTGTGAGTGAACATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTGTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACCTACTATGCAGACTCTGTGAAGGGTCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACCGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGAGAAGTCAGTGAGAGCCCA", "repository_name": "GenBank", "repository_ref": "ON052062", "patch_no": "1", "gff_seqid": null, "gff_start": 302, "gff_end": 788, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample KC713950\r\nVDJbase example haplotype: P1_I12\r\nMapped by P1_I12 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02975", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-35*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV3-35*02", "sequence": "ATGGAATTTGGGCTGAGCTGGGTTTTTCTTGCTGCTATTTTAAAAGGTGATTCATGAAGAACTAAGGATATTGAGTGAGTGGACATGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGATCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGTCCATCAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGCAGACTCTGTGAAGGGCCAATTCATCATCTCCAGAGACAATTCCAGGAACACCCTGTATCTGCAAACGAATAGCCTGAGGGCCGAGGACACGGCTGTGTATTACTGTGTGAGAAACACTGTGAGAGGACGGAAGTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGATCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGTCCATCAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGCAGACTCTGTGAAGGGCCAATTCATCATCTCCAGAGACAATTCCAGGAACACCCTGTATCTGCAAACGAATAGCCTGAGGGCCGAGGACACGGCTGTGTATTACTGTGTGAGAAA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "35", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 159, "gene_end": 454, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 148, "leader_2_end": 158, "v_rs_start": 455, "v_rs_end": 493, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGATCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGTCCATCAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGCAGACTCTGTGAAGGGCCAATTCATCATCTCCAGAGACAATTCCAGGAACACCCTGTATCTGCAAACGAATAGCCTGAGGGCCGAGGACACGGCTGTGTATTACTGTGTGAGAAA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGGGGATCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAACAGTGACATGAACTGGGTCCATCAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAAT......GGCAGTAGGACGCACTATGCAGACTCTGTGAAG...GGCCAATTCATCATCTCCAGAGACAATTCCAGGAACACCCTGTATCTGCAAACGAATAGCCTGAGGGCCGAGGACACGGCTGTGTATTACTGTGTGAGAAA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1422", "sequence": "ATGGAATTTGGGCTGAGCTGGGTTTTTCTTGCTGCTATTTTAAAAGGTGATTCATGAAGAACTAAGGATATTGAGTGAGTGGACATGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGATCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGTCCATCAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGCAGACTCTGTGAAGGGCCAATTCATCATCTCCAGAGACAATTCCAGGAACACCCTGTATCTGCAAACGAATAGCCTGAGGGCCGAGGACACGGCTGTGTATTACTGTGTGAGAAACACTGTGAGAGGACGGAAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AC240376", "patch_no": "3", "gff_seqid": null, "gff_start": 1836, "gff_end": 2328, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AC240376. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (34 samples). Example subject: P25_I12.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02972", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-25*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV3-25*03", "sequence": "ATGGAGTTTGTGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAACGTGATCTATAGAGAACTAGAGATATTGAGTATGAATGGATATGAGTGAGAAACAGTGGATACGTGTGGCAGTTTCTGACCGGGGTGTCTCTGTGTTTGCAGGTATCCAGTGTGAGATGCAGCTGGTGGAGTCTGGGGGAGGCTTGGCAAAGCCTGCGTGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTCAGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTGGACAAGTTAATCCTAATGGGGGTAGCACATACCTCATAGACTCCGGTAAGGACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTGTATTAGTGTACCAGAGACACAGTGAGGGGAGGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGATGCAGCTGGTGGAGTCTGGGGGAGGCTTGGCAAAGCCTGCGTGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTCAGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTGGACAAGTTAATCCTAATGGGGGTAGCACATACCTCATAGACTCCGGTAAGGACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTGTATTAGTGTACCAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": false, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "25", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 159, "gene_end": 454, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 148, "leader_2_end": 158, "v_rs_start": 455, "v_rs_end": 493, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGATGCAGCTGGTGGAGTCTGGGGGAGGCTTGGCAAAGCCTGCGTGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTCAGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTGGACAAGTTAATCCTAATGGGGGTAGCACATACCTCATAGACTCCGGTAAGGACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTGTATTAGTGTACCAGAGA", "aligned_sequence": "GAGATGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGCAAAGCCTGCGTGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTC............AGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTGGACAAGTTAATCCTAAT......GGGGGTAGCACATACCTCATAGACTCCGGTAAG...GACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTGTATTAGTGTACCAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1419", "sequence": "ATGGAGTTTGTGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAACGTGATCTATAGAGAACTAGAGATATTGAGTATGAATGGATATGAGTGAGAAACAGTGGATACGTGTGGCAGTTTCTGACCGGGGTGTCTCTGTGTTTGCAGGTATCCAGTGTGAGATGCAGCTGGTGGAGTCTGGGGGAGGCTTGGCAAAGCCTGCGTGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTCAGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTGGACAAGTTAATCCTAATGGGGGTAGCACATACCTCATAGACTCCGGTAAGGACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTGTATTAGTGTACCAGAGACACAGTGAGGGGAGGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 590366, "gff_end": 590858, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample GRCh38:CM000676.2. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (56 samples). Example subject: P25_I1.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02640", "allele_description_ref": "OGRDB:Homo sapiens:IGHJ2*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHJ2*01", "sequence": "TGTTTTTGTATGGGAGAAGCAGGAGGGCAGAGGCTGTGCTACTGGTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACTGTCTCCTCAG", "coding_sequence": "CTACTGGTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACTGTCTCCTCAG", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "J", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "2", "subgroup_designation": null, "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 39, "gene_end": 91, "j_codon_frame": 1, "j_cdr3_end": 91, "j_rs_start": 1, "j_rs_end": 38, "unrearranged_support": [ { "sequence_id": "1044", "sequence": "TGTTTTTGTATGGGAGAAGCAGGAGGGCAGAGGCTGTGCTACTGGTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACTGTCTCCTCAG", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 87731, "gff_end": 87821, "strand": null }, { "sequence_id": "1045", "sequence": "TGTTTTTGTATGGGAGAAGCAGGAGGGCAGAGGCTGTGCTACTGGTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACTGTCTCCTCAG", "repository_name": "GenBank", "repository_ref": "X86359", "patch_no": "1", "gff_seqid": null, "gff_start": 454, "gff_end": 544, "strand": null }, { "sequence_id": "1046", "sequence": "TGTTTTTGTATGGGAGAAGCAGGAGGGCAGAGGCTGTGCTACTGGTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACTGTCTCCTCAG", "repository_name": "GenBank", "repository_ref": "ON023002", "patch_no": "1", "gff_seqid": null, "gff_start": 46, "gff_end": 136, "strand": null }, { "sequence_id": "1047", "sequence": "TGTTTTTGTATGGGAGAAGCAGGAGGGCAGAGGCTGTGCTACTGGTACTTCGATCTCTGGGGCCGTGGCACCCTGGTCACTGTCTCCTCAG", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 1014556, "gff_end": 1014646, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02760", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-30-2*06.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-30-2*06", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGAGCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGCTGCAGCTGCAGGAGTCCGGCTCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGTCACCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAGGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCCAGAGACACAATGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "coding_sequence": "CAGCTGCAGCTGCAGGAGTCCGGCTCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGTCACCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAGGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCCAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4-30", "subgroup_designation": "2", "allele_designation": "06", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 140, "gene_end": 438, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 129, "leader_2_end": 139, "v_rs_start": 439, "v_rs_end": 477, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGCTGCAGCTGCAGGAGTCCGGCTCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGTCACCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAGGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCCAGAGA", "aligned_sequence": "CAGCTGCAGCTGCAGGAGTCCGGCTCA...GGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGC......AGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGTCACCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATCATAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACAGGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCCAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1328", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGAGCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGCTGCAGCTGCAGGAGTCCGGCTCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGTCACCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAGGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCCAGAGACACAATGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "KC162924", "patch_no": "1", "gff_seqid": null, "gff_start": 34530, "gff_end": 35006, "strand": null }, { "sequence_id": "1329", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGAGCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGCTGCAGCTGCAGGAGTCCGGCTCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGTCACCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAGGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCCAGAGACACAATGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AC231260", "patch_no": "2", "gff_seqid": null, "gff_start": 18382, "gff_end": 18858, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample KC162924", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02629", "allele_description_ref": "OGRDB:Homo sapiens:IGHD4-4*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD4-4*01", "sequence": "GCTTTTTGTGAAGGGTCCTCCTACTGTGTGACTACAGTAACTACCACAGTGATGAACCCAGCAGCAAAAACT", "coding_sequence": "TGACTACAGTAACTAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "4", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 44, "d_rs_3_prime_start": 45, "d_rs_3_prime_end": 72, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "1001", "sequence": "GCTTTTTGTGAAGGGTCCTCCTACTGTGTGACTACAGTAACTACCACAGTGATGAACCCAGCAGCAAAAACT", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 39958, "gff_end": 40029, "strand": null }, { "sequence_id": "1002", "sequence": "GCTTTTTGTGAAGGGTCCTCCTACTGTGTGACTACAGTAACTACCACAGTGATGAACCCAGCAGCAAAAACT", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 110417, "gff_end": 110488, "strand": null }, { "sequence_id": "1003", "sequence": "GCTTTTTGTGAAGGGTCCTCCTACTGTGTGACTACAGTAACTACCACAGTGATGAACCCAGCAGCAAAAACT", "repository_name": "GenBank", "repository_ref": "ON052110", "patch_no": "1", "gff_seqid": null, "gff_start": 158, "gff_end": 229, "strand": null }, { "sequence_id": "1004", "sequence": "GCTTTTTGTGAAGGGTCCTCCTACTGTGTGACTACAGTAACTACCACAGTGATGAACCCAGCAGCAAAAACT", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 966580, "gff_end": 966651, "strand": null } ], "rearranged_support": [], "paralogs": [ "IGHD4-11*01" ], "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02693", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-15*07.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-15*07", "sequence": "ATGGAGTTTGGGCTGAGCTGGATTTTCCTTGCTGCTATTTTAAAAGGTGATTTATGGAGAACTAGAGAGATTAAGTGTGAGTGGACGTGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGATCTTAGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCTGGGGGGTCCCTTAGACTCTCCTGTGCAGCCTCTGGTTTCACTTTCAGTAACGCCTGGATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCGGCCGTATTAAAAGCAAAACTGATGGTGGGACAACAGACTACGCTGCACCCGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCAAAAAACACGCTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACCACAGACACAGTGAGGGGAGGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCTGGGGGGTCCCTTAGACTCTCCTGTGCAGCCTCTGGTTTCACTTTCAGTAACGCCTGGATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCGGCCGTATTAAAAGCAAAACTGATGGTGGGACAACAGACTACGCTGCACCCGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCAAAAAACACGCTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACCACAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "15", "allele_designation": "07", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 462, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 463, "v_rs_end": 501, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCTGGGGGGTCCCTTAGACTCTCCTGTGCAGCCTCTGGTTTCACTTTCAGTAACGCCTGGATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCGGCCGTATTAAAAGCAAAACTGATGGTGGGACAACAGACTACGCTGCACCCGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCAAAAAACACGCTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACCACAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTAAAGCCTGGGGGGTCCCTTAGACTCTCCTGTGCAGCCTCTGGTTTCACTTTC............AGTAACGCCTGGATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCGGCCGTATTAAAAGCAAAACTGATGGTGGGACAACAGACTACGCTGCACCCGTGAAA...GGCAGATTCACCATCTCAAGAGATGATTCAAAAAACACGCTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACCACAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 180, "fwr3_start": 181, "fwr3_end": 294, "cdr3_start": 295, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1171", "sequence": "ATGGAGTTTGGGCTGAGCTGGATTTTCCTTGCTGCTATTTTAAAAGGTGATTTATGGAGAACTAGAGAGATTAAGTGTGAGTGGACGTGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGATCTTAGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCTGGGGGGTCCCTTAGACTCTCCTGTGCAGCCTCTGGTTTCACTTTCAGTAACGCCTGGATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCGGCCGTATTAAAAGCAAAACTGATGGTGGGACAACAGACTACGCTGCACCCGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCAAAAAACACGCTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACCACAGACACAGTGAGGGGAGGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052051", "patch_no": "1", "gff_seqid": null, "gff_start": 197, "gff_end": 697, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052051\r\nVDJbase example haplotype: P1_I10\r\nVDJbase example haplotype: P1_I23\r\nMapped by P1_I10 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02987", "allele_description_ref": "OGRDB:Homo sapiens:IGHV8-51-1*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV8-51-1*03", "sequence": "CTTGAGTTCCAGCACATCTTGGGAGGCCAAGCGGATGTTTGTGAAAGAAATAGTGGCTATGTGACAGTTTCTAACCAGAATATCTCTGTGTTTTCAGGTATCCAGGGTGAGGCCCAGCTTACAGAGTCTGGGGGAGACTTGGTACACTGAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTCAGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGTGAAAGTCATCAATACAATGCAGACTATGTTAGGGGCAGACTCACCACTTCCAGAGACAACACCAAGTACATGCTGTACATGCAAATGAACAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAACATCGTGATGGGAAGTCCACGTGGGCTCAGAGACAGACT", "coding_sequence": "GAGGCCCAGCTTACAGAGTCTGGGGGAGACTTGGTACACTGAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTCAGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGTGAAAGTCATCAATACAATGCAGACTATGTTAGGGGCAGACTCACCACTTCCAGAGACAACACCAAGTACATGCTGTACATGCAAATGAACAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": false, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "8-51", "subgroup_designation": "1", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 109, "gene_end": 404, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 52, "leader_2_start": 98, "leader_2_end": 108, "v_rs_start": 405, "v_rs_end": 443, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGCCCAGCTTACAGAGTCTGGGGGAGACTTGGTACACTGAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTCAGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGTGAAAGTCATCAATACAATGCAGACTATGTTAGGGGCAGACTCACCACTTCCAGAGACAACACCAAGTACATGCTGTACATGCAAATGAACAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAA", "aligned_sequence": "GAGGCCCAGCTTACAGAGTCTGGGGGA...GACTTGGTACACTGAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTC............AGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGT......GAAAGTCATCAATACAATGCAGACTATGTTAGG...GGCAGACTCACCACTTCCAGAGACAACACCAAGTACATGCTGTACATGCAAATGAACAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1434", "sequence": "CTTGAGTTCCAGCACATCTTGGGAGGCCAAGCGGATGTTTGTGAAAGAAATAGTGGCTATGTGACAGTTTCTAACCAGAATATCTCTGTGTTTTCAGGTATCCAGGGTGAGGCCCAGCTTACAGAGTCTGGGGGAGACTTGGTACACTGAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTCAGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGTGAAAGTCATCAATACAATGCAGACTATGTTAGGGGCAGACTCACCACTTCCAGAGACAACACCAAGTACATGCTGTACATGCAAATGAACAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAACATCGTGATGGGAAGTCCACGTGGGCTCAGAGACAGACT", "repository_name": "GenBank", "repository_ref": "AC279152", "patch_no": "1", "gff_seqid": null, "gff_start": 19801, "gff_end": 20243, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AC279152. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (92 samples). Example subject: P25_I5.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02751", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-73*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-73*02", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGGGAACTAGAGATACTGAGTGTGAGTGGACATGAGTGAGAGAAACAGTGGACGTGTGTGGCACTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCCGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAAACTCTCCTGTGCAGCCTCTGGGTTCACCTTCAGTGGCTCTGCTATGCACTGGGTCCGCCAGGCTTCCGGGAAAGGGCTGGAGTGGGTTGGCCGTATTAGAAGCAAAGCTAACAGTTACGCGACAGCATATGCTGCGTCGGTGAAAGGCAGGTTCACCATCTCCAGAGATGATTCAAAGAACACGGCGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTACTAGACACACAGTGAGGGGAGGTCAGTGTGAGCCCGGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCCGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAAACTCTCCTGTGCAGCCTCTGGGTTCACCTTCAGTGGCTCTGCTATGCACTGGGTCCGCCAGGCTTCCGGGAAAGGGCTGGAGTGGGTTGGCCGTATTAGAAGCAAAGCTAACAGTTACGCGACAGCATATGCTGCGTCGGTGAAAGGCAGGTTCACCATCTCCAGAGATGATTCAAAGAACACGGCGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTACTAGACA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "73", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 462, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 463, "v_rs_end": 501, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCCGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAAACTCTCCTGTGCAGCCTCTGGGTTCACCTTCAGTGGCTCTGCTATGCACTGGGTCCGCCAGGCTTCCGGGAAAGGGCTGGAGTGGGTTGGCCGTATTAGAAGCAAAGCTAACAGTTACGCGACAGCATATGCTGCGTCGGTGAAAGGCAGGTTCACCATCTCCAGAGATGATTCAAAGAACACGGCGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTACTAGACA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCCGGGGGA...GGCTTGGTCCAGCCTGGGGGGTCCCTGAAACTCTCCTGTGCAGCCTCTGGGTTCACCTTC............AGTGGCTCTGCTATGCACTGGGTCCGCCAGGCTTCCGGGAAAGGGCTGGAGTGGGTTGGCCGTATTAGAAGCAAAGCTAACAGTTACGCGACAGCATATGCTGCGTCGGTGAAA...GGCAGGTTCACCATCTCCAGAGATGATTCAAAGAACACGGCGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTACTAGACA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 180, "fwr3_start": 181, "fwr3_end": 294, "cdr3_start": 295, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1301", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGGGAACTAGAGATACTGAGTGTGAGTGGACATGAGTGAGAGAAACAGTGGACGTGTGTGGCACTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCCGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAAACTCTCCTGTGCAGCCTCTGGGTTCACCTTCAGTGGCTCTGCTATGCACTGGGTCCGCCAGGCTTCCGGGAAAGGGCTGGAGTGGGTTGGCCGTATTAGAAGCAAAGCTAACAGTTACGCGACAGCATATGCTGCGTCGGTGAAAGGCAGGTTCACCATCTCCAGAGATGATTCAAAGAACACGGCGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTACTAGACACACAGTGAGGGGAGGTCAGTGTGAGCCCGGACACAAACC", "repository_name": "GenBank", "repository_ref": "AB019437", "patch_no": "1", "gff_seqid": null, "gff_start": 78150, "gff_end": 78650, "strand": null }, { "sequence_id": "1302", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCCGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAAACTCTCCTGTGCAGCCTCTGGGTTCACCTTCAGTGGCTCTGCTATGCACTGGGTCCGCCAGGCTTCCGGGAAAGGGCTGGAGTGGGTTGGCCGTATTAGAAGCAAAGCTAACAGTTACGCGACAGCATATGCTGCGTCGGTGAAAGGCAGGTTCACCATCTCCAGAGATGATTCAAAGAACACGGCGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTACTAGACACACAGTGAGGGGAGGTCAATGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855697", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 351, "strand": null }, { "sequence_id": "1303", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGGGAACTAGAGATACTGAGTGTGAGTGGACATGAGTGAGAGAAACAGTGGACGTGTGTGGCACTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCCGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAAACTCTCCTGTGCAGCCTCTGGGTTCACCTTCAGTGGCTCTGCTATGCACTGGGTCCGCCAGGCTTCCGGGAAAGGGCTGGAGTGGGTTGGCCGTATTAGAAGCAAAGCTAACAGTTACGCGACAGCATATGCTGCGTCGGTGAAAGGCAGGTTCACCATCTCCAGAGATGATTCAAAGAACACGGCGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTACTAGACACACAGTGAGGGGAGGTCAGTGTGAGCCCGGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052076", "patch_no": "1", "gff_seqid": null, "gff_start": 193, "gff_end": 693, "strand": null }, { "sequence_id": "1304", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGGGAACTAGAGATACTGAGTGTGAGTGGACATGAGTGAGAGAAACAGTGGACGTGTGTGGCACTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCCGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAAACTCTCCTGTGCAGCCTCTGGGTTCACCTTCAGTGGCTCTGCTATGCACTGGGTCCGCCAGGCTTCCGGGAAAGGGCTGGAGTGGGTTGGCCGTATTAGAAGCAAAGCTAACAGTTACGCGACAGCATATGCTGCGTCGGTGAAAGGCAGGTTCACCATCTCCAGAGATGATTCAAAGAACACGGCGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTACTAGACACACAGTGAGGGGAGGTCAGTGTGAGCCCGGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 76692, "gff_end": 77192, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019437\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02637", "allele_description_ref": "OGRDB:Homo sapiens:IGHD6-6*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD6-6*01", "sequence": "AGTTTCTGAAGGTGTCTGTGTCACAGTGGAGTATAGCAGCTCGTCCCACAGTGACACTCGCCAGGCCAGAAACC", "coding_sequence": "GAGTATAGCAGCTCGTCC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "6", "subgroup_designation": "6", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 46, "d_rs_3_prime_start": 47, "d_rs_3_prime_end": 74, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "1032", "sequence": "AGTTTCTGAAGGTGTCTGTGTCACAGTGGAGTATAGCAGCTCGTCCCACAGTGACACTCGCCAGGCCAGAAACC", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 42767, "gff_end": 42840, "strand": null }, { "sequence_id": "1033", "sequence": "AGTTTCTGAAGGTGTCTGTGTCACAGTGGAGTATAGCAGCTCGTCCCACAGTGACACTCGCCAGGCCAGAAACC", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 113227, "gff_end": 113300, "strand": null }, { "sequence_id": "1034", "sequence": "AGTTTCTGAAGGTGTCTGTGTCACAGTGGAGTATAGCAGCTCGTCCCACAGTGACACTCGCCAGGCCAGAAACC", "repository_name": "GenBank", "repository_ref": "ON052118", "patch_no": "1", "gff_seqid": null, "gff_start": 192, "gff_end": 265, "strand": null }, { "sequence_id": "1035", "sequence": "AGTTTCTGAAGGTGTCTGTGTCACAGTGGAGTATAGCAGCTCGTCCCACAGTGACACTCGCCAGGCCAGAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 969390, "gff_end": 969463, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02784", "allele_description_ref": "OGRDB:Homo sapiens:IGHV7-4-1*04.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV7-4-1*04", "sequence": "TCGCGAGTCTCCACAGGTGCCACTCCCAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCATGGCATATCTGCAGATCAGCAGCCTAAAGGCTGAGGACACTGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCT", "coding_sequence": "CAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCATGGCATATCTGCAGATCAGCAGCCTAAAGGCTGAGGACACTGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "7-4", "subgroup_designation": "1", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 27, "gene_end": 322, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 17, "leader_2_end": 26, "v_rs_start": 323, "v_rs_end": 351, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCATGGCATATCTGCAGATCAGCAGCCTAAAGGCTGAGGACACTGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGCAATCTGGGTCT...GAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTC............ACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAAC......ACTGGGAACCCAACGTATGCCCAGGGCTTCACA...GGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCATGGCATATCTGCAGATCAGCAGCCTAAAGGCTGAGGACACTGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1399", "sequence": "GGTGCCACTCCCAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCATGGCATATCTGCAGATCAGCAGCCTAAAGGCTGAGGACACTGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCT", "repository_name": "GenBank", "repository_ref": "HM855485", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 330, "strand": null }, { "sequence_id": "1400", "sequence": "GTGCCCACTCCCAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCATGGCATATCTGCAGATCAGCAGCCTAAAGGCTGAGGACACTGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCACATCCT", "repository_name": "GenBank", "repository_ref": "HM855821", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 329, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855485", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02747", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-7*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-7*03", "sequence": "ATGGAGTTGGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGATTCATGGAAAACTAGGAAGATTGAGTGTGTGTGGATATGAGTGTGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "7", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 456, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 457, "v_rs_end": 495, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTT............AGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAAAGCAAGAT......GGAAGTGAGAAATACTATGTGGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1289", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCATTGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855741", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 345, "strand": null }, { "sequence_id": "1290", "sequence": "ATGGAGTTGGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGATTCATGGAAAACTAGGAAGATTGAGTGTGTGTGGATATGAGTGTGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052073", "patch_no": "1", "gff_seqid": null, "gff_start": 267, "gff_end": 761, "strand": null }, { "sequence_id": "1291", "sequence": "ATGGAGTTGGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGATTCATGGAAAACTAGGAAGATTGAGTGTGTGTGGATATGAGTGTGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 817241, "gff_end": 817735, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052073\r\nVDJbase example haplotype: P1_I29", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02765", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-34*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-34*01", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTCCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAGGAATGCGGATATGAAGATATGAGATGCTGCCTCTGATCCCAGGGCTCACTGTGGGTTTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTACAGCAGTGGGGCGCAGGACTGTTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCGCTGTCTATGGTGGGTCCTTCAGTGGTTACTACTGGAGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCAATCATAGTGGAAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCTGTGTATTACTGTGCGAGAGGCACAGTGAGGGGAGGTGAGTGTGAGCCCAGACAAAAACC", "coding_sequence": "CAGGTGCAGCTACAGCAGTGGGGCGCAGGACTGTTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCGCTGTCTATGGTGGGTCCTTCAGTGGTTACTACTGGAGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCAATCATAGTGGAAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCTGTGTATTACTGTGCGAGAGG", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "34", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 141, "gene_end": 433, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 130, "leader_2_end": 140, "v_rs_start": 434, "v_rs_end": 472, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTACAGCAGTGGGGCGCAGGACTGTTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCGCTGTCTATGGTGGGTCCTTCAGTGGTTACTACTGGAGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCAATCATAGTGGAAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCTGTGTATTACTGTGCGAGAGG", "aligned_sequence": "CAGGTGCAGCTACAGCAGTGGGGCGCA...GGACTGTTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCGCTGTCTATGGTGGGTCCTTC............AGTGGTTACTACTGGAGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCAATCATAGT.........GGAAGCACCAACTACAACCCGTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCTGTGTATTACTGTGCGAGAGG", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1343", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTCCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAGGAATGCGGATATGAAGATATGAGATGCTGCCTCTGATCCCAGGGCTCACTGTGGGTTTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTACAGCAGTGGGGCGCAGGACTGTTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCGCTGTCTATGGTGGGTCCTTCAGTGGTTACTACTGGAGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCAATCATAGTGGAAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCTGTGTATTACTGTGCGAGAGGCACAGTGAGGGGAGGTGAGTGTGAGCCCAGACAAAAACC", "repository_name": "GenBank", "repository_ref": "AB019439", "patch_no": "1", "gff_seqid": null, "gff_start": 59517, "gff_end": 59988, "strand": null }, { "sequence_id": "1344", "sequence": "GGGTCCTGTCCCAGGTGCAGCTACAGCAGTGGGGCGCAGGACTGTTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCGCTGTCTATGGTGGGTCCTTCAGTGGTTACTACTGGAGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCAATCATAGTGGAAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCTGTGTATTACTGTGCGAGAGGCACAGTGAGGGAGGTGAGTGTGAG", "repository_name": "GenBank", "repository_ref": "HM855815", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 328, "strand": null }, { "sequence_id": "1345", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTCCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAGGAATGCGGATATGAAGATATGAGATGCTGCCTCTGATCCCAGGGCTCACTGTGGGTTTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTACAGCAGTGGGGCGCAGGACTGTTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCGCTGTCTATGGTGGGTCCTTCAGTGGTTACTACTGGAGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCAATCATAGTGGAAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCTGTGTATTACTGTGCGAGAGGCACAGTGAGGGGAGGTGAGTGTGAGCCCAGACAAAAACC", "repository_name": "GenBank", "repository_ref": "ON052083", "patch_no": "1", "gff_seqid": null, "gff_start": 292, "gff_end": 763, "strand": null }, { "sequence_id": "1346", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTCCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAGGAATGCGGATATGAAGATATGAGATGCTGCCTCTGATCCCAGGGCTCACTGTGGGTTTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTACAGCAGTGGGGCGCAGGACTGTTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCGCTGTCTATGGTGGGTCCTTCAGTGGTTACTACTGGAGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCAATCATAGTGGAAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCTGTGTATTACTGTGCGAGAGGCACAGTGAGGGGAGGTGAGTGTGAGCCCAGACAAAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 505752, "gff_end": 506223, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019439\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02727", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-48*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-48*02", "sequence": "ATGGAGTTGGGGCTGTGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGATTCATGGAAAACTAGAGAGATTTAGTGTGTGTGGATATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAATGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGACGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAATGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGACGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "48", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 456, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 457, "v_rs_end": 495, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAATGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGACGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGT......AGTAGTACCATATACTACGCAGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAATGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGACGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1252", "sequence": "ATGGAGTTGGGGCTGTGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGATTCATGGAAAACTAGAGAGATTTAGTGTGTGTGGATATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAATGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGACGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AB019438", "patch_no": "1", "gff_seqid": null, "gff_start": 95274, "gff_end": 95768, "strand": null }, { "sequence_id": "1253", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAATGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGACGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAATGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855929", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 345, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019438\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02669", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-69*10.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-69*10", "sequence": "TAAGGGGCTTCCTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTGTCCACAGGTGTCCAGTCCCAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCCTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "coding_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCCTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "69", "allele_designation": "10", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 97, "gene_end": 392, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 86, "leader_2_end": 96, "v_rs_start": 393, "v_rs_end": 415, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCCTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGTCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTC............AGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATC......CTTGGTATAGCAAACTACGCACAGAAGTTCCAG...GGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1118", "sequence": "TAAGGGGCTTCCTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTGTCCACAGGTGTCCAGTCCCAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCCTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "repository_name": "GenBank", "repository_ref": "Z14300", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 392, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample Z14300\r\nVDJbase example haplotype: P1_I49\r\nVDJbase example haplotype: P1_I70\r\nMapped by P1_I49 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02734", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-53*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-53*02", "sequence": "ATGGAGTTTTGGCTGAGCTGGGTTTTCCTTGTTGCTATTTCAAAAGGTGATTCATGGAGAACTAGAGATATCGAGTGTGAGTGAACACGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTAACCAATGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGACTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGCCATTGTGCGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGACTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "53", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 159, "gene_end": 451, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 148, "leader_2_end": 158, "v_rs_start": 452, "v_rs_end": 490, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGACTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGACTGGAGGA...GGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTC............AGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGT.........GGTAGCACATACTACGCAGACTCCGTGAAG...GGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1267", "sequence": "ATGGAGTTTTGGCTGAGCTGGGTTTTCCTTGTTGCTATTTCAAAAGGTGATTCATGGAGAACTAGAGATATCGAGTGTGAGTGAACACGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTAACCAATGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGACTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGCCATTGTGCGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052067", "patch_no": "1", "gff_seqid": null, "gff_start": 456, "gff_end": 945, "strand": null }, { "sequence_id": "1268", "sequence": "ATGGAGTTTTGGCTGAGCTGGGTTTTCCTTGTTGCTATTTCAAAAGGTGATTCATGGAGAACTAGAGATATCGAGTGTGAGTGAACACGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTAACCAATGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGACTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGCCATTGTGCGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 286719, "gff_end": 287208, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052067\r\nVDJbase example haplotype: P1_I24", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02668", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-69*09.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-69*09", "sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCCTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "coding_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCCTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "69", "allele_designation": "09", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 296, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCCTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTC............AGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATC......CTTGGTATAGCAAACTACGCACAGAAGTTCCAG...GGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1117", "sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCCTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "repository_name": "GenBank", "repository_ref": "KY198939", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 296, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample KY198939\r\nVDJbase example haplotype: P1_I100\r\nVDJbase example haplotype: P1_I52\r\nMapped by P1_I100 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02732", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-49*05.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-49*05", "sequence": "TTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCAGGGCGGTCCCTGAGACTCTCCTGTACAGCTTCTGGATTCACCTTTGGTGATTATGCTATGAGCTGGTTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTAGGTTTCATTAGAAGCAAAGCTTATGGTGGGACAACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCCAAAAGCATCGCCTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACTAGAGACACAGTGAGGGGAAGTCAATGCTCGCGA", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCAGGGCGGTCCCTGAGACTCTCCTGTACAGCTTCTGGATTCACCTTTGGTGATTATGCTATGAGCTGGTTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTAGGTTTCATTAGAAGCAAAGCTTATGGTGGGACAACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCCAAAAGCATCGCCTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACTAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "49", "allele_designation": "05", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 22, "gene_end": 323, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 11, "leader_2_end": 21, "v_rs_start": 324, "v_rs_end": 352, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCAGGGCGGTCCCTGAGACTCTCCTGTACAGCTTCTGGATTCACCTTTGGTGATTATGCTATGAGCTGGTTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTAGGTTTCATTAGAAGCAAAGCTTATGGTGGGACAACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCCAAAAGCATCGCCTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACTAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTAAAGCCAGGGCGGTCCCTGAGACTCTCCTGTACAGCTTCTGGATTCACCTTT............GGTGATTATGCTATGAGCTGGTTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTAGGTTTCATTAGAAGCAAAGCTTATGGTGGGACAACAGAATACGCCGCGTCTGTGAAA...GGCAGATTCACCATCTCAAGAGATGATTCCAAAAGCATCGCCTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACTAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 180, "fwr3_start": 181, "fwr3_end": 294, "cdr3_start": 295, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855748\r\nVDJbase example haplotype: P1_I100\r\nMapped by P1_I100 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02772", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-4*08.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-4*08", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTCCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGGGATATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "4", "allele_designation": "08", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 140, "gene_end": 432, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 129, "leader_2_end": 139, "v_rs_start": 433, "v_rs_end": 471, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATC............AGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATACCAGT.........GGGAGCACCAACTACAACCCCTCCCTCAAG...AGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1364", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTCCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGGGATATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "KC713942", "patch_no": "1", "gff_seqid": null, "gff_start": 251, "gff_end": 721, "strand": null }, { "sequence_id": "1365", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTCCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGGGATATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AC241513", "patch_no": "1", "gff_seqid": null, "gff_start": 6233, "gff_end": 6703, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample KC713942", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02981", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-30-2*05.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV4-30-2*05", "sequence": "GGCTCACTGTGGGTTTCTCTGTTCACAGGGGTCCTGTCCCAGCTGCAGCTGCAGGAGTCCGGCTCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGCCACCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAGACACAATGAGGGGAGGTGAGTGTGAGCTCGCGA", "coding_sequence": "CAGCTGCAGCTGCAGGAGTCCGGCTCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGCCACCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4-30", "subgroup_designation": "2", "allele_designation": "05", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 40, "gene_end": 338, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 29, "leader_2_end": 39, "v_rs_start": 339, "v_rs_end": 370, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGCTGCAGCTGCAGGAGTCCGGCTCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGCCACCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAGA", "aligned_sequence": "CAGCTGCAGCTGCAGGAGTCCGGCTCA...GGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGC......AGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGCCACCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATCATAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1428", "sequence": "GGGTCCTGTCCCAGCTGCAGCTGCAGGAGTCCGGCTCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGCCACCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAGACACAATGAGGGGAGGTGAGTGTGAGCTCG", "repository_name": "GenBank", "repository_ref": "HM855593", "patch_no": "1", "gff_seqid": null, "gff_start": 29, "gff_end": 367, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855593. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (1 samples). Example subject: P25_I47.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00048", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-59*11.2_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 2, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-59*11", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTCACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAG", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTCACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": "A", "aliases": [ "IGHV4-59*i02" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "59", "allele_designation": "11", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 292, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTCACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATC............AGTAGTCACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGT.........GGGAGCACCAACTACAACCCCTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1373", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTCACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAG", "repository_name": "GenBank", "repository_ref": "MK471385", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 292, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Assessed by IARC on December 2, 2019 during meeting 46.\r\n\r\nThe committee considered IGHV4-59*01_S8652 (T109C) of Genotype B16 of submission S00010, which was previously evaluated as IGHV4-59*01_S5140 of submission S00006 at Meeting 12. It was affirmed as a Level 0 sequence at that time.\r\n\r\nThe sequence was seen in 3.03% of all unmutated rearrangements, with 18133 sequences including 8545 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. One other IGHV4-59 allele was present in the genotype, as well as two IGHV4-4 sequences and one IGHV4-61 sequences. Haplotype data is supportive of the inference, though the haplotype ratios likely reflect the presence of some chimeric sequences within the dataset. The ratios for the two IGHV4-59 sequences were 77:23 for the inference and 19:81 for the *01 allele, suggesting that the sequences are carried on different chromosomes. The sequence, up to and including nucleotide 319, was affirmed as a Level 1 sequence, but was subsequently identified as the recently reported allele IGHV4-59*11. The sequence submitted to Genbank lacked the 320th nucleotide that is noted in the IMGT sequence. In IARC and OGRDB communications, a dot at the 3' end of the sequence shows that the IARC believes there is a nucleotide missing from the sequence. The affirmed sequence will be submitted to IMGT as IGHV4-59*i02, as a record of the rearrangability (and therefore likely functionality) of the sequence.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MK471385\r\nMapped by IARC haplotype", "curational_tags": [ "likely_truncated" ] }, { "allele_description_id": "OGRDB:A02782", "allele_description_ref": "OGRDB:Homo sapiens:IGHV7-4-1*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV7-4-1*01", "sequence": "ATGGACTGGACCTGGAGGATCCTCTTCTTGGTGGCAGCAGCAACAGGTAAGGGGCTCCCCAGTCACTGGGCTGAGGGAGAAACCAGCACAGTCAAGTGAGACTTCATGCACTCCCATCTCCTCTCCACAGGTGCCCACTCCCAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCACGGCATATCTGCAGATCTGCAGCCTAAAGGCTGAGGACACTGCCGTGTATTACTGTGCGAGAGACACAGTGTGGAAACCCACATCCTGAGAGTGTCAAAAACC", "coding_sequence": "CAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCACGGCATATCTGCAGATCTGCAGCCTAAAGGCTGAGGACACTGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "7-4", "subgroup_designation": "1", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 142, "gene_end": 437, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 131, "leader_2_end": 141, "v_rs_start": 438, "v_rs_end": 476, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCACGGCATATCTGCAGATCTGCAGCCTAAAGGCTGAGGACACTGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGCAATCTGGGTCT...GAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTC............ACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAAC......ACTGGGAACCCAACGTATGCCCAGGGCTTCACA...GGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCACGGCATATCTGCAGATCTGCAGCCTAAAGGCTGAGGACACTGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1394", "sequence": "GTGTCCACTCCCAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCACGGCATATCTGCAGATCTGCAGCCTAAAGGCTGAGGACACTGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTCTCGCG", "repository_name": "GenBank", "repository_ref": "HM855910", "patch_no": "1", "gff_seqid": null, "gff_start": 10, "gff_end": 345, "strand": null }, { "sequence_id": "1395", "sequence": "ATGGACTGGACCTGGAGGATCCTCTTCTTGGTGGCAGCAGCAACAGGTAAGGGGCTCCCCAGTCACTGGGCTGAGGGAGAAACCAGCACAGTCAAGTGAGACTTCATGCACTCCCATCTCCTCTCCACAGGTGCCCACTCCCAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCACGGCATATCTGCAGATCTGCAGCCTAAAGGCTGAGGACACTGCCGTGTATTACTGTGCGAGAGACACAGTGTGGAAACCCACATCCTGAGAGTGTCAAAAACC", "repository_name": "GenBank", "repository_ref": "ON052092", "patch_no": "1", "gff_seqid": null, "gff_start": 307, "gff_end": 782, "strand": null }, { "sequence_id": "1396", "sequence": "ATGGACTGGACCTGGAGGATCCTCTTCTTGGTGGCAGCAGCAACAGGTAAGGGGCTCCCCAGTCACTGGGCTGAGGGAGAAACCAGCACAGTCAAGTGAGACTTCATGCACTCCCATCTCCTCTCCACAGGTGCCCACTCCCAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCACGGCATATCTGCAGATCTGCAGCCTAAAGGCTGAGGACACTGCCGTGTATTACTGTGCGAGAGACACAGTGTGGAAACCCACATCCTGAGAGTGTCAAAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 854264, "gff_end": 854739, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052092\r\nVDJbase example haplotype: P1_I15", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02776", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-61*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-61*02", "sequence": "ATGAAACATCTGTGGTTCTTCCTCCTCCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAGGGATCCAGACATGGGGATATGGGACGTGCCTCTGAGCCTAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGCGTATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACAAAAACC", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGCGTATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "61", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 140, "gene_end": 438, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 129, "leader_2_end": 139, "v_rs_start": 439, "v_rs_end": 477, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGCGTATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGC......AGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGCGTATCTATACCAGT.........GGGAGCACCAACTACAACCCCTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1378", "sequence": "GGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGCGTATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCTCG", "repository_name": "GenBank", "repository_ref": "HM855842", "patch_no": "1", "gff_seqid": null, "gff_start": 29, "gff_end": 367, "strand": null }, { "sequence_id": "1379", "sequence": "ATGAAACATCTGTGGTTCTTCCTCCTCCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAGGGATCCAGACATGGGGATATGGGACGTGCCTCTGAGCCTAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGCGTATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACAAAAACC", "repository_name": "GenBank", "repository_ref": "ON052088", "patch_no": "1", "gff_seqid": null, "gff_start": 268, "gff_end": 744, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052088\r\nVDJbase example haplotype: P1_I10", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02704", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-25*04.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-25*04", "sequence": "TCGCGAGTTGTTTGCAGGTGTCCAGTGTGAGACGCAGCTGGTGGAGTCTGGGGGAGGCTTGGCAAAGCCTGGGCGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTCAGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTGGACAAGTTAATCCTAATGGGGGTAGCACATACCTCATAGACTCCGGTAAGGACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTGTATTACTGTACCAGAGACACAGTGAGGGGAGGTCATTG", "coding_sequence": "GAGACGCAGCTGGTGGAGTCTGGGGGAGGCTTGGCAAAGCCTGGGCGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTCAGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTGGACAAGTTAATCCTAATGGGGGTAGCACATACCTCATAGACTCCGGTAAGGACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTGTATTACTGTACCAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "25", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 324, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 18, "leader_2_end": 28, "v_rs_start": 325, "v_rs_end": 353, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGACGCAGCTGGTGGAGTCTGGGGGAGGCTTGGCAAAGCCTGGGCGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTCAGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTGGACAAGTTAATCCTAATGGGGGTAGCACATACCTCATAGACTCCGGTAAGGACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTGTATTACTGTACCAGAGA", "aligned_sequence": "GAGACGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGCAAAGCCTGGGCGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTC............AGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTGGACAAGTTAATCCTAAT......GGGGGTAGCACATACCTCATAGACTCCGGTAAG...GACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTGTATTACTGTACCAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1198", "sequence": "GTGTCCAGTGTGAGACGCAGCTGGTGGAGTCTGGGGGAGGCTTGGCAAAGCCTGGGCGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTCAGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTGGACAAGTTAATCCTAATGGGGGTAGCACATACCTCATAGACTCCGGTAAGGACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTGTATTACTGTACCAGAGACACAGTGAGGGGAGGTCATTG", "repository_name": "GenBank", "repository_ref": "HM855933", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 328, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855933\r\nVDJbase example haplotype: P1_I55_S1", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02964", "allele_description_ref": "OGRDB:Homo sapiens:IGHV2-26*04.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV2-26*04", "sequence": "ATGGACACGCTTTGCTACACACTCCTGCTGCTGACCACCCCTTCCTGTGAGTGCTGTGGTCAGGGACTTCCTCAGAAGTGAAACATCAGTTGTCTCCTTTGTGGGCTTCATCTCCTTATGTCTTCTCCACAGGGGTCTTGTCCCAGGTCACCTTGAAGGAGTCTGGTCCTGTGCTGGTGAAACCCACAGAGACCCTCACGCTGACCTGCACCGTCTCTGGGTTCTCACTCAGCAATGCTAGAATGGGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACACATTTTTTCGAATGACGAAAAATCCTACAGCACATCTCTGAAGAGCAGGCTCACCATCTCCAAGGACACCTCCAAAAGCCAGGTGGTCCTTACCATGACCAATATGGACCCTGTGGACACAGCCACATATTACTGTGCATGGATACCACAGAGACACAGCCCAGGATGCCTCCTGTACAAGAACC", "coding_sequence": "CAGGTCACCTTGAAGGAGTCTGGTCCTGTGCTGGTGAAACCCACAGAGACCCTCACGCTGACCTGCACCGTCTCTGGGTTCTCACTCAGCAATGCTAGAATGGGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACACATTTTTTCGAATGACGAAAAATCCTACAGCACATCTCTGAAGAGCAGGCTCACCATCTCCAAGGACACCTCCAAAAGCCAGGTGGTCCTTACCATGACCAATATGGACCCTGTGGACACAGCCACATATTACTGTGCATGGATAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "2", "subgroup_designation": "26", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 144, "gene_end": 444, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 133, "leader_2_end": 143, "v_rs_start": 445, "v_rs_end": 483, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCACCTTGAAGGAGTCTGGTCCTGTGCTGGTGAAACCCACAGAGACCCTCACGCTGACCTGCACCGTCTCTGGGTTCTCACTCAGCAATGCTAGAATGGGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACACATTTTTTCGAATGACGAAAAATCCTACAGCACATCTCTGAAGAGCAGGCTCACCATCTCCAAGGACACCTCCAAAAGCCAGGTGGTCCTTACCATGACCAATATGGACCCTGTGGACACAGCCACATATTACTGTGCATGGATAC", "aligned_sequence": "CAGGTCACCTTGAAGGAGTCTGGTCCT...GTGCTGGTGAAACCCACAGAGACCCTCACGCTGACCTGCACCGTCTCTGGGTTCTCACTCAGC......AATGCTAGAATGGGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACACATTTTTTCGAAT.........GACGAAAAATCCTACAGCACATCTCTGAAG...AGCAGGCTCACCATCTCCAAGGACACCTCCAAAAGCCAGGTGGTCCTTACCATGACCAATATGGACCCTGTGGACACAGCCACATATTACTGTGCATGGATAC", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1411", "sequence": "ATGGACACGCTTTGCTACACACTCCTGCTGCTGACCACCCCTTCCTGTGAGTGCTGTGGTCAGGGACTTCCTCAGAAGTGAAACATCAGTTGTCTCCTTTGTGGGCTTCATCTCCTTATGTCTTCTCCACAGGGGTCTTGTCCCAGGTCACCTTGAAGGAGTCTGGTCCTGTGCTGGTGAAACCCACAGAGACCCTCACGCTGACCTGCACCGTCTCTGGGTTCTCACTCAGCAATGCTAGAATGGGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACACATTTTTTCGAATGACGAAAAATCCTACAGCACATCTCTGAAGAGCAGGCTCACCATCTCCAAGGACACCTCCAAAAGCCAGGTGGTCCTTACCATGACCAATATGGACCCTGTGGACACAGCCACATATTACTGTGCATGGATACCACAGAGACACAGCCCAGGATGCCTCCTGTACAAGAACC", "repository_name": "GenBank", "repository_ref": "AC280062", "patch_no": "1", "gff_seqid": null, "gff_start": 22934, "gff_end": 23416, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AC280062. VDJbase example haplotype: P1_I59. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (10 samples). Example subject: P25_I7.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02663", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-69-2*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-69-2*01", "sequence": "ATCCCTCCCCTACAGAAGCCCCCAGAGAGCAGCACCTCACCATGGACTGCACCTGGAGGATCCTCCTCTTGGTGGCAGCAGCTACAGGTAAGAGAATCCTTAGTTCCAGGGCTGATGAGGGGACTGGGTCCAGTTAAGTGGTGTCTCATCCACTCCTTTCTCTTCTCCACAGGCACCCACGCCGAGGTCCAGCTGGTACAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCTACAGTGAAAATCTCCTGCAAGGTTTCTGGATACACCTTCACCGACTACTACATGCACTGGGTGCAACAGGCCCCTGGAAAAGGGCTTGAGTGGATGGGACTTGTTGATCCTGAAGATGGTGAAACAATATACGCAGAGAAGTTCCAGGGCAGAGTCACCATAACCGCGGACACGTCTACAGACACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCAACAGACACAGTGTGAAAACCCACATGCTGAGAGTGT", "coding_sequence": "GAGGTCCAGCTGGTACAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCTACAGTGAAAATCTCCTGCAAGGTTTCTGGATACACCTTCACCGACTACTACATGCACTGGGTGCAACAGGCCCCTGGAAAAGGGCTTGAGTGGATGGGACTTGTTGATCCTGAAGATGGTGAAACAATATACGCAGAGAAGTTCCAGGGCAGAGTCACCATAACCGCGGACACGTCTACAGACACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCAACAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1-69", "subgroup_designation": "2", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 184, "gene_end": 479, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 173, "leader_2_end": 183, "v_rs_start": 480, "v_rs_end": 510, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTCCAGCTGGTACAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCTACAGTGAAAATCTCCTGCAAGGTTTCTGGATACACCTTCACCGACTACTACATGCACTGGGTGCAACAGGCCCCTGGAAAAGGGCTTGAGTGGATGGGACTTGTTGATCCTGAAGATGGTGAAACAATATACGCAGAGAAGTTCCAGGGCAGAGTCACCATAACCGCGGACACGTCTACAGACACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCAACAGA", "aligned_sequence": "GAGGTCCAGCTGGTACAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGGCTACAGTGAAAATCTCCTGCAAGGTTTCTGGATACACCTTC............ACCGACTACTACATGCACTGGGTGCAACAGGCCCCTGGAAAAGGGCTTGAGTGGATGGGACTTGTTGATCCTGAA......GATGGTGAAACAATATACGCAGAGAAGTTCCAG...GGCAGAGTCACCATAACCGCGGACACGTCTACAGACACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCAACAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1108", "sequence": "ATGGACTGCACCTGGAGGATCCTCCTCTTGGTGGCAGCAGCTACAGGTAAGAGAATCCTTAGTTCCAGGGCTGATGAGGGGACTGGGTCCAGTTAAGTGGTGTCTCATCCACTCCTTTCTCTTCTCCACAGGCACCCACGCCGAGGTCCAGCTGGTACAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCTACAGTGAAAATCTCCTGCAAGGTTTCTGGATACACCTTCACCGACTACTACATGCACTGGGTGCAACAGGCCCCTGGAAAAGGGCTTGAGTGGATGGGACTTGTTGATCCTGAAGATGGTGAAACAATATACGCAGAGAAGTTCCAGGGCAGAGTCACCATAACCGCGGACACGTCTACAGACACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCAACAGACACAGTGTGAAAACCCACATGCTGAGAGT", "repository_name": "GenBank", "repository_ref": "ON052037", "patch_no": "1", "gff_seqid": null, "gff_start": 42, "gff_end": 508, "strand": null }, { "sequence_id": "1109", "sequence": "ATGGACTGCACCTGGAGGATCCTCCTCTTGGTGGCAGCAGCTACAGGTAAGAGAATCCTTAGTTCCAGGGCTGATGAGGGGACTGGGTCCAGTTAAGTGGTGTCTCATCCACTCCTTTCTCTTCTCCACAGGCACCCACGCCGAGGTCCAGCTGGTACAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCTACAGTGAAAATCTCCTGCAAGGTTTCTGGATACACCTTCACCGACTACTACATGCACTGGGTGCAACAGGCCCCTGGAAAAGGGCTTGAGTGGATGGGACTTGTTGATCCTGAAGATGGTGAAACAATATACGCAGAGAAGTTCCAGGGCAGAGTCACCATAACCGCGGACACGTCTACAGACACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCAACAGACACAGTGTGAAAACCCACATGCTGAGAGTGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 142298, "gff_end": 142774, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052037\r\nVDJbase example haplotype: P1_I12_S1", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00005", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-43D*04.3_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 3, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-43D*04", "sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACATACTATGCAGACTCTGTGAAGGGTCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACCGCCTTGTATTACTGTGCAAAAGAT", "coding_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACATACTATGCAGACTCTGTGAAGGGTCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACCGCCTTGTATTACTGTGCAAAAGATA", "ext_3prime": "A", "aliases": [ "IGHV3-43D*i01" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "43D", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 297, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACATACTATGCAGACTCTGTGAAGGGTCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACCGCCTTGTATTACTGTGCAAAAGATA", "aligned_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGA...GTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTT............GATGATTATGCCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGAT......GGTGGTAGCACATACTATGCAGACTCTGTGAAG...GGTCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACCGCCTTGTATTACTGTGCAAAAGATA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1243", "sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACATACTATGCAGACTCTGTGAAGGGTCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACCGCCTTGTATTACTGTGCAAAAGAT", "repository_name": "GenBank", "repository_ref": "BK010573", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 297, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Originally approved by IARC on May 11, 2018.\r\n\r\n\"The sequence is present at low frequency (0.07%), in the IgDiscover analysis. It was inferred by IgDiscover. No information was provided by the submitter regarding analysis with partis or TIgGER. Haplotype analysis could not be performed. Analysis for chimerism did not provide evidence against the existence of the sequence. It was agreed that the sequence should be moved to Level 1, subject to the provision of additional information.\"\r\n\r\nFurther deliberation on May 25, 2018\r\n\"MO provided information regarding primers used to generate the data upon which the submission of Linnea Thornquist was based. It was agreed that the information was sufficient for the previous decisions of IARC to be ratified (see minutes Meeting 14).\"\r\n\r\nThe allele was incorporated into IMGT on October 4, 2018 as IGHV3-43D*04.\r\nThe other most similar allele IGHV3-43D*01 has since this inference was performed been renamed by IMGT as IGHV3-43D*03.\r\n\r\n(April 12, 2019) In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 321. A trailing \u201c.\u201d indicates IARC's opinion that the sequences likely to contain an additional/additional 3' nucleotide(s) for which there is insufficient evidence to make an affirmation.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample BK010573\r\nVDJbase example haplotype: P1_I23", "curational_tags": [ "likely_truncated" ] }, { "allele_description_id": "OGRDB:A02715", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-35*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-35*01", "sequence": "AAATAGGAGACATNCAAATAGGCCCCCCCCTTTCCTGATAAAAAGCAGCCCAGTCCTGACCCTGCAGCCCTGGGAGAGAAGCACCAGCCCTGGGATTCTCAGGTGTTTCCACTTTGTCATCAGCAACAAACAAATTACCATGGAATTTGGCCTGAGCTGGGTTTTCCTTGCTGCTATTTTAAAAGGTGATTCATGAAGAACTAAGGATATTGAGTGAGTGGACATGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGATCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGTCCATCAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGCAGACTCTGTGAAGGGCCGATTCATCATCTCCAGAGACAATTCCAGGAACACCCTGTATCTGCAAACGAATAGCCTGAGGGCCGAGGACACGGCTGTGTATTACTGTGTGAGAAACACTGTGAGAGGTCGGAAGTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGATCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGTCCATCAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGCAGACTCTGTGAAGGGCCGATTCATCATCTCCAGAGACAATTCCAGGAACACCCTGTATCTGCAAACGAATAGCCTGAGGGCCGAGGACACGGCTGTGTATTACTGTGTGAGAAA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "35", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 298, "gene_end": 593, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 287, "leader_2_end": 297, "v_rs_start": 594, "v_rs_end": 632, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGATCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGTCCATCAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGCAGACTCTGTGAAGGGCCGATTCATCATCTCCAGAGACAATTCCAGGAACACCCTGTATCTGCAAACGAATAGCCTGAGGGCCGAGGACACGGCTGTGTATTACTGTGTGAGAAA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGGGGATCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAACAGTGACATGAACTGGGTCCATCAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAAT......GGCAGTAGGACGCACTATGCAGACTCTGTGAAG...GGCCGATTCATCATCTCCAGAGACAATTCCAGGAACACCCTGTATCTGCAAACGAATAGCCTGAGGGCCGAGGACACGGCTGTGTATTACTGTGTGAGAAA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1224", "sequence": "ATGGAATTTGGCCTGAGCTGGGTTTTCCTTGCTGCTATTTTAAAAGGTGATTCATGAAGAACTAAGGATATTGAGTGAGTGGACATGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGATCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGTCCATCAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGCAGACTCTGTGAAGGGCCGATTCATCATCTCCAGAGACAATTCCAGGAACACCCTGTATCTGCAAACGAATAGCCTGAGGGCCGAGGACACGGCTGTGTATTACTGTGTGAGAAACACTGTGAGAGGTCGGAAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "M99666", "patch_no": "1", "gff_seqid": null, "gff_start": 140, "gff_end": 632, "strand": null }, { "sequence_id": "1225", "sequence": "ATGGAATTTGGGCTGAGCTGGGTTTTTCTTGCTGCTATTTTAAAAGGTGATTCATGAAGAACTAAGGATATTGAGTGAGTGGACATGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGATCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGTCCATCAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGCAGACTCTGTGAAGGGCCGATTCATCATCTCCAGAGACAATTCCAGGAACACCCTGTATCTGCAAACGAATAGCCTGAGGGCCGAGGACACGGCTGTGTATTACTGTGTGAGAAACACTGTGAGAGGTCGGAAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 490002, "gff_end": 490494, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample M99666\r\nVDJbase example haplotype: P1_I24 (2 exact matches)", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02672", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-69*17.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-69*17", "sequence": "GAGATAAATATAGATATATTGGTGCCCTGAGAGCATCACATAACAACCACATTCCTCCTCTGAAGAAGCCCCTGGGAGCACAGCTCATCACCATGGACTGGACCTGGAGGTTCCTCTTTGTGGTGGCAGCAGCTACAGGTAAGGGGCTTCCTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTCTCCACAGGTGTCCAGTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAAC", "coding_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "69", "allele_designation": "17", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 236, "gene_end": 531, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 225, "leader_2_end": 235, "v_rs_start": 532, "v_rs_end": 560, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTC............AGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATC......TTTGGTATAGCAAACTACGCACAGAAGTTCCAG...GGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1122", "sequence": "ATGGACTGGACCTGGAGGTTCCTCTTTGTGGTGGCAGCAGCTACAGGTAAGGGGCTTCCTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTCTCCACAGGTGTCCAGTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAAC", "repository_name": "GenBank", "repository_ref": "MH359407", "patch_no": "1", "gff_seqid": null, "gff_start": 93, "gff_end": 545, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MH359407\r\nVDJbase example haplotype: P1_I65\r\nVDJbase example haplotype: P1_I67", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02643", "allele_description_ref": "OGRDB:Homo sapiens:IGHJ5*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHJ5*02", "sequence": "AGTTCTTGCCTGGGGTCCTGGCATTGTTGTCACAATGTGACAACTGGTTCGACCCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG", "coding_sequence": "ACAACTGGTTCGACCCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "J", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "5", "subgroup_designation": null, "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 40, "gene_end": 90, "j_codon_frame": 2, "j_cdr3_end": 90, "j_rs_start": 1, "j_rs_end": 39, "unrearranged_support": [ { "sequence_id": "1056", "sequence": "AGTTCTTGCCTGGGGTCCTGGCATTGTTGTCACAATGTGACAACTGGTTCGACCCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 89117, "gff_end": 89206, "strand": null }, { "sequence_id": "1057", "sequence": "AGTTCTTGCCTGGGGTCCTGGCATTGTTGTCACAATGTGACAACTGGTTCGACCCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG", "repository_name": "GenBank", "repository_ref": "X86359", "patch_no": "1", "gff_seqid": null, "gff_start": 1839, "gff_end": 1928, "strand": null }, { "sequence_id": "1058", "sequence": "AGTTCTTGCCTGGGGTCCTGGCATTGTTGTCACAATGTGACAACTGGTTCGACCCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG", "repository_name": "GenBank", "repository_ref": "ON023005", "patch_no": "1", "gff_seqid": null, "gff_start": 115, "gff_end": 204, "strand": null }, { "sequence_id": "1059", "sequence": "AGTTCTTGCCTGGGGTCCTGGCATTGTTGTCACAATGTGACAACTGGTTCGACCCCTGGGGCCAGGGAACCCTGGTCACCGTCTCCTCAG", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 1015942, "gff_end": 1016031, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02762", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-30-4*07.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-30-4*07", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGTGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGCCACCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCCAGAGACACAATGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGCCACCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCCAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4-30", "subgroup_designation": "4", "allele_designation": "07", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 140, "gene_end": 438, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 129, "leader_2_end": 139, "v_rs_start": 439, "v_rs_end": 477, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGCCACCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCCAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGC......AGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGCCACCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCCAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1333", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGTGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGCCACCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCCAGAGACACAATGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "KC713946", "patch_no": "1", "gff_seqid": null, "gff_start": 251, "gff_end": 727, "strand": null }, { "sequence_id": "1334", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGTGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGCCACCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCCAGAGACACAATGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AC244411", "patch_no": "3", "gff_seqid": null, "gff_start": 23443, "gff_end": 23919, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample KC713946\r\nVDJbase example haplotype: P1_I47", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02973", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-25*05.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV3-25*05", "sequence": "TCGCGAGTTGTTTGCAGGTGTCCAGTGTGAGATGCAGCTGGTGGAGTCTGGGGGAGGCTTGGCAAAGCCTGCGTGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTCAGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTGGACAAGTTAATCCTAATGGGGGTAGCACATACCTCATAGACTCCGGTAAGGACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTCTATTAGTGTACCAGAGACACAGTGAGGGGAGGTCATTG", "coding_sequence": "GAGATGCAGCTGGTGGAGTCTGGGGGAGGCTTGGCAAAGCCTGCGTGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTCAGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTGGACAAGTTAATCCTAATGGGGGTAGCACATACCTCATAGACTCCGGTAAGGACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTCTATTAGTGTACCAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": false, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "25", "allele_designation": "05", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 324, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 18, "leader_2_end": 28, "v_rs_start": 325, "v_rs_end": 353, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGATGCAGCTGGTGGAGTCTGGGGGAGGCTTGGCAAAGCCTGCGTGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTCAGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTGGACAAGTTAATCCTAATGGGGGTAGCACATACCTCATAGACTCCGGTAAGGACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTCTATTAGTGTACCAGAGA", "aligned_sequence": "GAGATGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGCAAAGCCTGCGTGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTC............AGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTGGACAAGTTAATCCTAAT......GGGGGTAGCACATACCTCATAGACTCCGGTAAG...GACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTCTATTAGTGTACCAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1420", "sequence": "GTGTCCAGTGTGAGATGCAGCTGGTGGAGTCTGGGGGAGGCTTGGCAAAGCCTGCGTGGTCCCCGAGACTCTCCTGTGCAGCCTCTCAATTCACCTTCAGTAGCTACTACATGAACTGTGTCCGCCAGGCTCCAGGGAATGGGCTGGAGTTGGTTGGACAAGTTAATCCTAATGGGGGTAGCACATACCTCATAGACTCCGGTAAGGACCGATTCAATACCTCCAGAGATAACGCCAAGAACACACTTCATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCCTCTATTAGTGTACCAGAGACACAGTGAGGGGAGGTCATTG", "repository_name": "GenBank", "repository_ref": "HM855413", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 328, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855413. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (30 samples). Example subject: P25_I7.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02625", "allele_description_ref": "OGRDB:Homo sapiens:IGHD3-9*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD3-9*01", "sequence": "GGTTTAGAATGAGGTCTGTGTCACTGTGGTATTACGATATTTTGACTGGTTATTATAACCACAGTGTCACAGAGTCCATCAAAAACC", "coding_sequence": "GTATTACGATATTTTGACTGGTTATTATAAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "9", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 59, "d_rs_3_prime_start": 60, "d_rs_3_prime_end": 87, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "985", "sequence": "GGTTTAGAATGAGGTCTGTGTCACTGTGGTATTACGATATTTTGACTGGTTATTATAACCACAGTGTCACAGAGTCCATCAAAAACC", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 48484, "gff_end": 48570, "strand": null }, { "sequence_id": "986", "sequence": "GGTTTAGAATGAGGTCTGTGTCACTGTGGTATTACGATATTTTGACTGGTTATTATAACCACAGTGTCACAGAGTCCATCAAAAACC", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 118944, "gff_end": 119030, "strand": null }, { "sequence_id": "987", "sequence": "GGTTTAGAATGAGGTCTGTGTCACTGTGGTATTACGATATTTTGACTGGTTATTATAACCACAGTGTCACAGAGTCCATCAAAAACC", "repository_name": "GenBank", "repository_ref": "ON052106", "patch_no": "1", "gff_seqid": null, "gff_start": 239, "gff_end": 325, "strand": null }, { "sequence_id": "988", "sequence": "GGTTTAGAATGAGGTCTGTGTCACTGTGGTATTACGATATTTTGACTGGTTATTATAACCACAGTGTCACAGAGTCCATCAAAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 975106, "gff_end": 975192, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02645", "allele_description_ref": "OGRDB:Homo sapiens:IGHJ6*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHJ6*03", "sequence": "GGTTTTTGTGGGGTGAGGATGGACATTCTGCCATTGTGATTACTACTACTACTACTACATGGACGTCTGGGGCAAAGGGACCACGGTCACCGTCTCCTCAG", "coding_sequence": "ATTACTACTACTACTACTACATGGACGTCTGGGGCAAAGGGACCACGGTCACCGTCTCCTCAG", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "J", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "6", "subgroup_designation": null, "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 39, "gene_end": 101, "j_codon_frame": 2, "j_cdr3_end": 101, "j_rs_start": 1, "j_rs_end": 38, "unrearranged_support": [ { "sequence_id": "1062", "sequence": "GGTTTTTGTGGGGTGAGGATGGACATTCTGCCATTGTGATTACTACTACTACTACTACATGGACGTCTGGGGCAAAGGGACCACGGTCACCGTCTCCTCA", "repository_name": "GenBank", "repository_ref": "X86359", "patch_no": "1", "gff_seqid": null, "gff_start": 2444, "gff_end": 2543, "strand": null }, { "sequence_id": "1063", "sequence": "GGTTTTTGTGGGGTGAGGATGGACATTCTGCCATTGTGATTACTACTACTACTACTACATGGACGTCTGGGGCAAAGGGACCACGGTCACCGTCTCCTCAG", "repository_name": "GenBank", "repository_ref": "ON023007", "patch_no": "1", "gff_seqid": null, "gff_start": 30, "gff_end": 130, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON023007\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02730", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-49*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-49*03", "sequence": "ATGGAGTTTGGGCTTAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTAATTCATGGTGTACTAGAGATACTGAGTGTGAGGGGACATGAGTGGTAGAAACAGTGGATATGTGTGGCAGTTTCTGACCTTGGTGTTTCTGTGTTTGCAGGTGTCCAATGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCAGGGCGGTCCCTGAGACTCTCCTGTACAGCTTCTGGATTCACCTTTGGTGATTATGCTATGAGCTGGTTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTAGGTTTCATTAGAAGCAAAGCTTATGGTGGGACAACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCCAAAAGCATCGCCTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACTAGAGACACAGTGAGGGGAGGTCAATGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCAGGGCGGTCCCTGAGACTCTCCTGTACAGCTTCTGGATTCACCTTTGGTGATTATGCTATGAGCTGGTTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTAGGTTTCATTAGAAGCAAAGCTTATGGTGGGACAACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCCAAAAGCATCGCCTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACTAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "49", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 462, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 463, "v_rs_end": 501, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCAGGGCGGTCCCTGAGACTCTCCTGTACAGCTTCTGGATTCACCTTTGGTGATTATGCTATGAGCTGGTTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTAGGTTTCATTAGAAGCAAAGCTTATGGTGGGACAACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCCAAAAGCATCGCCTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACTAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCAGGGCGGTCCCTGAGACTCTCCTGTACAGCTTCTGGATTCACCTTT............GGTGATTATGCTATGAGCTGGTTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTAGGTTTCATTAGAAGCAAAGCTTATGGTGGGACAACAGAATACGCCGCGTCTGTGAAA...GGCAGATTCACCATCTCAAGAGATGATTCCAAAAGCATCGCCTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACTAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 180, "fwr3_start": 181, "fwr3_end": 294, "cdr3_start": 295, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1258", "sequence": "ATGGAGTTTGGGCTTAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTAATTCATGGTGTACTAGAGATACTGAGTGTGAGGGGACATGAGTGGTAGAAACAGTGGATATGTGTGGCAGTTTCTGACCTTGGTGTTTCTGTGTTTGCAGGTGTCCAATGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCAGGGCGGTCCCTGAGACTCTCCTGTACAGCTTCTGGATTCACCTTTGGTGATTATGCTATGAGCTGGTTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTAGGTTTCATTAGAAGCAAAGCTTATGGTGGGACAACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCCAAAAGCATCGCCTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACTAGAGACACAGTGAGGGGAGGTCAATGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AB019438", "patch_no": "1", "gff_seqid": null, "gff_start": 76144, "gff_end": 76644, "strand": null }, { "sequence_id": "1259", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCAGGGCGGTCCCTGAGACTCTCCTGTACAGCTTCTGGATTCACCTTTGGTGATTATGCTATGAGCTGGTTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTAGGTTTCATTAGAAGCAAAGCTTATGGTGGGACAACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCCAAAAGCATCGCCTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACTAGAGACACAGTGAGGGGAAGTCATTG", "repository_name": "GenBank", "repository_ref": "HM855917", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 334, "strand": null }, { "sequence_id": "1260", "sequence": "ATGGAGTTTGGGCTTAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTAATTCATGGTGTACTAGAGATACTGAGTGTGAGGGGACATGAGTGGTAGAAACAGTGGATATGTGTGGCAGTTTCTGACCTTGGTGTTTCTGTGTTTGCAGGTGTCCAATGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCAGGGCGGTCCCTGAGACTCTCCTGTACAGCTTCTGGATTCACCTTTGGTGATTATGCTATGAGCTGGTTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTAGGTTTCATTAGAAGCAAAGCTTATGGTGGGACAACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCCAAAAGCATCGCCTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACTAGAGACACAGTGAGGGGAGGTCAATGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052065", "patch_no": "1", "gff_seqid": null, "gff_start": 335, "gff_end": 835, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019438\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02652", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-24*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-24*01", "sequence": "CCCAGAGACCATCACACAACAGCCACATCCCTCCCCTACAGAAGCCCCCAGAGCGCAGCACCTCACCATGGACTGCACCTGGAGGATCCTCTTCTTGGTGGCAGCAGCTACAGGCAAGAGAATCCTGAGTTCCAGGTCTGATGAGGGGACTGGGTCCAGTTAAGTGGTGTCTCATCCACTCCTCTGTCCTCTCCACAGGCACCCACGCCCAGGTCCAGCTGGTACAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGTTTCCGGATACACCCTCACTGAATTATCCATGCACTGGGTGCGACAGGCTCCTGGAAAAGGGCTTGAGTGGATGGGAGGTTTTGATCCTGAAGATGGTGAAACAATCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCGAGGACACATCTACAGACACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCAACAGACACAGTGTGAAAACCCACATCCTGAGAGCGTCAGAAACC", "coding_sequence": "CAGGTCCAGCTGGTACAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGTTTCCGGATACACCCTCACTGAATTATCCATGCACTGGGTGCGACAGGCTCCTGGAAAAGGGCTTGAGTGGATGGGAGGTTTTGATCCTGAAGATGGTGAAACAATCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCGAGGACACATCTACAGACACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCAACAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "24", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 210, "gene_end": 505, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 199, "leader_2_end": 209, "v_rs_start": 506, "v_rs_end": 544, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCCAGCTGGTACAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGTTTCCGGATACACCCTCACTGAATTATCCATGCACTGGGTGCGACAGGCTCCTGGAAAAGGGCTTGAGTGGATGGGAGGTTTTGATCCTGAAGATGGTGAAACAATCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCGAGGACACATCTACAGACACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCAACAGA", "aligned_sequence": "CAGGTCCAGCTGGTACAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGTTTCCGGATACACCCTC............ACTGAATTATCCATGCACTGGGTGCGACAGGCTCCTGGAAAAGGGCTTGAGTGGATGGGAGGTTTTGATCCTGAA......GATGGTGAAACAATCTACGCACAGAAGTTCCAG...GGCAGAGTCACCATGACCGAGGACACATCTACAGACACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCAACAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1077", "sequence": "ATGGACTGCACCTGGAGGATCCTCTTCTTGGTGGCAGCAGCTACAGGCAAGAGAATCCTGAGTTCCAGGTCTGATGAGGGGACTGGGTCCAGTTAAGTGGTGTCTCATCCACTCCTCTGTCCTCTCCACAGGCACCCACGCCCAGGTCCAGCTGGTACAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGTTTCCGGATACACCCTCACTGAATTATCCATGCACTGGGTGCGACAGGCTCCTGGAAAAGGGCTTGAGTGGATGGGAGGTTTTGATCCTGAAGATGGTGAAACAATCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCGAGGACACATCTACAGACACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCAACAGACACAGTGTGAAAACCCACATCCTGAGAGCGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "M99642", "patch_no": "1", "gff_seqid": null, "gff_start": 68, "gff_end": 544, "strand": null }, { "sequence_id": "1078", "sequence": "CAGGGCTGATGAGGGGACTGGGTCCAGTTAAGTGGTGTCTCATCCACTCCTTTCTCTTCTCCACAGGCACCCACGCCCAGGTCCAGCTGGTACAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGTTTCCGGATACACCCTCACTGAATTATCCATGCACTGGGTGCGACAGGCTCCTGGAAAAGGGCTTGAGTGGATGGGAGGTTTTGATCCTGAAGATGGTGAAACAATCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCGAGGACACATCTACAGACACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCAACAGACACAGTGTGAAAACCCAC", "repository_name": "GenBank", "repository_ref": "MG719316", "patch_no": "1", "gff_seqid": null, "gff_start": 49, "gff_end": 439, "strand": null }, { "sequence_id": "1079", "sequence": "ATGGACTGCACCTGGAGGATCCTCTTCTTGGTGGCAGCAGCTACAGGCAAGAGAATCCTTAGTTCCAGGGCTGATGAGGGGACTGGGTCCAGTTAAGTGGTGTCTCATCCACTCCTCTGTCCTCTCCACAGGCACCCACGCCCAGGTCCAGCTGGTACAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGTTTCCGGATACACCCTCACTGAATTATCCATGCACTGGGTGCGACAGGCTCCTGGAAAAGGGCTTGAGTGGATGGGAGGTTTTGATCCTGAAGATGGTGAAACAATCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCGAGGACACATCTACAGACACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCAACAGACACAGTGTGAAAACCCACATCCTGAGAGC", "repository_name": "GenBank", "repository_ref": "ON052031", "patch_no": "1", "gff_seqid": null, "gff_start": 235, "gff_end": 701, "strand": null }, { "sequence_id": "1080", "sequence": "ATGGACTGCACCTGGAGGATCCTCTTCTTGGTGGCAGCAGCTACAGGCAAGAGAATCCTTAGTTCCAGGGCTGATGAGGGGACTGGGTCCAGTTAAGTGGTGTCTCATCCACTCCTCTGTCCTCTCCACAGGCACCCACGCCCAGGTCCAGCTGGTACAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGTTTCCGGATACACCCTCACTGAATTATCCATGCACTGGGTGCGACAGGCTCCTGGAAAAGGGCTTGAGTGGATGGGAGGTTTTGATCCTGAAGATGGTGAAACAATCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCGAGGACACATCTACAGACACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCAACAGACACAGTGTGAAAACCCACATCCTGAGAGCGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 602862, "gff_end": 603338, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample M99642\r\nVDJbase example haplotype: P1_I10_S1", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02961", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-69*13.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV1-69*13", "sequence": "ATGGACTGGACCTGGAGGGTCCTCTTTGTGGTGGCAGCTACAGGTGTCCAGTCCCAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGA", "coding_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "69", "allele_designation": "13", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 55, "gene_end": 350, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 44, "leader_2_end": 54, "v_rs_start": 351, "v_rs_end": 373, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGTCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTC............AGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATC......TTTGGTACAGCAAACTACGCACAGAAGTTCCAG...GGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1408", "sequence": "GTGTCCAGTCCCAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTG", "repository_name": "GenBank", "repository_ref": "Z14214", "patch_no": "1", "gff_seqid": null, "gff_start": 44, "gff_end": 359, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample Z14214. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (3 samples). Example subject: P25_I76.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02644", "allele_description_ref": "OGRDB:Homo sapiens:IGHJ6*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHJ6*02", "sequence": "GGTTTTTGTGGGGTGAGGATGGACATTCTGCCATTGTGATTACTACTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG", "coding_sequence": "ATTACTACTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "J", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "6", "subgroup_designation": null, "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 39, "gene_end": 101, "j_codon_frame": 2, "j_cdr3_end": 101, "j_rs_start": 1, "j_rs_end": 38, "unrearranged_support": [ { "sequence_id": "1060", "sequence": "GGTTTTTGTGGGGTGAGGATGGACATTCTGCCATTGTGATTACTACTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 89722, "gff_end": 89822, "strand": null }, { "sequence_id": "1061", "sequence": "GGTTTTTGTGGGGTGAGGATGGACATTCTGCCATTGTGATTACTACTACTACTACGGTATGGACGTCTGGGGCCAAGGGACCACGGTCACCGTCTCCTCAG", "repository_name": "GenBank", "repository_ref": "ON023006", "patch_no": "1", "gff_seqid": null, "gff_start": 30, "gff_end": 130, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02616", "allele_description_ref": "OGRDB:Homo sapiens:IGHD2-2*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD2-2*02", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGGATATTGTAGTAGTACCAGCTGCTATACCCACAGTGACACAGCCCCATTCCCAAAGC", "coding_sequence": "AGGATATTGTAGTAGTACCAGCTGCTATACC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": "Genomic only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "2", "subgroup_designation": "2", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 59, "d_rs_3_prime_start": 60, "d_rs_3_prime_end": 87, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "958", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGGATATTGTAGTAGTACCAGCTGCTATACCCACAGTGACACAGCCCCATTCCCAAAGC", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 36339, "gff_end": 36425, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02958", "allele_description_ref": "OGRDB:Homo sapiens:IGHD5-18*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHD5-18*02", "sequence": "GTGAATATAGTGGCTACGATTAC", "coding_sequence": "GTGAATATAGTGGCTACGATTAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "5", "subgroup_designation": "18", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 23, "d_rs_3_prime_start": null, "d_rs_3_prime_end": null, "d_rs_5_prime_start": null, "d_rs_5_prime_end": null, "unrearranged_support": [ { "sequence_id": "1405", "sequence": "GTGAATATAGTGGCTACGATTAC", "repository_name": "GenBank", "repository_ref": "HM774576", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 23, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM774576. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (16 samples). Example subject: p25_I30.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02983", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-4*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV4-4*01", "sequence": "TCGCGAGGGCTCACTGTGTGTTTCTCTGTTCACAGGGGTCCTGTCTCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTCCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTAGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGTGGGAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTGCTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAG", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTCCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTAGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGTGGGAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTGCTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "4", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 47, "gene_end": 342, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 36, "leader_2_end": 46, "v_rs_start": 343, "v_rs_end": 371, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTCCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTAGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGTGGGAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTGCTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTCCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGC.........AGTAGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGT.........GGGAGCACCAACTACAACCCGTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTGCTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 102, "fwr2_start": 103, "fwr2_end": 153, "cdr2_start": 154, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1430", "sequence": "GGGTCCTGTCTCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTCCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTAGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGTGGGAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTGCTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAG", "repository_name": "GenBank", "repository_ref": "HM855944", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 332, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855944. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (6 samples). Example subject: P25_I28.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02957", "allele_description_ref": "OGRDB:Homo sapiens:IGHD3-16*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHD3-16*03", "sequence": "GGTTTGAAGTGAGGTCTGTGTCACTGTGGTATTATGATTACATTTGGGGGAGTTATCGTTATACCCACAGCATCACACGGTCCATCAGAAACC", "coding_sequence": "GTATTATGATTACATTTGGGGGAGTTATCGTTATACC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "16", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 65, "d_rs_3_prime_start": 66, "d_rs_3_prime_end": 93, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "898", "sequence": "GGTTTGAAGTGAGGTCTGTGTCACTGTGGTATTATGATTACATTTGGGGGAGTTATCGTTATACCCACAGCATCACACGGTCCATCAGAAACC", "repository_name": "VDJbase", "repository_ref": "P25_I30", "patch_no": null, "gff_seqid": null, "gff_start": 1, "gff_end": 93, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on data from VDJbase subject P25_I30. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (16 samples). Example subject: P25_I30.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02641", "allele_description_ref": "OGRDB:Homo sapiens:IGHJ3*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHJ3*02", "sequence": "GGTTTGTGTCTGGGCAGGAACAGGGACTGTGTCCCTGTGTGATGCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTCTCTTCAG", "coding_sequence": "TGATGCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTCTCTTCAG", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "J", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": null, "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 40, "gene_end": 89, "j_codon_frame": 1, "j_cdr3_end": 89, "j_rs_start": 1, "j_rs_end": 39, "unrearranged_support": [ { "sequence_id": "1048", "sequence": "GGTTTGTGTCTGGGCAGGAACAGGGACTGTGTCCCTGTGTGATGCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTCTCTTCAG", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 88345, "gff_end": 88433, "strand": null }, { "sequence_id": "1049", "sequence": "GGTTTATGTCTGGGCAGGAACAGGGACTGTGTCCCTGTGTGATGCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTCTCTTCAG", "repository_name": "GenBank", "repository_ref": "X86359", "patch_no": "1", "gff_seqid": null, "gff_start": 1068, "gff_end": 1156, "strand": null }, { "sequence_id": "1050", "sequence": "GGTTTATGTCTGGGCAGGAACAGGGACTGTGTCCCTGTGTGATGCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTCTCTTCAG", "repository_name": "GenBank", "repository_ref": "ON023003", "patch_no": "1", "gff_seqid": null, "gff_start": 37, "gff_end": 125, "strand": null }, { "sequence_id": "1051", "sequence": "GGTTTATGTCTGGGCAGGAACAGGGACTGTGTCCCTGTGTGATGCTTTTGATATCTGGGGCCAAGGGACAATGGTCACCGTCTCTTCAG", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 1015170, "gff_end": 1015258, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00010", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-59*12.4_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 4, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-59*12", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": "A", "aliases": [ "IGHV4-59*i01" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "59", "allele_designation": "12", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 292, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATC............AGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGT.........GGGAGCACCAACTACAACCCCTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1374", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "repository_name": "GenBank", "repository_ref": "MK321692", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 292, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "This sequence represents IGHV4-59*01 T288C in terms of the IMGT numbering system. The committee noted a rearrangement frequency of about 1.7%, with 1515 alignments including 341 perfect matches to the inferred allele. IGHV4-59*01 is also present in the genotype and is represented by larger number of reads than IGHV4-59*01 T288C (ratio: 17:83). The S0007 submission noted that haplotyping was not possible, but MC indicated that it was possible to haplotype this individual using the IGHJ4 locus. He suggested that a previously unreported J4 allele was present in this individual, and agreed to send his analysis to members of the committee. Diverse reads representing the IGHV4-59*01 T288C inference have been submitted to SRA/ENA under accession numbers SRR8298738 and SRR8298744. All members of the committee agreed that the sequence should be accepted as a Level 1 sequence at IARC Meeting 31 on February 8th, 2019. In line with previous policy, the submitted sequence will be recognized up to and including nucleotide 319.\r\n\r\n(April 12, 2019) A trailing \".\" in the sequence indicates IARC's opinion that the sequence is likely to contain additional 3' nucleotides for which there is insufficient evidence to make an affirmation.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MK321692\r\nVDJbase example haplotype: P1_I64\r\nMapped by IARC haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02770", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-4*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-4*02", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTCCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGGGGTATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCTCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTAGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGTGGGAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTAGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGTGGGAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "4", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 140, "gene_end": 435, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 129, "leader_2_end": 139, "v_rs_start": 436, "v_rs_end": 474, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTAGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGTGGGAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGC.........AGTAGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGT.........GGGAGCACCAACTACAACCCGTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 102, "fwr2_start": 103, "fwr2_end": 153, "cdr2_start": 154, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1358", "sequence": "GGGTCCTGTCTCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTAGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGTGGGAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCTCG", "repository_name": "GenBank", "repository_ref": "HM855888", "patch_no": "1", "gff_seqid": null, "gff_start": 29, "gff_end": 364, "strand": null }, { "sequence_id": "1359", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTCCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGGGGTATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCTCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTAGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGTGGGAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052086", "patch_no": "1", "gff_seqid": null, "gff_start": 268, "gff_end": 741, "strand": null }, { "sequence_id": "1360", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTCCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGGGGTATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCTCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTAGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGTGGGAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 867489, "gff_end": 867962, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052086\r\nVDJbase example haplotype: P1_I12\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02628", "allele_description_ref": "OGRDB:Homo sapiens:IGHD4-23*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD4-23*01", "sequence": "GCTTTTTGTGAAGGGCCCTCCTGCTGTGTGACTACGGTGGTAACTCCCACAGTGATGAAACCAGCAGCAAAAACT", "coding_sequence": "TGACTACGGTGGTAACTCC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "23", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 47, "d_rs_3_prime_start": 48, "d_rs_3_prime_end": 75, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "997", "sequence": "GCTTTTTGTGAAGGGCCCTCCTGCTGTGTGACTACGGTGGTAACTCCCACAGTGATGAAACCAGCAGCAAAAACT", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 68306, "gff_end": 68380, "strand": null }, { "sequence_id": "998", "sequence": "GCTTTTTGTGAAGGGCCCTCCTGCTGTGTGACTACGGTGGTAACTCCCACAGTGATGAAACCAGCAGCAAAAACT", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 138765, "gff_end": 138839, "strand": null }, { "sequence_id": "999", "sequence": "GCTTTTTGTGAAGGGCCCTCCTGCTGTGTGACTACGGTGGTAACTCCCACAGTGATGAAACCAGCAGCAAAAACT", "repository_name": "GenBank", "repository_ref": "ON052109", "patch_no": "1", "gff_seqid": null, "gff_start": 75, "gff_end": 149, "strand": null }, { "sequence_id": "1000", "sequence": "GCTTTTTGTGAAGGGCCCTCCTGCTGTGTGACTACGGTGGTAACTCCCACAGTGATGAAACCAGCAGCAAAAACT", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 994929, "gff_end": 995003, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02974", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-33*06.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV3-33*06", "sequence": "TTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAAAGACACAGTGAGGGGAGGTCAGTGCTCGCGA", "coding_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAAAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "33", "allele_designation": "06", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 22, "gene_end": 317, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 11, "leader_2_end": 21, "v_rs_start": 318, "v_rs_end": 346, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAAAGA", "aligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTC............AGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGAT......GGAAGTAATAAATACTATGCAGACTCCGTGAAG...GGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAAAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1421", "sequence": "GTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAAAGACACAGTGAGGGGAGGTCAGTGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855436", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 345, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855436. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (25 samples). Example subject: P25_I9.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02691", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-13*05.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-13*05", "sequence": "CTCAGATGTCCCACCCCAGAGCTTGCTATATAGTAACAGACATGCAAATAGTTGACTCCCTCTCCTGATGAAAACCAGCCCAGCCCTGACCCTGCAGCTCTGGGAGTGGAGCCCCAGCCTTGGGATTCCCAAGTGTTTGTATTCAGTGATCAGGACTGAACACACAGGACTCACCATGGAGTTGGGGCTGAGCTGGGTTTTCCTTGTTGCTATATTAGAAGGTGATTCATGGAGAACTAGAGATATTGAGTGTGAATGGGCATGAATGAGAGAAACAGTGGGTATGTGTGGCAATTTCTGACTTTTGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAGTGGGTCTCAGCTATTGGTACTGCTGGTGACCCATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGGGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGGAAGTCAGTATGAGCCCAGA", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAGTGGGTCTCAGCTATTGGTACTGCTGGTGACCCATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGGGGACACGGCTGTGTATTACTGTGCAAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "13", "allele_designation": "05", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 336, "gene_end": 628, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 325, "leader_2_end": 335, "v_rs_start": 629, "v_rs_end": 659, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAGTGGGTCTCAGCTATTGGTACTGCTGGTGACCCATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGGGGACACGGCTGTGTATTACTGTGCAAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAGTGGGTCTCAGCTATTGGTACTGCT.........GGTGACCCATACTATCCAGGCTCCGTGAAG...GGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGGGGACACGGCTGTGTATTACTGTGCAAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1164", "sequence": "ATGGAGTTGGGGCTGAGCTGGGTTTTCCTTGTTGCTATATTAGAAGGTGATTCATGGAGAACTAGAGATATTGAGTGTGAATGGGCATGAATGAGAGAAACAGTGGGTATGTGTGGCAATTTCTGACTTTTGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAGTGGGTCTCAGCTATTGGTACTGCTGGTGACCCATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGGGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGGAAGTCAGTATGAGCCCA", "repository_name": "GenBank", "repository_ref": "ON052049", "patch_no": "1", "gff_seqid": null, "gff_start": 176, "gff_end": 657, "strand": null }, { "sequence_id": "1165", "sequence": "ATGGAGTTGGGGCTGAGCTGGGTTTTCCTTGTTGCTATATTAGAAGGTGATTCATGGAGAACTAGAGATATTGAGTGTGAATGGGCATGAATGAGAGAAACAGTGGGTATGTGTGGCAATTTCTGACTTTTGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAGTGGGTCTCAGCTATTGGTACTGCTGGTGACCCATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGGGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGGAAGTCAGTATGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 749853, "gff_end": 750344, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052049\r\nVDJbase example haplotype: P1_I27_S1", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02646", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-18*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-18*01", "sequence": "CAAACACCCCTCCTTGGGAGAATCCCCTAGATCACAGCTCCTCACCATGGACTGGACCTGGAGCATCCTTTTCTTGGTGGCAGCACCAACAGGTAACGGACTCCCCAGTCCCAGGGCTGAGAGAGAAACCAGGCCAGTCATGTGAGACTTCACCCACTCCTGTGTCCTCTCCACAGGTGCCCACTCCCAGGTTCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTACCAGCTATGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTACAATGGTAACACAAACTATGCACAGAAGCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGGGTTTCAGAAACC", "coding_sequence": "CAGGTTCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTACCAGCTATGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTACAATGGTAACACAAACTATGCACAGAAGCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "18", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 188, "gene_end": 483, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 177, "leader_2_end": 187, "v_rs_start": 484, "v_rs_end": 522, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTTCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTACCAGCTATGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTACAATGGTAACACAAACTATGCACAGAAGCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTTCAGCTGGTGCAGTCTGGAGCT...GAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTT............ACCAGCTATGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTAC......AATGGTAACACAAACTATGCACAGAAGCTCCAG...GGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1064", "sequence": "ATGGACTGGACCTGGAGCATCCTTTTCTTGGTGGCAGCACCAACAGGTAACGGACTCCCCAGTCCCAGGGCTGAGAGAGAAACCAGGCCAGTCATGTGAGACTTCACCCACTCCTGTGTCCTCTCCACAGGTGCCCACTCCCAGGTTCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTACCAGCTATGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTACAATGGTAACACAAACTATGCACAGAAGCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGGGTTTCAGAAACC", "repository_name": "GenBank", "repository_ref": "M99641", "patch_no": "1", "gff_seqid": null, "gff_start": 47, "gff_end": 522, "strand": null }, { "sequence_id": "1065", "sequence": "GTGTCCACTCCCAGGTTCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTACCAGCTATGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTACAATGGTAACACAAACTATGCACAGAAGCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCACATCCT", "repository_name": "GenBank", "repository_ref": "HM855840", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 329, "strand": null }, { "sequence_id": "1066", "sequence": "ATGGACTGGACCTGGAGCATCCTTTTCTTGGTGGCAGCAGCAACAGGTAACGGACTCCCCAGTCCCAGGGCTGAGAGAGAAACCAGGCCAGTCATGTGAGACTTCACCCACTCCTGTGTCCTCTCCACAGGTGCCCACTCCCAGGTTCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTACCAGCTATGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTACAATGGTAACACAAACTATGCACAGAAGCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAG", "repository_name": "GenBank", "repository_ref": "ON052029", "patch_no": "1", "gff_seqid": null, "gff_start": 208, "gff_end": 670, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample M99641\r\nVDJbase example haplotype: P1_I10_S1", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02712", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-30*04.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-30*04", "sequence": "GCCCTCCCTCTACTGATGAAAACCAGCCCAGCCCTGACCCTGCAGCTCTGGGAGACGAGCCCAGCACTGGAAGTCGCCGGTGTTTCCATTCGGTGATCAGCACTGAACACAGAGGACTCACCATGGAGTTTGGGCTGAGCTGGGTTTTCCTCGTTGCTCTTTTAAGAGGTGATTCATGGAGAAATAGAGAGACTGAGTGTGAGTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCATTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCATTGTGCGCCCAGACACAAACC", "coding_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "30", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 281, "gene_end": 576, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 270, "leader_2_end": 280, "v_rs_start": 577, "v_rs_end": 615, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGAT......GGAAGTAATAAATACTACGCAGACTCCGTGAAG...GGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1214", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTCGTTGCTCTTTTAAGAGGTGATTCATGGAGAAATAGAGAGACTGAGTGTGAGTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCATTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCATTGTGCGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052057", "patch_no": "1", "gff_seqid": null, "gff_start": 123, "gff_end": 615, "strand": null } ], "rearranged_support": [], "paralogs": [ "IGHV3-30-3*03" ], "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052057\r\nVDJbase example haplotype: P1_I29\r\nVDJbase example haplotype: P1_I10", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02960", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-69*05.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV1-69*05", "sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCACGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGATCTCCTACAATTGTGACGAGAGA", "coding_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCACGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "69", "allele_designation": "05", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 296, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": 297, "v_rs_end": 319, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCACGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTC............AGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATC......TTTGGTACAGCAAACTACGCACAGAAGTTCCAG...GGCAGAGTCACGATTACCACGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1407", "sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCACGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGATCTCCTACAATTGTGACGAGAGA", "repository_name": "GenBank", "repository_ref": "AC279960", "patch_no": "1", "gff_seqid": null, "gff_start": 8443, "gff_end": 8147, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AC279960. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (5 samples). Example subject: P25_I78.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02729", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-48*04.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-48*04", "sequence": "ATGGAGTTGGGGCTGTGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGATTCATGGAAAACTAGAGAGATTTAGTGTGTGTGGATATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGATCTTGGTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "48", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 456, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 457, "v_rs_end": 495, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGT......AGTAGTACCATATACTACGCAGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1256", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAATG", "repository_name": "GenBank", "repository_ref": "HM855904", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 328, "strand": null }, { "sequence_id": "1257", "sequence": "ATGGAGTTGGGGCTGTGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGATTCATGGAAAACTAGAGAGATTTAGTGTGTGTGGATATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGATCTTGGTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATAGCATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052064", "patch_no": "1", "gff_seqid": null, "gff_start": 269, "gff_end": 763, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052064\r\nVDJbase example haplotype: P1_I22_S1\r\nMapped by P1_I22 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00044", "allele_description_ref": "OGRDB:Homo sapiens:IGHV2-70*20.2_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 2, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV2-70*20", "sequence": "CAGGTCACCTTGAGGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGTGTGTGAGCTGGGTCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACTCATTGATTGGGATGATGATAAATACTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGA", "coding_sequence": "CAGGTCACCTTGAGGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGTGTGTGAGCTGGGTCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACTCATTGATTGGGATGATGATAAATACTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATAC", "ext_3prime": "TAC", "aliases": [ "IGHV2-70*i01" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "2", "subgroup_designation": "70", "allele_designation": "20", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 298, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCACCTTGAGGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGTGTGTGAGCTGGGTCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACTCATTGATTGGGATGATGATAAATACTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATAC", "aligned_sequence": "CAGGTCACCTTGAGGGAGTCTGGTCCT...GCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGC......ACTAGTGGAATGTGTGTGAGCTGGGTCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACTCATTGATTGGGAT.........GATGATAAATACTACAGCACATCTCTGAAG...ACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATAC", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1147", "sequence": "CAGGTCACCTTGAGGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGTGTGTGAGCTGGGTCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACTCATTGATTGGGATGATGATAAATACTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGA", "repository_name": "GenBank", "repository_ref": "MK471379", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 298, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Assessed by IARC on November 18, 2019 during meeting 45.\r\n\r\nThe committee considered IGHV2-70*01_S6619 (A124G) of Genotype B12 of submission S00010, which was previously evaluated as IGHV2-70*01_S4660 of submission S00004 at Meeting 8. It was affirmed as a Level 0 sequence at that time. \r\n\r\nThe sequence was seen in just 0.05% of all unmutated rearrangements, with 296 sequences including 93 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. Two other alleles were present in the genotype, and it is possible that one of these three sequences is an IGHV2-70D sequence. Haplotype data is supportive of the inference, but in light of the very low frequency of rearrangements seen and the complicated haplotype of this subject, it was affirmed as a Level 0 sequence. The sequence was affirmed up to and including nucleotide 319 even though alleles of IGHV2-70/IGHV2-70D in general extend up to and including base 322. However, the nucleotide composition of the subsequent three bases of genes associated with this inferred allele did not support their inference. It is however likely that three additional 3\u2019 nucleotides are present in the sequence, and this is indicated in IARC and OGRDB publications by three dots at the end of the sequence.\r\n\r\nAt the IARC Meeting 68, April 26th 2021, it was agreed that sequences affirmed by the IARC as Level 0 sequences, that subsequently have entered the IMGT germline gene database by other means, should be elevated to Level 1.\r\n\r\nAt the IARC Meeting 69, May 18th 2021, IGHV2-70*i01 was elevated to Level 1. This sequence was incorporated into the IMGT germline gene database as a consequence of the IMGT-NC Report #2020-2-1008 (October 8th, 2020). The sequence was submitted to IMGT by Abdullah Gamal Dorgham, William Sinclair Gibson, Oscar Rodriguez and Corey Watson. The sequence recorded in OGRDB remains the sequence that was affirmed as the original IGHV2-70*i01 sequence. The sequence that is now recognized as IGHV2-70*20 includes the final three nucleotides of the sequence - TAC.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MK471379\r\nMapped by IARC haplotype", "curational_tags": [ "likely_truncated" ] }, { "allele_description_id": "OGRDB:A02763", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-31*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-31*01", "sequence": "TCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCTAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGACACA", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCTAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "31", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 27, "gene_end": 325, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 16, "leader_2_end": 26, "v_rs_start": 326, "v_rs_end": 348, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCTAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGC......AGTGGTGGTTACTACTGGAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCTAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1337", "sequence": "GGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCTAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGACAC", "repository_name": "GenBank", "repository_ref": "L10098", "patch_no": "1", "gff_seqid": null, "gff_start": 16, "gff_end": 328, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample L10098\r\nVDJbase example haplotype: P1_I40\r\nVDJbase example haplotype: P1_I100\r\nMapped by P1_I23 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02633", "allele_description_ref": "OGRDB:Homo sapiens:IGHD5-5*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD5-5*01", "sequence": "GGTTATTGTCAGGGGGTGTCAGACTGTGGTGGATACAGCTATGGTTACCACAGTGGTGCTGCCCATAGCAGCAACC", "coding_sequence": "GTGGATACAGCTATGGTTAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "5", "subgroup_designation": "5", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 48, "d_rs_3_prime_start": 49, "d_rs_3_prime_end": 76, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "1016", "sequence": "GGTTATTGTCAGGGGGTGTCAGACTGTGGTGGATACAGCTATGGTTACCACAGTGGTGCTGCCCATAGCAGCAACC", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 40919, "gff_end": 40994, "strand": null }, { "sequence_id": "1017", "sequence": "GGTTATTGTCAGGGGGTGTCAGACTGTGGTGGATACAGCTATGGTTACCACAGTGGTGCTGCCCATAGCAGCAACC", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 111378, "gff_end": 111453, "strand": null }, { "sequence_id": "1018", "sequence": "GGTTATTGTCAGGGGGTGTCAGACTGTGGTGGATACAGCTATGGTTACCACAGTGGTGCTGCCCATAGCAGCAACC", "repository_name": "GenBank", "repository_ref": "ON052113", "patch_no": "1", "gff_seqid": null, "gff_start": 135, "gff_end": 210, "strand": null }, { "sequence_id": "1019", "sequence": "GGTTATTGTCAGGGGGTGTCAGACTGTGGTGGATACAGCTATGGTTACCACAGTGGTGCTGCCCATAGCAGCAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 967541, "gff_end": 967616, "strand": null } ], "rearranged_support": [], "paralogs": [ "IGHD5-18*01" ], "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02783", "allele_description_ref": "OGRDB:Homo sapiens:IGHV7-4-1*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV7-4-1*02", "sequence": "GATCCTCTTCTTGGTGGCAGCAGCAACAGGTAAGGGGCTCCCCAGTCACTGGGCTGAGGGAGAAACCAGCACAGTCAAGTGAGACTTCATGCACTCCCATCTCCTCTCCACAGGTGCCCACTCCCAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCACGGCATATCTGCAGATCAGCAGCCTAAAGGCTGAGGACACTGCCGTGTATTACTGTGCGAGAGACACAGTGTGGAAACCCAC", "coding_sequence": "CAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCACGGCATATCTGCAGATCAGCAGCCTAAAGGCTGAGGACACTGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "7-4", "subgroup_designation": "1", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 125, "gene_end": 420, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 114, "leader_2_end": 124, "v_rs_start": 421, "v_rs_end": 449, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCACGGCATATCTGCAGATCAGCAGCCTAAAGGCTGAGGACACTGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGCAATCTGGGTCT...GAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTC............ACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAAC......ACTGGGAACCCAACGTATGCCCAGGGCTTCACA...GGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCACGGCATATCTGCAGATCAGCAGCCTAAAGGCTGAGGACACTGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1397", "sequence": "CTGGGCTGAGGGAGAAACCAGCACAGTCAAGTGAGACTTCATGCACTCCCATCTCCTCTCCACAGGTGCCCACTCCCAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCACGGCATATCTGCAGATCAGCAGCCTAAAGGCTGAGGACACTGCCGTGTATTACTGTGCGAGAGACACAGTGTGGAAACCCAC", "repository_name": "GenBank", "repository_ref": "MG719329", "patch_no": "1", "gff_seqid": null, "gff_start": 49, "gff_end": 438, "strand": null }, { "sequence_id": "1398", "sequence": "GTGTCCACTCCCAGGTGCAGCTGGTGCAATCTGGGTCTGAGTTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGAATTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACACCAACACTGGGAACCCAACGTATGCCCAGGGCTTCACAGGACGGTTTGTCTTCTCCTTGGACACCTCTGTCAGCACGGCATATCTGCAGATCAGCAGCCTAAAGGCTGAGGACACTGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAAACCACATCCT", "repository_name": "GenBank", "repository_ref": "HM855930", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 330, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MG719329\r\nVDJbase example haplotype: P1_I70", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00050", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-69*18.2_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 2, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-69*18", "sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAG", "coding_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": "A", "aliases": [ "IGHV1-69*i02" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "69", "allele_designation": "18", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 295, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTC............AGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATC......TTTGGTACAGCAAACTACGCACAGAAGTTCCAG...GGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1123", "sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAG", "repository_name": "GenBank", "repository_ref": "MK471382", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 295, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Assessed by IARC on November 18, 2019 during meeting 45 and on December 2, 2019 during meeting 46.\r\n\r\nThe committee considered IGHV1-69*01_S7220 (G163A) of submission S00010 of Genotype B16, which was previously evaluated as IGHV1-69*01_S5096 of submission S00006 at Meeting 10. It was affirmed as a Level 0 sequence at that time.\r\n\r\nThe sequence was seen in 8.02% of all unmutated rearrangements, with 53668 sequences including 22586 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. Three other alleles were present in the genotype, with IGHV1-69*02 also being present in the haplotype with this allele, likely a consequence of the presence of the IGHV1-69D gene in the haplotype in question. The inferred sequence includes six differences to the *02 allele. Haplotype data is supportive of the inference. There was strong support for the sequence being affirmed up to and including nucleotide 319, in line with IARC policy, as a Level 1 sequence, with one additional 3\u2019 nucleotide being likely present in the sequence. This is indicated in IARC and OGRDB publications by one dot at the end of the sequence. It is noted that this sequences represents a 5\u2019- and a 3\u2019-extension of the partial allele IGHV1-69*07 already recognized by IMGT.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MK471382", "curational_tags": [ "likely_truncated" ] }, { "allele_description_id": "OGRDB:A02664", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-69*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-69*01", "sequence": "ATTCCTCCTCTAAAGAAGCCCCTGGGAGCACAGCTCATCACCATGGACTGGACCTGGAGGTTCCTCTTTGTGGTGGCAGCAGCTACAGGTAAGGGGCTTCCTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTCTCCACAGGTGTCCAGTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGAGTGT", "coding_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "69", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 186, "gene_end": 481, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 175, "leader_2_end": 185, "v_rs_start": 482, "v_rs_end": 512, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTC............AGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATC......TTTGGTACAGCAAACTACGCACAGAAGTTCCAG...GGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1110", "sequence": "ATGGACTGGACCTGGAGGTTCCTCTTTGTGGTGGCAGCAGCTACAGGTAAGGGGCTTCCTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTCTCCACAGGTGTCCAGTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGAGT", "repository_name": "GenBank", "repository_ref": "ON052038", "patch_no": "1", "gff_seqid": null, "gff_start": 43, "gff_end": 510, "strand": null } ], "rearranged_support": [], "paralogs": [ "IGHV1-69D*01" ], "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052038\r\nVDJbase example haplotype: P1_I22_S1\r\nMapped by P1_I22 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02777", "allele_description_ref": "OGRDB:Homo sapiens:IGHV5-10-1*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV5-10-1*01", "sequence": "ATGGGGTCAACCGCCATCCTTGGCCTCCTCCTGGCTGTTCTCCAAGGTCAGTCCTGCCGAGGGCTTGAGGTCACAGAGGAGAACGGGTGGAAAGCAACTCCTGATTCAAATTTTGTGTCTTCCATACAGGAGTCTGTGCCGAAGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAGGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCAGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGAGGATTGATCCTAGTGACTCTTATACCAACTACAGCCCGTCCTTCCAAGGCCACGTCACCATCTCAGCTGACAAGTCCATCAGCACTGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACACACAGTGAGAGAAACCAGCACTGAGCCCGTCTAAAACC", "coding_sequence": "GAAGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAGGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCAGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGAGGATTGATCCTAGTGACTCTTATACCAACTACAGCCCGTCCTTCCAAGGCCACGTCACCATCTCAGCTGACAAGTCCATCAGCACTGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "5-10", "subgroup_designation": "1", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 141, "gene_end": 436, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 130, "leader_2_end": 140, "v_rs_start": 437, "v_rs_end": 474, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAAGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAGGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCAGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGAGGATTGATCCTAGTGACTCTTATACCAACTACAGCCCGTCCTTCCAAGGCCACGTCACCATCTCAGCTGACAAGTCCATCAGCACTGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACA", "aligned_sequence": "GAAGTGCAGCTGGTGCAGTCTGGAGCA...GAGGTGAAAAAGCCCGGGGAGTCTCTGAGGATCTCCTGTAAGGGTTCTGGATACAGCTTT............ACCAGCTACTGGATCAGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGAGGATTGATCCTAGT......GACTCTTATACCAACTACAGCCCGTCCTTCCAA...GGCCACGTCACCATCTCAGCTGACAAGTCCATCAGCACTGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1383", "sequence": "ATGGGGTCAACCGCCATCCTTGGCCTCCTCCTGGCTGTTCTCCAAGGTCAGTCCTGCCGAGGGCTTGAGGTCACAGAGGAGAACGGGTGGAAAGCAACTCCTGATTCAAATTTTGTGTCTTCCATACAGGAGTCTGTGCCGAAGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAGGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCAGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGAGGATTGATCCTAGTGACTCTTATACCAACTACAGCCCGTCCTTCCAAGGCCACGTCACCATCTCAGCTGACAAGTCCATCAGCACTGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACACACAGTGAGAGAAACCAGCACTGAGCCCGTCTAAAACC", "repository_name": "GenBank", "repository_ref": "ON360771", "patch_no": "1", "gff_seqid": null, "gff_start": 76619, "gff_end": 77092, "strand": null }, { "sequence_id": "1384", "sequence": "ATGGGGTCAACCGCCATCCTCGCCCTCCTCCTGGCTGTTCTCCAAGGTCAGTCCTGCCGAGGGCTTGAGGTCACAGAGGAGAACGGGTGGAAAGCAACTCCTGATTCAAATTTTGTGTCTTCCATACAGGAGTCTGTGCCGAAGTGCAGCTGGTGCAGTCCGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAGGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCAGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGAGGATTGATCCTAGTGACTCTTATACCAACTACAGCCCGTCCTTCCAAGGCCACGTCACCATCTCAGCTGACAAGTCCATCAGCACTGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACACACAGTGAGAGAAACCAGCACTGAGCCCGTCTAAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676", "patch_no": null, "gff_seqid": null, "gff_start": 771438, "gff_end": 771911, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON360771\r\nVDJbase example haplotype: P1_I15\r\nVDJbase example haplotype: P1_I52\r\nFour nucleotide truncation at 3' end", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02963", "allele_description_ref": "OGRDB:Homo sapiens:IGHV2-26*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV2-26*02", "sequence": "TCCTCTGGGTTCAAAAGCCGAGCACGGGGCCTCGCTCAGTGACTCCTGTGCCCCACCATGGACACGCTTTGCTACACACTCCTGCTGCTGACCACCCCTTCCTGTGAGTGCTGTGGTCAGGGACTTCCTCAGAAGCGAAACATCAGTTGTCTCCTTTGTGGGCTTCATCTCCTTATGTCTTCTCCACAGGGGTCTTGTCCCAGGTCACCTTGAAGGAGTCTGGTCCTGTGCTGGTGAAACCCACAGAGACCCTCACGCTGACCTGCACCGTCTCTGGGTTCTCACTCAGCAATGCTAGAATGGGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACACATTTTTTCGAATGACGAAAAATCCTACAGCACATCTCTGAAGAGCAGGCTCACCATCTCCAAGGACACCTCCAAAAGCCAGGTGGTCCTTACCATGACCAATATGGACCCTGTGGACACAGCCACATATTACTGTGCACGGATACCACAGAGACACAGCCCAGGATGCCTCCTGTACAAGAACC", "coding_sequence": "CAGGTCACCTTGAAGGAGTCTGGTCCTGTGCTGGTGAAACCCACAGAGACCCTCACGCTGACCTGCACCGTCTCTGGGTTCTCACTCAGCAATGCTAGAATGGGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACACATTTTTTCGAATGACGAAAAATCCTACAGCACATCTCTGAAGAGCAGGCTCACCATCTCCAAGGACACCTCCAAAAGCCAGGTGGTCCTTACCATGACCAATATGGACCCTGTGGACACAGCCACATATTACTGTGCACGGATAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "2", "subgroup_designation": "26", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 201, "gene_end": 501, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 190, "leader_2_end": 200, "v_rs_start": 502, "v_rs_end": 540, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCACCTTGAAGGAGTCTGGTCCTGTGCTGGTGAAACCCACAGAGACCCTCACGCTGACCTGCACCGTCTCTGGGTTCTCACTCAGCAATGCTAGAATGGGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACACATTTTTTCGAATGACGAAAAATCCTACAGCACATCTCTGAAGAGCAGGCTCACCATCTCCAAGGACACCTCCAAAAGCCAGGTGGTCCTTACCATGACCAATATGGACCCTGTGGACACAGCCACATATTACTGTGCACGGATAC", "aligned_sequence": "CAGGTCACCTTGAAGGAGTCTGGTCCT...GTGCTGGTGAAACCCACAGAGACCCTCACGCTGACCTGCACCGTCTCTGGGTTCTCACTCAGC......AATGCTAGAATGGGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACACATTTTTTCGAAT.........GACGAAAAATCCTACAGCACATCTCTGAAG...AGCAGGCTCACCATCTCCAAGGACACCTCCAAAAGCCAGGTGGTCCTTACCATGACCAATATGGACCCTGTGGACACAGCCACATATTACTGTGCACGGATAC", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1410", "sequence": "ATGGACACGCTTTGCTACACACTCCTGCTGCTGACCACCCCTTCCTGTGAGTGCTGTGGTCAGGGACTTCCTCAGAAGCGAAACATCAGTTGTCTCCTTTGTGGGCTTCATCTCCTTATGTCTTCTCCACAGGGGTCTTGTCCCAGGTCACCTTGAAGGAGTCTGGTCCTGTGCTGGTGAAACCCACAGAGACCCTCACGCTGACCTGCACCGTCTCTGGGTTCTCACTCAGCAATGCTAGAATGGGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACACATTTTTTCGAATGACGAAAAATCCTACAGCACATCTCTGAAGAGCAGGCTCACCATCTCCAAGGACACCTCCAAAAGCCAGGTGGTCCTTACCATGACCAATATGGACCCTGTGGACACAGCCACATATTACTGTGCACGGATACCACAGAGACACAGCCCAGGATGCCTCCTGTACAAGAACC", "repository_name": "GenBank", "repository_ref": "MG719335", "patch_no": "1", "gff_seqid": null, "gff_start": 58, "gff_end": 540, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MG719335. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (6 samples). Example subject: P25_I69.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02624", "allele_description_ref": "OGRDB:Homo sapiens:IGHD3-3*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD3-3*01", "sequence": "GGTTTGGGGTGAGGTCTGTGTCACTGTGGTATTACGATTTTTGGAGTGGTTATTATACCCACAGTGTCACAGAGTCCATCAAAAACC", "coding_sequence": "GTATTACGATTTTTGGAGTGGTTATTATACC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "3", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 59, "d_rs_3_prime_start": 60, "d_rs_3_prime_end": 87, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "981", "sequence": "GGTTTGGGGTGAGGTCTGTGTCACTGTGGTATTACGATTTTTGGAGTGGTTATTATACCCACAGTGTCACAGAGTCCATCAAAAACC", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 38806, "gff_end": 38892, "strand": null }, { "sequence_id": "982", "sequence": "GGTTTGGGGTGAGGTCTGTGTCACTGTGGTATTACGATTTTTGGAGTGGTTATTATACCCACAGTGTCACAGAGTCCATCAAAAACC", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 109265, "gff_end": 109351, "strand": null }, { "sequence_id": "983", "sequence": "GGTTTGGGGTGAGGTCTGTGTCACTGTGGTATTACGATTTTTGGAGTGGTTATTATACCCACAGTGTCACAGAGTCCATCAAAAACC", "repository_name": "GenBank", "repository_ref": "ON052105", "patch_no": "1", "gff_seqid": null, "gff_start": 131, "gff_end": 217, "strand": null }, { "sequence_id": "984", "sequence": "GGTTTGGGGTGAGGTCTGTGTCACTGTGGTATTACGATTTTTGGAGTGGTTATTATACCCACAGTGTCACAGAGTCCATCAAAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 965428, "gff_end": 965514, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02567", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-61*i04.2_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 2, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-61*i04", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAGGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAG", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAGGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": "A", "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "61", "allele_designation": "i04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 298, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAGGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAGGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGC......AGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGT.........GGGAGCACCAACTACAACCCCTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1382", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAGGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGA", "repository_name": "GenBank", "repository_ref": "OX384050", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 297, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "The inference of IGHV4-61*01_A41G was considered at IARC meeting 116 on Feb 27th, 2023.\r\n\r\nIGHV4-61*01_A41G has been inferred in one genotype (P1_I23) in VDJbase P1 data set. The genotype also carries IGHV4-61*01. IGHV4-61*01_A41G represents 0.32% of the total unmutated population. It is represented by 91 unmutated error-free sequences and 91 unique CDR3s of different lengths in the error-free set. Haplotyping based on allelic diversity in IGHJ6 demonstrates association of the haplotype defined by IGHJ6*02 (100:0 ratio) (IGHV4-61*01 shows a haplotype ratio of 7:93).\r\n\r\nOther genes carry alleles defined by IMGT, alleles that are highly similar to IGHV4-61*01 A41G. These genes include IGHV4-59 and IGHV4-4 (>97% sequence identity). In no case do these alleles carry the A41G SNP.\r\n\r\nIARC affirms the sequence as IGHV4-61*i04 at Level 1 up to and including base 319. It is acknowledged that the allele most likely carries 1 additional base, typically A, at base positions 320. Trailing \u201c.\u201d indicates IARC\u2019s opinion that the sequence is likely to contain additional 3\u2019-nucleotides for which there is insufficient evidence to make an affirmation. For use in a reference germline gene set, IARC recommends the use of the expected full length sequence.\r\n\r\n>IGHV4-61*i04\r\nCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAGGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAG.\r\n\r\nThe locus on chromosome 14 that carries human IGHV genes is highly complex. Genes may be duplicated or deleted, and identical sequences may be found in more than one gene. The name (with an \u201ci\u201d allele designation) of an inferred allele does not imply that its precise genetic location is known. It just relates to the most similar allele presently found in the IMGT database, or to the gene with the lowest alphanumeric value, should alleles of multiple genes be equally matched to the novel allele in question. Other similar genes have been mentioned above.\r\n\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample OX384050", "curational_tags": [ "likely_truncated" ] }, { "allele_description_id": "OGRDB:A02679", "allele_description_ref": "OGRDB:Homo sapiens:IGHV2-5*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV2-5*01", "sequence": "ATGGACACACTTTGCTCCACGCTCCTGCTGCTGACCATCCCTTCATGTGAGTGCTGTGGTCAGGGACTCCTTCACGGGTGAAACATCAGTTTTCTTGTTTGTGGGCTTCATCTTCTTATGCTTTCTCCACAGGGGTCTTGTCCCAGATCACCTTGAAGGAGTCTGGTCCTACGCTGGTGAAACCCACACAGACCCTCACGCTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAGTGGGTGTGGGCTGGATCCGTCAGCCCCCAGGAAAGGCCCTGGAGTGGCTTGCACTCATTTATTGGAATGATGATAAGCGCTACAGCCCATCTCTGAAGAGCAGGCTCACCATCACCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACACAGACCACAAAGACACAGCCCAGGGCACCTCCTGTACAAAAACC", "coding_sequence": "CAGATCACCTTGAAGGAGTCTGGTCCTACGCTGGTGAAACCCACACAGACCCTCACGCTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAGTGGGTGTGGGCTGGATCCGTCAGCCCCCAGGAAAGGCCCTGGAGTGGCTTGCACTCATTTATTGGAATGATGATAAGCGCTACAGCCCATCTCTGAAGAGCAGGCTCACCATCACCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACACAGAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "2", "subgroup_designation": "5", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 144, "gene_end": 444, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 133, "leader_2_end": 143, "v_rs_start": 445, "v_rs_end": 483, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGATCACCTTGAAGGAGTCTGGTCCTACGCTGGTGAAACCCACACAGACCCTCACGCTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAGTGGGTGTGGGCTGGATCCGTCAGCCCCCAGGAAAGGCCCTGGAGTGGCTTGCACTCATTTATTGGAATGATGATAAGCGCTACAGCCCATCTCTGAAGAGCAGGCTCACCATCACCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACACAGAC", "aligned_sequence": "CAGATCACCTTGAAGGAGTCTGGTCCT...ACGCTGGTGAAACCCACACAGACCCTCACGCTGACCTGCACCTTCTCTGGGTTCTCACTCAGC......ACTAGTGGAGTGGGTGTGGGCTGGATCCGTCAGCCCCCAGGAAAGGCCCTGGAGTGGCTTGCACTCATTTATTGGAAT.........GATGATAAGCGCTACAGCCCATCTCTGAAG...AGCAGGCTCACCATCACCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACACAGAC", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1139", "sequence": "ATGGACACACTTTGCTCCACGCTCCTGCTGCTGACCATCCCTTCATGTGAGTGCTGTGGTCAGGGACTCCTTCACGGGTGAAACATCAGTTTTCTTGTTTGTGGGCTTCATCTTCTTATGCTTTCTCCACAGGGGTCTTGTCCCAGATCACCTTGAAGGAGTCTGGTCCTACGCTGGTGAAACCCACACAGACCCTCACGCTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAGTGGGTGTGGGCTGGATCCGTCAGCCCCCAGGAAAGGCCCTGGAGTGGCTTGCACTCATTTATTGGAATGATGATAAGCGCTACAGCCCATCTCTGAAGAGCAGGCTCACCATCACCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACACAGACCACAAAGACACAGCCCAGGGCACCTCCTGTACAAAAACC", "repository_name": "GenBank", "repository_ref": "AB019440", "patch_no": "1", "gff_seqid": null, "gff_start": 194964, "gff_end": 195446, "strand": null }, { "sequence_id": "1140", "sequence": "ATGGACACACTTTGCTCCACGCTCCTGCTGCTGACCATCCCTTCATGTGAGTGCTGTGGTCAGGGACTCCTTCACGGGTGAAACATCAGTTTTCTTGTTTGTGGGCTTCATCTTCTTATGCTTTCTCCACAGGGGTCTTGTCCCAGATCACCTTGAAGGAGTCTGGTCCTACGCTGGTGAAACCCACACAGACCCTCACGCTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAGTGGGTGTGGGCTGGATCCGTCAGCCCCCAGGAAAGGCCCTGGAGTGGCTTGCACTCATTTATTGGAATGATGATAAGCGCTACAGCCCATCTCTGAAGAGCAGGCTCACCATCACCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACACAGACCACAAAGACACAGCCCAGGGCACCTCCTGTACAAAAACC", "repository_name": "GenBank", "repository_ref": "MG719330", "patch_no": "1", "gff_seqid": null, "gff_start": 59, "gff_end": 541, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019440\r\nVDJbase example haplotype: P1_I43", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02977", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-64*07.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV3-64*07", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTTAAAGGTGATTCATGAGGAAATAGAGATATTGAGTGTGAGTGGACATGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATATTATGCAGACTCTGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGGGCAGCCTGAGAGCTGAGGACATGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGAGAAGTTAATGTGGGACCATGCAGAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATATTATGCAGACTCTGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGGGCAGCCTGAGAGCTGAGGACATGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "64", "allele_designation": "07", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 456, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 457, "v_rs_end": 499, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATATTATGCAGACTCTGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGGGCAGCCTGAGAGCTGAGGACATGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAAT......GGGGGTAGCACATATTATGCAGACTCTGTGAAG...GGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGGGCAGCCTGAGAGCTGAGGACATGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1424", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTTAAAGGTGATTCATGAGGAAATAGAGATATTGAGTGTGAGTGGACATGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATATTATGCAGACTCTGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGGGCAGCCTGAGAGCTGAGGACATGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGAGAAGTTAATGTGGGACCATGCAGAAACC", "repository_name": "GenBank", "repository_ref": "AC279963", "patch_no": "1", "gff_seqid": null, "gff_start": 31284, "gff_end": 31778, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AC279963.\r\n\r\nSequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (7 samples). Example subject: P25_I69.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02989", "allele_description_ref": "OGRDB:Homo sapiens:IGHV8-51-1*05.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV8-51-1*05", "sequence": "CTTGAGTTCCAGCACATCTTGGGAGGCCAAGCGGATGTTTGTGAAAGAAATAGTGGCTATGTGACAGTTTCTAACCAGAATATCTCTGTGTTTTCAGGTATCCAGGGTGAGGCCCAGCTTACAGAGTCTGGGGGAGACTTGGTACACTTAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTCAGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGTGAAAGTCATCAATACAATGCAGACTATGTTAGGGGCAGACTCACCACTTCCAGAGACAACACCAAGTACGTGCTGTACATGCAAATGAACAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAACATCGTGATGGGAAGTCCACGTGGGCTCAGAGACAGACT", "coding_sequence": "GAGGCCCAGCTTACAGAGTCTGGGGGAGACTTGGTACACTTAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTCAGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGTGAAAGTCATCAATACAATGCAGACTATGTTAGGGGCAGACTCACCACTTCCAGAGACAACACCAAGTACGTGCTGTACATGCAAATGAACAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "8-51", "subgroup_designation": "1", "allele_designation": "05", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 109, "gene_end": 404, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 52, "leader_2_start": 98, "leader_2_end": 108, "v_rs_start": 405, "v_rs_end": 443, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGCCCAGCTTACAGAGTCTGGGGGAGACTTGGTACACTTAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTCAGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGTGAAAGTCATCAATACAATGCAGACTATGTTAGGGGCAGACTCACCACTTCCAGAGACAACACCAAGTACGTGCTGTACATGCAAATGAACAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAA", "aligned_sequence": "GAGGCCCAGCTTACAGAGTCTGGGGGA...GACTTGGTACACTTAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTC............AGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGT......GAAAGTCATCAATACAATGCAGACTATGTTAGG...GGCAGACTCACCACTTCCAGAGACAACACCAAGTACGTGCTGTACATGCAAATGAACAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1436", "sequence": "CTTGAGTTCCAGCACATCTTGGGAGGCCAAGCGGATGTTTGTGAAAGAAATAGTGGCTATGTGACAGTTTCTAACCAGAATATCTCTGTGTTTTCAGGTATCCAGGGTGAGGCCCAGCTTACAGAGTCTGGGGGAGACTTGGTACACTTAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTCAGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGTGAAAGTCATCAATACAATGCAGACTATGTTAGGGGCAGACTCACCACTTCCAGAGACAACACCAAGTACGTGCTGTACATGCAAATGAACAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAACATCGTGATGGGAAGTCCACGTGGGCTCAGAGACAGACT", "repository_name": "GenBank", "repository_ref": "AC239196", "patch_no": "3", "gff_seqid": null, "gff_start": 23287, "gff_end": 23729, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AC239196. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (57 samples). Example subject: P25_I3.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02689", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-13*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-13*01", "sequence": "ATGGAGTTGGGGCTGAGCTGGGTTTTCCTTGTTGCTATATTAGAAGGTGATTCATGGAGAACTAGAGATATTGAGTGTGAATGGGCATGAATGAGAGAAACAGTGGGTATGTGTGGCAATTTCTGACTTTTGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAGTGGGTCTCAGCTATTGGTACTGCTGGTGACACATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGGGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGGAAGTCAGTATGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAGTGGGTCTCAGCTATTGGTACTGCTGGTGACACATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGGGGACACGGCTGTGTATTACTGTGCAAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "13", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 453, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 454, "v_rs_end": 492, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAGTGGGTCTCAGCTATTGGTACTGCTGGTGACACATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGGGGACACGGCTGTGTATTACTGTGCAAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAGTGGGTCTCAGCTATTGGTACTGCT.........GGTGACACATACTATCCAGGCTCCGTGAAG...GGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGGGGACACGGCTGTGTATTACTGTGCAAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1160", "sequence": "ATGGAGTTGGGGCTGAGCTGGGTTTTCCTTGTTGCTATATTAGAAGGTGATTCATGGAGAACTAGAGATATTGAGTGTGAATGGGCATGAATGAGAGAAACAGTGGGTATGTGTGGCAATTTCTGACTTTTGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAGTGGGTCTCAGCTATTGGTACTGCTGGTGACACATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGGGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGGAAGTCAGTATGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AB019440", "patch_no": "1", "gff_seqid": null, "gff_start": 102954, "gff_end": 103445, "strand": null }, { "sequence_id": "1161", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAGTGGGTCTCAGCTATTGGTACTGCTGGTGACACATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGGGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGAGGTCATTG", "repository_name": "GenBank", "repository_ref": "HM855896", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 324, "strand": null }, { "sequence_id": "1162", "sequence": "ATGGAGTTGGGGCTGAGCTGGGTTTTCCTTGTTGCTATATTAGAAGGTGATTCATGGAGAACTAGAGATATTGAGTGTGAATGGGCATGAATGAGAGAAACAGTGGGTATGTGTGGCAATTTCTGACTTTTGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAGTGGGTCTCAGCTATTGGTACTGCTGGTGACACATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGGGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGGAAGTCAGTATGAGCCCA", "repository_name": "GenBank", "repository_ref": "ON052048", "patch_no": "1", "gff_seqid": null, "gff_start": 176, "gff_end": 657, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019440\r\nVDJbase example haplotype: P1_I40", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02769", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-39*07.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-39*07", "sequence": "ATGAAGCACCTGTGGTTCTTCCTCCTGCTGGTGGCGGCTCCCAGATGTGAGTGTTTCTAGGATGCAGACATGGAGATATGGGAGGCTGCCTCTGATCCCAGGGCTCACTGTGGGTTTTTCTGTTCACAGGGGTCCTGTCCCAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACAAAAACC", "coding_sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "39", "allele_designation": "07", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 141, "gene_end": 439, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 130, "leader_2_end": 140, "v_rs_start": 440, "v_rs_end": 478, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGC......AGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1354", "sequence": "ATGAAGCACCTGTGGTTCTTCCTCCTGCTGGTGGCGGCTCCCAGATGTGAGTGTTTCTAGGATGCAGACATGGAGATATGGGAGGCTGCCTCTGATCCCAGGGCTCACTGTGGGTTTTTCTGTTCACAGGGGTCCTGTCCCAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACAAAAACC", "repository_name": "GenBank", "repository_ref": "AC234225", "patch_no": "4", "gff_seqid": null, "gff_start": 34673, "gff_end": 35150, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AC234225\r\nVDJbase example haplotype: P1_I22_S1\r\nVDJbase example haplotype: P1_I22_S1", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00073", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-61*11.2_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 2, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-61*11", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGCGTATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGCGTATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": "A", "aliases": [ "IGHV4-61*i03" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "61", "allele_designation": "11", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 298, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGCGTATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGC......AGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGCGTATCTATACCAGT.........GGGAGCACCAACTACAACCCCTCCCTCAAG...AGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1381", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGCGTATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "repository_name": "GenBank", "repository_ref": "OU596109", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 298, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "IARC meeting 63, Nov 20th, 2020:\r\nThe meeting considered the inference of the variant IGHV4-61*02_a234g, in the VDJbase dataset of sample P1_I86_S1. The sequence was seen in ten samples, including 4 P1 samples. The meeting focused on sample P1_I86_S1, in which the inferences was seen in 1.82% of all unmutated rearrangements, with 592 sequences including 519 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. IGHV4-61*01 was also present in the genotype, at a lower frequency (0.38% of all unmutated sequences, 116 sequences, 107 unmutated sequences). Haplotyping data showed perfect separation of the assigned alleles. Plots of the final 3\u2019 nucleotides of the inference were unavailable. The inferred sequence was tentatively affirmed as a Level 1 sequence. The final 3\u2019 nucleotides will be considered at a later date, at which time the affirmed sequence will be noted in the IARC minutes.\r\n\r\n\r\nIARC meeting 84, Oct 25th, 2021:\r\nIGHV4-61*02_A234G was inferred in subject S82 (P1_I86_S1; ERR2567259). This inference has previously been pre-assessed at IARC meeting 63 (https://www.antibodysociety.org/wordpress/wp-content/uploads/2020/12/Meeting-63-24_11_20-minutes.pdf). The inference was supported by many sequences (613) and unmutated sequences (530) a high allelic frequency (84%), a high overall frequency in the unmutated population (2.2%) and many unique CDR3s (528) in the unmutated sequence set. The related gene set IGHV4-4, IGHV4-59 and IGHV4-61 were represented by the following inferred alleles IGHV4-4*07 (haplotyping ratio: 2:98), IGHV4-59*01 (haplotyping ratio: 36:64), IGHV4-61*01 (haplotyping ratio 100:0), and IGHV4-61*02_A234G (haplotyping ratio: 0:100). In a separate study it has been proposed that the IGHJ6*02-related haplotype in this subject was occupied by poorly expressed allele IGHV4-4*01 (DOI: 10.3389/fimmu.2020.603980). IGHV4-61*02_A234G was found to be expressed at higher frequency than the poorly expressed allele IGHV4-61*01 (528 vs 107 unique CDR3s in the unmutated sequence set). Overall expression levels, diversity and haplotyping strongly supports the inference. In addition, the upstream region of IGHV4-61*02_A234G (DOI: 10.3389/fimmu.2021.730105) in this subject is different from that of the other alleles of these three genes that are present in this subject (including the previously published upstream region of IGHV4-4*01).\r\n\r\nIt has been noted that IGHV4-61*02_A234G was also found in subject S39 (P1_I42_S1; ERR2567216) used to assess the inference of IGHV4-4*i03 (although this data set was not submitted to IARC for assessment of IGHV4-61*02_A234G). In this sample, IGHV4-61*02_A234G was supported by many sequences (476) and unmutated sequences (395), a high overall frequency in the unmutated population (2.4%) and many unique CDR3s (390) in the unmutated sequence set. No other allele named as IGHV4-61 had been inferred in this subject but IGHV4-59*08, an allele suspected to residue in gene IGHV4-61 (DOI: 10.1038/ncomms14946), was found. The allelic ratio of IGHV4-61*02_A234G in this context would be 61%. Haplotyping of this subject was possible based on an allele of IGHD3-10 (10.3389/fimmu.2019.00987) not documented by the IMGT database. In this context, the two alleles of the genotype believed to be associated to IGHV4-61, IGHV4-61*02_A234G and IGHV4-59*08, showed excellent separation (see also documentation associated to the affirmation of IGHV4-4*i03). \r\n\r\nIARC, taking all of the collective evidence under consideration, affirms the sequence at level 1 up to and including base 319 in agreement with past practice. It is acknowledged that the allele most likely carries one additional base, typically A at base position 320. Although there is nothing in the data, including haplotype assessment, that suggest that the allele does not reside in gene IGHV4-61, it must be recognised, in particular in view of the similarity of alleles linked to IGHV4-4/IGHV4-59/IGHV4-61, that IARC gene naming does not reflect an absolute position on the precise location of the allele to a specific gene. The allele is given the name IGHV4-61*i03.\r\n\r\n>IGHV4-61*i03\r\nCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGCGTATCTATACCAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAG.\r\n\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample OU596109\r\nVDJbase example haplotype: P1_I86\r\nThe IARC states that its location is uncertain", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02620", "allele_description_ref": "OGRDB:Homo sapiens:IGHD2-8*02.2_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 2, "release_date": "16-Aug-2023", "release_description": "Added additional evidence from Rodriguez et al., 2023", "label": "IGHD2-8*02", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGGATATTGTACTGGTGGTGTATGCTATACCCACAGTGACACAGCCCCATTCCCAAAGC", "coding_sequence": "AGGATATTGTACTGGTGGTGTATGCTATACC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "2", "subgroup_designation": "8", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 59, "d_rs_3_prime_start": 60, "d_rs_3_prime_end": 87, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "969", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGGATATTGTACTGGTGGTGTATGCTATACCCACAGTGACACAGCCCCATTCCCAAAGC", "repository_name": "GenBank", "repository_ref": "AH002720", "patch_no": "2", "gff_seqid": null, "gff_start": 189, "gff_end": 275, "strand": null }, { "sequence_id": "1438", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGGATATTGTACTGGTGGTGTATGCTATACCCACAGTGACACAGCCCCATTCCCAAAGC", "repository_name": "GenBank", "repository_ref": "OP255593", "patch_no": "1", "gff_seqid": null, "gff_start": 583, "gff_end": 669, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AH002720\r\nVDJbase example haplotype: P1_I100\r\nVDJbase example haplotype: P1_I49\r\nMapped by P1_I100 haplotype\r\nSequence observed in data from Rodriguez et al., 2023 as reported in VDJbase (15 samples). Example subject: P25_I3.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02665", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-69*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-69*02", "sequence": "GTTCCTCTTTGTGGTGGCAGCAGCTACAGGTAAGGGGCTTCCTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTCTCCACAGGTGTCCAGTCCCAGGTCCAGCTGGTGCAATCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATACTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCCTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCAC", "coding_sequence": "CAGGTCCAGCTGGTGCAATCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATACTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCCTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "69", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 127, "gene_end": 422, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 116, "leader_2_end": 126, "v_rs_start": 423, "v_rs_end": 451, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCCAGCTGGTGCAATCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATACTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCCTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTCCAGCTGGTGCAATCTGGGGCT...GAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTC............AGCAGCTATACTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATC......CTTGGTATAGCAAACTACGCACAGAAGTTCCAG...GGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1111", "sequence": "CTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTCTCCACAGGTGTCCAGTCCCAGGTCCAGCTGGTGCAATCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATACTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCCTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCAC", "repository_name": "GenBank", "repository_ref": "MG719325", "patch_no": "1", "gff_seqid": null, "gff_start": 42, "gff_end": 440, "strand": null }, { "sequence_id": "1112", "sequence": "ATGGACTGGACCTGGAGGTTCCTCTTTGTGGTGGCAGCAGCTACAGGTAAGGGGCTTCCTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTCTCCACAGGTGTCCAGTCCCAGGTCCAGCTGGTGCAATCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATACTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCCTTGGTATAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGAGT", "repository_name": "GenBank", "repository_ref": "ON052039", "patch_no": "1", "gff_seqid": null, "gff_start": 43, "gff_end": 510, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MG719325\r\nVDJbase example haplotype: P1_I100\r\nMapped by P1_I100 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02694", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-16*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-16*02", "sequence": "ATGGAATTTGGGCTGAGCTGGGTTTTTCTTGCTGGTATTTTAAAAGGTGATTCATGGAGAACTAAGGATATTGAGTGAGTGGACATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGCCCGCAAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGTGGACTCCGTGAAGCGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTCCCTGTATCTGCAAAAGAACAGACGGAGAGCCGAGGACATGGCTGTGTATTACTGTGTGAGAAATCCTGTGAGGGGACACAAGTGCGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGCCCGCAAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGTGGACTCCGTGAAGCGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTCCCTGTATCTGCAAAAGAACAGACGGAGAGCCGAGGACATGGCTGTGTATTACTGTGTGAGAAA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "16", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 159, "gene_end": 454, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 148, "leader_2_end": 158, "v_rs_start": 455, "v_rs_end": 493, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGCCCGCAAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGTGGACTCCGTGAAGCGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTCCCTGTATCTGCAAAAGAACAGACGGAGAGCCGAGGACATGGCTGTGTATTACTGTGTGAGAAA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAACAGTGACATGAACTGGGCCCGCAAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAAT......GGCAGTAGGACGCACTATGTGGACTCCGTGAAG...CGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTCCCTGTATCTGCAAAAGAACAGACGGAGAGCCGAGGACATGGCTGTGTATTACTGTGTGAGAAA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1172", "sequence": "ATGGAATTTGGGCTGAGCTGGGTTTTTCTTGCTGGTATTTTAAAAGGTGATTCATGGAGAACTAAGGATATTGAGTGAGTGGACATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGCCCGCAAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGTGGACTCCGTGAAGCGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTCCCTGTATCTGCAAAAGAACAGACGGAGAGCCGAGGACATGGCTGTGTATTACTGTGTGAGAAATCCTGTGAGGGGACACAAGTGCGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AB019440", "patch_no": "1", "gff_seqid": null, "gff_start": 67196, "gff_end": 67688, "strand": null }, { "sequence_id": "1173", "sequence": "ATGGAATTTGGGCTGAGCTGGGTTTTTCTTGCTGGTATTTTAAAAGGTGATTCATGGAGAACTAAGGATATTGAGTGAGTGGACATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGCCCGCAAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGTGGACTCCGTGAAGCGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTCCCTGTATCTGCAAAAGAACAGACGGAGAGCCGAGGACATGGCTGTGTATTACTGTGTGAGAAATCCTGTGAGGGGACACAAGTGCGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 714189, "gff_end": 714681, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019440", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02684", "allele_description_ref": "OGRDB:Homo sapiens:IGHV2-70D*14.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV2-70D*14", "sequence": "ATGGACATACTTTGTTCCACGCTCCTGCTACTGACTGTCCCGTCCTGTGAGTGCTGTGGTCAGGTAGTACTTCAGAAGCAAAAAATCTATTCTCTCCTTTGTGGGCTTCATCTTCTTATGTCTTCTCCACAGGGGTCTTATCCCAGGTCACCTTGAAGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGCGTGTGAGCTGGATCCGTCAGCCCCCAGGTAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATTCTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATACCACAGAGACACAGCCCAGGGCGCCTCCTGTACAAGAACC", "coding_sequence": "CAGGTCACCTTGAAGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGCGTGTGAGCTGGATCCGTCAGCCCCCAGGTAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATTCTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "2", "subgroup_designation": "70D", "allele_designation": "14", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 144, "gene_end": 444, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 133, "leader_2_end": 143, "v_rs_start": 445, "v_rs_end": 483, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCACCTTGAAGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGCGTGTGAGCTGGATCCGTCAGCCCCCAGGTAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATTCTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATAC", "aligned_sequence": "CAGGTCACCTTGAAGGAGTCTGGTCCT...GCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGC......ACTAGTGGAATGCGTGTGAGCTGGATCCGTCAGCCCCCAGGTAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGAT.........GATGATAAATTCTACAGCACATCTCTGAAG...ACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATAC", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1151", "sequence": "ATGGACATACTTTGTTCCACGCTCCTGCTACTGACTGTCCCGTCCTGTGAGTGCTGTGGTCAGGTAGTACTTCAGAAGCAAAAAATCTATTCTCTCCTTTGTGGGCTTCATCTTCTTATGTCTTCTCCACAGGGGTCTTATCCCAGGTCACCTTGAAGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGCGTGTGAGCTGGATCCGTCAGCCCCCAGGTAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATTCTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATACCACAGAGACACAGCCCAGGGCGCCTCCTGTACAAGAACC", "repository_name": "GenBank", "repository_ref": "KC713949", "patch_no": "1", "gff_seqid": null, "gff_start": 251, "gff_end": 733, "strand": null }, { "sequence_id": "1152", "sequence": "ATGGACATACTTTGTTCCACGCTCCTGCTACTGACTGTCCCGTCCTGTGAGTGCTGTGGTCAGGTAGTACTTCAGAAGCAAAAAATCTATTCTCTCCTTTGTGGGCTTCATCTTCTTATGTCTTCTCCACAGGGGTCTTATCCCAGGTCACCTTGAAGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGCGTGTGAGCTGGATCCGTCAGCCCCCAGGTAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATTCTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATACCACAGAGACACAGCCCAGGGCGCCTCCTGTACAAGAACC", "repository_name": "GenBank", "repository_ref": "AC234135", "patch_no": "3", "gff_seqid": null, "gff_start": 26415, "gff_end": 26897, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample KC713949", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02692", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-15*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-15*01", "sequence": "ATGGAGTTTGGGCTGAGCTGGATTTTCCTTGCTGCTATTTTAAAAGGTGATTTATGGAGAACTAGAGAGATTAAGTGTGAGTGGACGTGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGATCTTAGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCTGGGGGGTCCCTTAGACTCTCCTGTGCAGCCTCTGGATTCACTTTCAGTAACGCCTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTGGCCGTATTAAAAGCAAAACTGATGGTGGGACAACAGACTACGCTGCACCCGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCAAAAAACACGCTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACCACAGACACAGTGAGGGGAGGTCAGTGTGAGCCCGGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCTGGGGGGTCCCTTAGACTCTCCTGTGCAGCCTCTGGATTCACTTTCAGTAACGCCTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTGGCCGTATTAAAAGCAAAACTGATGGTGGGACAACAGACTACGCTGCACCCGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCAAAAAACACGCTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACCACAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "15", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 462, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 463, "v_rs_end": 501, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCTGGGGGGTCCCTTAGACTCTCCTGTGCAGCCTCTGGATTCACTTTCAGTAACGCCTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTGGCCGTATTAAAAGCAAAACTGATGGTGGGACAACAGACTACGCTGCACCCGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCAAAAAACACGCTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACCACAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTAAAGCCTGGGGGGTCCCTTAGACTCTCCTGTGCAGCCTCTGGATTCACTTTC............AGTAACGCCTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTGGCCGTATTAAAAGCAAAACTGATGGTGGGACAACAGACTACGCTGCACCCGTGAAA...GGCAGATTCACCATCTCAAGAGATGATTCAAAAAACACGCTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACCACAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 180, "fwr3_start": 181, "fwr3_end": 294, "cdr3_start": 295, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1167", "sequence": "ATGGAGTTTGGGCTGAGCTGGATTTTCCTTGCTGCTATTTTAAAAGGTGATTTATGGAGAACTAGAGAGATTAAGTGTGAGTGGACGTGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGATCTTAGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCTGGGGGGTCCCTTAGACTCTCCTGTGCAGCCTCTGGATTCACTTTCAGTAACGCCTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTGGCCGTATTAAAAGCAAAACTGATGGTGGGACAACAGACTACGCTGCACCCGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCAAAAAACACGCTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACCACAGACACAGTGAGGGGAGGTCAGTGTGAGCCCGGACACAAACC", "repository_name": "GenBank", "repository_ref": "AB019440", "patch_no": "1", "gff_seqid": null, "gff_start": 78769, "gff_end": 79269, "strand": null }, { "sequence_id": "1168", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCTGGGGGGTCCCTTAGACTCTCCTGTGCAGCCTCTGGATTCACTTTCAGTAACGCCTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTGGCCGTATTAAAAGCAAAACTGATGGTGGGACAACAGACTACGCTGCACCCGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCAAAAAACACGCTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACCACAGACACAGTGAGGGGAAGTCATTGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855885", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 351, "strand": null }, { "sequence_id": "1169", "sequence": "ATGGAGTTTGGGCTGAGCTGGATTTTCCTTGCTGCTATTTTAAAAGGTGATTTATGGAGAACTAGAGAGATTAAGTGTGAGTGGACGTGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGATCTTAGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCTGGGGGGTCCCTTAGACTCTCCTGTGCAGCCTCTGGATTCACTTTCAGTAACGCCTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTGGCCGTATTAAAAGCAAAACTGATGGTGGGACAACAGACTACGCTGCACCCGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCAAAAAACACGCTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACCACAGACACAGTGAGGGGAGGTCAGTGTGAGCCCGGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052050", "patch_no": "1", "gff_seqid": null, "gff_start": 197, "gff_end": 697, "strand": null }, { "sequence_id": "1170", "sequence": "ATGGAGTTTGGGCTGAGCTGGATTTTCCTTGCTGCTATTTTAAAAGGTGATTTATGGAGAACTAGAGAGATTAAGTGTGAGTGGACGTGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGATCTTAGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCTGGGGGGTCCCTTAGACTCTCCTGTGCAGCCTCTGGATTCACTTTCAGTAACGCCTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTGGCCGTATTAAAAGCAAAACTGATGGTGGGACAACAGACTACGCTGCACCCGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCAAAAAACACGCTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACAGCCGTGTATTACTGTACCACAGACACAGTGAGGGGAGGTCAGTGTGAGCCCGGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 725762, "gff_end": 726262, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019440\r\nVDJbase example haplotype: P1_I23", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00014", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-58*03.3_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 3, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-58*03", "sequence": "CAAATGCAGCTGGTGCAGTCTGGGCCTGAAGTGAAGAAGCCTGGGACCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATTCACCTTTACTAGCTCTGCTGTGCAGTGGGTGCGACAGGCTCGTGGACAACGCCTTGAGTGGATAGGATGGATCGTCGTTGGCAGTGGTAACACAAACTACGCACAGAAGTTCCAGGAAAGAGTCACCATTACCAGGGACATGTCCACAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCCGAGGACACGGCCGTGTATTACTGTGCGGCAGA", "coding_sequence": "CAAATGCAGCTGGTGCAGTCTGGGCCTGAAGTGAAGAAGCCTGGGACCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATTCACCTTTACTAGCTCTGCTGTGCAGTGGGTGCGACAGGCTCGTGGACAACGCCTTGAGTGGATAGGATGGATCGTCGTTGGCAGTGGTAACACAAACTACGCACAGAAGTTCCAGGAAAGAGTCACCATTACCAGGGACATGTCCACAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCCGAGGACACGGCCGTGTATTACTGTGCGGCAGA", "ext_3prime": "A", "aliases": [ "IGHV1-58*i01" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "58", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 295, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAAATGCAGCTGGTGCAGTCTGGGCCTGAAGTGAAGAAGCCTGGGACCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATTCACCTTTACTAGCTCTGCTGTGCAGTGGGTGCGACAGGCTCGTGGACAACGCCTTGAGTGGATAGGATGGATCGTCGTTGGCAGTGGTAACACAAACTACGCACAGAAGTTCCAGGAAAGAGTCACCATTACCAGGGACATGTCCACAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCCGAGGACACGGCCGTGTATTACTGTGCGGCAGA", "aligned_sequence": "CAAATGCAGCTGGTGCAGTCTGGGCCT...GAAGTGAAGAAGCCTGGGACCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATTCACCTTT............ACTAGCTCTGCTGTGCAGTGGGTGCGACAGGCTCGTGGACAACGCCTTGAGTGGATAGGATGGATCGTCGTTGGC......AGTGGTAACACAAACTACGCACAGAAGTTCCAG...GAAAGAGTCACCATTACCAGGGACATGTCCACAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCCGAGGACACGGCCGTGTATTACTGTGCGGCAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1107", "sequence": "CAAATGCAGCTGGTGCAGTCTGGGCCTGAAGTGAAGAAGCCTGGGACCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATTCACCTTTACTAGCTCTGCTGTGCAGTGGGTGCGACAGGCTCGTGGACAACGCCTTGAGTGGATAGGATGGATCGTCGTTGGCAGTGGTAACACAAACTACGCACAGAAGTTCCAGGAAAGAGTCACCATTACCAGGGACATGTCCACAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCCGAGGACACGGCCGTGTATTACTGTGCGGCAGA", "repository_name": "GenBank", "repository_ref": "MK321684", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 295, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "This sequence represents IGHV1-58*01+G33A in the IMGT numbering system. The committee noted a rearrangement frequency of 0.15%, with 178 alignments including 127 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. The genotype showed the individual to be heterozygous at the IGHV1-58 locus, with the alternative IGHV1-58*01 allele being associated with 214 sequences for an allele ratio of 45:55. This sequence has previously been catalogued by IgPdb as IGHV1-58*p04, though the IgPdb sequence is derived from the S0008 dataset. All members of the committee agreed that the sequence should be accepted as a Level 1 sequence at IARC Meeting 34 on March 29, 2019. In line with previous policy, the submitted sequence will be recognized up to and including nucleotide 319. A trailing \u201c.\u201d indicates IARC's opinion that the sequences likely to contain an additional/additional 3' nucleotide(s) for which there is insufficient evidence to make an affirmation.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MK321684", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02617", "allele_description_ref": "OGRDB:Homo sapiens:IGHD2-21*01.2_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 2, "release_date": "16-Aug-2023", "release_description": "Added additional evidence from Rodriguez et al., 2023", "label": "IGHD2-21*01", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGCATATTGTGGTGGTGATTGCTATTCCCACAGTGACACAACCCCATTCCTAAAGC", "coding_sequence": "AGCATATTGTGGTGGTGATTGCTATTCC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "2", "subgroup_designation": "21", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 56, "d_rs_3_prime_start": 57, "d_rs_3_prime_end": 84, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "960", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGCATATTGTGGTGGTGATTGCTATTCCCACAGTGACACAACCCCATTCCTAAAGC", "repository_name": "GenBank", "repository_ref": "AH002720", "patch_no": "2", "gff_seqid": null, "gff_start": 565, "gff_end": 648, "strand": null }, { "sequence_id": "1437", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGCATATTGTGGTGGTGATTGCTATTCCCACAGTGACACAACCCCATTCCTAAAGC", "repository_name": "GenBank", "repository_ref": "OP255040", "patch_no": "1", "gff_seqid": null, "gff_start": 2494, "gff_end": 2577, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AH002720\r\nVDJbase example haplotype: P1_I21\r\nVDJbase example haplotype: P1_I28\r\nMapped by P1_I21 haplotype\r\nSequence observed in data from Rodriguez et al., 2023 as reported in VDJbase (25 samples). Example subject: P25_I13.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02677", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-8*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-8*03", "sequence": "GATCCTCTTCTTGGTGGCAGCAGCTACAAGTAAGGGGCTTCCTAGTCTCAAAGCTGAGGAACGGATCCTGGTTCAGTCAAAGAGGATTTTATTCTCTCCTGTGTCCTCTCCACAGGTGCCCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCAGCTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAACAGTGGTAACACAGGCTATGCACAGAAGTTCCAGGGCAGAGTCACCATTACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGCACAGTGTGAAAAACCAC", "coding_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCAGCTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAACAGTGGTAACACAGGCTATGCACAGAAGTTCCAGGGCAGAGTCACCATTACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGG", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "8", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 127, "gene_end": 422, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 116, "leader_2_end": 126, "v_rs_start": 423, "v_rs_end": 451, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCAGCTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAACAGTGGTAACACAGGCTATGCACAGAAGTTCCAGGGCAGAGTCACCATTACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGG", "aligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTC............ACCAGCTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAAC......AGTGGTAACACAGGCTATGCACAGAAGTTCCAG...GGCAGAGTCACCATTACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGG", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1134", "sequence": "ACAAGTAAGGGGCTTCCTAGTCTCAAAGCTGAGGAACGGATCCTGGTTCAGTCAAAGAGGATTTTATTCTCTCCTGTGTCCTCTCCACAGGTGCCCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCAGCTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAACAGTGGTAACACAGGCTATGCACAGAAGTTCCAGGGCAGAGTCACCATTACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGCACAGTGTGAAAAACCAC", "repository_name": "GenBank", "repository_ref": "MG719312", "patch_no": "1", "gff_seqid": null, "gff_start": 26, "gff_end": 440, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MG719312\r\nVDJbase example haplotype: P1_I64", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02683", "allele_description_ref": "OGRDB:Homo sapiens:IGHV2-70D*04.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV2-70D*04", "sequence": "TCTCCTGGGTTCAAAAGACGAGGACAGGGCCTCGCTCAGTGAATCCTGCTCTCCACCATGGACATACTTTGTTCCACGCTCCTGCTACTGACTGTCCCGTCCTGTGAGTGCTGTGGTCAGGTAGTACTTCAGAAGCAAAAAATCTATTCTCTCCTTTGTGGGCTTCATCTTCTTATGTCTTCTCCACAGGGGTCTTATCCCAGGTCACCTTGAAGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGCGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATTCTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATACCACAGAGACACAGCCCAGGGCGCCTCCTGTACAAGAACC", "coding_sequence": "CAGGTCACCTTGAAGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGCGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATTCTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "2", "subgroup_designation": "70D", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 201, "gene_end": 501, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 190, "leader_2_end": 200, "v_rs_start": 502, "v_rs_end": 540, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCACCTTGAAGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGCGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATTCTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATAC", "aligned_sequence": "CAGGTCACCTTGAAGGAGTCTGGTCCT...GCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGC......ACTAGTGGAATGCGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGAT.........GATGATAAATTCTACAGCACATCTCTGAAG...ACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATAC", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1148", "sequence": "ATGGACATACTTTGTTCCACGCTCCTGCTACTGACTGTCCCGTCCTGTGAGTGCTGTGGTCAGGTAGTACTTCAGAAGCAAAAAATCTATTCTCTCCTTTGTGGGCTTCATCTTCTTATGTCTTCTCCACAGGGGTCTTATCCCAGGTCACCTTGAAGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGCGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATTCTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATACCACAGAGACACAGCCCAGGGCGCCTCCTGTACAAGAACC", "repository_name": "GenBank", "repository_ref": "MG719337", "patch_no": "1", "gff_seqid": null, "gff_start": 58, "gff_end": 540, "strand": null }, { "sequence_id": "1149", "sequence": "TCCTGTGAGTGCTGTGGTCAGGTAGTACTTCAGAAGCAAAAAATCTATTCTCTCCTTTGTGGACTTCATCTTCTTATGTCTTCTCCACAGGGGTCTTATCCCAGGTCACCTTGAAGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGCGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATTCTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATACCACAGAGACACAGCCCAGGGCGCCTCCTGTACAA", "repository_name": "GenBank", "repository_ref": "ON052045", "patch_no": "1", "gff_seqid": null, "gff_start": 292, "gff_end": 727, "strand": null }, { "sequence_id": "1150", "sequence": "ATGGACATACTTTGTTCCACGCTCCTGCTACTGACTGTCCCGTCCTGTGAGTGCTGTGGTCAGGTAGTACTTCAGAAGCAAAAAATCTATTCTCTCCTTTGTGGGCTTCATCTTCTTATGTCTTCTCCACAGGGGTCTTATCCCAGGTCACCTTGAAGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGCGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATTCTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATACCACAGAGACACAGCCCAGGGCGCCTCCTGTACAAGAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 155828, "gff_end": 156310, "strand": null } ], "rearranged_support": [], "paralogs": [ "IGHV2-70*04" ], "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MG719337\r\nVDJbase example haplotype: P1_I52", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02661", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-58*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-58*01", "sequence": "TCGCGAGTCTCCACAGGTGTCCACTCCCAAATGCAGCTGGTGCAGTCTGGGCCTGAGGTGAAGAAGCCTGGGACCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATTCACCTTTACTAGCTCTGCTGTGCAGTGGGTGCGACAGGCTCGTGGACAACGCCTTGAGTGGATAGGATGGATCGTCGTTGGCAGTGGTAACACAAACTACGCACAGAAGTTCCAGGAAAGAGTCACCATTACCAGGGACATGTCCACAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCCGAGGACACGGCCGTGTATTACTGTGCGGCAGACACAGTGTGAAAACCCACATCCT", "coding_sequence": "CAAATGCAGCTGGTGCAGTCTGGGCCTGAGGTGAAGAAGCCTGGGACCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATTCACCTTTACTAGCTCTGCTGTGCAGTGGGTGCGACAGGCTCGTGGACAACGCCTTGAGTGGATAGGATGGATCGTCGTTGGCAGTGGTAACACAAACTACGCACAGAAGTTCCAGGAAAGAGTCACCATTACCAGGGACATGTCCACAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCCGAGGACACGGCCGTGTATTACTGTGCGGCAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "58", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 28, "gene_end": 323, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 17, "leader_2_end": 27, "v_rs_start": 324, "v_rs_end": 352, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAAATGCAGCTGGTGCAGTCTGGGCCTGAGGTGAAGAAGCCTGGGACCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATTCACCTTTACTAGCTCTGCTGTGCAGTGGGTGCGACAGGCTCGTGGACAACGCCTTGAGTGGATAGGATGGATCGTCGTTGGCAGTGGTAACACAAACTACGCACAGAAGTTCCAGGAAAGAGTCACCATTACCAGGGACATGTCCACAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCCGAGGACACGGCCGTGTATTACTGTGCGGCAGA", "aligned_sequence": "CAAATGCAGCTGGTGCAGTCTGGGCCT...GAGGTGAAGAAGCCTGGGACCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATTCACCTTT............ACTAGCTCTGCTGTGCAGTGGGTGCGACAGGCTCGTGGACAACGCCTTGAGTGGATAGGATGGATCGTCGTTGGC......AGTGGTAACACAAACTACGCACAGAAGTTCCAG...GAAAGAGTCACCATTACCAGGGACATGTCCACAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCCGAGGACACGGCCGTGTATTACTGTGCGGCAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1102", "sequence": "ATGGACTGGATTTGGAGGATCCTCTTCTTGGTGGGAGCAGCGACAGGCAAGGAGATGCCAAGTCCCAGTGATGAGGAGGGGATTGAGTCCAGTCAAGGTGGCTTTCATCCACTCCTGTGTTCTCTCCACAGGTGCCCACTCCCAAATGCAGCTGGTGCAGTCTGGGCCTGAGGTGAAGAAGCCTGGGACCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATTCACCTTTACTAGCTCTGCTGTGCAGTGGGTGCGACAGGCTCGTGGACAACGCCTTGAGTGGATAGGATGGATCGTCGTTGGCAGTGGTAACACAAACTACGCACAGAAGTTCCAGGAAAGAGTCACCATTACCAGGGACATGTCCACAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCCGAGGACACGGCCGTGTATTACTGTGCGGCAGACACAGTGTGAAAACCCACATCCTGAGAGTGTCAGAAACG", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 257051, "gff_end": 257527, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855931\r\nVDJbase example haplotype: P1_I12_S1", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02705", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-30-3*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-30-3*01", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTCGTTGCTCTTTTAAGAGGTGATTCATGGAGAAATAGAGAGACTGAGTGTGAGTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCATTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGCAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCATTGTGCGCCCAGACACAAACC", "coding_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGCAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3-30", "subgroup_designation": "3", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 159, "gene_end": 454, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 148, "leader_2_end": 158, "v_rs_start": 455, "v_rs_end": 493, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGCAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGAT......GGAAGCAATAAATACTACGCAGACTCCGTGAAG...GGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1199", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTCGTTGCTCTTTTAAGAGGTGATTCATGGAGAAATAGAGAGACTGAGTGTGAGTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCATTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGCAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCATTGTGCGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AC244456", "patch_no": "2", "gff_seqid": null, "gff_start": 2095, "gff_end": 2587, "strand": null }, { "sequence_id": "1200", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTCGTTGCTCTTTTAAGAGGTGATTCATGGAGAAATAGAGAGACTGAGTGTGAGTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCATTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGCAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCATTGTGCGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AC234301", "patch_no": "2", "gff_seqid": null, "gff_start": 14015, "gff_end": 14507, "strand": null }, { "sequence_id": "1201", "sequence": "GTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGCAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCAATGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855914", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 345, "strand": null }, { "sequence_id": "1202", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTCGTTGCTCTTTTAAGAGGTGATTCATGGAGAAATAGAGAGACTGAGTGTGAGTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCATTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGCAATAAATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCATTGTGCGCCCAGACATAAACC", "repository_name": "GenBank", "repository_ref": "ON052056", "patch_no": "1", "gff_seqid": null, "gff_start": 123, "gff_end": 615, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AC244456\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02735", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-53*04.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-53*04", "sequence": "TCGCGAGTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGAGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGACACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCAATG", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGAGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGACACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "53", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 321, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 18, "leader_2_end": 28, "v_rs_start": 322, "v_rs_end": 350, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGAGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGACACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGAGGA...GGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTC............AGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGT.........GGTAGCACATACTACGCAGACTCCGTGAAG...GGCCGATTCACCATCTCCAGACACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1269", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGAGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGACACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCAATG", "repository_name": "GenBank", "repository_ref": "HM855879", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 325, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855879\r\nVDJbase example haplotype: P1_I12\r\nMapped by P1_I12 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02956", "allele_description_ref": "OGRDB:Homo sapiens:IGHD3-10*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHD3-10*03", "sequence": "GGTTTGGGGTGAGGTCTGTGTCACTGTGGTATTACTATGGTTCAGGGAGTTATTATAACCACAGTGTCACAGAGTCCATCAAAAACC", "coding_sequence": "GTATTACTATGGTTCAGGGAGTTATTATAAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "10", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 59, "d_rs_3_prime_start": 60, "d_rs_3_prime_end": 87, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "897", "sequence": "GGTTTGGGGTGAGGTCTGTGTCACTGTGGTATTACTATGGTTCAGGGAGTTATTATAACCACAGTGTCACAGAGTCCATCAAAAACC", "repository_name": "VDJbase", "repository_ref": "P25_I19", "patch_no": null, "gff_seqid": null, "gff_start": 1, "gff_end": 87, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on data from VDJbase subject P25_I19. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (14 samples). Example subject: P25_I19.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02686", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-11*04.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-11*04", "sequence": "GTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGGGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCATTGCTCGCGA", "coding_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGGGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "11", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 22, "gene_end": 317, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 11, "leader_2_end": 21, "v_rs_start": 318, "v_rs_end": 346, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGGGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGT......GGTAGTACCATATACTACGCAGACTCTGTGAAG...GGCCGATTCACCATCTCCAGGGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1156", "sequence": "GTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTGGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGGGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCATTGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855512", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 345, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855512\r\nVDJbase example haplotype: P1_I64", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02716", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-38-3*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-38-3*01", "sequence": "ATGCAGTTTGTGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGATGATTCATGGAGAACTACAGATGTTGAGTGTGAGTGGACATGAGTGAGCAAAACAGTGGGTATGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTCGGGGAGTCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGTCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGCATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTAAGAAAGACACAGTGAGGGGAGGTCATTGTGTGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTCGGGGAGTCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGTCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGCATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTAAGAAAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3-38", "subgroup_designation": "3", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 450, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 48, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 451, "v_rs_end": 489, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTCGGGGAGTCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGTCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGCATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTAAGAAAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTCGGGGA...GTCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTC............AGTAGCAATGAGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGTCTGGAGTGGGTCTCATCCATTAGTGGT............GGTAGCACATACTACGCAGACTCCAGGAAG...GGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGCATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTAAGAAAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 168, "fwr3_start": 169, "fwr3_end": 282, "cdr3_start": 283, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1226", "sequence": "ATGCAGTTTGTGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGATGATTCATGGAGAACTACAGATGTTGAGTGTGAGTGGACATGAGTGAGCAAAACAGTGGGTATGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTCGGGGAGTCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGTCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGCATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTAAGAAAGACACAGTGAGGGGAGGTCATTGTGTGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AC241995", "patch_no": "3", "gff_seqid": null, "gff_start": 38173, "gff_end": 38661, "strand": null }, { "sequence_id": "1227", "sequence": "ATGCAGTTTGTGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGATGATTCATGGAGAACTACAGATGTTGAGTGTGAGTGGACATGAGTGAGCAAAACAGTGGGTATGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTCGGGGAGTCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGTCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGCATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTAAGAAAGACACAGTGAGGGGAGGTCATTGTGTGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AC234225", "patch_no": "4", "gff_seqid": null, "gff_start": 10095, "gff_end": 10583, "strand": null }, { "sequence_id": "1228", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTCGGGGAGTCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGTCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGCATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTAAGAAAGACACAGTGAGGGGAGGTCAGTGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855932", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 339, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AC241995\r\nVDJbase example haplotype: P1_I12 (2 exact matches)", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02721", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-43*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-43*01", "sequence": "ATGGAGTTTGGACTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGATAAATAGAGATGTTGAGTGTGAGTGAACATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTGTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATACCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACATACTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAACTGAGGACACCGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGGGAAGTCAGCGAGAGCCCAGACAAAAACC", "coding_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATACCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACATACTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAACTGAGGACACCGCCTTGTATTACTGTGCAAAAGATA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "43", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 458, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 459, "v_rs_end": 497, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATACCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACATACTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAACTGAGGACACCGCCTTGTATTACTGTGCAAAAGATA", "aligned_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGA...GTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTT............GATGATTATACCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGAT......GGTGGTAGCACATACTATGCAGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAACTGAGGACACCGCCTTGTATTACTGTGCAAAAGATA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1236", "sequence": "ATGGAGTTTGGACTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGATAAATAGAGATGTTGAGTGTGAGTGAACATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTGTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATACCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACATACTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAACTGAGGACACCGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGGGAAGTCAGCGAGAGCCCAGACAAAAACC", "repository_name": "GenBank", "repository_ref": "M99672", "patch_no": "1", "gff_seqid": null, "gff_start": 170, "gff_end": 666, "strand": null }, { "sequence_id": "1237", "sequence": "GTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATACCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACATACTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAACTGAGGACACCGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGGGAAGTCATTG", "repository_name": "GenBank", "repository_ref": "HM855751", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 330, "strand": null }, { "sequence_id": "1238", "sequence": "ATGGAGTTTGGACTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGATAAATAGAGATGTTGAGTGTGAGTGAACATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTGTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATACCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACATACTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAACTGAGGACACCGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGGGAAGTCAGCGAGAGCCCA", "repository_name": "GenBank", "repository_ref": "ON052061", "patch_no": "1", "gff_seqid": null, "gff_start": 180, "gff_end": 666, "strand": null }, { "sequence_id": "1239", "sequence": "ATGGAGTTTGGACTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGATAAATAGAGATGTTGAGTGTGAGTGAACATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTGTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATACCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACATACTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAACTGAGGACACCGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGGGAAGTCAGCGAGAGCCCAGACAAAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 409125, "gff_end": 409621, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample M99672\r\nVDJbase example haplotype: P1_I10", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02779", "allele_description_ref": "OGRDB:Homo sapiens:IGHV5-51*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV5-51*01", "sequence": "AGGTTCTGGGTTATAAACNCTGTAGACTCCTCCCTTCAGGGCAGGNTGACCAACTATGCAAATGCAAGTGGGGGCCTCCCCACTTAAACCCAGGGCTCCCCTCCACAGTGAGTCTCCCTCACTGCCCAGCTGGGATCTCAGGGCTTCATTTTCTGTCCTCCACCATCATGGGGTCAACCGCCATCCTCGCCCTCCTCCTGGCTGTTCTCCAAGGTCAGTCCTGCCGAGGGCTTGAGGTCACAGAGGAGAACGGGTGGAAAGGAGCCCCTGATTCAAATTTTGTGTCTCCCCCACAGGAGTCTGTTCCGAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACACACAGTGAGAGAAACCAGCCCCGAGCCCGTCTAAAACC", "coding_sequence": "GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "5", "subgroup_designation": "51", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 308, "gene_end": 603, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 297, "leader_2_end": 307, "v_rs_start": 604, "v_rs_end": 641, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACA", "aligned_sequence": "GAGGTGCAGCTGGTGCAGTCTGGAGCA...GAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTT............ACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGT......GACTCTGATACCAGATACAGCCCGTCCTTCCAA...GGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1387", "sequence": "ATGGGGTCAACCGCCATCCTCGCCCTCCTCCTGGCTGTTCTCCAAGGTCAGTCCTGCCGAGGGCTTGAGGTCACAGAGGAGAACGGGTGGAAAGGAGCCCCTGATTCAAATTTTGTGTCTCCCCCACAGGAGTCTGTGCCGAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACACACAGTGAGAGAAACCAGCCCCGAGCCCGTCTAAAACC", "repository_name": "GenBank", "repository_ref": "MT078123", "patch_no": "1", "gff_seqid": null, "gff_start": 186, "gff_end": 659, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample M99686\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02675", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-8*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-8*01", "sequence": "CACTCCACCAACCACATCTGTCCTCTAGAGAAAACCCTGTGAGCACACCTCCTCACCATGGACTGGACCTGGAGGATCCTCTTCTTGGTGGCAGCAGCTACAAGTAAGGGGCTTCCTAGTCTCAAAGCTGAGGAACGGATCCTGGTTCAGTCAAAGAGGATTTTATTCTCTCCTGTGTTCTCTCCACAGGTGCCCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCAGTTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAACAGTGGTAACACAGGCTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGCACAGTGTGAAAAACCACATCCTCAGAGAGTCAGAAACC", "coding_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCAGTTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAACAGTGGTAACACAGGCTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGG", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "8", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 201, "gene_end": 496, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 190, "leader_2_end": 200, "v_rs_start": 497, "v_rs_end": 535, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCAGTTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAACAGTGGTAACACAGGCTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGG", "aligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTC............ACCAGTTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAAC......AGTGGTAACACAGGCTATGCACAGAAGTTCCAG...GGCAGAGTCACCATGACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGG", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1127", "sequence": "ATGGACTGGACCTGGAGGATCCTCTTCTTGGTGGCAGCAGCTACAAGTAAGGGGCTTCCTAGTCTCAAAGCTGAGGAACGGATCCTGGTTCAGTCAAAGAGGATTTTATTCTCTCCTGTGTTCTCTCCACAGGTGCCCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCAGTTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAACAGTGGTAACACAGGCTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGCACAGTGTGAAAAACCACATCCTCAGAGAGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "M99637", "patch_no": "1", "gff_seqid": null, "gff_start": 58, "gff_end": 535, "strand": null }, { "sequence_id": "1128", "sequence": "ATAGTCTCAAAGCTGAGGAACGGATCCTGGTTCAGTCAAAGAGGATTTTATTCTCTCCTGTGTTCTCTCCACAGGTGCCCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCAGTTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAACAGTGGTAACACAGGCTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGCACAGTGTGAAAAACCAC", "repository_name": "GenBank", "repository_ref": "MG719310", "patch_no": "1", "gff_seqid": null, "gff_start": 42, "gff_end": 440, "strand": null }, { "sequence_id": "1129", "sequence": "GTGTCCACTCTCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCAGTTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAACAGTGGTAACACAGGCTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGCACAGTGTGAAAACCCACATCCTCTCGCG", "repository_name": "GenBank", "repository_ref": "HM855769", "patch_no": "1", "gff_seqid": null, "gff_start": 10, "gff_end": 345, "strand": null }, { "sequence_id": "1130", "sequence": "ATGGACTGGACCTGGAGGATCCTCTTCTTGGTGGCAGCAGCTACAAGTAAGGGGCTTCCTAGTCTCAAAGCTGAGGAACGGATCCTGGTTCAGTCAAAGAGGATTTTATTCTCTCCTGTGTTCTCTCCACAGGTGCCCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCAGTTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAACAGTGGTAACACAGGCTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGCACAGTGTGAAAAACCACATCCTCAGAGAGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "ON052041", "patch_no": "1", "gff_seqid": null, "gff_start": 310, "gff_end": 787, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample M99637\r\nVDJbase example haplotype: P1_I12_S1", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02719", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-38*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-38*03", "sequence": "ATGCAGTTTGTGCTGAGCTGGGTTTTCCTTGTTGGTATTTTAAAAGGTGATTCATGGAGAACTACAGATGTTGAGTGTGAGTGGACATGAGTGAGCAAAACAGTGGGTTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTAGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGTCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAACCTGAGAGCTGAGGGCACGGCCGTGTATTACTGTGCCAGATATACACAGAGGGGAAGTCATTGTGCGCCCAGACACAAACCTC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTAGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGTCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAACCTGAGAGCTGAGGGCACGGCCGTGTATTACTGTGCCAGATATA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "38", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 452, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 453, "v_rs_end": 491, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTAGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGTCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAACCTGAGAGCTGAGGGCACGGCCGTGTATTACTGTGCCAGATATA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTAGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTC............AGTAGCAATGAGATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGTCTGGAGTGGGTCTCATCCATTAGTGGT............GGTAGCACATACTACGCAGACTCCAGGAAG...GGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAACCTGAGAGCTGAGGGCACGGCCGTGTATTACTGTGCCAGATATA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 168, "fwr3_start": 169, "fwr3_end": 282, "cdr3_start": 283, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1232", "sequence": "ATGCAGTTTGTGCTGAGCTGGGTTTTCCTTGTTGGTATTTTAAAAGGTGATTCATGGAGAACTACAGATGTTGAGTGTGAGTGGACATGAGTGAGCAAAACAGTGGGTTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTAGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGTCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAACCTGAGAGCTGAGGGCACGGCCGTGTATTACTGTGCCAGATATACACAGAGGGGAAGTCATTGTGCGCCCAGACACAAACCTC", "repository_name": "GenBank", "repository_ref": "KC162926", "patch_no": "1", "gff_seqid": null, "gff_start": 21938, "gff_end": 22428, "strand": null }, { "sequence_id": "1233", "sequence": "ATGCAGTTTGTGCTGAGCTGGGTTTTCCTTGTTGGTATTTTAAAAGGTGATTCATGGAGAACTACAGATGTTGAGTGTGAGTGGACATGAGTGAGCAAAACAGTGGGTTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTAGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAATGAGATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGTCTGGAGTGGGTCTCATCCATTAGTGGTGGTAGCACATACTACGCAGACTCCAGGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAACCTGAGAGCTGAGGGCACGGCCGTGTATTACTGTGCCAGATATACACAGAGGGGAAGTCATTGTGCGCCCAGACACAAACCTC", "repository_name": "GenBank", "repository_ref": "KC713943", "patch_no": "1", "gff_seqid": null, "gff_start": 251, "gff_end": 741, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample KC162926", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02986", "allele_description_ref": "OGRDB:Homo sapiens:IGHV8-51-1*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV8-51-1*02", "sequence": "TAAGATTTATCTCCTTTTTTGTTTCTCCTTCTGTCTATATTCTCTCTGTCTCTCTCTTCCTCCCTCTTTCTCTCTCTCTCTCCATCTCTCTCTCTCTGTCTCTCTCTCACACACAAATACACACACATGCAATCGTTGACAGTATATAGGCTAATTAAGAATATATTCCCATATGATTTAAAAATAACAGTTTTACAAATATTTGCCTTTAATTTTTCAAAGAAAATTAAATCCAAATGCCAGTGATTTTTTATGTGACTTTTAAAATTTAAATTGTTAATTTTTGTTTTCATCAATGCTTGTATGTGTGCTTTTGTATTCTTTCAGATTATTTGGTGCCTTCACAGAATTAAACATGTGAAACTCTCCACTTGAATTTCTGTGACTCAGGACTGGTGAGCAAAAAGTTAGAAGTCACTCTCCTGATCCTTCCCTACAGCTGCAGATTCCTGAAGGTAATGACCTCACAGTAGACCAAGGCCCTCAAAGGTGACCTTGAGTTCCAGCACATCTTGGGAGGCCAAGCGGATGTTTGTGAAAGAAATAGTGGCTATGTGACAGTTTCTAACCAGAATATCTCTGTGTTTTCAGGTATCCAGGGTGAGGCCCAGCTTACAGAGTCTGGGGGAGACTTGGTACACTTAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTCAGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGTGAAAGTCATCAATACAATGCAGACTATGTTAGGGGCAGACTCACCACTTCCAGAGACAACACCAAGTACATGCTGTACATGCAAATGATCAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAACATCGTGATGGGAAGTCCACGTGGGCTCAGAGACAGACT", "coding_sequence": "GAGGCCCAGCTTACAGAGTCTGGGGGAGACTTGGTACACTTAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTCAGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGTGAAAGTCATCAATACAATGCAGACTATGTTAGGGGCAGACTCACCACTTCCAGAGACAACACCAAGTACATGCTGTACATGCAAATGATCAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": false, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "8-51", "subgroup_designation": "1", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 603, "gene_end": 898, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 48, "leader_2_start": 592, "leader_2_end": 602, "v_rs_start": 899, "v_rs_end": 937, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGCCCAGCTTACAGAGTCTGGGGGAGACTTGGTACACTTAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTCAGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGTGAAAGTCATCAATACAATGCAGACTATGTTAGGGGCAGACTCACCACTTCCAGAGACAACACCAAGTACATGCTGTACATGCAAATGATCAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAA", "aligned_sequence": "GAGGCCCAGCTTACAGAGTCTGGGGGA...GACTTGGTACACTTAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTC............AGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGT......GAAAGTCATCAATACAATGCAGACTATGTTAGG...GGCAGACTCACCACTTCCAGAGACAACACCAAGTACATGCTGTACATGCAAATGATCAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1433", "sequence": "TAAGATTTATCTCCTTTTTTGTTTCTCCTTCTGTCTATATTCTCTCTGTCTCTCTCTTCCTCCCTCTTTCTCTCTCTCTCTCCATCTCTCTCTCTCTGTCTCTCTCTCACACACAAATACACACACATGCAATCGTTGACAGTATATAGGCTAATTAAGAATATATTCCCATATGATTTAAAAATAACAGTTTTACAAATATTTGCCTTTAATTTTTCAAAGAAAATTAAATCCAAATGCCAGTGATTTTTTATGTGACTTTTAAAATTTAAATTGTTAATTTTTGTTTTCATCAATGCTTGTATGTGTGCTTTTGTATTCTTTCAGATTATTTGGTGCCTTCACAGAATTAAACATGTGAAACTCTCCACTTGAATTTCTGTGACTCAGGACTGGTGAGCAAAAAGTTAGAAGTCACTCTCCTGATCCTTCCCTACAGCTGCAGATTCCTGAAGGTAATGACCTCACAGTAGACCAAGGCCCTCAAAGGTGACCTTGAGTTCCAGCACATCTTGGGAGGCCAAGCGGATGTTTGTGAAAGAAATAGTGGCTATGTGACAGTTTCTAACCAGAATATCTCTGTGTTTTCAGGTATCCAGGGTGAGGCCCAGCTTACAGAGTCTGGGGGAGACTTGGTACACTTAGAGGGGCCCCTGAGGCTCTCCTGTGCAGCCTCTTGGTTCACCTTCAGTATCTATGAGATTCACTGGGTTTGCCAGGCCTCAGGGAAGGGGCTGGAATGGGTTGCAGTTATATGGCGTGGTGAAAGTCATCAATACAATGCAGACTATGTTAGGGGCAGACTCACCACTTCCAGAGACAACACCAAGTACATGCTGTACATGCAAATGATCAGCCTGAGAACCCAGAACATGGCAGCATTTAACTGTGCAGGAAACATCGTGATGGGAAGTCCACGTGGGCTCAGAGACAGACT", "repository_name": "GenBank", "repository_ref": "AC244452", "patch_no": "3", "gff_seqid": null, "gff_start": 187666, "gff_end": 188602, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AC244452. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (28 samples). Example subject: P_25_I1.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02780", "allele_description_ref": "OGRDB:Homo sapiens:IGHV5-51*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV5-51*03", "sequence": "AGGCCAGCCTTTTTCTGCATTTGAGGTTCTGGGTTATAAACGCTGTAGACTCCTCCCTTCAGGGCAGGGTGACAACTATGCAAATGCAAGTGGGGGCCTCCCCACTTAAACCCAGGGCTCCCCTCCACAGTGAGTCTCCCTCACTGCCCAGCTGGGATCTCAGGGCTTCATTTTCTGTCCTCCACCATCATGGGGTCAACCGCCATCCTCGCCCTCCTCCTGGCTGTTCTCCAAGGTCAGTCCTGCCGAGGGCTTGAGGTCACAGAGGAGAACGGGTGGAAAGGAGCCCCTGATTCAAATTTTGTGTCTCCCCCACAGGAGTCTGTGCCGAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCGGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACACACAGTGAGAGAAACCAGCCCCGAGCCCGTCTAAAACC", "coding_sequence": "GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCGGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "5", "subgroup_designation": "51", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 330, "gene_end": 625, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 319, "leader_2_end": 329, "v_rs_start": 626, "v_rs_end": 663, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCGGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACA", "aligned_sequence": "GAGGTGCAGCTGGTGCAGTCTGGAGCA...GAGGTGAAAAAGCCGGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTT............ACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGT......GACTCTGATACCAGATACAGCCCGTCCTTCCAA...GGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1389", "sequence": "ATGGGGTCAACCGCCATCCTCGCCCTCCTCCTGGCTGTTCTCCAAGGTCAGTCCTGCCGAGGGCTTGAGGTCACAGAGGAGAACGGGTGGAAAGGAGCCCCTGATTCAAATTTTGTGTCTCCCCCACAGGAGTCTGTGCCGAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCGGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCGCCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACACACAGTGAGAGAAACCAGCCCCGAGCCCGTCTAAAACC", "repository_name": "GenBank", "repository_ref": "ON052090", "patch_no": "1", "gff_seqid": null, "gff_start": 190, "gff_end": 663, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052090\r\nVDJbase example haplotype: P1_I23\r\nVDJbase example haplotype: P1_I24", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00068", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-33*08.2_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 2, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-33*08", "sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "coding_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": "A", "aliases": [ "IGHV3-33*i01" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "33", "allele_designation": "08", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 295, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGAT......GGAAGTAATAAATACTATGCAGACTCCGTGAAG...GGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1223", "sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "repository_name": "GenBank", "repository_ref": "OU596104", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 295, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "IARC meeting 62 (Nov 3rd, 2020):\r\nThe meeting considered the inference of the variant IGHV3-33*01_g75c in the VDJbase datasets of samples P1_I46_S1 and P1_I93_S1. Similar frequencies were seen in the two samples, and data recorded here comes from the P1_I46 sample. The sequence was seen in 1.94% of all unmutated rearrangements, with 386 sequences including 314 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. IGHV3-33*01 was also present in the genotype, at a similar frequency (2.40% of all unmutated sequences, 466 sequences, 388 unmutated sequences). Plots of the final 3\u2019 nucleotides were unavailable. Haplotyping data strongly supported the inference. The sequence was tentatively affirmed as a Level 1 sequence, and the final 3\u2019 nucleotides will be considered at a later date, when terminal nucleotide plots become available, at which time the affirmed sequence will be noted in the IARC minutes.\r\n\r\niARC meeting 82 (Oct 11th, 2021):\r\nIGHV3-33*01_G75C was inferred in a genotype (VDJbase P1_I46). This inference has previously been pre-assessed at IARC meeting 62 (https://www.antibodysociety.org/wordpress/wp-content/uploads/2021/04/Meeting-62-3_11_20-minutes.pdf). Among alleles of the IGHV3-30/IGHV3-30-3/IGHV3-33 set the genotype in addition only carried IGHV3-33*01 as defined by OGRDB. The two alleles were supported by similar numbers of sequences (allelic frequency 46%). IGHV3-33*01_G75C was associated to multiple (388) unique CDR3s. The genotype of this subject as defined by VDJbase also features IGHV3-30*18/IGHV3-30-5*01. IgDiscover-based analysis has also identified IGHV3-30*18 in this genotype. This lack of definition of this allele in the haplotyped data in VDJbase is being addressed. Haplotyping based on alleles of IGHJ6 supported its presence (ratio: 99:1 (IGHV3-33*01) and 2:98 (IGHV3-33*01_G75C), respectively). IGHV3-33*01_G75C is identical to IGHV3-33*08 that entered into the IMGT-DB on March 5th, 2021 based on its presence in GenBank entry accession number AC279998. IARC affirms, based on information in the transcriptome of this subject, the sequence as a level 1 sequence up to and including base 319 in agreement with past practice. A trailing \u201c.\u201d indicates IARC\u2019s opinion that the sequence is likely to contain an additional 3\u2019 nucleotide for which there is insufficient evidence to make an affirmation. It is acknowledged that the allele most likely carry one additional base, typically A at base position 320. The allele is given the name IGHV3-33*i01. We recognise that this allele might have been located at IGHV3-30, IGHV3-30-3, IGHV3-30-5, and/or IGHV3-33 in this subject and IARC gene naming does not reflect a position on this matter.\r\n\r\n>IGHV3-33*i01\r\nCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATGGTATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAG.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample OU596104\r\nVDJbase example haplotype: P1_I93\r\nMapped by P1_I93 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02722", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-43*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-43*02", "sequence": "TCGCGAGCTGTTTGCAGGTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGTCAAGCTCCAGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTGGGGATGGTGGTAGCACATACTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAACTGAGGACACCGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGGGAGGTCAGTG", "coding_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGTCAAGCTCCAGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTGGGGATGGTGGTAGCACATACTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAACTGAGGACACCGCCTTGTATTACTGTGCAAAAGATA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "43", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 326, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 18, "leader_2_end": 28, "v_rs_start": 327, "v_rs_end": 355, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGTCAAGCTCCAGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTGGGGATGGTGGTAGCACATACTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAACTGAGGACACCGCCTTGTATTACTGTGCAAAAGATA", "aligned_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGA...GGCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTT............GATGATTATGCCATGCACTGGGTCCGTCAAGCTCCAGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTGGGGAT......GGTGGTAGCACATACTATGCAGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAACTGAGGACACCGCCTTGTATTACTGTGCAAAAGATA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1240", "sequence": "GTGTCCAGTGTGAAGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGTCAAGCTCCAGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTGGGGATGGTGGTAGCACATACTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAACTGAGGACACCGCCTTGTATTACTGTGCAAAAGATACACAGTGAGGGGAGGTCAGTG", "repository_name": "GenBank", "repository_ref": "HM855590", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 330, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855590\r\nVDJbase example haplotype: P1_I41_S1\r\nMapped by P1_I41 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02662", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-58*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-58*02", "sequence": "ATGGACTGGATTTGGAGGGTCCTCTTCTTGGTGGGAGCAGCGACAGGCAAGGAGATGCCAAGTCCCAGTGATGAGGAGGGGATTGAGTCCAGTCAAGGTGGCTTTCATCCACTCCTGTGTTCTCTCCACAGGTGCCCACTCCCAAATGCAGCTGGTGCAGTCTGGGCCTGAGGTGAAGAAGCCTGGGACCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATTCACCTTTACTAGCTCTGCTATGCAGTGGGTGCGACAGGCTCGTGGACAACGCCTTGAGTGGATAGGATGGATCGTCGTTGGCAGTGGTAACACAAACTACGCACAGAAGTTCCAGGAAAGAGTCACCATTACCAGGGACATGTCCACAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCCGAGGACACGGCCGTGTATTACTGTGCGGCAGACACAGTGTGAAAACCCACATCCTGAGAGTGTCAGAAACG", "coding_sequence": "CAAATGCAGCTGGTGCAGTCTGGGCCTGAGGTGAAGAAGCCTGGGACCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATTCACCTTTACTAGCTCTGCTATGCAGTGGGTGCGACAGGCTCGTGGACAACGCCTTGAGTGGATAGGATGGATCGTCGTTGGCAGTGGTAACACAAACTACGCACAGAAGTTCCAGGAAAGAGTCACCATTACCAGGGACATGTCCACAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCCGAGGACACGGCCGTGTATTACTGTGCGGCAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "58", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 143, "gene_end": 438, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 61, "leader_2_start": 132, "leader_2_end": 142, "v_rs_start": 439, "v_rs_end": 477, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAAATGCAGCTGGTGCAGTCTGGGCCTGAGGTGAAGAAGCCTGGGACCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATTCACCTTTACTAGCTCTGCTATGCAGTGGGTGCGACAGGCTCGTGGACAACGCCTTGAGTGGATAGGATGGATCGTCGTTGGCAGTGGTAACACAAACTACGCACAGAAGTTCCAGGAAAGAGTCACCATTACCAGGGACATGTCCACAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCCGAGGACACGGCCGTGTATTACTGTGCGGCAGA", "aligned_sequence": "CAAATGCAGCTGGTGCAGTCTGGGCCT...GAGGTGAAGAAGCCTGGGACCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATTCACCTTT............ACTAGCTCTGCTATGCAGTGGGTGCGACAGGCTCGTGGACAACGCCTTGAGTGGATAGGATGGATCGTCGTTGGC......AGTGGTAACACAAACTACGCACAGAAGTTCCAG...GAAAGAGTCACCATTACCAGGGACATGTCCACAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCCGAGGACACGGCCGTGTATTACTGTGCGGCAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1104", "sequence": "ATGAGGAGGGGATTGAGTCCAGTCAAGGTGGCTTTCATCCACTCCTGTGTTCTCTCCACAGGTGCCCACTCCCAAATGCAGCTGGTGCAGTCTGGGCCTGAGGTGAAGAAGCCTGGGACCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATTCACCTTTACTAGCTCTGCTATGCAGTGGGTGCGACAGGCTCGTGGACAACGCCTTGAGTGGATAGGATGGATCGTCGTTGGCAGTGGTAACACAAACTACGCACAGAAGTTCCAGGAAAGAGTCACCATTACCAGGGACATGTCCACAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCCGAGGACACGGCCGTGTATTACTGTGCGGCAGACACAGTGTGAAAACCCAC", "repository_name": "GenBank", "repository_ref": "MG719324", "patch_no": "1", "gff_seqid": null, "gff_start": 54, "gff_end": 439, "strand": null }, { "sequence_id": "1106", "sequence": "ATGGACTGGATTTGGAGGGTCCTCTTCTTGGTGGGAGCAGCGACAGGCAAGGAGATGCCAAGTCCCAGTGATGAGGAGGGGATTGAGTCCAGTCAAGGTGGCTTTCATCCACTCCTGTGTTCTCTCCACAGGTGCCCACTCCCAAATGCAGCTGGTGCAGTCTGGGCCTGAGGTGAAGAAGCCTGGGACCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATTCACCTTTACTAGCTCTGCTATGCAGTGGGTGCGACAGGCTCGTGGACAACGCCTTGAGTGGATAGGATGGATCGTCGTTGGCAGTGGTAACACAAACTACGCACAGAAGTTCCAGGAAAGAGTCACCATTACCAGGGACATGTCCACAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCCGAGGACACGGCCGTGTATTACTGTGCGGCAGACACAGTGTGAAAACCCACATCCTGAGAGTGTCAGAAACG", "repository_name": "GenBank", "repository_ref": "ON052036", "patch_no": "1", "gff_seqid": null, "gff_start": 279, "gff_end": 755, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019438\r\nVDJbase example haplotype: P1_I10", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02746", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-7*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-7*01", "sequence": "ATGGAATTGGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGATTCATGGAAAACTAGGAAGATTGAGTGTGTGTGGATATGAGTGTGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "7", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 456, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 457, "v_rs_end": 495, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTT............AGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAAAGCAAGAT......GGAAGTGAGAAATACTATGTGGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1286", "sequence": "ATGGAATTGGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGATTCATGGAAAACTAGGAAGATTGAGTGTGTGTGGATATGAGTGTGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "M99649", "patch_no": "1", "gff_seqid": null, "gff_start": 184, "gff_end": 678, "strand": null }, { "sequence_id": "1287", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCAATGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855935", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 345, "strand": null }, { "sequence_id": "1288", "sequence": "ATGGAATTGGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGATTCATGGAAAACTAGGAAGATTGAGTGTGTGTGGATATGAGTGTGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052072", "patch_no": "1", "gff_seqid": null, "gff_start": 267, "gff_end": 761, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample M99649\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02627", "allele_description_ref": "OGRDB:Homo sapiens:IGHD4-17*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD4-17*01", "sequence": "GCTTTTTGTGAAGGCCCCTCCTACTGTGTGACTACGGTGACTACCACAGTGATGAAACTAGCAGCAAAAACT", "coding_sequence": "TGACTACGGTGACTAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "17", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 44, "d_rs_3_prime_start": 45, "d_rs_3_prime_end": 72, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "993", "sequence": "GCTTTTTGTGAAGGCCCCTCCTACTGTGTGACTACGGTGACTACCACAGTGATGAAACTAGCAGCAAAAACT", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 58671, "gff_end": 58742, "strand": null }, { "sequence_id": "994", "sequence": "GCTTTTTGTGAAGGCCCCTCCTACTGTGTGACTACGGTGACTACCACAGTGATGAAACTAGCAGCAAAAACT", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 129131, "gff_end": 129202, "strand": null }, { "sequence_id": "995", "sequence": "GCTTTTTGTGAAGGCCCCTCCTACTGTGTGACTACGGTGACTACCACAGTGATGAAACTAGCAGCAAAAACT", "repository_name": "GenBank", "repository_ref": "ON052108", "patch_no": "1", "gff_seqid": null, "gff_start": 75, "gff_end": 146, "strand": null }, { "sequence_id": "996", "sequence": "GCTTTTTGTGAAGGCCCCTCCTACTGTGTGACTACGGTGACTACCACAGTGATGAAACTAGCAGCAAAAACT", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 985294, "gff_end": 985365, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02749", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-72*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-72*01", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGTTATTTTACAAGGTGATTTATGGAGAACTAGAGATGTTAAGTGTGAGTGGACGTGAGTGAGAGAAACAGTGGATTTGTGTGACAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACCACTACATGGACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTGGCCGTACTAGAAACAAAGCTAACAGTTACACCACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCAAAGAACTCACTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTGCTAGAGACACAGCGAGGGGAGGTCAGTGTGAGCCCGGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACCACTACATGGACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTGGCCGTACTAGAAACAAAGCTAACAGTTACACCACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCAAAGAACTCACTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTGCTAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "72", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 462, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 463, "v_rs_end": 501, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACCACTACATGGACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTGGCCGTACTAGAAACAAAGCTAACAGTTACACCACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCAAAGAACTCACTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTGCTAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTCCAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTGACCACTACATGGACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTGGCCGTACTAGAAACAAAGCTAACAGTTACACCACAGAATACGCCGCGTCTGTGAAA...GGCAGATTCACCATCTCAAGAGATGATTCAAAGAACTCACTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTGCTAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 180, "fwr3_start": 181, "fwr3_end": 294, "cdr3_start": 295, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1295", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGTTATTTTACAAGGTGATTTATGGAGAACTAGAGATGTTAAGTGTGAGTGGACGTGAGTGAGAGAAACAGTGGATTTGTGTGACAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACCACTACATGGACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTGGCCGTACTAGAAACAAAGCTAACAGTTACACCACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCAAAGAACTCACTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTGCTAGAGACACAGCGAGGGGAGGTCAGTGTGAGCCCGGACACAAACC", "repository_name": "GenBank", "repository_ref": "AB019437", "patch_no": "1", "gff_seqid": null, "gff_start": 90150, "gff_end": 90650, "strand": null }, { "sequence_id": "1296", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACCACTACATGGACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTGGCCGTACTAGAAACAAAGCTAACAGTTACACCACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCAAAGAACTCACTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTGCTAGAGACACAGTGGAGGGGAGTCAATGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855891", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 351, "strand": null }, { "sequence_id": "1297", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGTTATTTTACAAGGTGATTTATGGAGAACTAGAGATGTTAAGTGTGAGTGGACGTGAGTGAGAGAAACAGTGGATTTGTGTGACAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACCACTACATGGACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTGGCCGTACTAGAAACAAAGCTAACAGTTACACCACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCAAAGAACTCACTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTGCTAGAGACACAGCGAGGGGAGGTCAGTGTGAGC", "repository_name": "GenBank", "repository_ref": "ON052074", "patch_no": "1", "gff_seqid": null, "gff_start": 203, "gff_end": 690, "strand": null }, { "sequence_id": "1298", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGTTATTTTACAAGGTGATTTATGGAGAACTAGAGATGTTAAGTGTGAGTGGACGTGAGTGAGAGAAACAGTGGATTTGTGTGACAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACCACTACATGGACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTGGCCGTACTAGAAACAAAGCTAACAGTTACACCACAGAATACGCCGCGTCTGTGAAAGGCAGATTCACCATCTCAAGAGATGATTCAAAGAACTCACTGTATCTGCAAATGAACAGCCTGAAAACCGAGGACACGGCCGTGTATTACTGTGCTAGAGACACAGCGAGGGGAGGTCAGTGTGAGCCCGGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 88692, "gff_end": 89192, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019437\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02713", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-30*18.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-30*18", "sequence": "GCCCTCCCTCTACTGATGAAAACCAGCCCAGCCCTGACCCTGCAGCTCTGGGAGAGGAGCCCAGCACTAGAAGTCGGCGGTGTTTCCATTCGGTGATCAGCACTGAACACAGAGGACTCACCATGGAGTTTGGGCTGAGCTGGGTTTTCCTCGTTGCTCTTTTAAGAGGTGATTCATGGAGAAATAGAGAGACTGAGTGTGAGTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCATTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGACACAGTGAGGGGAAGTCATTGTGCGCCCAGACACAAACC", "coding_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "30", "allele_designation": "18", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 281, "gene_end": 576, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 270, "leader_2_end": 280, "v_rs_start": 577, "v_rs_end": 615, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGA", "aligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGAT......GGAAGTAATAAATACTATGCAGACTCCGTGAAG...GGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1215", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTCGTTGCTCTTTTAAGAGGTGATTCATGGAGAAATAGAGAGACTGAGTGTGAGTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCATTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGACACAGTGAGGGGAAGTCATTGTGCGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052058", "patch_no": "1", "gff_seqid": null, "gff_start": 123, "gff_end": 615, "strand": null }, { "sequence_id": "1216", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTCGTTGCTCTTTTAAGAGGTGATTCATGGAGAAATAGAGAGACTGAGTGTGAGTGAACATGAGTGAGAAAAACTGGATTTGTGTGGCATTTTCTGATAACGGTGTCCTTCTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGACACAGTGAGGGGAAGTCATTGTGCGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 544312, "gff_end": 544804, "strand": null } ], "rearranged_support": [], "paralogs": [ "IGHV3-30-5*01" ], "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052058\r\nVDJbase example haplotype: P1_I40", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02736", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-64*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-64*01", "sequence": "AGCTCTGGGAGAGGAGCCCCCCCCCTGGGATTCCCAGGTGTTTTCATTTGGTGATCAGCACTGAACACAGAAGAGTCATGACGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTTAAAGGTGATTCATGAGGAAATAGAGATATTGAGTGTGAGTGGACATGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATATTATGCAAACTCTGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGGGCAGCCTGAGAGCTGAGGACATGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGAGAAGTTAATGTGGGACCATGCAGAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATATTATGCAAACTCTGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGGGCAGCCTGAGAGCTGAGGACATGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "64", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 241, "gene_end": 536, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 230, "leader_2_end": 240, "v_rs_start": 537, "v_rs_end": 575, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATATTATGCAAACTCTGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGGGCAGCCTGAGAGCTGAGGACATGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAAT......GGGGGTAGCACATATTATGCAAACTCTGTGAAG...GGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGGGCAGCCTGAGAGCTGAGGACATGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1271", "sequence": "ATGACGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTTAAAGGTGATTCATGAGGAAATAGAGATATTGAGTGTGAGTGGACATGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATATTATGCAAACTCTGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGGGCAGCCTGAGAGCTGAGGACATGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGAGAAGTTAATGTGGGACCATGCAGAAACC", "repository_name": "GenBank", "repository_ref": "M99682", "patch_no": "1", "gff_seqid": null, "gff_start": 78, "gff_end": 575, "strand": null }, { "sequence_id": "1272", "sequence": "ATGACGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTTAAAGGTGATTCATGAGGAAATAGAGATATTGAGTGTGAGTGGACATGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATATTATGCAAACTCTGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGGGCAGCCTGAGAGCTGAGGACATGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGAGAAGTTAATGTGGGACCATGCAGAAACC", "repository_name": "GenBank", "repository_ref": "ON052068", "patch_no": "1", "gff_seqid": null, "gff_start": 191, "gff_end": 688, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample M99682\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02621", "allele_description_ref": "OGRDB:Homo sapiens:IGHD3-10*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD3-10*01", "sequence": "GGTTTGGGGTGAGGTCTGTGTCACTGTGGTATTACTATGGTTCGGGGAGTTATTATAACCACAGTGTCACAGAGTCCATCAAAAACC", "coding_sequence": "GTATTACTATGGTTCGGGGAGTTATTATAAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "10", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 59, "d_rs_3_prime_start": 60, "d_rs_3_prime_end": 87, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "970", "sequence": "GGTTTGGGGTGAGGTCTGTGTCACTGTGGTATTACTATGGTTCGGGGAGTTATTATAACCACAGTGTCACAGAGTCCATCAAAAACC", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 48668, "gff_end": 48754, "strand": null }, { "sequence_id": "971", "sequence": "GGTTTGGGGTGAGGTCTGTGTCACTGTGGTATTACTATGGTTCGGGGAGTTATTATAACCACAGTGTCACAGAGTCCATCAAAAACC", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 119128, "gff_end": 119214, "strand": null }, { "sequence_id": "972", "sequence": "GGTTTGGGGTGAGGTCTGTGTCACTGTGGTATTACTATGGTTCGGGGAGTTATTATAACCACAGTGTCACAGAGTCCATCAAAAACC", "repository_name": "GenBank", "repository_ref": "ON052102", "patch_no": "1", "gff_seqid": null, "gff_start": 96, "gff_end": 182, "strand": null }, { "sequence_id": "973", "sequence": "GGTTTGGGGTGAGGTCTGTGTCACTGTGGTATTACTATGGTTCGGGGAGTTATTATAACCACAGTGTCACAGAGTCCATCAAAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 975290, "gff_end": 975376, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02687", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-11*05.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-11*05", "sequence": "CTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTTACACAAACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCATTGCTCGCGA", "coding_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTTACACAAACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "11", "allele_designation": "05", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 22, "gene_end": 317, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 11, "leader_2_end": 21, "v_rs_start": 318, "v_rs_end": 346, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTTACACAAACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGT......AGTAGTTACACAAACTACGCAGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1157", "sequence": "GTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTTACACAAACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCATTGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855737", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 345, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855737\r\nVDJbase example haplotype: P1_I27_S1", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02671", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-69*14.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-69*14", "sequence": "ATGGACTGGACCTGGAGGTTCCTCTTTGTGGTGGCAGCAGCTACAGGTAAGGGGCTTCCTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTCTCCACAGGTGTCCAGTCCCAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGAGTGTCAGAAACC", "coding_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "69", "allele_designation": "14", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 144, "gene_end": 439, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 133, "leader_2_end": 143, "v_rs_start": 440, "v_rs_end": 478, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTC............AGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATC......TTTGGTACAGCAAACTACGCACAGAAGTTCCAG...GGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1120", "sequence": "ATGGACTGGACCTGGAGGTTCCTCTTTGTGGTGGCAGCAGCTACAGGTAAGGGGCTTCCTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTCTCCACAGGTGTCCAGTCCCAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGAGTGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "KC713948", "patch_no": "1", "gff_seqid": null, "gff_start": 251, "gff_end": 728, "strand": null }, { "sequence_id": "1121", "sequence": "ATGGACTGGACCTGGAGGTTCCTCTTTGTGGTGGCAGCAGCTACAGGTAAGGGGCTTCCTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTCTCCACAGGTGTCCAGTCCCAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACAAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGAGTGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "AC234135", "patch_no": "3", "gff_seqid": null, "gff_start": 35310, "gff_end": 35787, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample KC713948", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02757", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-28*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-28*01", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGAGCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGTGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "28", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 140, "gene_end": 435, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 129, "leader_2_end": 139, "v_rs_start": 436, "v_rs_end": 474, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGC.........AGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 102, "fwr2_start": 103, "fwr2_end": 153, "cdr2_start": 154, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1320", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGAGCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGTGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AB019439", "patch_no": "1", "gff_seqid": null, "gff_start": 108596, "gff_end": 109069, "strand": null }, { "sequence_id": "1321", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGAGCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "KC162924", "patch_no": "1", "gff_seqid": null, "gff_start": 9518, "gff_end": 9991, "strand": null }, { "sequence_id": "1322", "sequence": "GGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAACACAGTGAGGGAGGTGAGTGTGACGC", "repository_name": "GenBank", "repository_ref": "HM855856", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 333, "strand": null }, { "sequence_id": "1323", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGAGCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAAACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052079", "patch_no": "1", "gff_seqid": null, "gff_start": 267, "gff_end": 740, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019439\r\nVDJbase example haplotype: P1_I15 (2 exact matches)", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02648", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-18*04.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-18*04", "sequence": "ATGGACTGGACCTGGAGCATCCTTTTCTTGGTGGCAGCAGCAACAGGTAACGGACTCCCCAGTCCCAGGGCTGAGAGAGAAACCAGGCCAGTCATGTGAGACTTCACCCACTCCTGTGTCCTCTCCACAGGTGCCCACTCCCAGGTTCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTACCAGCTACGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTACAATGGTAACACAAACTATGCACAGAAGCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGGGTTTCAGAAACC", "coding_sequence": "CAGGTTCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTACCAGCTACGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTACAATGGTAACACAAACTATGCACAGAAGCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "18", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 142, "gene_end": 437, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 131, "leader_2_end": 141, "v_rs_start": 438, "v_rs_end": 476, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTTCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTACCAGCTACGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTACAATGGTAACACAAACTATGCACAGAAGCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTTCAGCTGGTGCAGTCTGGAGCT...GAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTT............ACCAGCTACGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTAC......AATGGTAACACAAACTATGCACAGAAGCTCCAG...GGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1069", "sequence": "ATGGACTGGACCTGGAGCATCCTTTTCTTGGTGGCAGCAGCAACAGGTAACGGACTCCCCAGTCCCAGGGCTGAGAGAGAAACCAGGCCAGTCATGTGAGACTTCACCCACTCCTGTGTCCTCTCCACAGGTGCCCACTCCCAGGTTCAGCTGGTGCAGTCTGGAGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGTTACACCTTTACCAGCTACGGTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAGCGCTTACAATGGTAACACAAACTATGCACAGAAGCTCCAGGGCAGAGTCACCATGACCACAGACACATCCACGAGCACAGCCTACATGGAGCTGAGGAGCCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGGGTTTCAGAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 694510, "gff_end": 694985, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample GRCh38:CM000676.2\r\nVDJbase example haplotype: P1_I12_S1", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02766", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-38-2*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-38-2*01", "sequence": "GGCGCCTCTCTCATCCCTTTTCACTGCTCCGTACAAAGGCACCACCCACATGCAAATCCTCACTTAGGCGCCCACAGGAAGCCACAACACATTTCCTTAAATTCAGGTCCAACTCATAAGGGAAATGCTTTCTGAGAGTCATGGACCTCCTGTGCAAGAACATGAAGCACCTGTGGTTTTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAGGGATCCAGACGTGAAGATATGGGAAGTGCCTCTGATCCCAGGGCTCACCGTGGGTTTTTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTGGTTACTACTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCC", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTGGTTACTACTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4-38", "subgroup_designation": "2", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 301, "gene_end": 596, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 290, "leader_2_end": 300, "v_rs_start": 597, "v_rs_end": 625, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTGGTTACTACTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGC.........AGTGGTTACTACTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATCATAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 102, "fwr2_start": 103, "fwr2_end": 153, "cdr2_start": 154, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1347", "sequence": "ATGAAGCACCTGTGGTTTTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAGGGATCCAGACGTGAAGATATGGGAAGTGCCTCTGATCCCAGGGCTCACCGTGGGTTTTTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTGGTTACTACTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCC", "repository_name": "GenBank", "repository_ref": "ON052084", "patch_no": "1", "gff_seqid": null, "gff_start": 162, "gff_end": 623, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052084\r\nVDJbase example haplotype: P1_I23\r\nVDJbase example haplotype: P1_I16\r\nMapped by P1_I23 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02756", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-NL1*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-NL1*01", "sequence": "CTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGTAGCACATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGACACAGTGGAGGGGAGGTCAATGCTCGCGA", "coding_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGTAGCACATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "NL1", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 22, "gene_end": 317, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 11, "leader_2_end": 21, "v_rs_start": 318, "v_rs_end": 346, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGTAGCACATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGA", "aligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTC............AGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGT......GGTAGTAGCACATACTATGCAGACTCCGTGAAG...GGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1318", "sequence": "GTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGTAGCACATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGACACAGTGGAGGGGAGGTCAATGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855939", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 346, "strand": null }, { "sequence_id": "1319", "sequence": "GTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCGTCTGGATTCACCTTCAGTAGCTATGGCATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGTAGCACATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGACACAGTGAGGGGAAGTCAGTGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855685", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 345, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855939", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02748", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-7*05.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-7*05", "sequence": "ATGGAGTTGGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGATTCATGGAAAACTAGGAAGATTGAGTGTGTGTGGATATGAGTGTGAGAAACAGTGGATTTGTGTGTCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAAGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAAGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "7", "allele_designation": "05", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 456, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 457, "v_rs_end": 495, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAAGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTT............AGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAAGGGCTGGAGTGGGTGGCCAACATAAAGCAAGAT......GGAAGTGAGAAATACTATGTGGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1294", "sequence": "ATGGAGTTGGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGATTCATGGAAAACTAGGAAGATTGAGTGTGTGTGGATATGAGTGTGAGAAACAGTGGATTTGTGTGTCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAAGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "MN337619", "patch_no": "1", "gff_seqid": null, "gff_start": 165, "gff_end": 659, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MN337619\r\nVDJbase example haplotype: P1_I67\r\nMapped by P1_I67 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00071", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-39*09.2_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 2, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-39*09", "sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCAGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "coding_sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCAGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": "A", "aliases": [ "IGHV4-39*i02" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "39", "allele_designation": "09", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 298, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCAGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGC......AGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCAGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1356", "sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCAGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "repository_name": "GenBank", "repository_ref": "OU596103", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 298, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "IARC meeting 63, Nov 24th, 2020:\r\nThe meeting considered the inference of the variant IGHV4-39*07_c288a in the VDJbase datasets of sample P1_I29_S1. (It was present in two other VDJbase samples). The sequence was seen in 4.61% of all unmutated rearrangements, with 1201 sequences including 1068 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. IGHV4-39*01 was also present in the genotype, at a similar frequency (4.35% of all unmutated sequences, 1135 sequences, 1009 unmutated sequences). Plots of the final 3\u2019 nucleotides were unavailable. Haplotyping data strongly supported the inference. The sequence was tentatively affirmed as a Level 1 sequence, and the final 3\u2019 nucleotides will be considered at a later date, when terminal nucleotide plots become available, at which time the affirmed sequence will be noted in the IARC minutes.\r\n\r\nIARC-meeting 84, Oct 25th, 2021:\r\nIGHV4-39*07_C288A was inferred in subject S29 (VDJ-base: P1_I29_S1). This inference has previously been pre-assessed at IARC meeting 63 (https://www.antibodysociety.org/wordpress/wp-content/uploads/2020/12/Meeting-63-24_11_20-minutes.pdf). The genotype also carried IGHV4-39*01. The inference was supported by many sequences (1304) and unmutated sequences (1107) a balanced allelic frequency (52%), a high overall frequency in the unmutated population (5.7%) and many unique CDR3s (1086) in the unmutated sequence set. Haplotyping based on allelic diversity in IGHJ6 was possible and the alleles distributed well between haplotypes (IGHV4-39*07_C288A: 99:1; IGHV4-39*01: 0:100). IARC infers the sequence at level 1 up to and including base 319 in agreement with past practice. It is acknowledged that the allele most likely carry one additional base, typically A at base position 320. The allele is given the name IGHV4-39*i02.\r\n\r\n>IGHV4-39*i02 (IGHV4-39*07_C288A)\r\nCAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCAGCGGACACGGCCGTGTATTACTGTGCGAGAG.\r\n\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample OU596103\r\nVDJbase example haplotype: P1_I29 (*07_c288a)\r\nVDJbase example haplotype: P1_I29 (*07_c288a)\r\nMapped by P1_I29 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02673", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-69*19.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-69*19", "sequence": "CCATGGACTGGACCTGGAGGTTCCTCTTTGTGGTGGCAGCAGCTACAGGTAAGGGGCTTCCTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTCTCCACAGGTGTCCAGTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGATGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGA", "coding_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGATGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "69", "allele_designation": "19", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 146, "gene_end": 441, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 135, "leader_2_end": 145, "v_rs_start": 442, "v_rs_end": 464, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGATGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTC............AGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATC......TTTGGTACAGCAAACTACGCACAGAAGTTCCAG...GGCAGAGTCACGATTACCGCGGATGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1124", "sequence": "ATGGACTGGACCTGGAGGTTCCTCTTTGTGGTGGCAGCAGCTACAGGTAAGGGGCTTCCTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTCTCCACAGGTGTCCAGTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAGGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGATGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTG", "repository_name": "GenBank", "repository_ref": "MN337618", "patch_no": "1", "gff_seqid": null, "gff_start": 3, "gff_end": 450, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MN337618\r\nVDJbase example haplotype: P1_I38", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00012", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-31*11.4_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 4, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-31*11", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": "A", "aliases": [ "IGHV4-31*i01" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "31", "allele_designation": "11", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 298, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGC......AGTGGTGGTTACTACTGGAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCGAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1342", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTACTGGAGCTGGATCCGCCAGCACCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCTAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "repository_name": "GenBank", "repository_ref": "MK321691", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 298, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "This sequence represents IGHV4-31*03 A70G in the IMGT numbering system. The committee noted a rearrangement frequency of 0.9%, with 812 alignments including 293 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. There was no alternative allele present in the genotype, but there are published reports (eg Gidoni et al 2019) of a deletion polymorphism involving the IGHV4-31 locus. All members of the committee agreed that the sequence should be accepted as a Level 1 sequence. Sequences have been submitted to SRA/ENA with acession numbers SRR8298743 and SRR8298742. The sequence was affirmed at level 1 at IARC Meeting 32 on March 1, 2019. In line with previous policy, the submitted sequence will be recognized up to and including nucleotide 319.\r\n\r\n(April 12, 2019) A trailing \".\" in the sequence indicates IARC's opinion that the sequence is likely to contain additional 3' nucleotides for which there is insufficient evidence to make an affirmation.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MK321691", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02660", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-46*04.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-46*04", "sequence": "ATGGACTGGACCTGGAGGGTCTTCTGCTTGCTGGCTGTAGCTCCAGGTAAAGGGCCAACTGGTTCCAGGGCTGAGGAAGGGATTTTTTCCAGTTTAGAGGACTGTCATTCTCTACTGTGTCCTCTCCGCAGGTGCTCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCAGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGTGGTGGTAGCACAAGCTACGCACAGAAGTTGCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAGAAACCACATCCTCAGAGTGTCAGAAACC", "coding_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCAGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGTGGTGGTAGCACAAGCTACGCACAGAAGTTGCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "46", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 143, "gene_end": 438, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 132, "leader_2_end": 142, "v_rs_start": 439, "v_rs_end": 477, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCAGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGTGGTGGTAGCACAAGCTACGCACAGAAGTTGCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTC............ACCAGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGT......GGTGGTAGCACAAGCTACGCACAGAAGTTGCAG...GGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1100", "sequence": "ATGGACTGGACCTGGAGGGTCTTCTGCTTGCTGGCTGTAGCTCCAGGTAAAGGGCCAACTGGTTCCAGGGCTGAGGAAGGGATTTTTTCCAGTTTAGAGGACTGTCATTCTCTACTGTGTCCTCTCCGCAGGTGCTCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCAGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGTGGTGGTAGCACAAGCTACGCACAGAAGTTGCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAGAAACCACATCCTCAGAGTGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "MN337617", "patch_no": "1", "gff_seqid": null, "gff_start": 175, "gff_end": 651, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MN337617\r\nVDJbase example haplotype: P1_I93_S1\r\nMapped by P1_I93 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02678", "allele_description_ref": "OGRDB:Homo sapiens:IGHV2-26*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV2-26*01", "sequence": "AGTGACTCCTGTGCCCCACCATGGACACACTTTGCTACACACTCCTGCTGCTGACCACCCCTTCCTGTGAGTGCTGTGGTCAGGGACTTCCTCAGAAGTGAAACATCAGTTGTCTCCTTTGTGGGCTTCATCTTCTTATGTCTTCTCCACAGGGGTCTTGTCCCAGGTCACCTTGAAGGAGTCTGGTCCTGTGCTGGTGAAACCCACAGAGACCCTCACGCTGACCTGCACCGTCTCTGGGTTCTCACTCAGCAATGCTAGAATGGGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACACATTTTTTCGAATGACGAAAAATCCTACAGCACATCTCTGAAGAGCAGGCTCACCATCTCCAAGGACACCTCCAAAAGCCAGGTGGTCCTTACCATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACGGATACCACAGAGACACAGCCCAGGATGCCTCCTGTACAAGAACC", "coding_sequence": "CAGGTCACCTTGAAGGAGTCTGGTCCTGTGCTGGTGAAACCCACAGAGACCCTCACGCTGACCTGCACCGTCTCTGGGTTCTCACTCAGCAATGCTAGAATGGGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACACATTTTTTCGAATGACGAAAAATCCTACAGCACATCTCTGAAGAGCAGGCTCACCATCTCCAAGGACACCTCCAAAAGCCAGGTGGTCCTTACCATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACGGATAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "2", "subgroup_designation": "26", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 164, "gene_end": 464, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 153, "leader_2_end": 163, "v_rs_start": 465, "v_rs_end": 503, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCACCTTGAAGGAGTCTGGTCCTGTGCTGGTGAAACCCACAGAGACCCTCACGCTGACCTGCACCGTCTCTGGGTTCTCACTCAGCAATGCTAGAATGGGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACACATTTTTTCGAATGACGAAAAATCCTACAGCACATCTCTGAAGAGCAGGCTCACCATCTCCAAGGACACCTCCAAAAGCCAGGTGGTCCTTACCATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACGGATAC", "aligned_sequence": "CAGGTCACCTTGAAGGAGTCTGGTCCT...GTGCTGGTGAAACCCACAGAGACCCTCACGCTGACCTGCACCGTCTCTGGGTTCTCACTCAGC......AATGCTAGAATGGGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACACATTTTTTCGAAT.........GACGAAAAATCCTACAGCACATCTCTGAAG...AGCAGGCTCACCATCTCCAAGGACACCTCCAAAAGCCAGGTGGTCCTTACCATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACGGATAC", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1135", "sequence": "ATGGACACACTTTGCTACACACTCCTGCTGCTGACCACCCCTTCCTGTGAGTGCTGTGGTCAGGGACTTCCTCAGAAGTGAAACATCAGTTGTCTCCTTTGTGGGCTTCATCTTCTTATGTCTTCTCCACAGGGGTCTTGTCCCAGGTCACCTTGAAGGAGTCTGGTCCTGTGCTGGTGAAACCCACAGAGACCCTCACGCTGACCTGCACCGTCTCTGGGTTCTCACTCAGCAATGCTAGAATGGGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACACATTTTTTCGAATGACGAAAAATCCTACAGCACATCTCTGAAGAGCAGGCTCACCATCTCCAAGGACACCTCCAAAAGCCAGGTGGTCCTTACCATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACGGATACCACAGAGACACAGCCCAGGATGCCTCCTGTACAAGAACC", "repository_name": "GenBank", "repository_ref": "M99648", "patch_no": "1", "gff_seqid": null, "gff_start": 21, "gff_end": 503, "strand": null }, { "sequence_id": "1136", "sequence": "ATGGACACACTTTGCTACATACTCCTGCTGCTGACCACCCCTTCCTGTGAGTGCTGTGGTCAGGGACTTCCTCAGAAGTGAAACATCAGTTGTCTCCTTTGTGGGCTTCATCTTCTTATGTCTTCTCCACAGGGGTCTTGTCCCAGGTCACCTTGAAGGAGTCTGGTCCTGTGCTGGTGAAACCCACAGAGACCCTCACGCTGACCTGCACCGTCTCTGGGTTCTCACTCAGCAATGCTAGAATGGGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACACATTTTTTCGAATGACGAAAAATCCTACAGCACATCTCTGAAGAGCAGGCTCACCATCTCCAAGGACACCTCCAAAAGCCAGGTGGTCCTTACCATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACGGATACCACAGAGACACAGCCCAGGATGCCTCCTGTACAAGAACC", "repository_name": "GenBank", "repository_ref": "MG719334", "patch_no": "1", "gff_seqid": null, "gff_start": 58, "gff_end": 540, "strand": null }, { "sequence_id": "1137", "sequence": "TCCTGTGAGTGCTGTGGTCAGGGACTTCCTCAGAAGTGAAACATCAGTTGTCTCCTTTGTGGGCTTCATCTTCTTATGTCTTCTCCACAGGGGTCTTGTCCCAGGTCACCTTGAAGGAGTCTGGTCCTGTGCTGGTGAAACCCACAGAGACCCTCACGCTGACCTGCACCGTCTCTGGGTTCTCACTCAGCAATGCTAGAATGGGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACACATTTTTTCGAATGACGAAAAATCCTACAGCACATCTCTGAAGAGCAGGCTCACCATCTCCAAGGACACCTCCAAAAGCCAGGTGGTCCTTACCATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACGGATACCACAGAGACACAGCCCAGGATGCCTCCTGTACAAGAA", "repository_name": "GenBank", "repository_ref": "ON052042", "patch_no": "1", "gff_seqid": null, "gff_start": 247, "gff_end": 685, "strand": null }, { "sequence_id": "1138", "sequence": "ATGGACACACTTTGCTACACACTCCTGCTGCTGACCACCCCTTCCTGTGAGTGCTGTGGTCAGGGACTTCCTCAGAAGTGAAACATCAGTTGTCTCCTTTGTGGGCTTCATCTTCTTATGTCTTCTCCACAGGGGTCTTGTCCCAGGTCACCTTGAAGGAGTCTGGTCCTGTGCTGGTGAAACCCACAGAGACCCTCACGCTGACCTGCACCGTCTCTGGGTTCTCACTCAGCAATGCTAGAATGGGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACACATTTTTTCGAATGACGAAAAATCCTACAGCACATCTCTGAAGAGCAGGCTCACCATCTCCAAGGACACCTCCAAAAGCCAGGTGGTCCTTACCATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACGGATACCACAGAGACACAGCCCAGGATGCCTCCTGTACAAGAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 578007, "gff_end": 578489, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample M99648\r\nVDJbase example haplotype: P1_I10", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00049", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-61*10.2_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 2, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-61*10", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAG", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": "A", "aliases": [ "IGHV4-61*i02" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "61", "allele_designation": "10", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 298, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGC......AGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGT.........GGGAGCACCAACTACAACCCCTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1380", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCGCCGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAG", "repository_name": "GenBank", "repository_ref": "MK471386", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 298, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Assessed by IARC on November 18, 2019 during meeting 45 and on December 2, 2019 during meeting 46.\r\n\r\nThe committee considered IGHV4-61*01_S5549 (C136G A138G) of Genotype B16 of submission S00010, which was previously evaluated as IGHV4-61*01_S0787 of submission S00006 at Meeting 12. It was affirmed as a Level 0 sequence at that time.\r\n\r\nThe sequence was seen in 1.68% of all unmutated rearrangements, with 11,785 sequences including 4732 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. No other allele of IGHV4-61 was present in the genotype. Haplotype data is supportive of the inference, with the sequence being strongly associated with one haplotype. However, two alleles of IGHV4-4 (a gene closely related to IGHV4-61) were present on the other haplotype, highlighting the possibility that one of these alleles might be an allele of IGHV4-61. There was strong support for the sequence being affirmed up to and including nucleotide 319, in line with IARC policy, as a Level 1 sequence, with one additional 3\u2019 nucleotide being likely present in the sequence. This is indicated in IARC and OGRDB publications by one dot at the end of the sequence.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MK471386", "curational_tags": [ "likely_truncated" ] }, { "allele_description_id": "OGRDB:A02609", "allele_description_ref": "OGRDB:Homo sapiens:IGHD1-1*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD1-1*01", "sequence": "AGATTCTGAACAGCCCCGAGTCACGGTGGGTACAACTGGAACGACCACCGTGAGAAAAACTGTGTCCAAAACT", "coding_sequence": "GGTACAACTGGAACGAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "1", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 45, "d_rs_3_prime_start": 46, "d_rs_3_prime_end": 73, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "932", "sequence": "AGATTCTGAACAGCCCCGAGTCACGGTGGGTACAACTGGAACGACCACCGTGAGAAAAACTGTGTCCAAAACT", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 33686, "gff_end": 33758, "strand": null }, { "sequence_id": "933", "sequence": "AGATTCTGAACAGCCCCGAGTCACGGTGGGTACAACTGGAACGACCACCGTGAGAAAAACTGTGTCCAAAACT", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 104136, "gff_end": 104208, "strand": null }, { "sequence_id": "934", "sequence": "AGATTCTGAACAGCCCCGAGTCACGGTGGGTACAACTGGAACGACCACCGTGAGAAAAACTGTGTCCAAAACT", "repository_name": "GenBank", "repository_ref": "ON052093", "patch_no": "1", "gff_seqid": null, "gff_start": 119, "gff_end": 191, "strand": null }, { "sequence_id": "935", "sequence": "AGATTCTGAACAGCCCCGAGTCACGGTGGGTACAACTGGAACGACCACCGTGAGAAAAACTGTGTCCAAAACT", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 960299, "gff_end": 960371, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02688", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-11*06.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-11*06", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTATAAAAGGTGATTTATGGAGAACTAGAGACATTGAGTGGACGTGAGTGAGATAAGCAGTGAATATATGTGGCAGTTTCTGACCAGGTTGTCTCTGTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTTACACAAACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTTACACAAACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "11", "allele_designation": "06", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 155, "gene_end": 450, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 144, "leader_2_end": 154, "v_rs_start": 451, "v_rs_end": 489, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTTACACAAACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGT......AGTAGTTACACAAACTACGCAGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1158", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTATAAAAGGTGATTTATGGAGAACTAGAGACATTGAGTGGACGTGAGTGAGATAAGCAGTGAATATATGTGGCAGTTTCTGACCAGGTTGTCTCTGTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTTACACAAACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052047", "patch_no": "1", "gff_seqid": null, "gff_start": 214, "gff_end": 702, "strand": null }, { "sequence_id": "1159", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTATAAAAGGTGATTTATGGAGAACTAGAGACATTGAGTGGACGTGAGTGAGATAAGCAGTGAATATATGTGGCAGTTTCTGACCAGGTTGTCTCTGTGTTTGCAGGTGTCCAGTGTCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCAAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAGCTGGATCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTTTCATACATTAGTAGTAGTAGTAGTTACACAAACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 762761, "gff_end": 763249, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052047\r\nVDJbase example haplotype: P1_I27_S1", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02655", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-3*05.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-3*05", "sequence": "ATGGACTGGACCTGGAGGATCCTCTTTTTGGTGGCAGCAGCCACAGGTAAGGGGCTGCCAAATCCCAGTGAGGAGGAAGGGATCGAGGCCAGTCAAGGGGAATTCCATCCACTCCTGTGTCTTCTCTACAGGTGCCCACTCCCAGGTCCAGCTTGTGCAGTCTGGGGCTGAGGAGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGATCAACGCTGGCAATGGTAACACAAAATATTCACAGAAGTTCCAGGGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAAGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGAGTGTCAGAAACC", "coding_sequence": "CAGGTCCAGCTTGTGCAGTCTGGGGCTGAGGAGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGATCAACGCTGGCAATGGTAACACAAAATATTCACAGAAGTTCCAGGGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAAGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "3", "allele_designation": "05", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 143, "gene_end": 438, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 132, "leader_2_end": 142, "v_rs_start": 439, "v_rs_end": 477, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCCAGCTTGTGCAGTCTGGGGCTGAGGAGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGATCAACGCTGGCAATGGTAACACAAAATATTCACAGAAGTTCCAGGGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAAGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTCCAGCTTGTGCAGTCTGGGGCT...GAGGAGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTC............ACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGATCAACGCTGGC......AATGGTAACACAAAATATTCACAGAAGTTCCAG...GGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAAGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1088", "sequence": "ATGGACTGGACCTGGAGGATCCTCTTTTTGGTGGCAGCAGCCACAGGTAAGGGGCTGCCAAATCCCAGTGAGGAGGAAGGGATCGAGGCCAGTCAAGGGGAATTCCATCCACTCCTGTGTCTTCTCTACAGGTGCCCACTCCCAGGTCCAGCTTGTGCAGTCTGGGGCTGAGGAGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCTTCTGGATACACCTTCACTAGCTATGCTATGCATTGGGTGCGCCAGGCCCCCGGACAAAGGCTTGAGTGGATGGGATGGATCAACGCTGGCAATGGTAACACAAAATATTCACAGAAGTTCCAGGGCAGAGTCACCATTACCAGGGACACATCCGCGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAAGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGAGTGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "MN337616", "patch_no": "1", "gff_seqid": null, "gff_start": 252, "gff_end": 728, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MN337616\r\nVDJbase example haplotype: P1_I89", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02676", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-8*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-8*02", "sequence": "GATCCTCTTCTTGGTGGCAGCAGCTACAAGTAAGGGGCTTCCTAGTCTCAAAGCTGAGGAACGGATCCTGGTTCAGTCAAAGAGGATTTTATTCTCTCCTGTGTCCTCTCCACAGGTGCCCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCAGCTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAACAGTGGTAACACAGGCTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGCACAGTGTGAAAAACCAC", "coding_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCAGCTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAACAGTGGTAACACAGGCTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGG", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "8", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 127, "gene_end": 422, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 116, "leader_2_end": 126, "v_rs_start": 423, "v_rs_end": 451, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCAGCTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAACAGTGGTAACACAGGCTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGG", "aligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTC............ACCAGCTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAAC......AGTGGTAACACAGGCTATGCACAGAAGTTCCAG...GGCAGAGTCACCATGACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGG", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1131", "sequence": "ACAAGTAAGGGGCTTCCTAGTCTCAAAGCTGAGGAACGGATCCTGGTTCAGTCAAAGAGGATTTTATTCTCTCCTGTGTCCTCTCCACAGGTGCCCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCAGCTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAACAGTGGTAACACAGGCTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGCACAGTGTGAAAAACCAC", "repository_name": "GenBank", "repository_ref": "MG719311", "patch_no": "1", "gff_seqid": null, "gff_start": 26, "gff_end": 440, "strand": null }, { "sequence_id": "1132", "sequence": "GTGTCCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCAGCTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAACAGTGGTAACACAGGCTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGCACAGTGTGAAAAACCACATCCTCTCGCG", "repository_name": "GenBank", "repository_ref": "HM855859", "patch_no": "1", "gff_seqid": null, "gff_start": 10, "gff_end": 345, "strand": null }, { "sequence_id": "1133", "sequence": "GTGCCCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCAGCTATGATATCAACTGGGTGCGACAGGCCACTGGACAAGGGCTTGAGTGGATGGGATGGATGAACCCTAACAGTGGTAACACAGGCTATGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGAACACCTCCATAAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGGCACAGTGTGAAAACCCACATCCT", "repository_name": "GenBank", "repository_ref": "HM855563", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 330, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MG719311", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02967", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-16*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV3-16*03", "sequence": "ATGGAATTTGGGCTGAGCTGGGTTTTTCTTGCTGGTATTTTAAAAGGTGATTCATGGAGAAATAAGGATATTGAGTGAGTGGACATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGCCTGCAAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGTGGACTCCGTGAAGCGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTCCCTGTATCTGCAAAAGAACAGACGGAGAGCCGAGGACATGGCTGTGTATTACTGTGTGAGAAATCCTGTGAGGGGACACAAGTGCGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGCCTGCAAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGTGGACTCCGTGAAGCGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTCCCTGTATCTGCAAAAGAACAGACGGAGAGCCGAGGACATGGCTGTGTATTACTGTGTGAGAAA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "16", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 159, "gene_end": 454, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 148, "leader_2_end": 158, "v_rs_start": 455, "v_rs_end": 493, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGCCTGCAAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGTGGACTCCGTGAAGCGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTCCCTGTATCTGCAAAAGAACAGACGGAGAGCCGAGGACATGGCTGTGTATTACTGTGTGAGAAA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAACAGTGACATGAACTGGGCCTGCAAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAAT......GGCAGTAGGACGCACTATGTGGACTCCGTGAAG...CGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTCCCTGTATCTGCAAAAGAACAGACGGAGAGCCGAGGACATGGCTGTGTATTACTGTGTGAGAAA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1414", "sequence": "ATGGAATTTGGGCTGAGCTGGGTTTTTCTTGCTGGTATTTTAAAAGGTGATTCATGGAGAAATAAGGATATTGAGTGAGTGGACATGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGCCTGCAAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGTGGACTCCGTGAAGCGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTCCCTGTATCTGCAAAAGAACAGACGGAGAGCCGAGGACATGGCTGTGTATTACTGTGTGAGAAATCCTGTGAGGGGACACAAGTGCGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON360771", "patch_no": "1", "gff_seqid": null, "gff_start": 133835, "gff_end": 134327, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON360771. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (21 samples). Example subject: P25_I19.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02657", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-45*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-45*03", "sequence": "AATCCTCTTCTTGGTGGCAGCAGCCACAGGTAAGGGGCTCCCAAGTCCCAGTGATGAGGAGGGGATTGAGTCCAGTCAAGGTGGCTTTTATCCACTCCTGTGTCCCCTCCACAGATGCCTACTCCCAGATGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGACTGGGTCCTCAGTGAAGGTTTCCTGCAAGGCTTCCGGATACACCTTCACCTACCGCTACCTGCACTGGGTGCGACAGGCCCCCAGACAAGCGCTTGAGTGGATGGGATGGATCACACCTTTCAATGGTAACACCAACTACGCACAGAAATTCCAGGACAGAGTCACCATTACCAGGGACAGGTCTATGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACAGCCATGTATTACTGTGCAAGATACACAGTGTGAAAACCCAC", "coding_sequence": "CAGATGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGACTGGGTCCTCAGTGAAGGTTTCCTGCAAGGCTTCCGGATACACCTTCACCTACCGCTACCTGCACTGGGTGCGACAGGCCCCCAGACAAGCGCTTGAGTGGATGGGATGGATCACACCTTTCAATGGTAACACCAACTACGCACAGAAATTCCAGGACAGAGTCACCATTACCAGGGACAGGTCTATGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACAGCCATGTATTACTGTGCAAGATA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "45", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 126, "gene_end": 421, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 115, "leader_2_end": 125, "v_rs_start": 422, "v_rs_end": 450, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGATGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGACTGGGTCCTCAGTGAAGGTTTCCTGCAAGGCTTCCGGATACACCTTCACCTACCGCTACCTGCACTGGGTGCGACAGGCCCCCAGACAAGCGCTTGAGTGGATGGGATGGATCACACCTTTCAATGGTAACACCAACTACGCACAGAAATTCCAGGACAGAGTCACCATTACCAGGGACAGGTCTATGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACAGCCATGTATTACTGTGCAAGATA", "aligned_sequence": "CAGATGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGACTGGGTCCTCAGTGAAGGTTTCCTGCAAGGCTTCCGGATACACCTTC............ACCTACCGCTACCTGCACTGGGTGCGACAGGCCCCCAGACAAGCGCTTGAGTGGATGGGATGGATCACACCTTTC......AATGGTAACACCAACTACGCACAGAAATTCCAG...GACAGAGTCACCATTACCAGGGACAGGTCTATGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACAGCCATGTATTACTGTGCAAGATA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1093", "sequence": "ATGAGGAGGGGATTGAGTCCAGTCAAGGTGGCTTTTATCCACTCCTGTGTCCCCTCCACAGATGCCTACTCCCAGATGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGACTGGGTCCTCAGTGAAGGTTTCCTGCAAGGCTTCCGGATACACCTTCACCTACCGCTACCTGCACTGGGTGCGACAGGCCCCCAGACAAGCGCTTGAGTGGATGGGATGGATCACACCTTTCAATGGTAACACCAACTACGCACAGAAATTCCAGGACAGAGTCACCATTACCAGGGACAGGTCTATGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACAGCCATGTATTACTGTGCAAGATACACAGTGTGAAAACCCAC", "repository_name": "GenBank", "repository_ref": "MG719320", "patch_no": "1", "gff_seqid": null, "gff_start": 54, "gff_end": 439, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MG719320\r\nVDJbase example haplotype: P1_I41 (2 exact matches)", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02745", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-69-1*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-69-1*02", "sequence": "TCGCGAGTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTTTATTACTGTGCGAGAGACACAGTGAGGGAGTCATG", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTTTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3-69", "subgroup_designation": "1", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 321, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 18, "leader_2_end": 28, "v_rs_start": 322, "v_rs_end": 350, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTTTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTAAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTGACTACTACATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGT.........AGTACCATATACTACGCAGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTTTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1285", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAAAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTGACTACTACATGAACTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCATCCATTAGTAGTAGTAGTACCATATACTACGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTTTATTACTGTGCGAGAGACACAGTGAGGGAGTCATG", "repository_name": "GenBank", "repository_ref": "HM855923", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 322, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855923\r\nVDJbase example haplotype: P1_I52 (1 exact match)", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02724", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-47*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-47*01", "sequence": "TCGCGAGGTGTTTGCAGGTGTCCAGTGTGAGGATCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGACCCTCCTGTGCAGCCTCTGGATTCGCCTTCAGTAGCTATGCTCTGCACTGGGTTCGCCGGGCTCCAGGGAAGGGTCTGGAGTGGGTATCAGCTATTGGTACTGGTGGTGATACATACTATGCAGACTCCGTGATGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAAGTCCTTGTATCTTCATATGAACAGCCTGATAGCTGAGGACATGGCTGTGTATTATTGTGCAAGAGACACAGTGAGGGGAAGTCAATG", "coding_sequence": "GAGGATCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGACCCTCCTGTGCAGCCTCTGGATTCGCCTTCAGTAGCTATGCTCTGCACTGGGTTCGCCGGGCTCCAGGGAAGGGTCTGGAGTGGGTATCAGCTATTGGTACTGGTGGTGATACATACTATGCAGACTCCGTGATGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAAGTCCTTGTATCTTCATATGAACAGCCTGATAGCTGAGGACATGGCTGTGTATTATTGTGCAAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "47", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 321, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 18, "leader_2_end": 28, "v_rs_start": 322, "v_rs_end": 350, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGATCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGACCCTCCTGTGCAGCCTCTGGATTCGCCTTCAGTAGCTATGCTCTGCACTGGGTTCGCCGGGCTCCAGGGAAGGGTCTGGAGTGGGTATCAGCTATTGGTACTGGTGGTGATACATACTATGCAGACTCCGTGATGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAAGTCCTTGTATCTTCATATGAACAGCCTGATAGCTGAGGACATGGCTGTGTATTATTGTGCAAGAGA", "aligned_sequence": "GAGGATCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGGGGGTCCCTGCGACCCTCCTGTGCAGCCTCTGGATTCGCCTTC............AGTAGCTATGCTCTGCACTGGGTTCGCCGGGCTCCAGGGAAGGGTCTGGAGTGGGTATCAGCTATTGGTACTGGT.........GGTGATACATACTATGCAGACTCCGTGATG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAAGTCCTTGTATCTTCATATGAACAGCCTGATAGCTGAGGACATGGCTGTGTATTATTGTGCAAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1245", "sequence": "GTGTCCAGTGTGAGGATCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGACCCTCCTGTGCAGCCTCTGGATTCGCCTTCAGTAGCTATGCTCTGCACTGGGTTCGCCGGGCTCCAGGGAAGGGTCTGGAGTGGGTATCAGCTATTGGTACTGGTGGTGATACATACTATGCAGACTCCGTGATGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAAGTCCTTGTATCTTCATATGAACAGCCTGATAGCTGAGGACATGGCTGTGTATTATTGTGCAAGAGACACAGTGAGGGGAAGTCAATG", "repository_name": "GenBank", "repository_ref": "HM855878", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 325, "strand": null }, { "sequence_id": "1246", "sequence": "AGGGAGTTTGTGCTAAGCTGGGTTTTCCTTGTTGCTATATTAAAATGTGATTCATGGAGAACTAGAGAGATTGAGTGTGAGTTACATGAGTGAGAGAAACAGTGGATATGTTTGGCAATTTCTGACCTTGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGATCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGCGACCCTCCTGTGCAGCCTCTGGATTCGCCTTCAGTAGCTATGCTCTGCACTGGGTTCGCCGGGCTCCAGGGAAGGGTCTGGAGTGGGTATCAGCTATTGGTACTGGTGGTGATACATACTATGCAGACTCCGTGATGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAAGTCCTTGTATCTTCATATGAACAGCCTGATAGCTGAGGACATGGCTGTGTATTATTGTGCAAGAGACACAGTGAGGGGAAGTCAATGTGAGCCCAGATACAAACT", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 360815, "gff_end": 361305, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855878", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02636", "allele_description_ref": "OGRDB:Homo sapiens:IGHD6-25*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD6-25*01", "sequence": "GGTTTCTGAAGCTGTCTGTGTCACAGTCGGGTATAGCAGCGGCTACCACAATGACACTGGGCAGGACAGAAACC", "coding_sequence": "GGGTATAGCAGCGGCTAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "6", "subgroup_designation": "25", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 46, "d_rs_3_prime_start": 47, "d_rs_3_prime_end": 74, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "1028", "sequence": "GGTTTCTGAAGCTGTCTGTGTCACAGTCGGGTATAGCAGCGGCTACCACAATGACACTGGGCAGGACAGAAACC", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 71638, "gff_end": 71711, "strand": null }, { "sequence_id": "1029", "sequence": "GGTTTCTGAAGCTGTCTGTGTCACAGTCGGGTATAGCAGCGGCTACCACAATGACACTGGGCAGGACAGAAACC", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 142095, "gff_end": 142168, "strand": null }, { "sequence_id": "1030", "sequence": "GGTTTCTGAAGCTGTCTGTGTCACAGTCGGGTATAGCAGCGGCTACCACAATGACACTGGGCAGGACAGAAACC", "repository_name": "GenBank", "repository_ref": "ON052117", "patch_no": "1", "gff_seqid": null, "gff_start": 179, "gff_end": 252, "strand": null }, { "sequence_id": "1031", "sequence": "GGTTTCTGAAGCTGTCTGTGTCACAGTCGGGTATAGCAGCGGCTACCACAATGACACTGGGCAGGACAGAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 998261, "gff_end": 998334, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02775", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-61*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-61*01", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTCCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAGGGATCCAGACATGGGGGTATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "61", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 140, "gene_end": 438, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 129, "leader_2_end": 139, "v_rs_start": 439, "v_rs_end": 477, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGC......AGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGT.........GGGAGCACCAACTACAACCCCTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1376", "sequence": "GGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAG", "repository_name": "GenBank", "repository_ref": "HM855707", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 335, "strand": null }, { "sequence_id": "1377", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTCCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAGGGATCCAGACATGGGGGTATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCGTCAGCAGTGGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 240289, "gff_end": 240765, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample GRCh38:CM000676.2\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02630", "allele_description_ref": "OGRDB:Homo sapiens:IGHD5-12*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD5-12*01", "sequence": "GGTTATTGTCAGGCGATGTCAGACTGTGGTGGATATAGTGGCTACGATTACCACAGTGGTGCCGCCCATAGCAGCAACC", "coding_sequence": "GTGGATATAGTGGCTACGATTAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "5", "subgroup_designation": "12", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 51, "d_rs_3_prime_start": 52, "d_rs_3_prime_end": 79, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "1005", "sequence": "GGTTATTGTCAGGCGATGTCAGACTGTGGTGGATATAGTGGCTACGATTACCACAGTGGTGCCGCCCATAGCAGCAACC", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 50523, "gff_end": 50601, "strand": null }, { "sequence_id": "1006", "sequence": "GGTTATTGTCAGGCGATGTCAGACTGTGGTGGATATAGTGGCTACGATTACCACAGTGGTGCCGCCCATAGCAGCAACC", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 120984, "gff_end": 121062, "strand": null }, { "sequence_id": "1007", "sequence": "GGTTATTGTCAGGCGATGTCAGACTGTGGTGGATATAGTGGCTACGATTACCACAGTGGTGCCGCCCATAGCAGCAACC", "repository_name": "GenBank", "repository_ref": "ON052111", "patch_no": "1", "gff_seqid": null, "gff_start": 138, "gff_end": 216, "strand": null }, { "sequence_id": "1008", "sequence": "GGTTATTGTCAGGCGATGTCAGACTGTGGTGGATATAGTGGCTACGATTACCACAGTGGTGCCGCCCATAGCAGCAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 977146, "gff_end": 977224, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02611", "allele_description_ref": "OGRDB:Homo sapiens:IGHD1-20*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD1-20*01", "sequence": "GGATTCTGAACAGCCCCGAGTCACAGTGGGTATAACTGGAACGACCACCGTGAGAAAAACTGTGTCCAAAACT", "coding_sequence": "GGTATAACTGGAACGAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "20", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 45, "d_rs_3_prime_start": 46, "d_rs_3_prime_end": 73, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "940", "sequence": "GGATTCTGAACAGCCCCGAGTCACAGTGGGTATAACTGGAACGACCACCGTGAGAAAAACTGTGTCCAAAACT", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 61987, "gff_end": 62059, "strand": null }, { "sequence_id": "941", "sequence": "GGATTCTGAACAGCCCCGAGTCACAGTGGGTATAACTGGAACGACCACCGTGAGAAAAACTGTGTCCAAAACT", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 132446, "gff_end": 132518, "strand": null }, { "sequence_id": "942", "sequence": "GGATTCTGAACAGCCCCGAGTCACAGTGGGTATAACTGGAACGACCACCGTGAGAAAAACTGTGTCCAAAACT", "repository_name": "GenBank", "repository_ref": "ON052095", "patch_no": "1", "gff_seqid": null, "gff_start": 141, "gff_end": 213, "strand": null }, { "sequence_id": "943", "sequence": "GGATTCTGAACAGCCCCGAGTCACAGTGGGTATAACTGGAACGACCACCGTGAGAAAAACTGTGTCCAAAACT", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 988610, "gff_end": 988682, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02969", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-20*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV3-20*02", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGATCAATAGAGATGTTGAGTGTGAGTGAACACGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGTGTGGTACGGCCTGGGGGGTCCCTGAGACTCTCCTTTGCAGCCTCTGGATTCACCTTTGATGATTATGGCATGAGCTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGAGTGGGTCTCTGGTATTAATTGGAATGGTGGTAGCACAGGTTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCCTTGTATCACTGTGCGAGAGACACAGTGAGGGGAAGCCAGTGAGAGCCCAGACACAAACG", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGTGTGGTACGGCCTGGGGGGTCCCTGAGACTCTCCTTTGCAGCCTCTGGATTCACCTTTGATGATTATGGCATGAGCTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGAGTGGGTCTCTGGTATTAATTGGAATGGTGGTAGCACAGGTTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCCTTGTATCACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "20", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 456, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 457, "v_rs_end": 495, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGTGTGGTACGGCCTGGGGGGTCCCTGAGACTCTCCTTTGCAGCCTCTGGATTCACCTTTGATGATTATGGCATGAGCTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGAGTGGGTCTCTGGTATTAATTGGAATGGTGGTAGCACAGGTTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCCTTGTATCACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGTGTGGTACGGCCTGGGGGGTCCCTGAGACTCTCCTTTGCAGCCTCTGGATTCACCTTT............GATGATTATGGCATGAGCTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGAGTGGGTCTCTGGTATTAATTGGAAT......GGTGGTAGCACAGGTTATGCAGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCCTTGTATCACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1416", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGATCAATAGAGATGTTGAGTGTGAGTGAACACGAGTGAGAGAAACAGTGGATTTGTGTGGCAGTTTCTGACCAGGGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGTGTGGTACGGCCTGGGGGGTCCCTGAGACTCTCCTTTGCAGCCTCTGGATTCACCTTTGATGATTATGGCATGAGCTGGGTCCGCCAAGCTCCAGGGAAGGGGCTGGAGTGGGTCTCTGGTATTAATTGGAATGGTGGTAGCACAGGTTATGCAGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCCGAGGACACGGCCTTGTATCACTGTGCGAGAGACACAGTGAGGGGAAGCCAGTGAGAGCCCAGACACAAACG", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 668454, "gff_end": 668948, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample GRCh38:CM000676.2. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (43 samples). Example subject: P25_1.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02725", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-47*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-47*02", "sequence": "TGTTTGCAGGTGTCCAGTGTGAGGATCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACCCTCCTGTGCAGCCTCTGGATTCGCCTTCAGTAGCTATGTTCTGCACTGGGTTCGCCGGGCTCCAGGGAAGGGTCCGGAGTGGGTATCAGCTATTGGTACTGGTGGTGATACATACTATGCAGACTCCGTGATGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAAGTCCTTGTATCTTCAAATGAACAGCCTGATAGCTGAGGACATGGCTGTGTATTATTGTGCAAGAGACACAGTGAGGGGAGGTCAATGCTCGCGA", "coding_sequence": "GAGGATCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACCCTCCTGTGCAGCCTCTGGATTCGCCTTCAGTAGCTATGTTCTGCACTGGGTTCGCCGGGCTCCAGGGAAGGGTCCGGAGTGGGTATCAGCTATTGGTACTGGTGGTGATACATACTATGCAGACTCCGTGATGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAAGTCCTTGTATCTTCAAATGAACAGCCTGATAGCTGAGGACATGGCTGTGTATTATTGTGCAAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "47", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 21, "gene_end": 313, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 10, "leader_2_end": 20, "v_rs_start": 314, "v_rs_end": 342, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGATCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACCCTCCTGTGCAGCCTCTGGATTCGCCTTCAGTAGCTATGTTCTGCACTGGGTTCGCCGGGCTCCAGGGAAGGGTCCGGAGTGGGTATCAGCTATTGGTACTGGTGGTGATACATACTATGCAGACTCCGTGATGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAAGTCCTTGTATCTTCAAATGAACAGCCTGATAGCTGAGGACATGGCTGTGTATTATTGTGCAAGAGA", "aligned_sequence": "GAGGATCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGGGGGTCCCTGAGACCCTCCTGTGCAGCCTCTGGATTCGCCTTC............AGTAGCTATGTTCTGCACTGGGTTCGCCGGGCTCCAGGGAAGGGTCCGGAGTGGGTATCAGCTATTGGTACTGGT.........GGTGATACATACTATGCAGACTCCGTGATG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAAGTCCTTGTATCTTCAAATGAACAGCCTGATAGCTGAGGACATGGCTGTGTATTATTGTGCAAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1247", "sequence": "AGGGAGTTTGTGCTAAGCTGGGTTTTCCTTGTTGCTATATTAAAATGTGATTCATGGAGAACTAGAGAGATTGAGTGTGAGTTACATGAGTGAGAGAAACAGTGGATATGTTTGGCAATTTCTGACTTTTGTGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGATCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACCCTCCTGTGCAGCCTCTGGATTCGCCTTCAGTAGCTATGTTCTGCACTGGGTTCGCCGGGCTCCAGGGAAGGGTCCGGAGTGGGTATCAGCTATTGGTACTGGTGGTGATACATACTATGCAGACTCCGTGATGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAAGTCCTTGTATCTTCAAATGAACAGCCTGATAGCTGAGGACATGGCTGTGTATTATTGTGCAAGAGACACAGTGAGGGGAAGTCAATGTGAGCCCAGATACAAACT", "repository_name": "GenBank", "repository_ref": "AB019438", "patch_no": "1", "gff_seqid": null, "gff_start": 114584, "gff_end": 115074, "strand": null }, { "sequence_id": "1248", "sequence": "GTGTCCAGTGTGAGGATCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACCCTCCTGTGCAGCCTCTGGATTCGCCTTCAGTAGCTATGTTCTGCACTGGGTTCGCCGGGCTCCAGGGAAGGGTCCGGAGTGGGTATCAGCTATTGGTACTGGTGGTGATACATACTATGCAGACTCCGTGATGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAAGTCCTTGTATCTTCAAATGAACAGCCTGATAGCTGAGGACATGGCTGTGTATTATTGTGCAAGAGACACAGTGAGGGGAGGTCAATGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855819", "patch_no": "1", "gff_seqid": null, "gff_start": 10, "gff_end": 341, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855819\r\nVDJbase example haplotype: P1_I97 (1 exact match)", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02656", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-45*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-45*02", "sequence": "ATGGACTGGACCTGGAGAATCCTCTTCTTGGTGGCAGCAGCCACAGGTAAGGGGCTCCCAAGTCCCAGTGATGAGGAGGGGATTGAGTCCAGTCAAGGTGGCTTTTATCCACTCCTGTGTCCCCTCCACAGATGCCTACTCCCAGATGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGACTGGGTCCTCAGTGAAGGTTTCCTGCAAGGCTTCCGGATACACCTTCACCTACCGCTACCTGCACTGGGTGCGACAGGCCCCCGGACAAGCGCTTGAGTGGATGGGATGGATCACACCTTTCAATGGTAACACCAACTACGCACAGAAATTCCAGGACAGAGTCACCATTACCAGGGACAGGTCTATGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACAGCCATGTATTACTGTGCAAGATACACAGTGTGAAAACCCACATCCTGAGACCGTCAGAAACC", "coding_sequence": "CAGATGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGACTGGGTCCTCAGTGAAGGTTTCCTGCAAGGCTTCCGGATACACCTTCACCTACCGCTACCTGCACTGGGTGCGACAGGCCCCCGGACAAGCGCTTGAGTGGATGGGATGGATCACACCTTTCAATGGTAACACCAACTACGCACAGAAATTCCAGGACAGAGTCACCATTACCAGGGACAGGTCTATGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACAGCCATGTATTACTGTGCAAGATA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "45", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 143, "gene_end": 438, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 132, "leader_2_end": 142, "v_rs_start": 439, "v_rs_end": 477, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGATGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGACTGGGTCCTCAGTGAAGGTTTCCTGCAAGGCTTCCGGATACACCTTCACCTACCGCTACCTGCACTGGGTGCGACAGGCCCCCGGACAAGCGCTTGAGTGGATGGGATGGATCACACCTTTCAATGGTAACACCAACTACGCACAGAAATTCCAGGACAGAGTCACCATTACCAGGGACAGGTCTATGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACAGCCATGTATTACTGTGCAAGATA", "aligned_sequence": "CAGATGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGACTGGGTCCTCAGTGAAGGTTTCCTGCAAGGCTTCCGGATACACCTTC............ACCTACCGCTACCTGCACTGGGTGCGACAGGCCCCCGGACAAGCGCTTGAGTGGATGGGATGGATCACACCTTTC......AATGGTAACACCAACTACGCACAGAAATTCCAG...GACAGAGTCACCATTACCAGGGACAGGTCTATGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACAGCCATGTATTACTGTGCAAGATA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1089", "sequence": "ATGGACTGGACCTGGAGAATCCTCTTCTTGGTGGCAGCAGCCACAGGTAAGGGGCTCCCAAGTCCCAGTGATGAGGAGGGGATTGAGTCCAGTCAAGGTGGCTTTTATCCACTCCTGTGTCCCCTCCACAGATGCCTACTCCCAGATGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGACTGGGTCCTCAGTGAAGGTTTCCTGCAAGGCTTCCGGATACACCTTCACCTACCGCTACCTGCACTGGGTGCGACAGGCCCCCGGACAAGCGCTTGAGTGGATGGGATGGATCACACCTTTCAATGGTAACACCAACTACGCACAGAAATTCCAGGACAGAGTCACCATTACCAGGGACAGGTCTATGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACAGCCATGTATTACTGTGCAAGATACACAGTGTGAAAACCCACATCCTGAGACCGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "AB019438", "patch_no": "1", "gff_seqid": null, "gff_start": 126175, "gff_end": 126651, "strand": null }, { "sequence_id": "1090", "sequence": "ATGAGGAGGGGATTGAGTCCAATCAAGGTGGCTTTTATCCACTCCTGTGTCCCCTCCACAGATGCCTACTCCCAGATGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGACTGGGTCCTCAGTGAAGGTTTCCTGCAAGGCTTCCGGATACACCTTCACCTACCGCTACCTGCACTGGGTGCGACAGGCCCCCGGACAAGCGCTTGAGTGGATGGGATGGATCACACCTTTCAATGGTAACACCAACTACGCACAGAAATTCCAGGACAGAGTCACCATTACCAGGGACAGGTCTATGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACAGCCATGTATTACTGTGCAAGATACACAGTGTGAAAACCCAC", "repository_name": "GenBank", "repository_ref": "MG719319", "patch_no": "1", "gff_seqid": null, "gff_start": 54, "gff_end": 439, "strand": null }, { "sequence_id": "1091", "sequence": "ATGGACTGGACCTGGAGAATCCTCTTCTTGGTGGCAGCAGCCACAGGTAAGGGGCTCCCAAGTCCCAGTGATGAGGAGGGGATTGAGTCCAGTCAAGGTGGCTTTTATCCACTCCTGTGTCCCCTCCACAGATGCCTACTCCCAGATGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGACTGGGTCCTCAGTGAAGGTTTCCTGCAAGGCTTCCGGATACACCTTCACCTACCGCTACCTGCACTGGGTGCGACAGGCCCCCGGACAAGCGCTTGAGTGGATGGGATGGATCACACCTTTCAATGGTAACACCAACTACGCACAGAAATTCCAGGACAGAGTCACCATTACCAGGGACAGGTCTATGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACAGCCATGTATTACTGTGCAAGATACACAGTGTGAAAACCCACATCCTGAGAC", "repository_name": "GenBank", "repository_ref": "ON052033", "patch_no": "1", "gff_seqid": null, "gff_start": 274, "gff_end": 739, "strand": null }, { "sequence_id": "1092", "sequence": "ATGGACTGGACCTGGAGAATCCTCTTCTTGGTGGCAGCAGTCACAGGTAAGGGGCTCCCAAGTCCCAGTGATGAGGAGGGGATTGAGTCCAGTCAAGGTGGCTTTTATCCACTCCTGTGTCCCCTCCACAGATGCCTACTCCCAGATGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGACTGGGTCCTCAGTGAAGGTTTCCTGCAAGGCTTCCGGATACACCTTCACCTACCGCTACCTGCACTGGGTGCGACAGGCCCCCGGACAAGCGCTTGAGTGGATGGGATGGATCACACCTTTCAATGGTAACACCAACTACGCACAGAAATTCCAGGACAGAGTCACCATTACCAGGGACAGGTCTATGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACAGCCATGTATTACTGTGCAAGATACACAGTGTGAAAACCCACATCCTGAGACCGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 372412, "gff_end": 372888, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019438\r\nVDJbase example haplotype: P1_I30 (3 exact matches)", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00069", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-9*04.2_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 2, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-9*04", "sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATCACTGTGCAAAAGATA", "coding_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATCACTGTGCAAAAGATA", "ext_3prime": "ATA", "aliases": [ "IGHV3-9*i01" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "9", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 295, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATCACTGTGCAAAAGATA", "aligned_sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTT............GATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAAT......AGTGGTAGCATAGGCTATGCGGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATCACTGTGCAAAAGATA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1316", "sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATCACTGTGCAAAAGATA", "repository_name": "GenBank", "repository_ref": "MN337621", "patch_no": "2", "gff_seqid": null, "gff_start": 78, "gff_end": 372, "strand": null }, { "sequence_id": "1317", "sequence": "GAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATCACTGTGCAAAAGATA", "repository_name": "GenBank", "repository_ref": "OU596108", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 295, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "IARC meeting 62 (Nov 3rd, 2020):\r\nThe meeting considered the inference of the variant IGHV3-9*01_t307c, in the VDJbase dataset of sample P1_I86_S1. The sequence was seen in 1.29% of all unmutated rearrangements, with 433 sequences including 368 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. IGHV3-9*01 was also present in the genotype, at a similar frequency (2.25% of all unmutated sequences, 748 sequences, 641 unmutated sequences). Haplotyping data showed almost perfect separation of the assigned alleles. Plots of the final 3\u2019 nucleotides of the inference were unavailable. The inferred sequence was tentatively affirmed as a Level 1 sequence. The final 3\u2019 nucleotides will be considered at a later date, at which time the affirmed sequence will be noted in the IARC minutes.\r\n\r\nIARC meeting 83 (Oct 18, 2021):\r\nIGHV3-9*01_T307C was inferred in subject S82 (P1_I86_S1; ERR2567259), a genotype that also expressed IGHV3-9*01. This inference has previously been pre-assessed at IARC meeting 62 (https://www.antibodysociety.org/wordpress/wp-content/uploads/2021/04/Meeting-62-3_11_20-minutes.pdf). IGHV3-9*01_T307C was well expressed, represented by 453 sequences, allelic frequency 36%, represented 1.6% of the unmutated population, and had 373 unique CDR3s in the unmutated population. It showed a haplotype ratio (based on association with alleles of IGHJ6) of 100:0 while IGHV3-9*01 showed a ratio of 1:99. IARC affirms the sequence up to and including base 319 as a level 1 sequence. It is acknowledged that the allele most likely carries 3 additional bases, typically ATA at base position 320-322. The trailing \u201c...\u201d indicates IARC\u2019s opinion that the sequence is likely to contain three additional 3\u2019 nucleotides for which there is insufficient evidence to make an affirmation. The allele is given the name IGHV3-9*i01.\r\n\r\n>IGHV3-9*i01\r\nGAAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGCAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGGCAAGCTCCAGGGAAGGGCCTGGAGTGGGTCTCAGGTATTAGTTGGAATAGTGGTAGCATAGGCTATGCGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACGGCCTTGTATCACTGTGCAAAAG...\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MN337621\r\nVDJbase example haplotype: P1_I86\r\nMapped by P1_I86 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02659", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-46*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-46*03", "sequence": "GGTCTTCTGCTTGCTGGCTGTAGCTCCAGGTAAAGGGCCAACTGGTTCCAGGGCTGAGGAAGGGATTTTTTCCAGTTTAGAGGACTGTCATTCTCTACTGTGTCCTCTCCGCAGGTGCTCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCAGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGTGGTGGTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCTAGAGACACAGTGTGAAAACCCAC", "coding_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCAGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGTGGTGGTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCTAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "46", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 126, "gene_end": 421, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 115, "leader_2_end": 125, "v_rs_start": 422, "v_rs_end": 450, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCAGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGTGGTGGTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCTAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTC............ACCAGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGT......GGTGGTAGCACAAGCTACGCACAGAAGTTCCAG...GGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCTAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1098", "sequence": "CTGAGGAAGGGATTTTTTCCAGTTTAGAGGACTGTCATTCTCTACTGTGTCCTCTCCGCAGGTGCTCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCAGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGTGGTGGTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCTAGAGACACAGTGTGAAAACCCAC", "repository_name": "GenBank", "repository_ref": "MG719322", "patch_no": "1", "gff_seqid": null, "gff_start": 54, "gff_end": 439, "strand": null }, { "sequence_id": "1099", "sequence": "ATGGACTGGACCTGGAGGGTCTTCTGCTTGCTGGCTGTAGCTCCAGGTAAAGGGCCAACTGGTTCCAGGGCTGAGGAAGGGATTTTTTCCAGTTTAGAGGACTGTCATTCTCTACTGTGTCCTCTCCGCAGGTGCTCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTTTCCTGCAAGGCATCTGGATACACCTTCACCAGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAATAATCAACCCTAGTGGTGGTAGCACAAGCTACGCACAGAAGTTCCAGGGCAGAGTCACCATGACCAGGGACACGTCCACGAGCACAGTCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCTAGAGACACAGTGTGAGAAACCACATCCTCAGAGT", "repository_name": "GenBank", "repository_ref": "ON052035", "patch_no": "1", "gff_seqid": null, "gff_start": 391, "gff_end": 857, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MG719322\r\nVDJbase example haplotype: P1_I43\r\nMapped by P1_I43 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02733", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-53*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-53*01", "sequence": "ATGGAGTTTTGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGAGAACTAGAGATATTGAGTGTGAGTGAACACGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTAACCAATGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCATTGTGCGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Genomic only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "53", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 159, "gene_end": 451, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 148, "leader_2_end": 158, "v_rs_start": 452, "v_rs_end": 490, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGAGGA...GGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTC............AGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGT.........GGTAGCACATACTACGCAGACTCCGTGAAG...GGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1264", "sequence": "ATGGAGTTTTGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGAGAACTAGAGATATTGAGTGTGAGTGAACACGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTAACCAATGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCATTGTGCGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "M99679", "patch_no": "1", "gff_seqid": null, "gff_start": 38, "gff_end": 527, "strand": null }, { "sequence_id": "1265", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGTGAGGCTTGGTACAGCCTGGAGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTCCTGGATGCACTGGGTCTGCCAGGCTCCGGAGAAGGGGCAGGAGTGGGTGGCCGACATAAAGTGTGACGGAAGTGAGAAATACTATGTAGACTCTGTGAAGGGCCGATTGACCATCTCCAGAGACAATGCCAAGAACTCCCTCTATCTGCAAGTGAACAGCCTGAGAGCTGAGGACATGACCGTGTATTACTGTGTGAGAGGCACAGTGAGGGGAGGTCAATGCTCGCGA", "repository_name": "GenBank", "repository_ref": "HM855940", "patch_no": "1", "gff_seqid": null, "gff_start": 11, "gff_end": 345, "strand": null }, { "sequence_id": "1266", "sequence": "ATGGAGTTTTGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGAGAACTAGAGATATTGAGTGTGAGTGAACACGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTAACCAATGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCATTGTGCGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052066", "patch_no": "1", "gff_seqid": null, "gff_start": 447, "gff_end": 936, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample M99679\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02741", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-66*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-66*01", "sequence": "TCGCGAGGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAATG", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "66", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 321, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 18, "leader_2_end": 28, "v_rs_start": 322, "v_rs_end": 350, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTC............AGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGT.........GGTAGCACATACTACGCAGACTCCGTGAAG...GGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1279", "sequence": "GTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAAGTCAATG", "repository_name": "GenBank", "repository_ref": "HM855533", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 325, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855533\r\nVDJbase example haplotype: P1_I12\r\nMapped by P1_I10 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02615", "allele_description_ref": "OGRDB:Homo sapiens:IGHD2-2*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD2-2*01", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGGATATTGTAGTAGTACCAGCTGCTATGCCCACAGTGACACAGCCCCATTCCCAAAGC", "coding_sequence": "AGGATATTGTAGTAGTACCAGCTGCTATGCC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "2", "subgroup_designation": "2", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 59, "d_rs_3_prime_start": 60, "d_rs_3_prime_end": 87, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "956", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGGATATTGTAGTAGTACCAGCTGCTATGCCCACAGTGACACAGCCCCATTCCCAAAGC", "repository_name": "GenBank", "repository_ref": "ON052099", "patch_no": "1", "gff_seqid": null, "gff_start": 140, "gff_end": 226, "strand": null }, { "sequence_id": "957", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGGATATTGTAGTAGTACCAGCTGCTATGCCCACAGTGACACAGCCCCATTCCCAAAGC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 962961, "gff_end": 963047, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052099", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00009", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-30-4*08.5_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 5, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-30-4*08", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGATTACTACTGGAGCTGGATCCGCCAGCCCCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAG", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGATTACTACTGGAGCTGGATCCGCCAGCCCCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAGA", "ext_3prime": "A", "aliases": [ "IGHV4-30-4*i01" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4-30", "subgroup_designation": "4", "allele_designation": "08", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 298, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGATTACTACTGGAGCTGGATCCGCCAGCCCCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGC......AGTGGTGATTACTACTGGAGCTGGATCCGCCAGCCCCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1335", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGATTACTACTGGAGCTGGATCCGCCAGCCCCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAG", "repository_name": "GenBank", "repository_ref": "MH779624", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 298, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Originally approved by IARC on April 13, 2018.\r\n\r\n\"The sequence is present at high frequency (1.3%), in the IgDiscover analysis. It was inferred by IgDiscover, TIger and Partis. Haplotype analysis was supportive of the inference, as the sequence was strongly associated with the IGHJ6*03 haplotype. The sequence has previously been reported from genomic sequencing, and by inference from VDJ data, and is documented in IgPdb as IGHV4-30-4*p08. It was agreed that the sequence should be moved to Level 1.\"\r\n\r\nIn line with IARC policy, the submitted sequence was recognized up to and including nucleotide 319.\r\n\r\n(April 12, 2019) A trailing \".\" in the sequence indicates IARC's opinion that the sequence is likely to contain additional 3' nucleotides for which there is insufficient evidence to make an affirmation.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MH779624\r\nVDJbase example haplotype: P1_I64", "curational_tags": [ "likely_truncated" ] }, { "allele_description_id": "OGRDB:A02695", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-19*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-19*01", "sequence": "CAAGACACTAAGGGCTCCTCACCCAACCCCCTTTCGTGAGGAGTTGGCCTGGGTAAACAGATCCTCAGCATTTCAAAGGAGCCCAATTAACTGATAAGGTACCCACACCAACAATGTATGAAGTTCCCAGGAATTTTCTCCAAGAGATAACAACATGAAACCTTGAGTTTGTGTCCGGCATAGACCCTATATCTAATTATAATAAAAGATTTAGAACCTTGCACCTGGTACCGTTGCTCTTCTTGTAACCATTTGTCTTTTAAGTTGTTTATCACTCTGTAACTATTTTGATTATTTTGATTCTTGCATGTTTTTACTTCTGTAAAATTATTACATTTGAGTCCCTCTCCCCTTCCTAAACCTAGGTATAAAATTTACTCGAGCCCCTTCCTCGTGGCCGAGAGAATTTTGAGCATGAGCTGTCTCTTTGGCAGCCGGCTTAATAAAGGACTCTTAATTCGTCTCAAAGTGTGGCGTTTTCTTAACTCACCTGGGTACAACAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAGAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGTCCGCCAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGCAGACTCTGTGAAGGGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTTCCTGTATCAGCAAATGAACAGCCTGAGGCCCGAGGACATGGCTGTGTATTACTGTGTGAGAAACACTGTGAGAGGACGGAAGTGTGAGCCCAGACACAAACC", "coding_sequence": "ACAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAGAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGTCCGCCAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGCAGACTCTGTGAAGGGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTTCCTGTATCAGCAAATGAACAGCCTGAGGCCCGAGGACATGGCTGTGTATTACTGTGTGAGAAA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": false, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "19", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 500, "gene_end": 795, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 489, "leader_2_end": 499, "v_rs_start": 796, "v_rs_end": 834, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "ACAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAGAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGTCCGCCAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGCAGACTCTGTGAAGGGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTTCCTGTATCAGCAAATGAACAGCCTGAGGCCCGAGGACATGGCTGTGTATTACTGTGTGAGAAA", "aligned_sequence": "ACAGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTAGAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAACAGTGACATGAACTGGGTCCGCCAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAAT......GGCAGTAGGACGCACTATGCAGACTCTGTGAAG...GGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTTCCTGTATCAGCAAATGAACAGCCTGAGGCCCGAGGACATGGCTGTGTATTACTGTGTGAGAAA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1174", "sequence": "ATGAGCTGTCTCTTTGGCAGCCGGCTTAATAAAGGACTCTTAATTCGTCTCAAAGTGTGGCGTTTTCTTAACTCACCTGGGTACAACAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAGAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGTCCGCCAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGCAGACTCTGTGAAGGGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTTCCTGTATCAGCAAATGAACAGCCTGAGGCCCGAGGACATGGCTGTGTATTACTGTGTGAGAAACACTGTGAGAGGACGGAAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "M99656", "patch_no": "1", "gff_seqid": null, "gff_start": 211, "gff_end": 630, "strand": null }, { "sequence_id": "1175", "sequence": "TTGCACCTGGTACCGTTGCTCTTCTTGTAACCATTTGTCTTTTAAGTTGTTTATCACTCTGTAACTATTTTGATTATTTTGATTCTTGCATGTTTTTACTTCTGTAAAATTATTACATTTGAGTCCCTCTCCCCTTCCTAAACCTAGGTATAAAATTTACTCGAGCCCCTTCCTCGTGGCCGAGAGAATTTTGAGCATGAGCTGTCTCTTTGGCAGCCGGCTTAATAAAGGACTCTTAATTCGTCTCAAAGTGTGGCGTTTTCTTAACTCACCTGGGTACAACAGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTAGAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAACAGTGACATGAACTGGGTCCGCCAGGCTCCAGGAAAGGGGCTGGAGTGGGTATCGGGTGTTAGTTGGAATGGCAGTAGGACGCACTATGCAGACTCTGTGAAGGGCCGATTCATCATCTCCAGAGACAATTCCAGGAACTTCCTGTATCAGCAAATGAACAGCCTGAGGCCCGAGGACATGGCTGTGTATTACTGTGTGAGAAACACTGTGAGAGGACGGAAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 682571, "gff_end": 683186, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample GRCh38:CM000676.2\r\nVDJbase example haplotype: P1_I43_S1 (1 exact sequence)", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02569", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-30*i02.2_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 2, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-30*i02", "sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGA", "coding_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGA", "ext_3prime": "A", "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "30", "allele_designation": "i02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 295, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGA", "aligned_sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGAT......GGAAGTAATAAATACTATGCAGACTCCGTGAAG...GGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1218", "sequence": "CAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAGA", "repository_name": "GenBank", "repository_ref": "OX384049", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 295, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "The inference IGHV3-30*i02 was considered at IARC meeting 116 on February 27th, 2023\r\n\r\nIGHV3-30*04 C201T has been inferred in one genotype (P1_I70) in VDJbase P1 data set. The genotype also carries related alleles like IGHV3-30-3*01 and IGHV3-30*18. It is represented by 394 error-free sequences and 374 unique CDR3s of different lengths in the error-free set. Haplotyping based on allelic diversity in IGHJ6 demonstrates association of the haplotype defined by IGHJ6*03 (99:1 ratio). IGHV3-30-3*01 and IGHV3-30*18 are more abundant but also present on both haplotypes. On the haplotype in question IGHV3-30-3*01, IGHV3-30*18, and inferred IGHV3-30*04 C201T are present at approximately a 2:2:1 ratio. \r\n\r\nInspection of the sequences associated with the inference demonstrates that base 317 is A, not G as implied by the outcome of the inference, demonstrating that IGHV3-30*04 C201T G317A (a sequence identical to IGHV3-30*18 G113C C114T) is the allele in question. A past study has, using IgDiscover v.0.12, inferred IGHV3-30*04 C201T G317A/IGHV3-30*18 G113C C114T in this data set (Huang et al. Front Immunol 12:730105; DOI: 10.3389/fimmu.2021.730105). Upstream regions of these alleles were also inferred in that study. The upstream region of IGHV3-30*04 C201T G317A was identical to that of IGHV3-30*18 but differed in four positions from that of IGHV3-30-3*01.\r\n\r\nIARC affirmed the sequence at Level 0 at Meeting 115, to possibly be upgraded to level 1 pending further discussion. IARC now affirms the sequence at level 1 up to and including base 319. It is acknowledged that the allele most likely carries 1 additional base, typically A, at base positions 320. The trailing \u201c.\u201d indicates IARC\u2019s opinion that the sequence is likely to contain one additional 3\u2019-nucleotide for which there is insufficient evidence to make an affirmation. The GenBank record (OX384049) is publicly available and reports the sequence of IGHV3-30*04 C201T G317A, up to and including base 320. For use in a reference germline gene set, IARC recommends the use of the expected full length sequence.\r\n\r\n>IGHV3-30*i02\r\nCAGGTGCAGCTGGTGGAGTCTGGGGGAGGCGTGGTCCAGCCTGGGAGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGCAAGGGGCTGGAGTGGGTGGCAGTTATATCATATGATGGAAGTAATAAATACTATGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAAAG.\r\n\r\nThe locus on chromosome 14 that carries human IGHV genes is highly complex. Genes may be duplicated or deleted, and identical sequences may be found in more than one gene. The IGHV3-30, IGHV3-30-3, IGHV3-30-5, and IGHV3-33 harbors very similar alleles, some of which are identical. For instance IGHV3-30*18 is found at both IGHV3-30 and IGHV3-30-5 (in that case: IGHV3-30-5*01) and IGHV3-30*04 is also found at IGHV3-30-3 (as IGHV3-30-3*03). Inference does not provide proof of the gene of the inferred allele. The gene of the inferred allele IGHV3-30*04 C201T G317A cannot be defined. Any name (with an \u201ci\u201d allele designation) of an inferred allele does not imply that its precise genetic location is known. It just, according to past practice of IARC, relates to the most similar allele that has previously been recognised, or to the gene with the lowest alphanumeric value, should alleles of multiple genes be equally matched to the novel allele in question. Other similar genes have been mentioned above.\r\n\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample OX384049\r\nVDJbase example haplotype: P1_I70", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02984", "allele_description_ref": "OGRDB:Homo sapiens:IGHV5-51*07.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV5-51*07", "sequence": "ATGGGGTCAACCGCCATCCTCGCCCTCCTCCTGGCTGTTCTCCAAGGTCAGTCCTGCCGAGGGCTTGAGGTCACAGAGGAGAACGGGTGGAAAGGAGCCCCTGATTCAAATTTTGTGTCTCCCCCACAGGAGTCTGTGCCGAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCACCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACACACAGTGAGAGAAACCAGCCCCGAGCCCGTCTAAAACC", "coding_sequence": "GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCACCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "5", "subgroup_designation": "51", "allele_designation": "07", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 141, "gene_end": 436, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 130, "leader_2_end": 140, "v_rs_start": 437, "v_rs_end": 474, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCACCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACA", "aligned_sequence": "GAGGTGCAGCTGGTGCAGTCTGGAGCA...GAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTT............ACCAGCTACTGGATCGGCTGGGTGCACCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGT......GACTCTGATACCAGATACAGCCCGTCCTTCCAA...GGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1431", "sequence": "ATGGGGTCAACCGCCATCCTCGCCCTCCTCCTGGCTGTTCTCCAAGGTCAGTCCTGCCGAGGGCTTGAGGTCACAGAGGAGAACGGGTGGAAAGGAGCCCCTGATTCAAATTTTGTGTCTCCCCCACAGGAGTCTGTGCCGAGGTGCAGCTGGTGCAGTCTGGAGCAGAGGTGAAAAAGCCCGGGGAGTCTCTGAAGATCTCCTGTAAGGGTTCTGGATACAGCTTTACCAGCTACTGGATCGGCTGGGTGCACCAGATGCCCGGGAAAGGCCTGGAGTGGATGGGGATCATCTATCCTGGTGACTCTGATACCAGATACAGCCCGTCCTTCCAAGGCCAGGTCACCATCTCAGCCGACAAGTCCATCAGCACCGCCTACCTGCAGTGGAGCAGCCTGAAGGCCTCGGACACCGCCATGTATTACTGTGCGAGACACACAGTGAGAGAAACCAGCCCCGAGCCCGTCTAAAACC", "repository_name": "GenBank", "repository_ref": "AC279152", "patch_no": "1", "gff_seqid": null, "gff_start": 15042, "gff_end": 15515, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AC279152. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (2 samples). Example subject: P25_I44.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02962", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-69*15.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV1-69*15", "sequence": "GTTCCTCTTTGTGGTGGCAGCAGCTACAGGTAAGGGGCTTCCTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTGTCCACAGGTGTCCAGTTCCAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCAC", "coding_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "69", "allele_designation": "15", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 127, "gene_end": 422, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 116, "leader_2_end": 126, "v_rs_start": 423, "v_rs_end": 451, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTCCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTC............AGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATC......TTTGGTACAGCAAACTACGCACAGAAGTTCCAG...GGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1409", "sequence": "CTAGTCCTAAGGCTGAGGAAGGGATCCTGGTTTAGTTAAAGAGGATTTTATTCACCCCTGTGTCCTGTCCACAGGTGTCCAGTTCCAGGTCCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGTCCTCGGTGAAGGTCTCCTGCAAGGCTTCTGGAGGCACCTTCAGCAGCTATGCTATCAGCTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGAAGGATCATCCCTATCTTTGGTACAGCAAACTACGCACAGAAGTTCCAGGGCAGAGTCACGATTACCGCGGACGAATCCACGAGCACAGCCTACATGGAGCTGAGCAGCCTGAGATCTGAGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCAC", "repository_name": "GenBank", "repository_ref": "MG719326", "patch_no": "1", "gff_seqid": null, "gff_start": 42, "gff_end": 440, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MG719326. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (2 samples). Example subject: P25_I55.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00070", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-39*08.2_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 2, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-39*08", "sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACGTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCTGTGTATTACTGTGCGAGACA", "coding_sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACGTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCTGTGTATTACTGTGCGAGACA", "ext_3prime": "A", "aliases": [ "IGHV4-39*i01" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "39", "allele_designation": "08", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 298, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACGTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCTGTGTATTACTGTGCGAGACA", "aligned_sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACGTGCACTGTCTCTGGTGGCTCCATCAGC......AGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCTGTGTATTACTGTGCGAGACA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1355", "sequence": "CAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACGTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCTGTGTATTACTGTGCGAGACA", "repository_name": "GenBank", "repository_ref": "OU596110", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 298, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "IARC meeting 62 (Nov 3rd, 2020):\r\nThe meeting considered the inference of the variant IGHV4-39*01_c66g, in the VDJbase dataset of sample P1_I90_S1. The sequence was seen in 2.74% of all unmutated rearrangements, with 1217 sequences including 1098 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. IGHV4-39*01 was also present in the genotype, at a similar frequency (3.09% of all unmutated sequences,\r\n1360 sequences, 1239 unmutated sequences). Haplotyping data showed almost perfect separation of the assigned alleles. Plots of the final 3\u2019 nucleotides of the inference were unavailable. The inferred sequence was tentatively affirmed as a Level 1 sequence. The final 3\u2019 nucleotides will be considered at a later date, at which time the affirmed sequence will be noted in the IARC minutes.\r\n\r\nIARC meeting 83 (Oct 18th, 2021):\r\nIGHV4-39*01_C66G was inferred in subject S86 (VDJbase: P1_I90_S1), a genotype that also carries IGHV4-39*01. This inference has previously been pre-assessed at IARC meeting 62 (https://www.antibodysociety.org/wordpress/wp-content/uploads/2021/04/Meeting-62-3_11_20-minutes.pdf). IGHV4-39*01_C66G was well expressed, represented by 1305 sequences, 1135 unmutated sequences, 1131 unique CDR3s in the unmutated sequence set, showed an allelic frequency of 48%, and represented 3.3% of all unmutated reads of the genotype. Haplotyping based on allelic diversity in IGHJ6 was possible and the alleles distributed well between haplotypes (IGHV4-39*01_C66G: 2:98; IGHV4-39*01: 100:0). IARC affirms the sequence as a level 1 sequence up to and including base 319 in agreement with past practice. It is acknowledged that the allele most likely carries one additional base, typically A at base position 320. A trailing \u201c.\u201d indicates IARC\u2019s opinion that the sequence is likely to contain an additional 3\u2019 nucleotide for which there is insufficient evidence to make an affirmation. It is known that the second last base of alleles of IGHV4-39 may be either C or G. The data describing the final bases of this inferred allele strongly supports that this base (319) is a C. The inference of IGHV4-39*07_C288A in data set VDJbase: P1_I29_S1 in contrast suggests that this allele features a G as the penultimate residue, illustrating that the inference process can pick up a difference at the second last base of alleles. The allele representing IGHV4-39*01_C66G is given the name IGHV4-39*i01.\r\n\r\n>IGHV4-39*i01\r\nCAGCTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACGTGCACTGTCTCTGGTGGCTCCATCAGCAGTAGTAGTTACTACTGGGGCTGGATCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGAGTATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCCGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCAGACACGGCTGTGTATTACTGTGCGAGAC.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample OU596110\r\nVDJbase example haplotype: P1_I90 (*01_c66g)\r\nVDJbase example haplotype: P1_I90 (*01_c66g)\r\nMapped by P1_I90 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02682", "allele_description_ref": "OGRDB:Homo sapiens:IGHV2-70*15.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV2-70*15", "sequence": "TCCCCTGGGTTCAAAAGACGAGGACAGGGCCTCGCTCAGTGAATCCTGCTCCCCACCATGGACATACTTTGTTCCACGCTCCTGCTACTGACTGTCCCGTCCTGTGAGTGCTGTGGTCAGGTAGTACTTCAGAAGCAAAAAATCTATTCTCTCCTTTGTGGGCTTCATCTTCTTATGTCTTCTCCACAGGGGTCTTATCCCAGGTCACCTTGAGGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGTGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATACTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATACCACAGAGGCACAGCCCAGGGCGCCTCCTGTACAAGAACC", "coding_sequence": "CAGGTCACCTTGAGGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGTGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATACTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "2", "subgroup_designation": "70", "allele_designation": "15", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 201, "gene_end": 501, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 190, "leader_2_end": 200, "v_rs_start": 502, "v_rs_end": 540, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCACCTTGAGGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGTGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATACTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATAC", "aligned_sequence": "CAGGTCACCTTGAGGGAGTCTGGTCCT...GCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGC......ACTAGTGGAATGTGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGAT.........GATGATAAATACTACAGCACATCTCTGAAG...ACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATAC", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1146", "sequence": "ATGGACATACTTTGTTCCACGCTCCTGCTACTGACTGTCCCGTCCTGTGAGTGCTGTGGTCAGGTAGTACTTCAGAAGCAAAAAATCTATTCTCTCCTTTGTGGGCTTCATCTTCTTATGTCTTCTCCACAGGGGTCTTATCCCAGGTCACCTTGAGGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGTGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATACTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATACCACAGAGGCACAGCCCAGGGCGCCTCCTGTACAAGAACC", "repository_name": "GenBank", "repository_ref": "MG719339", "patch_no": "1", "gff_seqid": null, "gff_start": 58, "gff_end": 540, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MG719339\r\nVDJbase example haplotype: P1_I57\r\nMapped by P1_I43 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00003", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-2*06.4_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 4, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-2*06", "sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGACGGATCAACCCTAACAGTGGTGGCACAAACTATGCACAGAAGTTTCAGGGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAG", "coding_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGACGGATCAACCCTAACAGTGGTGGCACAAACTATGCACAGAAGTTTCAGGGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": "A", "aliases": [ "IGHV1-2*i01" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "2", "allele_designation": "06", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 295, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGACGGATCAACCCTAACAGTGGTGGCACAAACTATGCACAGAAGTTTCAGGGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTC............ACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGACGGATCAACCCTAAC......AGTGGTGGCACAAACTATGCACAGAAGTTTCAG...GGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1075", "sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGACGGATCAACCCTAACAGTGGTGGCACAAACTATGCACAGAAGTTTCAGGGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAG", "repository_name": "GenBank", "repository_ref": "MH779621", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 295, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Originally approved by IARC on March 9, 2018.\r\n\r\n\"The sequence was inferred by Martin Corcoran using IgDiscover, and by Duncan Ralph using both Partis and TIgGER. The number of unique CDR3 used by sequences with exact matches to the inferred germline allele represents 1.9% [NOTE: 1.77% using the herein used approach to define number of exact matches] of all unique CDR3 associated to exact IGHV matches in the genotype,according to IgDiscover. There were at least 739 unique rearrangements, utilizing 19 D genes and 7 J genes, and hundreds of exact matches. The allele was the more frequently utilized allele, with an expression ratio of 70:30 with the *01 allele. The inference was supported by haplotype analysis using IGHJ6*02/*03. The sequence is present in the IgPdb as IGHV1-2*p06. The full length sequence was first reported to IgPdb in 2015 by Scheepers and colleagues (see J Immunol 194:4371-8) from genomic sequencing, and it was separately reported to IgPdb in 2016 by Kirik and colleagues (see Mol Immunol 87:12-22), as an inference from VDJ rearrangements.\"\r\n\r\nIn line with IARC policy, the submitted sequence was recognized up to and including nucleotide 319.\r\n\r\n(April 12, 2019) A trailing \".\" in the sequence indicates IARC's opinion that the sequence is likely to contain additional 3' nucleotides for which there is insufficient evidence to make an affirmation.\r\n\r\nThe allele was incorporated into IMGT on July 24, 2018 as IGHV1-2*06.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MH779621\r\nVDJbase example haplotype: P1_I27_S1\r\nMapped by P1_I27 haplotype", "curational_tags": [ "likely_truncated" ] }, { "allele_description_id": "OGRDB:A02966", "allele_description_ref": "OGRDB:Homo sapiens:IGHV2-70*05.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV2-70*05", "sequence": "ATGGACATACTTTGTTCCACGCTCCTGCTACTGACTGTCCCGTCCTGTGAGTGCTGTGGTCAGGTAGTACTTCAGAAGCAAAAAATCTATTCTCTCCTTTGTGGGCTTCATCTTCGTATGTCTTCTCCACAGGGGTCTTATCCCAGGTCACCTTGAAGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGCGTGCGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATTCTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATACCACAGAGACACAGCCCAGGGCGCCTCCTGTACAA", "coding_sequence": "CAGGTCACCTTGAAGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGCGTGCGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATTCTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "2", "subgroup_designation": "70", "allele_designation": "05", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 144, "gene_end": 444, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 133, "leader_2_end": 143, "v_rs_start": 445, "v_rs_end": 478, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCACCTTGAAGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGCGTGCGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATTCTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATAC", "aligned_sequence": "CAGGTCACCTTGAAGGAGTCTGGTCCT...GCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGC......ACTAGTGGAATGCGTGCGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGAT.........GATGATAAATTCTACAGCACATCTCTGAAG...ACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATAC", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1413", "sequence": "TCCTGTGAGTGCTGTGGTCAGGTAGTACTTCAGAAGCAAAAAATCTATTCTCTCCTTTGTGGGCTTCATCTTCGTATGTCTTCTCCACAGGGGTCTTATCCCAGGTCACCTTGAAGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGCGTGCGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACGCATTGATTGGGATGATGATAAATTCTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATACCACAGAGACACAGCCCAGGGCGCCTCCTGTACAA", "repository_name": "GenBank", "repository_ref": "OP913455", "patch_no": "1", "gff_seqid": null, "gff_start": 292, "gff_end": 727, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample OP913455. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (20 samples). Example subject: P25_I9.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02759", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-30-2*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-30-2*01", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGAGCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGCTGCAGCTGCAGGAGTCCGGCTCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGCCACCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAGGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCCAGAGACACAATGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "coding_sequence": "CAGCTGCAGCTGCAGGAGTCCGGCTCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGCCACCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAGGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCCAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4-30", "subgroup_designation": "2", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 140, "gene_end": 438, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 129, "leader_2_end": 139, "v_rs_start": 439, "v_rs_end": 477, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGCTGCAGCTGCAGGAGTCCGGCTCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGCCACCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAGGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCCAGAGA", "aligned_sequence": "CAGCTGCAGCTGCAGGAGTCCGGCTCA...GGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGC......AGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGCCACCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATCATAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACAGGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCCAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1325", "sequence": "GGGTCCTGTCCCAGCTGCAGCTGCAGGAGTCCGGCTCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGCCACCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAGGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCCAGAGACACAATGAGGGGAGGTGAGTGTGAGCTCG", "repository_name": "GenBank", "repository_ref": "HM855793", "patch_no": "1", "gff_seqid": null, "gff_start": 29, "gff_end": 367, "strand": null }, { "sequence_id": "1326", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGAGCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGCTGCAGCTGCAGGAGTCCGGCTCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGCCACCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAGGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCCAGAGACACAATGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052080", "patch_no": "1", "gff_seqid": null, "gff_start": 246, "gff_end": 722, "strand": null }, { "sequence_id": "1327", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGAGCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCCCAGCTGCAGCTGCAGGAGTCCGGCTCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTGGTTACTCCTGGAGCTGGATCCGGCAGCCACCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATCATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAGGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCCAGAGACACAATGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 530125, "gff_end": 530601, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052080\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02614", "allele_description_ref": "OGRDB:Homo sapiens:IGHD2-15*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD2-15*01", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGGATATTGTAGTGGTGGTAGCTGCTACTCCCACAGTGACACAGACCCATTCCCAAAGC", "coding_sequence": "AGGATATTGTAGTGGTGGTAGCTGCTACTCC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "2", "subgroup_designation": "15", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 59, "d_rs_3_prime_start": 60, "d_rs_3_prime_end": 87, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "952", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGGATATTGTAGTGGTGGTAGCTGCTACTCCCACAGTGACACAGACCCATTCCCAAAGC", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 55207, "gff_end": 55293, "strand": null }, { "sequence_id": "953", "sequence": "AGGATATTGTAGTGGTGGTAGCTGCTACTCC", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 31, "strand": null }, { "sequence_id": "954", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGGATATTGTAGTGGTGGTAGCTGCTACTCCCACAGTGACACAGACCCATTCCCAAAGC", "repository_name": "GenBank", "repository_ref": "ON052098", "patch_no": "1", "gff_seqid": null, "gff_start": 112, "gff_end": 198, "strand": null }, { "sequence_id": "955", "sequence": "GGATTTTGTGGGGGCTCGTGTCACTGTGAGGATATTGTAGTGGTGGTAGCTGCTACTCCCACAGTGACACAGACCCATTCCCAAAGC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 981830, "gff_end": 981916, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02758", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-28*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-28*03", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGGGGTATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCTCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCC", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "28", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 140, "gene_end": 435, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 129, "leader_2_end": 139, "v_rs_start": 436, "v_rs_end": 464, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGC.........AGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 102, "fwr2_start": 103, "fwr2_end": 153, "cdr2_start": 154, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1324", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGGGGTATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGGGTCTCTCTGTTCACAGGGGTCCTGTCTCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGACACCCTGTCCCTCACCTGCGCTGTCTCTGGTTACTCCATCAGCAGTAGTAACTGGTGGGGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTACATCTATTATAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTCACCATGTCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGTGGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGTGAGTGTGAGCCC", "repository_name": "GenBank", "repository_ref": "X92233", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 463, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X92233\r\nVDJbase example haplotype: P1_I15 (1 exact match)\r\nVDJbase example haplotype: P1_I35 (1 exact match)", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02649", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-2*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV1-2*02", "sequence": "ATGGACTGGACCTGGAGGATCCTCTTCTTGGTGGCAGCAGCCACAGGTAAGAGGCTCCCTAGTCCCAGTGATGAGAAAGAGATTGAGTCCAGTCCAGGGAGATCTCATCCACTTCTGTGTTCTCTCCACAGGAGCCCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACCCTAACAGTGGTGGCACAAACTATGCACAGAAGTTTCAGGGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGGGTGTCAGAAACC", "coding_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACCCTAACAGTGGTGGCACAAACTATGCACAGAAGTTTCAGGGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "2", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 143, "gene_end": 438, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 132, "leader_2_end": 142, "v_rs_start": 439, "v_rs_end": 477, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACCCTAACAGTGGTGGCACAAACTATGCACAGAAGTTTCAGGGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTC............ACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACCCTAAC......AGTGGTGGCACAAACTATGCACAGAAGTTTCAG...GGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1070", "sequence": "ATGGACTGGACCTGGAGGATCCTCTTCTTGGTGGCAGCAGCCACAGGTAAGAGGCTCCCTAGTCCCAGTGATGAGAAAGAGATTGAGTCCAGTCCAGGGAGATCTCATCCACTTCTGTGTTCTCTCCACAGGAGCCCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACCCTAACAGTGGTGGCACAAACTATGCACAGAAGTTTCAGGGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTGAGGGTGTCAGAAACC", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 36435, "gff_end": 36911, "strand": null }, { "sequence_id": "1071", "sequence": "GTGTCCACTCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGATGGATCAACCCTAACAGTGGTGGCACAAACTATGCACAGAAGTTTCAGGGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGCCGTGTATTACTGTGCGAGAGACACAGTGTGAAAACCCACATCCTCTCGCG", "repository_name": "GenBank", "repository_ref": "HM855734", "patch_no": "1", "gff_seqid": null, "gff_start": 10, "gff_end": 345, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019441\r\nVDJbase example haplotype: P1_I12_S1", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02985", "allele_description_ref": "OGRDB:Homo sapiens:IGHV6-1*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV6-1*03", "sequence": "ATGTCTGTCTCCTTCCTCATCTTCCTGCCCGTGCTGGGCCTCCCATGGGGTCAGTGTCAGGGAGATGCCGTATTCACAGCAGCATTCACAGACTGAGGGGTGTTTCACTTTGCTGTTTCCTTTTGTCTCCAGGTGTCCTGTCACAGGTACAGCTGCAGCAGTCAGGTCCAGGACTGGTGAAGCCCTCGCAGACCCTCTCACTCACCTGTGCCATCTCCGGGGACAGTGTCTCTAGCAACAGTGCTGCTTGGAACTGGATCAGGCAGTCCCCATCGAGAGGCCTTGAGTGGCTGGGAAGGACATACTACAGGTCCAAGTGGTATAATGATTATGCAGTATCTGTGAAAAGTTGAATAACCATCAACCCAGACACATCCAAGAACCAGTTCTCCCTGCAGCTGAACTCTGTGACTCCCGAGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "CAGGTACAGCTGCAGCAGTCAGGTCCAGGACTGGTGAAGCCCTCGCAGACCCTCTCACTCACCTGTGCCATCTCCGGGGACAGTGTCTCTAGCAACAGTGCTGCTTGGAACTGGATCAGGCAGTCCCCATCGAGAGGCCTTGAGTGGCTGGGAAGGACATACTACAGGTCCAAGTGGTATAATGATTATGCAGTATCTGTGAAAAGTTGAATAACCATCAACCCAGACACATCCAAGAACCAGTTCTCCCTGCAGCTGAACTCTGTGACTCCCGAGGACACGGCTGTGTATTACTGTGCAAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": false, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "6", "subgroup_designation": "1", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 144, "gene_end": 448, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 49, "leader_2_start": 133, "leader_2_end": 143, "v_rs_start": 449, "v_rs_end": 487, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTACAGCTGCAGCAGTCAGGTCCAGGACTGGTGAAGCCCTCGCAGACCCTCTCACTCACCTGTGCCATCTCCGGGGACAGTGTCTCTAGCAACAGTGCTGCTTGGAACTGGATCAGGCAGTCCCCATCGAGAGGCCTTGAGTGGCTGGGAAGGACATACTACAGGTCCAAGTGGTATAATGATTATGCAGTATCTGTGAAAAGTTGAATAACCATCAACCCAGACACATCCAAGAACCAGTTCTCCCTGCAGCTGAACTCTGTGACTCCCGAGGACACGGCTGTGTATTACTGTGCAAGAGA", "aligned_sequence": "CAGGTACAGCTGCAGCAGTCAGGTCCA...GGACTGGTGAAGCCCTCGCAGACCCTCTCACTCACCTGTGCCATCTCCGGGGACAGTGTCTCT......AGCAACAGTGCTGCTTGGAACTGGATCAGGCAGTCCCCATCGAGAGGCCTTGAGTGGCTGGGAAGGACATACTACAGGTCC...AAGTGGTATAATGATTATGCAGTATCTGTGAAA...AGTTGAATAACCATCAACCCAGACACATCCAAGAACCAGTTCTCCCTGCAGCTGAACTCTGTGACTCCCGAGGACACGGCTGTGTATTACTGTGCAAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 183, "fwr3_start": 184, "fwr3_end": 297, "cdr3_start": 298, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1432", "sequence": "ATGTCTGTCTCCTTCCTCATCTTCCTGCCCGTGCTGGGCCTCCCATGGGGTCAGTGTCAGGGAGATGCCGTATTCACAGCAGCATTCACAGACTGAGGGGTGTTTCACTTTGCTGTTTCCTTTTGTCTCCAGGTGTCCTGTCACAGGTACAGCTGCAGCAGTCAGGTCCAGGACTGGTGAAGCCCTCGCAGACCCTCTCACTCACCTGTGCCATCTCCGGGGACAGTGTCTCTAGCAACAGTGCTGCTTGGAACTGGATCAGGCAGTCCCCATCGAGAGGCCTTGAGTGGCTGGGAAGGACATACTACAGGTCCAAGTGGTATAATGATTATGCAGTATCTGTGAAAAGTTGAATAACCATCAACCCAGACACATCCAAGAACCAGTTCTCCCTGCAGCTGAACTCTGTGACTCCCGAGGACACGGCTGTGTATTACTGTGCAAGAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AC279151", "patch_no": "1", "gff_seqid": null, "gff_start": 24046, "gff_end": 24532, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AC279151. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (7 samples). Example subject: P25_I55.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02564", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-59*i03.2_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 2, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-59*i03", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTAAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTAAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": "A", "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "59", "allele_designation": "i03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 292, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTAAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATC............AGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGT.........GGGAGCACCAACTACAACCCCTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTAAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1375", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGTAGTTACTACTGGAGCTGGATCCGGCAGCCCCCAGGGAAGGGACTGGAGTGGATTGGGTATATCTATTACAGTGGGAGCACCAACTACAACCCCTCCCTCAAGAGTCGAGTCACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTAAAGCTGAGCTCTGTGACCGCTGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "repository_name": "GenBank", "repository_ref": "OW151138", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 292, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "This inference was assessed at IARC meeting 100 (June 8th, 2022) and meeting 101 (July 21st, 2022).\r\n\r\nIGHV4-59*01_G267A was inferred in subject S36 (VDJ-base: P1_I39_S1). The genotype carried one other allele of IGHV4-59. This sample carries few IGHV reads. The inference was consequently supported by a relative small number of sequences (60) and unmutated sequences (43), a relatively low overall frequency in the unmutated population (0.58%) and a small but diverse set of unique CDR3s (43) in the unmutated sequence set. Its allelic ratio was 31%. Haplotyping based on allelic diversity in IGHJ6 was possible with excellent separation from reads associated to IGHV4-59*01 (IGHV4-59*01_G267A: 0:100; IGHV4-59*01: 100:0). IARC affirms the sequence at level 1 up to and including base 319 in agreement with past practice. It is acknowledged that the allele most likely carries one additional base, typically A at base position 320. A trailing \u201c.\u201d indicates IARC\u2019s opinion that the sequence is likely to contain one additional 3\u2019-nucleotides for which there is insufficient evidence to make an affirmation. The allele is given the name IGHV4-59*i03.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample OW151138", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00008", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-4*03.3_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 3, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-4*03", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTCCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTAGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGTGGGAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAG", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTCCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTAGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGTGGGAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": "A", "aliases": [ "IGHV4-4*i01" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "4", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 295, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTCCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTAGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGTGGGAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTCCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGC.........AGTAGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGT.........GGGAGCACCAACTACAACCCGTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 102, "fwr2_start": 103, "fwr2_end": 153, "cdr2_start": 154, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1361", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTCCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTAGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGTGGGAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAG", "repository_name": "GenBank", "repository_ref": "MH779623", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 295, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Originally approved by IARC on April 13, 2018.\r\n\r\n\"The sequence is present at relatively high frequency (0.6%), in the IgDiscover analysis. It was inferred by IgDiscover, TIger and Partis. Haplotype analysis showed two IGHV4-4-like sequences associated with the IGHJ6*02 haplotype - this inference and a second inference that is most similar to IGHV4-4*08. The likely major duplication of B16 is associated with the IGHJ6*03 haplotype. Given the similarities between IGHV4-4*08 and IGHV4-61, and given that this haplotype does not include an IGHV4-61 sequence, the committee concluded that this sequence could be accepted as Level 1. Although in this analysis the sequence was shown to be most similar to IGHV4-4*01, the committee believes that this inference extends the partial sequence IGHV4-4*03.\"\r\n\r\n(April 12, 2019) In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 319. A trailing \u201c.\u201d indicates IARC's opinion that the sequences likely to contain an additional/additional 3' nucleotide(s) for which there is insufficient evidence to make an affirmation.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MH779623", "curational_tags": [ "likely_truncated" ] }, { "allele_description_id": "OGRDB:A02639", "allele_description_ref": "OGRDB:Homo sapiens:IGHJ1*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHJ1*01", "sequence": "GGTTTCTGTAGCCCCTGGCTCAGGGCTGACTCACCGTGGCTGAATACTTCCAGCACTGGGGCCAGGGCACCCTGGTCACCGTCTCCTCAG", "coding_sequence": "GCTGAATACTTCCAGCACTGGGGCCAGGGCACCCTGGTCACCGTCTCCTCAG", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "J", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": null, "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 39, "gene_end": 90, "j_codon_frame": null, "j_cdr3_end": 90, "j_rs_start": 1, "j_rs_end": 38, "unrearranged_support": [ { "sequence_id": "1040", "sequence": "GGTTTCTGTAGCCCCTGGCTCAGGGCTGACTCACCGTGGCTGAATACTTCCAGCACTGGGGCCAGGGCACCCTGGTCACCGTCTCCTCAG", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 87524, "gff_end": 87613, "strand": null }, { "sequence_id": "1041", "sequence": "GGTTTCTGTAGCCCCTGGCTCAGGGCTGACTCACCGTGGCTGAATACTTCCAGCACTGGGGCCAGGGCACCCTGGTCACCGTCTCCTCAG", "repository_name": "GenBank", "repository_ref": "X86359", "patch_no": "1", "gff_seqid": null, "gff_start": 247, "gff_end": 336, "strand": null }, { "sequence_id": "1042", "sequence": "GGTTTCTGTAGCCCCTGGCTCAGGGCTGACTCACCGTGGCTGAATACTTCCAGCACTGGGGCCAGGGCACCCTGGTCACCGTCTCCTCAG", "repository_name": "GenBank", "repository_ref": "ON023001", "patch_no": "1", "gff_seqid": null, "gff_start": 83, "gff_end": 172, "strand": null }, { "sequence_id": "1043", "sequence": "GGTTTCTGTAGCCCCTGGCTCAGGGCTGACTCACCGTGGCTGAATACTTCCAGCACTGGGGCCAGGGCACCCTGGTCACCGTCTCCTCAG", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 1014349, "gff_end": 1014438, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02959", "allele_description_ref": "OGRDB:Homo sapiens:IGHV1-2*05.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV1-2*05", "sequence": "ATATCGCGAGTCTCCACAGGTGCCCATCCCAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGACGGATCAACCCTAACAGTGGTGGCACAAACTATGCACAGAAGTTTCAGGGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGTCGTGTATTACTGTGCGAGAGACACAGTGTGAAAAACCACATCCT", "coding_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGACGGATCAACCCTAACAGTGGTGGCACAAACTATGCACAGAAGTTTCAGGGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGTCGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "1", "subgroup_designation": "2", "allele_designation": "05", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 30, "gene_end": 325, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 20, "leader_2_end": 29, "v_rs_start": 326, "v_rs_end": 354, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCTGAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTCACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGACGGATCAACCCTAACAGTGGTGGCACAAACTATGCACAGAAGTTTCAGGGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGTCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGGTGCAGTCTGGGGCT...GAGGTGAAGAAGCCTGGGGCCTCAGTGAAGGTCTCCTGCAAGGCTTCTGGATACACCTTC............ACCGGCTACTATATGCACTGGGTGCGACAGGCCCCTGGACAAGGGCTTGAGTGGATGGGACGGATCAACCCTAAC......AGTGGTGGCACAAACTATGCACAGAAGTTTCAG...GGCAGGGTCACCATGACCAGGGACACGTCCATCAGCACAGCCTACATGGAGCTGAGCAGGCTGAGATCTGACGACACGGTCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample HM855681. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (26 samples). Example subject: P25_I25.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02635", "allele_description_ref": "OGRDB:Homo sapiens:IGHD6-19*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHD6-19*01", "sequence": "GGTTTCTGAAGCTGTCTGTATCACAGTGGGGTATAGCAGTGGCTGGTACCACAGTGACACTCGCCAGGCCAGAAACC", "coding_sequence": "GGGTATAGCAGTGGCTGGTAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "D", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "6", "subgroup_designation": "19", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 29, "gene_end": 49, "d_rs_3_prime_start": 50, "d_rs_3_prime_end": 77, "d_rs_5_prime_start": 1, "d_rs_5_prime_end": 28, "unrearranged_support": [ { "sequence_id": "1024", "sequence": "GGTTTCTGAAGCTGTCTGTATCACAGTGGGGTATAGCAGTGGCTGGTACCACAGTGACACTCGCCAGGCCAGAAACC", "repository_name": "GenBank", "repository_ref": "X97051", "patch_no": "1", "gff_seqid": null, "gff_start": 61475, "gff_end": 61551, "strand": null }, { "sequence_id": "1025", "sequence": "GGTTTCTGAAGCTGTCTGTATCACAGTGGGGTATAGCAGTGGCTGGTACCACAGTGACACTCGCCAGGCCAGAAACC", "repository_name": "GenBank", "repository_ref": "AB019441", "patch_no": "1", "gff_seqid": null, "gff_start": 131934, "gff_end": 132010, "strand": null }, { "sequence_id": "1026", "sequence": "GGTTTCTGAAGCTGTCTGTATCACAGTGGGGTATAGCAGTGGCTGGTACCACAGTGACACTCGCCAGGCCAGAAACC", "repository_name": "GenBank", "repository_ref": "ON052116", "patch_no": "1", "gff_seqid": null, "gff_start": 139, "gff_end": 215, "strand": null }, { "sequence_id": "1027", "sequence": "GGTTTCTGAAGCTGTCTGTATCACAGTGGGGTATAGCAGTGGCTGGTACCACAGTGACACTCGCCAGGCCAGAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 988098, "gff_end": 988174, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample X97051\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00006", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-7*04.5_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 5, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-7*04", "sequence": "ATGGAGTTGGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGATTCATGGAAAACTAGGAAGATTGAGTGTGTGTGGATATGAGTGTGAGAAACAGTGGATTTGTGTGTCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAAGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGGGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAAGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGGGA", "ext_3prime": "A", "aliases": [ "IGHV3-7*i01" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "7", "allele_designation": "04", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 161, "gene_end": 455, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 150, "leader_2_end": 160, "v_rs_start": 457, "v_rs_end": 495, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAAGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGGGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTT............AGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAAGGGCTGGAGTGGGTGGCCAACATAAAGCAAGAT......GGAAGTGAGAAATACTATGTGGACTCTGTGAAG...GGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGGGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1292", "sequence": "ATGGAGTTGGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAGAAGGTGATTCATGGAAAACTAGGAAGATTGAGTGTGTGTGGATATGAGTGTGAGAAACAGTGGATTTGTGTGTCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAAGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGGGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "MN337620", "patch_no": "1", "gff_seqid": null, "gff_start": 165, "gff_end": 659, "strand": null }, { "sequence_id": "1293", "sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAAGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGGGA", "repository_name": "GenBank", "repository_ref": "BK010574", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 295, "strand": null } ], "rearranged_support": [ { "sequence_id": "85", "sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGTAGCTATTGGATGAGCTGGGTCCGCCAGGCTCCAGGGAAAGGGCTGGAGTGGGTGGCCAACATAAAGCAAGATGGAAGTGAGAAATACTATGTGGACTCTGTGAAGGGCCGATTCACCATCTCCAGAGACAACGCCAAGAACTCACTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCTGTGTATTACTGTGCGAGGGA", "derivation": null, "observation_type": "inference from repertoire", "repository_name": "ENA", "repository_ref": "MN244239", "deposited_version": "1", "sequence_start": 1, "sequence_end": 296 } ], "paralogs": null, "curation": "Originally assessed by IARC on May 11, 2018.\r\n\r\n\"The sequence is present at a moderate frequency (0.5%), in the IgDiscover analysis. No information was provided by the submitter regarding analysis with partis or TIgGER. Haplotype analysis could not be performed. Analysis for chimerism did not provide evidence against the existence of the sequence.\r\nExtensive analysis was submitted, including four additional IgDiscover analyses using modified germline gene reference datasets. Although IARC were strongly persuaded by the submitted data, it was agreed that the sequence should be moved to Level 0. Issues relating to the end nucleotides deserve wider discussion by the Working Group before IMGT is notified of such a potentially controversial decision. This will be raised by AC at the forthcoming WG meeting.\"\r\n\r\nIt has been noted that neither partis not TIgGER had been able to infer IGHV3-7*02 or any variant thereof while these tools inferred IGHV3-7*01 (see supplementary information privided with the submission ).\r\n\r\n(April 12, 2019) In line with IARC policy, the submitted sequence was recognized up to and including nucleotide 319. A trailing \u201c.\u201d indicates IARC's opinion that the sequences likely to contain an additional/additional 3' nucleotide(s) for which there is insufficient evidence to make an affirmation.\r\n\r\n(August 7th 2019) At the 40th meeting of the IARC, the committee considered the inference of this sequence in S00028. The committee noted a rearrangement frequency of 0.7%, with 10188 alignments, though only 2443 perfect matches to the inferred allele. Alignments were also seen to three other IGHV3-7 sequences, though only one of these sequences was abundant (IGHV3-7*03: 20569 alignments, 4062 unmutated alignments). Haplotyping based on IGHJ6 alleles confirmed the segregation of reads associated with the two abundant alleles to the different haplotypes. Alignments to the *01 allele were at a trivial level (<0.01% of \u2018unmutated\u2019 alignments), though alignments to the *02 allele were seen in 0.09% of all unmutated sequences. They likely originated from an introduction of A318 as part of the V-DJ rearrangement process. This represented 3% of all alignments to the IGHV3-7 gene. There were 933 different CDR3s associated with the inference, including 233 different CDR3s associated with unmutated alignments. The committee agreed that the sequence should be accepted as a valid inference, which raises this sequence from Level 0 to Level 2. In line with previous policy, the submitted sequence is recognized up to and including nucleotide 319. A trailing \u201c.\u201d in the affirmed sequence indicates the IARC\u2019s opinion that the sequence is likely to contain an additional 3\u2019 nucleotide for which there is insufficient evidence to make an affirmation. \r\n\r\nReanalysis of the original submission at Meeting 43 of the IARC on October 7, 2019 again identified the same novel allele IGHV3-7*02_A318G with 12640 sequences and 2796 perfect matches and 269 Unique CDR3s with unmutated Seqs. In this analysis only one other allele of IGHV3-7 was seen (as very rare inferences had been removed by IgDiscover filtering), IGHV3-7*03 with 21677 sequences and 4120 perfect matches giving a 37:63 allelic ratio. These alleles were very well separated by IGHJ6-based haplotype analysis (100:0 and 1:99, respectively). The re-analysis thus confirmed the inference of IGHV3-7*i01 as a Level 2 sequence. In line with previous policy, the submitted sequence is recognized up to and including nucleotide 319. A trailing \u201c.\u201d in the affirmed sequence indicates IARC\u2019s opinion that the sequence is likely to contain an additional 3\u2019 nucleotide for which there is insufficient evidence to make an affirmation.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MN337620\r\nVDJbase example haplotype: P1_I29\r\nMapped by P1_I29 haplotype", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02680", "allele_description_ref": "OGRDB:Homo sapiens:IGHV2-5*02.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV2-5*02", "sequence": "TCCTCTGGGTTGAAAAAGCCGAGCACAGGTCCCAGCTCAGTGACTCCTGTGCCCCACCATGGACACACTTTGCTCCACGCTCCTGCTGCTGACCATCCCTTCATGTGAGTGCTGTGGTCAGGGACTCCTTCATGGGTGAAACATCAGTTTTCTTGTTTGTGGGCTTCATCTTCTTATGCTTTCTCCACAGGGGTCTTGTCCCAGATCACCTTGAAGGAGTCTGGTCCTACGCTGGTGAAACCCACACAGACCCTCACGCTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAGTGGGTGTGGGCTGGATCCGTCAGCCCCCAGGAAAGGCCCTGGAGTGGCTTGCACTCATTTATTGGGATGATGATAAGCGCTACAGCCCATCTCTGAAGAGCAGGCTCACCATCACCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACACAGACCACAAAGACACAGCCCAGGGCACCTCCTGTACAAAAACC", "coding_sequence": "CAGATCACCTTGAAGGAGTCTGGTCCTACGCTGGTGAAACCCACACAGACCCTCACGCTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAGTGGGTGTGGGCTGGATCCGTCAGCCCCCAGGAAAGGCCCTGGAGTGGCTTGCACTCATTTATTGGGATGATGATAAGCGCTACAGCCCATCTCTGAAGAGCAGGCTCACCATCACCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACACAGAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "2", "subgroup_designation": "5", "allele_designation": "02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 202, "gene_end": 502, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": 191, "leader_2_end": 201, "v_rs_start": 503, "v_rs_end": 541, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGATCACCTTGAAGGAGTCTGGTCCTACGCTGGTGAAACCCACACAGACCCTCACGCTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAGTGGGTGTGGGCTGGATCCGTCAGCCCCCAGGAAAGGCCCTGGAGTGGCTTGCACTCATTTATTGGGATGATGATAAGCGCTACAGCCCATCTCTGAAGAGCAGGCTCACCATCACCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACACAGAC", "aligned_sequence": "CAGATCACCTTGAAGGAGTCTGGTCCT...ACGCTGGTGAAACCCACACAGACCCTCACGCTGACCTGCACCTTCTCTGGGTTCTCACTCAGC......ACTAGTGGAGTGGGTGTGGGCTGGATCCGTCAGCCCCCAGGAAAGGCCCTGGAGTGGCTTGCACTCATTTATTGGGAT.........GATGATAAGCGCTACAGCCCATCTCTGAAG...AGCAGGCTCACCATCACCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACACAGAC", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1141", "sequence": "ATGGACACACTTTGCTCCACGCTCCTGCTGCTGACCATCCCTTCATGTGAGTGCTGTGGTCAGGGACTCCTTCATGGGTGAAACATCAGTTTTCTTGTTTGTGGGCTTCATCTTCTTATGCTTTCTCCACAGGGGTCTTGTCCCAGATCACCTTGAAGGAGTCTGGTCCTACGCTGGTGAAACCCACACAGACCCTCACGCTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAGTGGGTGTGGGCTGGATCCGTCAGCCCCCAGGAAAGGCCCTGGAGTGGCTTGCACTCATTTATTGGGATGATGATAAGCGCTACAGCCCATCTCTGAAGAGCAGGCTCACCATCACCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACACAGACCACAAAGACACAGCCCAGGGCACCTCCTGTACAAAAACC", "repository_name": "GenBank", "repository_ref": "MG719332", "patch_no": "1", "gff_seqid": null, "gff_start": 59, "gff_end": 541, "strand": null }, { "sequence_id": "1142", "sequence": "ATGGACACACTTTGCTCCACGCTCCTGCTGCTGACCATCCCTTCATGTGAGTGCTGTGGTCAGGGACTCCTTCATGGGTGAAACATCAGTTTTCTTGTTTGTGGGCTTCATCTTCTTATGCTTTCTCCACAGGGGTCTTGTCCCAGATCACCTTGAAGGAGTCTGGTCCTACGCTGGTGAAACCCACACAGACCCTCACGCTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAGTGGGTGTGGGCTGGATCCGTCAGCCCCCAGGAAAGGCCCTGGAGTGGCTTGCACTCATTTATTGGGATGATGATAAGCGCTACAGCCCATCTCTGAAGAGCAGGCTCACCATCACCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACACAGACCACAAAGACACAGCCCAGGGCACCTCCTGTACAAAAAC", "repository_name": "GenBank", "repository_ref": "ON052043", "patch_no": "1", "gff_seqid": null, "gff_start": 139, "gff_end": 620, "strand": null }, { "sequence_id": "1143", "sequence": "ATGGACACACTTTGCTCCACGCTCCTGCTGCTGACCATCCCTTCATGTGAGTGCTGTGGTCAGGGACTCCTTCACGGGTGAAACATCAGTTTTCTTGTTTGTGGGCTTCATCTTCTTATGCTTTCTCCACAGGGGTCTTGTCCCAGATCACCTTGAAGGAGTCTGGTCCTACGCTGGTGAAACCCACACAGACCCTCACGCTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAGTGGGTGTGGGCTGGATCCGTCAGCCCCCAGGAAAGGCCCTGGAGTGGCTTGCACTCATTTATTGGGATGATGATAAGCGCTACAGCCCATCTCTGAAGAGCAGGCTCACCATCACCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACATATTACTGTGCACACAGACCACAAAGACACAGCCCAGGGCACCTCCTGTACAAAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 841500, "gff_end": 841982, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample MG719332\r\nVDJbase example haplotype: P1_I43", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A00072", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-4*10.4_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 4, "release_date": "16-Aug-2023", "release_description": "Further D sequences added with the support of Rodriguez et al. 'Likely' extensions added to three IGHV alleles. See Notes for details.", "label": "IGHV4-4*10", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGTGGGAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGTGGGAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "ext_3prime": "A", "aliases": [ "IGHV4-4*i03" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4", "subgroup_designation": "4", "allele_designation": "10", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 295, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGTGGGAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGC.........AGTGGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGT.........GGGAGCACCAACTACAACCCGTCCCTCAAG...AGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 102, "fwr2_start": 103, "fwr2_end": 153, "cdr2_start": 154, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1367", "sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGTGGGAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAGA", "repository_name": "GenBank", "repository_ref": "OU596101", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 295, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "IARC meeting 63, Nov 24th, 2020:\r\nThe meeting considered the inference of the variant IGHV4-4*02_a106g, in the VDJbase dataset of sample P1_I42_S1. The sequence was seen in 1.27% of all unmutated rearrangements, with 268 sequences including 234 perfect matches to the inferred allele. There was abundant variation in the CDR3 regions of the aligned sequences. IGHV4-4*07 was also present in the genotype, at a lower frequency (0.73% of all unmutated sequences, 157 sequences, 135 unmutated sequences). Haplotyping data was not available. Plots of the final 3\u2019 nucleotides of the inference were also unavailable. In light of the low sequence counts and the lack of haplotyping, the inferred sequence was affirmed as a Level 0 sequence. The final 3\u2019 nucleotides will be considered at a later date, at which time the affirmed sequence will be noted in the IARC minutes.\r\n\r\nIARC meeting 84; Oct 25th, 2021:\r\nIGHV4-4*02_A106G was inferred in subject S39 (P1_I42_S1; ERR2567216). This inference has previously been pre-assessed at IARC meeting 63 (https://www.antibodysociety.org/wordpress/wp-content/uploads/2020/12/Meeting-63-24_11_20-minutes.pdf). The inference was supported by many sequences (294) and unmutated sequences (253) a high allelic frequency (64%), a high overall frequency in the unmutated population (1.5%) and many unique CDR3s (243) in the unmutated sequence set. Haplotyping based on alleles of IGHJ6 was not possible. Haplotyping based on different variant sequences of IGHD3-10*01 (DOI: 10.3389/fimmu.2019.00987), one of which is not recorded in the IMGT database, was possible (but was not part of the OGRDB submission as the variant IGHD allele is not present in the database used for inference). Separate analysis following IgDiscover-based inference suggested complete separation of IGHV4-4*02_A106G (IGHV4-4*02_S2599) relative to the other allele of IGHV4-4. Overall, the genotype also carried IGHV4-4*07, IGHV4-59*01, IGHV4-59*08, and IGHV4-61*02_A234G among this set of similar genes. The upstream regions of all these alleles have been inferred in this subject in the past (DOI: 10.3389/fimmu.2021.730105) and the upstream region of IGHV4-4*02_A106G is different from those of the other alleles of this set of genes. IARC now affirms, based on the extensive validation, the sequence at level 1 up to and including base 319 in agreement with past practice. It is acknowledged that the allele most likely carries one additional base, typically A at base position 320. We recognise that alleles of IGHV4-4/IGHV4-59/IGHV4-61 may residue in gene locations different from that associated to the most similar allele in the IMGT database. Although there is nothing in the data, including haplotype assessment, that suggest that the allele does not reside in gene IGHV4-4, it must be recognized that IARC gene naming does not reflect a position on the precise gene location of the allele to a specific gene. The allele is given the name IGHV4-4*i03.\r\n\r\n>IGHV4-4*i03\r\nCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCGGGGACCCTGTCCCTCACCTGCGCTGTCTCTGGTGGCTCCATCAGCAGTGGTAACTGGTGGAGTTGGGTCCGCCAGCCCCCAGGGAAGGGGCTGGAGTGGATTGGGGAAATCTATCATAGTGGGAGCACCAACTACAACCCGTCCCTCAAGAGTCGAGTCACCATATCAGTAGACAAGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACCGCCGCGGACACGGCCGTGTATTACTGTGCGAGAG.\r\n\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample OU596101\r\nVDJbase example haplotype: P1_I42\r\nOne nucleotide truncation at 3' end. The IARC states that its location is uncertain", "curational_tags": [ "likely_truncated" ] }, { "allele_description_id": "OGRDB:A02971", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-23*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "15-Aug-2023", "release_description": "Sequences added following discussion at IARC meeting on 9th August 2023", "label": "IGHV3-23*03", "sequence": "GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCTATGCCATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGTAGCACATACTATGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGAGATAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAAAGA", "coding_sequence": "GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCTATGCCATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGTAGCACATACTATGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGAGATAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAAAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "23", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 296, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCTATGCCATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGTAGCACATACTATGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGAGATAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAAAGA", "aligned_sequence": "GAGGTGCAGCTGTTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTT............AGCAGCTATGCCATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGT......GGTAGTAGCACATACTATGCAGACTCCGTGAAG...GGCCGGTTCACCATCTCCAGAGATAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAAAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1418", "sequence": "GAGGTGCAGCTGTTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTAGCAGCTATGCCATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCGGTGGTAGTAGCACATACTATGCAGACTCCGTGAAGGGCCGGTTCACCATCTCCAGAGATAATTCCAAGAACACGCTGTATCTGCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTATATTACTGTGCGAAAGA", "repository_name": "GenBank", "repository_ref": "AM940223", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 296, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AM940223. Sequence observed in data from Rodriguez et al.\r\n2023 as reported in VDJbase (8 samples). Example subject: P25_I7.", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02681", "allele_description_ref": "OGRDB:Homo sapiens:IGHV2-70*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV2-70*01", "sequence": "ATGGACATACTTTGTTCCACGCTCCTGCTACTGACTGTCCCGTCCTGTGAGTGCTGTGGTCAGGTAGTACTTCAGAAGCAAAAAATCTATTCTCTCCTTTGTGGGCTTCATCTTCTTATGTCTTCTCCACAGGGGTCTTATCCCAGGTCACCTTGAGGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGTGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACTCATTGATTGGGATGATGATAAATACTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATACCACAGAGACACAGCCCAGGGCGCCTCCTGTACAA", "coding_sequence": "CAGGTCACCTTGAGGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGTGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACTCATTGATTGGGATGATGATAAATACTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATAC", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "2", "subgroup_designation": "70", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 144, "gene_end": 444, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 133, "leader_2_end": 143, "v_rs_start": 445, "v_rs_end": 478, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTCACCTTGAGGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGTGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACTCATTGATTGGGATGATGATAAATACTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATAC", "aligned_sequence": "CAGGTCACCTTGAGGGAGTCTGGTCCT...GCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGC......ACTAGTGGAATGTGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACTCATTGATTGGGAT.........GATGATAAATACTACAGCACATCTCTGAAG...ACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATAC", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1144", "sequence": "TCCTGTGAGTGCTGTGGTCAGGTAGTACTTCAGAAGCAAAAAATCTATTCTCTCCTTTGTGGGCTTCATCTTCTTATGTCTTCTCCACAGGGGTCTTATCCCAGGTCACCTTGAGGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGTGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACTCATTGATTGGGATGATGATAAATACTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATACCACAGAGACACAGCCCAGGGCGCCTCCTGTACAA", "repository_name": "GenBank", "repository_ref": "ON052044", "patch_no": "1", "gff_seqid": null, "gff_start": 292, "gff_end": 727, "strand": null }, { "sequence_id": "1145", "sequence": "ATGGACATACTTTGTTCCACGCTCCTGCTACTGACTGTCCCGTCCTGTGAGTGCTGTGGTCAGGTAGTACTTCAGAAGCAAAAAATCTATTCTCTCCTTTGTGGGCTTCATCTTCTTATGTCTTCTCCACAGGGGTCTTATCCCAGGTCACCTTGAGGGAGTCTGGTCCTGCGCTGGTGAAACCCACACAGACCCTCACACTGACCTGCACCTTCTCTGGGTTCTCACTCAGCACTAGTGGAATGTGTGTGAGCTGGATCCGTCAGCCCCCAGGGAAGGCCCTGGAGTGGCTTGCACTCATTGATTGGGATGATGATAAATACTACAGCACATCTCTGAAGACCAGGCTCACCATCTCCAAGGACACCTCCAAAAACCAGGTGGTCCTTACAATGACCAACATGGACCCTGTGGACACAGCCACGTATTACTGTGCACGGATACCACAGAGACACAGCCCAGGGCGCCTCCTGTACAAGAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 108825, "gff_end": 109307, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052044\r\nVDJbase example haplotype: P1_I12\r\nVDJbase example haplotype: P1_I100", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02761", "allele_description_ref": "OGRDB:Homo sapiens:IGHV4-30-4*01.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV4-30-4*01", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGTGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGATTACTACTGGAGTTGGATCCGCCAGCCCCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAGACACAATGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "coding_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGATTACTACTGGAGTTGGATCCGCCAGCCCCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "4-30", "subgroup_designation": "4", "allele_designation": "01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 140, "gene_end": 438, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 129, "leader_2_end": 139, "v_rs_start": 439, "v_rs_end": 477, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGATTACTACTGGAGTTGGATCCGCCAGCCCCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAGA", "aligned_sequence": "CAGGTGCAGCTGCAGGAGTCGGGCCCA...GGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGC......AGTGGTGATTACTACTGGAGTTGGATCCGCCAGCCCCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGT.........GGGAGCACCTACTACAACCCGTCCCTCAAG...AGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 105, "fwr2_start": 106, "fwr2_end": 156, "cdr2_start": 157, "cdr2_end": 177, "fwr3_start": 178, "fwr3_end": 291, "cdr3_start": 292, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1330", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGTGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGATTACTACTGGAGTTGGATCCGCCAGCCCCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAGACACAATGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AC244456", "patch_no": "2", "gff_seqid": null, "gff_start": 15866, "gff_end": 16342, "strand": null }, { "sequence_id": "1331", "sequence": "GGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGATTACTACTGGAGTTGGATCCGCCAGCCCCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAGACACAATGAGGGGAGGTGAGTGTGAG", "repository_name": "GenBank", "repository_ref": "HM855703", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 335, "strand": null }, { "sequence_id": "1332", "sequence": "ATGAAACACCTGTGGTTCTTCCTCCTGCTGGTGGCAGCTCCCAGATGTGAGTGTCTCAAGGCTGCAGACATGGAGATATGGGAGGTGCCTCTGATCCCAGGGCTCACTGTGTGTCTCTCTGTTCACAGGGGTCCTGTCCCAGGTGCAGCTGCAGGAGTCGGGCCCAGGACTGGTGAAGCCTTCACAGACCCTGTCCCTCACCTGCACTGTCTCTGGTGGCTCCATCAGCAGTGGTGATTACTACTGGAGTTGGATCCGCCAGCCCCCAGGGAAGGGCCTGGAGTGGATTGGGTACATCTATTACAGTGGGAGCACCTACTACAACCCGTCCCTCAAGAGTCGAGTTACCATATCAGTAGACACGTCCAAGAACCAGTTCTCCCTGAAGCTGAGCTCTGTGACTGCCGCAGACACGGCCGTGTATTACTGTGCCAGAGACACAATGAGGGGAGGTGAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052081", "patch_no": "1", "gff_seqid": null, "gff_start": 246, "gff_end": 722, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AC244456\r\nVDJbase example haplotype: P1_I12", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02738", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-64D*06.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-64D*06", "sequence": "ATGGAGTTCTGGCTGAGCTGGGTTCTCCTTGTTGCCATTTTAAAAGGTAATTCATGGAGAACTAGAGATAGTGTGAGTGGACGTGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGATGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTTCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATACTACGCAGACTCCGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAGCAGTCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGTGAAAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTTCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATACTACGCAGACTCCGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAGCAGTCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGTGAAAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "64D", "allele_designation": "06", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 157, "gene_end": 452, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 146, "leader_2_end": 156, "v_rs_start": 453, "v_rs_end": 491, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTTCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATACTACGCAGACTCCGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAGCAGTCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGTGAAAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTTCAGCCTCTGGATTCACCTTC............AGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAAT......GGGGGTAGCACATACTACGCAGACTCCGTGAAG...GGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAGCAGTCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGTGAAAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1275", "sequence": "ATGGAGTTCTGGCTGAGCTGGGTTCTCCTTGTTGCCATTTTAAAAGGTAATTCATGGAGAACTAGAGATAGTGTGAGTGGACGTGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGATGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTTCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATACTACGCAGACTCCGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAGCAGTCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGTGAAAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "ON052069", "patch_no": "1", "gff_seqid": null, "gff_start": 194, "gff_end": 684, "strand": null }, { "sequence_id": "1276", "sequence": "ATGGAGTTCTGGCTGAGCTGGGTTCTCCTTGTTGCCATTTTAAAAGGTAATTCATGGAGAACTAGAGATAGTGTGAGTGGACGTGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTGACCTTGGTGTCTCTTTGTTTGCAGATGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTTCAGCCTCTGGATTCACCTTCAGTAGCTATGCTATGCACTGGGTCCGCCAGGCTCCAGGGAAGGGACTGGAATATGTTTCAGCTATTAGTAGTAATGGGGGTAGCACATACTACGCAGACTCCGTGAAGGGCAGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAGCAGTCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGTGAAAGACACAGTGAGGGGAAGTCAGTGTGAGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 791272, "gff_end": 791762, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample ON052069\r\nVDJbase example haplotype: P1_I56", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02743", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-66*03.1_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 1, "release_date": "10-Jul-2023", "release_description": "Bulk upload of sequences for the AIRR-C Human IG germline sets", "label": "IGHV3-66*03", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGAGAACTAGAGATATTGAGTGTGAGTGAACACGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTAACCAATGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCTGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGCCATTGTGCGCCCAGACACAAACC", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCTGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "ext_3prime": null, "aliases": null, "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": null, "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "66", "allele_designation": "03", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 159, "gene_end": 451, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": 1, "leader_1_end": 46, "leader_2_start": 148, "leader_2_end": 158, "v_rs_start": 452, "v_rs_end": 490, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCTGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGAGGA...GGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTC............AGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCTGT.........GGTAGCACATACTACGCAGACTCCGTGAAG...GGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1281", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGAGAACTAGAGATATTGAGTGTGAGTGAACACGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTAACCAATGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCTGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGCCATTGTGCGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "AB019437", "patch_no": "1", "gff_seqid": null, "gff_start": 158060, "gff_end": 158549, "strand": null }, { "sequence_id": "1282", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGAGAACTAGAGATATTGAGTGTGAGTGAACACGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTAACCAATGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCTGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGCCATTGTGCGCCCA", "repository_name": "GenBank", "repository_ref": "ON052071", "patch_no": "1", "gff_seqid": null, "gff_start": 198, "gff_end": 677, "strand": null }, { "sequence_id": "1283", "sequence": "ATGGAGTTTGGGCTGAGCTGGGTTTTCCTTGTTGCTATTTTAAAAGGTGATTCATGGAGAACTAGAGATATTGAGTGTGAGTGAACACGAGTGAGAGAAACAGTGGATATGTGTGGCAGTTTCTAACCAATGTCTCTGTGTTTGCAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGAGGAGGCTTGATCCAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGGTTCACCGTCAGTAGCAACTACATGAGCTGGGTCCGCCAGGCTCCAGGGAAGGGGCTGGAGTGGGTCTCAGTTATTTATAGCTGTGGTAGCACATACTACGCAGACTCCGTGAAGGGCCGATTCACCATCTCCAGAGACAATTCCAAGAACACGCTGTATCTTCAAATGAACAGCCTGAGAGCTGAGGACACGGCTGTGTATTACTGTGCGAGAGACACAGTGAGGGGAGGCCATTGTGCGCCCAGACACAAACC", "repository_name": "GenBank", "repository_ref": "GRCh38:CM000676.2", "patch_no": null, "gff_seqid": null, "gff_start": 204380, "gff_end": 204869, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "Information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample AB019437", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02558", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-43D*05.3_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 3, "release_date": "11-Jan-2024", "release_description": "First published version.", "label": "IGHV3-43D*05", "sequence": "GAAATGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACATACTATGCAGACTCTGTGAAGGGTCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACCGCCTTGTATTACTGTGCAAAAGATA", "coding_sequence": "GAAATGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACATACTATGCAGACTCTGTGAAGGGTCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACCGCCTTGTATTACTGTGCAAAAGATA", "ext_3prime": null, "aliases": [ "IGHV3-43D*i02" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "43D", "allele_designation": "i02", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 298, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAAATGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACATACTATGCAGACTCTGTGAAGGGTCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACCGCCTTGTATTACTGTGCAAAAGATA", "aligned_sequence": "GAAATGCAGCTGGTGGAGTCTGGGGGA...GTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTT............GATGATTATGCCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGAT......GGTGGTAGCACATACTATGCAGACTCTGTGAAG...GGTCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACCGCCTTGTATTACTGTGCAAAAGATA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 174, "fwr3_start": 175, "fwr3_end": 288, "cdr3_start": 289, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1244", "sequence": "GAAATGCAGCTGGTGGAGTCTGGGGGAGTCGTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTTGATGATTATGCCATGCACTGGGTCCGTCAAGCTCCGGGGAAGGGTCTGGAGTGGGTCTCTCTTATTAGTTGGGATGGTGGTAGCACATACTATGCAGACTCTGTGAAGGGTCGATTCACCATCTCCAGAGACAACAGCAAAAACTCCCTGTATCTGCAAATGAACAGTCTGAGAGCTGAGGACACCGCCTTGTATTACTGTGCAAAAGATA", "repository_name": "GenBank", "repository_ref": "OW151136", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 297, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "This inferred allele was assessed at IARC meeting 100 on June 8th, 2022. IGHV3-43D*04_G4A was inferred in subject S10 (VDJ-base: P1_I10_S1). The genotype also carried IGHV3-43*01 but no other allele of IGHV3-43D. The inference was supported by a relatively small number of sequences (104) and unmutated sequences (93), a low overall frequency in the unmutated population (0.3%) and a small but diverse set of unique CDR3s (89) in the unmutated sequence set. Its allelic ratio was 100%. Haplotyping based on allelic diversity in IGHJ6 was possible and the alleles distributed to one haplotype, a haplotype different from that associated with the allele IGHV3-43 (IGHV3-43D*04_G4A: 100:0; IGHV3-43*01: 0:100). Reads of IGHV3-43D*04_G4A were associated to the same haplotype as those of IGHV4-38-2, a common duplication combination. Reads of IGHV3-43D*04_G4A were associated to an upstream region similar to that of other alleles of IGHV3-43D (but not similar to alleles of IGHV3-43) (doi: 10.3389/fimmu.2021.730105). Altogether, the association of this allele to IGHV3-43D is reasonable. IARC affirms the sequence at level 1 up to and including base 321 in agreement with past practice. It is acknowledged that the allele most likely carries one additional base, typically A at base position 322. A trailing \u201c.\u201d indicates IARC\u2019s opinion that the sequence is likely to contain one additional 3\u2019-nucleotides for which there is insufficient evidence to make an affirmation. The allele is given the name IGHV3-43D*i02.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample OW151136\r\nVDJbase example haplotype: Y\r\nMapped by IARC haplotype\r\n\r\nTR-IG NRC Report (2023-1a) allocated the IUIS name IGHV3-43D*05 to this allele\r\n\r\nThe report stated:\r\n\r\nThe TR-IG NRC have determined that the IARC-affirmed inferred sequence IGHV3-43D*i02 should be confirmed as IGHV3-43D*05. The missing terminal nucleotide of the sequence can be confirmed as \u2018A\u2019 by reference to recent genomic sequences of Rodriguez and colleagues that are reported in the VDJbase database from three individuals. This evidence is accessible via the VDJbase genomic data gene table (https://vdjbase.org/genetable ). The location of the sequence was well described in the IARC report, and is demonstrated by good haplotypable AIRR-seq data. Data strongly suggests that the novel allele is at the IGHV3-43D locus rather than the IGHV3-43 locus, and IGHV3-43 and IGHV3-43D are at least 22 nucleotides different from other IGHV genes. ", "curational_tags": [ "likely_full_length" ] }, { "allele_description_id": "OGRDB:A02566", "allele_description_ref": "OGRDB:Homo sapiens:IGHV3-13*06.3_ext", "maintainer": "William Lees", "acknowledgements": null, "lab_address": "Birkbeck College, University of London, Malet Street, London", "release_version": 3, "release_date": "11-Jan-2024", "release_description": "First published version.", "label": "IGHV3-13*06", "sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAGTGGGTCTCAGCTATTGGTACTGCTGGTGACACATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCAAGAGA", "coding_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAGTGGGTCTCAGCTATTGGTACTGCTGGTGACACATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCAAGAGA", "ext_3prime": null, "aliases": [ "IGHV3-13*i01" ], "locus": "IGH", "chromosome": 14, "sequence_type": "V", "functional": true, "inference_type": "Rearranged only", "species": { "id": "NCBITAXON:9606", "label": "Homo sapiens" }, "species_subgroup": null, "species_subgroup_type": null, "status": null, "gene_designation": "3", "subgroup_designation": "13", "allele_designation": "i01", "allele_similarity_cluster_designation": null, "allele_similarity_cluster_member_id": null, "gene_start": 1, "gene_end": 293, "utr_5_prime_start": null, "utr_5_prime_end": null, "leader_1_start": null, "leader_1_end": null, "leader_2_start": null, "leader_2_end": null, "v_rs_start": null, "v_rs_end": null, "v_gene_delineations": [ { "sequence_delineation_id": "1", "delineation_scheme": "IMGT", "unaligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAGTGGGTCTCAGCTATTGGTACTGCTGGTGACACATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCAAGAGA", "aligned_sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGA...GGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTC............AGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAGTGGGTCTCAGCTATTGGTACTGCT.........GGTGACACATACTATCCAGGCTCCGTGAAG...GGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCAAGAGA", "fwr1_start": 1, "fwr1_end": 75, "cdr1_start": 76, "cdr1_end": 99, "fwr2_start": 100, "fwr2_end": 150, "cdr2_start": 151, "cdr2_end": 171, "fwr3_start": 172, "fwr3_end": 285, "cdr3_start": 286, "alignment_labels": [ "1", "2", "3", "4", "5", "6", "7", "8", "9", "10", "11", "12", "13", "14", "15", "16", "17", "18", "19", "20", "21", "22", "23", "24", "25", "26", "27", "28", "29", "30", "31", "32", "33", "34", "35", "36", "37", "38", "39", "40", "41", "42", "43", "44", "45", "46", "47", "48", "49", "50", "51", "52", "53", "54", "55", "56", "57", "58", "59", "60", "61", "62", "63", "64", "65", "66", "67", "68", "69", "70", "71", "72", "73", "74", "75", "76", "77", "78", "79", "80", "81", "82", "83", "84", "85", "86", "87", "88", "89", "90", "91", "92", "93", "94", "95", "96", "97", "98", "99", "100", "101", "102", "103", "104" ] } ], "unrearranged_support": [ { "sequence_id": "1166", "sequence": "GAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAGTGGGTCTCAGCTATTGGTACTGCTGGTGACACATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCAAGAGA", "repository_name": "GenBank", "repository_ref": "OX384051", "patch_no": "1", "gff_seqid": null, "gff_start": 1, "gff_end": 292, "strand": null } ], "rearranged_support": [], "paralogs": null, "curation": "The inference IGHV3\u221213*01_G290A_T300C was considered at IARC meeting 116 on Feb 27th, 2023.\r\n\r\nIGHV3\u221213*01_G290A_T300C has been inferred in one genotype (P1_I10) in VDJbase P1 data set. The genotype does not carry a related allele and the opposite haplotype carries a large deletion that involves IGHV3-13 (Gidoni et al. (2019) Nat Commun 10, 628. DOI: 10.1038/s41467-019-08489-3). It represents 0.23% of the total unmutated population, it is represented by 71 unmutated error-free sequences and 68 unique CDR3s of different lengths in the error-free set. Haplotyping based on allelic diversity in IGHJ6 demonstrates association of the haplotype defined by IGHJ6*03 (100:0 ratio). This allele is also inferred in multiple other data sets, two of which can be haplotyped. In both cases the inferred allele separates appropriately from IGHV3-13*05 (P1_I69) and IGHV3-13*04 (P1_I93) as determined by haplotyping.\r\n\r\nIARC affirms the sequence as IGHV3-13*i01 at Level 1 up to and including base 319. It is acknowledged that the allele most likely carries 1 additional base, typically A, at base positions 320. Trailing \u201c.\u201d indicates IARC\u2019s opinion that the sequence is likely to contain additional 3\u2019-nucleotides for which there is insufficient evidence to make an affirmation. For use in a reference germline gene set, IARC recommends the use of the expected full length sequence.\r\n\r\n>IGHV3-13*i01\r\nGAGGTGCAGCTGGTGGAGTCTGGGGGAGGCTTGGTACAGCCTGGGGGGTCCCTGAGACTCTCCTGTGCAGCCTCTGGATTCACCTTCAGTAGCTACGACATGCACTGGGTCCGCCAAGCTACAGGAAAAGGTCTGGAGTGGGTCTCAGCTATTGGTACTGCTGGTGACACATACTATCCAGGCTCCGTGAAGGGCCGATTCACCATCTCCAGAGAAAATGCCAAGAACTCCTTGTATCTTCAAATGAACAGCCTGAGAGCCGAGGACACGGCCGTGTATTACTGTGCAAGAG.\r\n\r\nThe locus on chromosome 14 that carries human IGHV genes is highly complex. Genes may be duplicated or deleted, and identical sequences may be found in more than one gene. The name (with an \u201ci\u201d allele designation) of an inferred allele does not imply that its precise genetic location is known. It just relates to the most similar allele presently found in the IMGT database, or to the gene with the lowest alphanumeric value, should alleles of multiple genes be equally matched to the novel allele in question. No other highly similar genes have been described.\r\n\r\nAdditional information for this sequence was imported into OGRDB via bulk update with the following notes:\r\nSequence annotation is based on Genbank sample OX384051\r\nVDJbase example haplotype: P1_I10\r\nVDJbase example haplotype: P1_I69\r\nMapped by P1_I10 haplotype\r\n\r\nTR-IG NRC Report (2023-1a) allocated the IUIS name IGHV3-13*06 to this allele\r\n\r\nThe report stated:\r\n\r\nThe missing terminal nucleotide of the sequence can be confirmed as \u2018A\u2019 by reference to recent genomic sequences of Rodriguez and colleagues that are reported in the VDJbase database from eight individuals. This evidence of the terminal nucleotide is accessible via the VDJbase genomic data gene table ", "curational_tags": [ "likely_full_length" ] } ], "curation": "*Version 7*\r\nRemoved 3-30-42*01 after further review, as it is a pseudogene and there are no known ORFs at that gene position.\r\n\r\n*Version 6*\r\nAdded IGHV3-30-42*01, a paralog of IGHV3-29*01. The existence of this sequence at gene position 3-30-42 was reported in Watson et al., \"Complete Haplotype Sequence of the Human Immunoglobulin Heavy-Chain Variable, Diversity, and Joining Genes and Characterization of Allelic and Copy-Number Variation\", 2013. Existence of the sequence in AIRR-seq repertoires is confirmed by VDJbase sample P1_I64_S1.\r\n\r\n*Version 5*\r\nAdded IGHD2-21*01, IGHD2-8*02 having considered support for these alleles in Rodriguez et. al., DOI 10.1038/s41467-023-40070-x and published in VDJbase\r\nAdded likely extensions to IGHV4-30-4*i02(A), IGHV4-4*10(A) and IGHV5-51*06(CA) based on the sequences of other alleles.\r\n\r\n*Version 4*\r\nAdded 31 IGHV alleles and 3 IGHD alleles that are supported by data reported by Rodriguez et. al., DOI 10.1038/s41467-023-40070-x and published in VDJbase. The IGHV alleles and IGHD5-18*02 are supported by other observations reported in GenBank. IGHD3-10*03 and IGHD3-16*03 are observed in 14+ subjects studied by Rodriguez et al. and this is considered to provide sufficient confidence for their inclusion.\r\n\r\n*Version 3*\r\nPutative extensions were removed from alleles IGHV4-4*10, IGHV5-51*06 and IGHV4-30-3*i02 because, after further review, it was decided that the extensions had insufficient support.\r\n\r\n*Version 2*\r\nAlleles removed from this version:\r\nIGHD2-21*01, IGHD2-8*02 - Genomic evidence for these sequences (AH002720, 1981) is not considered sufficiently strong without more recent evidence.\r\nIGHV3-42D*01 - This sequence has good overall alignment with that of the closest functional allele IGHV3-72*01, and the leader intron and L-PART2 are in good agreement. In this alignment, however, there are multiple stop codons in the coding region. We consider this alignment to be more representative than that previously shown, which identified an ORF in the coding region by extending 2nt at the 5' end, hence breaking the alignment with IGHV3-72*01. In the preferred alignment, the absence of an ORF excludes this allele from the germline set.\r\n\r\n" } ] }